Krt222 (keratin 222) - Rat Genome Database

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Gene: Krt222 (keratin 222) Mus musculus
Analyze
Symbol: Krt222
Name: keratin 222
RGD ID: 1312338
MGI Page MGI
Description: Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Orthologous to human KRT222 (keratin 222).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 6330509G02Rik; keratin-222; keratin-like protein KRT222; MGC100296
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,123,587 - 99,134,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,123,587 - 99,134,911 (-)EnsemblGRCm39 Ensembl
GRCm381199,232,761 - 99,244,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,232,761 - 99,244,085 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,094,412 - 99,105,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,049,188 - 99,060,157 (-)NCBIMGSCv36mm8
Celera11108,900,276 - 108,911,243 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16831889   PMID:21267068  


Genomics

Comparative Map Data
Krt222
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391199,123,587 - 99,134,973 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1199,123,587 - 99,134,911 (-)EnsemblGRCm39 Ensembl
GRCm381199,232,761 - 99,244,147 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1199,232,761 - 99,244,085 (-)EnsemblGRCm38mm10GRCm38
MGSCv371199,094,412 - 99,105,381 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361199,049,188 - 99,060,157 (-)NCBIMGSCv36mm8
Celera11108,900,276 - 108,911,243 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1162.92NCBI
KRT222
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381740,654,665 - 40,665,177 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1740,654,665 - 40,665,181 (-)EnsemblGRCh38hg38GRCh38
GRCh371738,810,917 - 38,821,429 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361736,065,398 - 36,074,942 (-)NCBINCBI36Build 36hg18NCBI36
Celera1735,473,458 - 35,483,002 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1734,606,449 - 34,615,992 (-)NCBIHuRef
CHM1_11739,047,218 - 39,056,765 (-)NCBICHM1_1
T2T-CHM13v2.01741,519,043 - 41,529,554 (-)NCBIT2T-CHM13v2.0
Krt222
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81084,680,331 - 84,693,374 (-)NCBIGRCr8
mRatBN7.21084,184,137 - 84,196,122 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1084,186,173 - 84,196,015 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1089,127,723 - 89,139,567 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01088,625,843 - 88,637,687 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01084,017,832 - 84,029,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01087,143,200 - 87,154,142 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1087,142,116 - 87,153,982 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01086,940,303 - 86,950,131 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1082,924,965 - 82,935,907 (-)NCBICelera
Cytogenetic Map10q31NCBI
Krt222
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545115,156,315 - 15,164,917 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545115,156,315 - 15,164,607 (-)NCBIChiLan1.0ChiLan1.0
KRT222
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21924,285,935 - 24,296,577 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11726,178,036 - 26,188,669 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01716,617,558 - 16,628,193 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11716,844,671 - 16,854,197 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1716,844,671 - 16,854,197 (+)Ensemblpanpan1.1panPan2
KRT222
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1922,000,847 - 22,010,014 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl922,000,847 - 22,009,985 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha921,473,839 - 21,483,005 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0922,793,991 - 22,803,156 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl922,794,066 - 22,803,249 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1921,568,394 - 21,577,601 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0921,827,257 - 21,836,423 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0921,951,724 - 21,960,893 (+)NCBIUU_Cfam_GSD_1.0
LOC101976803
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560221,361,796 - 21,410,052 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649015,664,764 - 15,675,220 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493649015,710,649 - 15,713,290 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649015,665,846 - 15,713,288 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT222
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1221,768,304 - 21,778,892 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11221,768,053 - 21,778,893 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21222,121,795 - 22,127,114 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT222
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11665,521,578 - 65,532,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1665,521,496 - 65,532,372 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607736,403,465 - 36,414,356 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt222
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247952,698,150 - 2,706,607 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247952,698,194 - 2,708,754 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Krt222
341 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1298
Count of miRNA genes:530
Interacting mature miRNAs:630
Transcripts:ENSMUST00000038214, ENSMUST00000103132, ENSMUST00000154622
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226783Tibl5_mtibia length 5, 5 week (mouse)1168190826101890826Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166733420100733652Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1558812Rafar_mretinoic acid induced forelimb autopod reduction (mouse)Not determined1170691198104691366Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
1301404Sbmd4_mspinal bone mineral density 4 (mouse)Not determined1172019649106019734Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226758Femd3_mfemur midshaft diameter 3, 5 week (mouse)1180890826101890826Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1301681Sle13_msystematic lupus erythematosus susceptibility 13 (mouse)Not determined1170691198104691366Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166733420100733652Mouse
4141339Nilac2_mnicotine induced locomotor activity 2 (mouse)Not determined1170691198104691366Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
1357631Motr1_mmodifier of tubby retinal degeneration 1 (mouse)Not determined1187691198103274115Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172726125106726289Mouse
1301153Estq3_mestradiol regulated response QTL 3 (mouse)Not determined119689769399327028Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172818615106818733Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
1300651Pcyts3_mplasmacytoma susceptibility 3 (mouse)Not determined1170691198104691366Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166733420100733652Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
10043865T2dm5sa_mtype 2 diabetes mellitus 5 in SMXA RI mice (mouse)Not determined1179813759104502698Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172818615106818733Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166733420100733652Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166733420100733652Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66733420100733652Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
1302124Eae7_msusceptibility to experimental allergic encephalomyelitis 7 (mouse)Not determined117757387399377820Mouse

Markers in Region
D11Mit249  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381199,241,471 - 99,241,580UniSTSGRCm38
MGSCv371199,102,785 - 99,102,894UniSTSGRCm37
Celera11108,908,648 - 108,908,757UniSTS
Cytogenetic Map11DUniSTS
cM Map1161.0UniSTS
Whitehead Genetic1162.3UniSTS
Whitehead_YAC11 UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSMUST00000038214   ⟹   ENSMUSP00000044561
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,124,716 - 99,134,911 (-)Ensembl
GRCm38.p6 Ensembl1199,233,890 - 99,244,085 (-)Ensembl
Ensembl Acc Id: ENSMUST00000103132   ⟹   ENSMUSP00000099421
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,123,587 - 99,134,893 (-)Ensembl
GRCm38.p6 Ensembl1199,232,761 - 99,244,067 (-)Ensembl
Ensembl Acc Id: ENSMUST00000154622
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1199,125,769 - 99,129,701 (-)Ensembl
GRCm38.p6 Ensembl1199,234,943 - 99,238,875 (-)Ensembl
RefSeq Acc Id: NM_001361584   ⟹   NP_001348513
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,123,587 - 99,134,973 (-)NCBI
GRCm381199,232,761 - 99,244,147 (-)NCBI
Sequence:
RefSeq Acc Id: NM_172946   ⟹   NP_766534
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391199,123,587 - 99,134,973 (-)NCBI
GRCm381199,232,761 - 99,244,147 (-)NCBI
MGSCv371199,094,412 - 99,105,381 (-)RGD
Celera11108,900,276 - 108,911,243 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: NP_766534   ⟸   NM_172946
- Peptide Label: isoform 1
- UniProtKB: Q8CCX5 (UniProtKB/Swiss-Prot),   Q3UU52 (UniProtKB/Swiss-Prot),   Q68FD8 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001348513   ⟸   NM_001361584
- Peptide Label: isoform 2
Ensembl Acc Id: ENSMUSP00000099421   ⟸   ENSMUST00000103132
Ensembl Acc Id: ENSMUSP00000044561   ⟸   ENSMUST00000038214
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8CCX5-F1-model_v2 AlphaFold Q8CCX5 1-294 view protein structure

Promoters
RGD ID:6821158
Promoter ID:MM_KWN:9651
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Spleen
Transcripts:OTTMUST00000014718
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361199,099,771 - 99,100,271 (-)MPROMDB
RGD ID:6821157
Promoter ID:MM_KWN:9652
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain
Transcripts:OTTMUST00000014716,   UC007LIL.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361199,105,171 - 99,105,671 (-)MPROMDB
RGD ID:8676556
Promoter ID:EPDNEW_M16308
Type:initiation region
Name:Krt222_1
Description:Mus musculus keratin 222 , transcript variant 5, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381199,244,067 - 99,244,127EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2442728 AgrOrtholog
Ensembl Genes ENSMUSG00000035849 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000038214 ENTREZGENE
  ENSMUST00000038214.7 UniProtKB/Swiss-Prot
  ENSMUST00000103132 ENTREZGENE
  ENSMUST00000103132.10 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_Keratin-like UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_I UniProtKB/Swiss-Prot
KEGG Report mmu:268481 UniProtKB/Swiss-Prot
MGD MGI:2442728 ENTREZGENE
NCBI Gene 268481 ENTREZGENE
PANTHER KERATIN-LIKE PROTEIN KRT222 UniProtKB/Swiss-Prot
  KERATIN-LIKE PROTEIN KRT222 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
PhenoGen Krt222 PhenoGen
PRINTS TYPE1KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt KT222_MOUSE UniProtKB/Swiss-Prot
  Q3UU52 ENTREZGENE
  Q68FD8 ENTREZGENE
  Q8CCX5 ENTREZGENE
UniProt Secondary Q3UU52 UniProtKB/Swiss-Prot
  Q68FD8 UniProtKB/Swiss-Prot