Gdf1 (growth differentiation factor 1) - Rat Genome Database
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Gene: Gdf1 (growth differentiation factor 1) Mus musculus
Analyze
Symbol: Gdf1
Name: growth differentiation factor 1
RGD ID: 1312262
MGI Page MGI
Description: Is expressed in several structures, including embryo mesoderm; female reproductive system; future midbrain; nervous system; and primitive streak. Used to study annular pancreas. Human ortholog(s) of this gene implicated in dextro-looped transposition of the great arteries 3 and visceral heterotaxy. Orthologous to human GDF1 (growth differentiation factor 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AI385651; embryonic growth/differentiation factor 1; Gdf-1
RGD Orthologs
Human
Rat
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,768,425 - 70,784,242 (+)NCBIGRCm39mm39
GRCm39 Ensembl870,768,425 - 70,784,242 (+)Ensembl
GRCm39 Ensembl870,782,467 - 70,784,237 (+)Ensembl
GRCm38870,315,775 - 70,331,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,315,775 - 70,331,592 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl870,329,817 - 70,331,587 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,839,674 - 72,855,487 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,252,436 - 73,260,555 (+)NCBImm8
Celera872,872,244 - 72,888,065 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal anterior visceral endoderm cell migration  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digestive system morphology  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal kidney morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal primitive streak elongation  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal vena cava morphology  (IAGP)
absent anterior visceral endoderm  (IAGP)
absent mandible  (IAGP)
absent mesoderm  (IAGP)
absent notochord  (IAGP)
absent prechordal plate  (IAGP)
absent tongue  (IAGP)
annular pancreas  (IAGP)
atrial septal defect  (IAGP)
cleft upper lip  (IAGP)
complete atrioventricular septal defect  (IAGP)
decreased survivor rate  (IAGP)
dextrocardia  (IAGP)
embryonic lethality between implantation and somite formation, incomplete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
fused first pharyngeal arch  (IAGP)
heterotaxia  (IAGP)
holoprosencephaly  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
nasal septum hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
right pulmonary isomerism  (IAGP)
rostral body truncation  (IAGP)
situs inversus  (IAGP)
transposition of great arteries  (IAGP)
truncated notochord  (IAGP)
ventricular septal defect  (IAGP)
References

Additional References at PubMed
PMID:1460021   PMID:1704486   PMID:2034669   PMID:10349636   PMID:10700179   PMID:11042159   PMID:11071769   PMID:11076861   PMID:11217851   PMID:11353399   PMID:11440720   PMID:11517919  
PMID:12231623   PMID:12466851   PMID:12477932   PMID:12514096   PMID:12654299   PMID:15342483   PMID:16141072   PMID:16141073   PMID:16368929   PMID:16564040   PMID:16602821   PMID:16679559  
PMID:17210915   PMID:17936261   PMID:18079174   PMID:18615710   PMID:18697220   PMID:18981480   PMID:19879143   PMID:21047506   PMID:21873635   PMID:22307612   PMID:22412348   PMID:22554696  
PMID:22560297   PMID:22627279   PMID:22983710   PMID:23742838   PMID:24275554   PMID:24780629   PMID:24798330   PMID:24801048   PMID:24952961   PMID:25224222   PMID:25726944   PMID:26212015  
PMID:29650695   PMID:31676717  


Genomics

Comparative Map Data
Gdf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39870,768,425 - 70,784,242 (+)NCBIGRCm39mm39
GRCm39 Ensembl870,768,425 - 70,784,242 (+)Ensembl
GRCm39 Ensembl870,782,467 - 70,784,237 (+)Ensembl
GRCm38870,315,775 - 70,331,592 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,315,775 - 70,331,592 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl870,329,817 - 70,331,587 (+)EnsemblGRCm38mm10GRCm38
MGSCv37872,839,674 - 72,855,487 (+)NCBIGRCm37mm9NCBIm37
MGSCv36873,252,436 - 73,260,555 (+)NCBImm8
Celera872,872,244 - 72,888,065 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
GDF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1918,868,545 - 18,896,158 (-)EnsemblGRCh38hg38GRCh38
GRCh381918,868,545 - 18,896,158 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371918,979,354 - 19,006,967 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,840,354 - 18,842,116 (-)NCBINCBI36hg18NCBI36
Build 341918,840,353 - 18,867,953NCBI
Celera1918,884,162 - 18,911,776 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1918,543,712 - 18,569,342 (-)NCBIHuRef
CHM1_11918,979,164 - 19,006,647 (-)NCBICHM1_1
Gdf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21619,097,309 - 19,112,519 (-)NCBI
Rnor_6.0 Ensembl1620,845,576 - 20,860,767 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01620,845,580 - 20,860,789 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01620,698,122 - 20,712,564 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,580,807 - 19,596,415 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11619,580,804 - 19,583,914 (-)NCBI
Celera1619,287,577 - 19,302,834 (-)NCBICelera
Cytogenetic Map16p14NCBI
GDF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,233,304 - 44,234,072 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gdf1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365962,467,428 - 2,469,213 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GDF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl258,951,726 - 58,974,672 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1258,972,918 - 58,976,294 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2258,560,688 - 58,564,421 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GDF1
(Chlorocebus sabaeus - African green monkey)
No map positions available.
Gdf1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249081,935,525 - 1,937,012 (-)NCBI

Position Markers
Gdf1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,381 - 70,331,527UniSTSGRCm38
MGSCv37872,855,280 - 72,855,426UniSTSGRCm37
Celera872,887,858 - 72,888,004UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map8 UniSTS
AI385651  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,438 - 70,331,536UniSTSGRCm38
MGSCv37872,855,337 - 72,855,435UniSTSGRCm37
Celera872,887,915 - 72,888,013UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8743.32UniSTS
UniSTS:235917  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,749 - 70,331,854UniSTSGRCm38
MGSCv37872,855,648 - 72,855,753UniSTSGRCm37
Celera872,888,226 - 72,888,331UniSTS
Cytogenetic Map8B3.3UniSTS
RH139099  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38870,331,392 - 70,331,538UniSTSGRCm38
MGSCv37872,855,291 - 72,855,437UniSTSGRCm37
Celera872,887,869 - 72,888,015UniSTS
Cytogenetic Map8B3.3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1558870Eae36_mexperimental allergic encephalomyelitis susceptibility 36 (mouse)Not determined81472316071045600Mouse
1357811Orq3_movulation rate QTL 3 (mouse)Not determined83201654471287993Mouse
4141437W10q14_mweight 10 weeks QTL 14 (mouse)Not determined3201654471287993Mouse
4141172W6q9_mweight 6 weeks QTL 9 (mouse)Not determined3201654471287993Mouse
4140966Egq12_mearly growth QTL 12 (mouse)Not determined3201654471287993Mouse
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:254
Count of miRNA genes:123
Interacting mature miRNAs:126
Transcripts:ENSMUST00000046516, ENSMUST00000165819
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000136257
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,318,350 - 70,322,689 (+)Ensembl
RefSeq Acc Id: ENSMUST00000140239   ⟹   ENSMUSP00000120598
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,315,787 - 70,331,587 (+)Ensembl
RefSeq Acc Id: ENSMUST00000165819   ⟹   ENSMUSP00000128325
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,315,775 - 70,331,592 (+)Ensembl
RefSeq Acc Id: ENSMUST00000207684   ⟹   ENSMUSP00000146749
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl870,329,817 - 70,331,587 (+)Ensembl
RefSeq Acc Id: NM_001163282   ⟹   NP_001156754
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,768,425 - 70,784,242 (+)NCBI
GRCm38870,315,775 - 70,331,592 (+)NCBI
MGSCv37872,839,674 - 72,855,487 (+)RGD
Celera872,872,244 - 72,888,069 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008107   ⟹   NP_032133
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39870,782,415 - 70,784,238 (+)NCBI
GRCm38870,329,765 - 70,331,588 (+)NCBI
MGSCv37872,839,674 - 72,855,487 (+)RGD
Celera872,872,244 - 72,888,069 (+)NCBI
cM Map8 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032133   ⟸   NM_008107
- Peptide Label: precursor
- UniProtKB: P20863 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001156754   ⟸   NM_001163282
- Peptide Label: precursor
- UniProtKB: P20863 (UniProtKB/Swiss-Prot),   A2RT05 (UniProtKB/TrEMBL),   Q3TRG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000128325   ⟸   ENSMUST00000165819
RefSeq Acc Id: ENSMUSP00000120598   ⟸   ENSMUST00000140239
RefSeq Acc Id: ENSMUSP00000146749   ⟸   ENSMUST00000207684
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:95683 AgrOrtholog
Ensembl Genes ENSMUSG00000087408 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSG00000109523 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000128325 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000146749 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000165819 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000207684 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLC-dom UniProtKB/TrEMBL
KEGG Report mmu:14559 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  mmu:93898 UniProtKB/TrEMBL
MGD MGI:95683 ENTREZGENE
NCBI Gene 14559 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRAM_LAG1_CLN8 UniProtKB/TrEMBL
PhenoGen Gdf1 PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TLC UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A2RT05 ENTREZGENE, UniProtKB/TrEMBL
  GDF1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3TRG1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6AXH1 UniProtKB/Swiss-Prot