Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (1->4)-beta-D-glucan | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TOLLIP mRNA | CTD | PMID:36331819 | 1,2-dimethylhydrazine | decreases expression | ISO | Tollip (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of TOLLIP mRNA | CTD | PMID:22206623 | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | 2,2',5,5'-tetrachlorobiphenyl | decreases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Tollip (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of TOLLIP mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in decreased expression of TOLLIP mRNA | CTD | PMID:25975270 | 2,4,6-tribromophenol | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:31675489 | 3,3',5,5'-tetrabromobisphenol A | decreases expression | EXP | | 6480464 | tetrabromobisphenol A results in decreased expression of TOLLIP protein | CTD | PMID:31675489 | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Tollip (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of TOLLIP mRNA | CTD | PMID:20188158 | 4,4'-diaminodiphenylmethane | increases expression | ISO | Tollip (Mus musculus) | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of TOLLIP mRNA | CTD | PMID:18648102 | 4,4'-sulfonyldiphenol | multiple interactions | ISO | Tollip (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TOLLIP mRNA | CTD | PMID:36041667 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of TOLLIP mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases methylation | EXP | | 6480464 | Aflatoxin B1 results in increased methylation of TOLLIP promoter | CTD | PMID:30157460 | aristolochic acid A | increases expression | EXP | | 6480464 | aristolochic acid I results in increased expression of TOLLIP mRNA | CTD | PMID:33212167 | arsane | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of TOLLIP gene | CTD | PMID:25304211 | arsenic atom | affects methylation | EXP | | 6480464 | Arsenic affects the methylation of TOLLIP gene | CTD | PMID:25304211 | benzo[a]pyrene | affects methylation | EXP | | 6480464 | Benzo(a)pyrene affects the methylation of TOLLIP 3' UTR and Benzo(a)pyrene affects the methylation of TOLLIP intron | CTD | PMID:27901495 and PMID:30157460 | bisphenol A | affects expression | ISO | Tollip (Rattus norvegicus) | 6480464 | bisphenol A affects the expression of TOLLIP mRNA | CTD | PMID:25181051 | bisphenol A | multiple interactions | ISO | Tollip (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TOLLIP mRNA | CTD | PMID:36041667 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TOLLIP gene | CTD | PMID:31601247 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of TOLLIP protein | CTD | PMID:31675489 and PMID:34186270 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of TOLLIP mRNA | CTD | PMID:29275510 | Bisphenol B | increases expression | EXP | | 6480464 | bisphenol B results in increased expression of TOLLIP protein | CTD | PMID:34186270 | bisphenol F | increases expression | EXP | | 6480464 | bisphenol F results in increased expression of TOLLIP protein | CTD | PMID:34186270 | bisphenol F | multiple interactions | ISO | Tollip (Rattus norvegicus) | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of TOLLIP mRNA | CTD | PMID:36041667 | butanal | decreases expression | EXP | | 6480464 | butyraldehyde results in decreased expression of TOLLIP mRNA | CTD | PMID:26079696 | C60 fullerene | decreases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | fullerene C60 results in decreased expression of TOLLIP mRNA | CTD | PMID:19167457 | cadmium dichloride | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Cadmium Chloride results in increased expression of TOLLIP mRNA | CTD | PMID:33453195 | cadmium dichloride | increases expression | EXP | | 6480464 | Cadmium Chloride results in increased expression of TOLLIP mRNA | CTD | PMID:33129824 | cadmium selenide | multiple interactions | EXP | | 6480464 | [cadmium selenide co-treated with zinc sulfide] results in increased expression of TOLLIP mRNA | CTD | PMID:22342292 | carbamazepine | affects expression | EXP | | 6480464 | Carbamazepine affects the expression of TOLLIP mRNA | CTD | PMID:25979313 | carbon nanotube | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 and PMID:25620056 | ceric oxide | decreases expression | EXP | | 6480464 | ceric oxide analog results in decreased expression of TOLLIP mRNA | CTD | PMID:24821434 | chloroprene | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Chloroprene results in increased expression of TOLLIP mRNA | CTD | PMID:23125180 | clobetasol | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Clobetasol results in increased expression of TOLLIP mRNA | CTD | PMID:27462272 | corn oil | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Corn Oil results in increased expression of TOLLIP mRNA | CTD | PMID:33263755 | decabromodiphenyl ether | decreases expression | EXP | | 6480464 | decabromobiphenyl ether results in decreased expression of TOLLIP protein | CTD | PMID:31675489 | dextran sulfate | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | 7-hydroxyl-1-methylindole-3-acetonitrile inhibits the reaction [Dextran Sulfate results in decreased expression of TOLLIP protein] and Mesalamine inhibits the reaction [Dextran Sulfate results in decreased expression of TOLLIP protein] | CTD | PMID:36543318 | dextran sulfate | decreases expression | ISO | Tollip (Mus musculus) | 6480464 | Dextran Sulfate results in decreased expression of TOLLIP protein | CTD | PMID:36543318 | doxorubicin | multiple interactions | ISO | Tollip (Rattus norvegicus) | 6480464 | [Doxorubicin co-treated with Fungal Polysaccharides] results in decreased expression of TOLLIP mRNA | CTD | PMID:27181935 | endosulfan | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Endosulfan results in increased expression of TOLLIP mRNA | CTD | PMID:29391264 | enzyme inhibitor | multiple interactions | EXP | | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of TOLLIP protein | CTD | PMID:23301498 | epoxiconazole | decreases expression | ISO | Tollip (Mus musculus) | 6480464 | epoxiconazole results in decreased expression of TOLLIP mRNA | CTD | PMID:35436446 | erlotinib hydrochloride | multiple interactions | EXP | | 6480464 | [Erlotinib Hydrochloride results in decreased susceptibility to Erlotinib Hydrochloride] which results in increased expression of TOLLIP mRNA | CTD | PMID:27738319 | ethanol | affects splicing | ISO | Tollip (Mus musculus) | 6480464 | Ethanol affects the splicing of TOLLIP mRNA | CTD | PMID:30319688 | ferroheme b | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Heme metabolite results in increased expression of TOLLIP mRNA | CTD | PMID:19191707 | fulvestrant | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Fulvestrant] results in increased methylation of TOLLIP gene | CTD | PMID:31601247 | gentamycin | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Gentamicins results in increased expression of TOLLIP mRNA | CTD | PMID:33387578 | heme b | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Heme metabolite results in increased expression of TOLLIP mRNA | CTD | PMID:19191707 | indoles | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Indoles results in increased expression of TOLLIP mRNA | CTD | PMID:20521778 | indoles | decreases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Indoles results in decreased expression of TOLLIP mRNA | CTD | PMID:20521778 | ivermectin | decreases expression | EXP | | 6480464 | Ivermectin results in decreased expression of TOLLIP protein | CTD | PMID:32959892 | mesalamine | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | Mesalamine inhibits the reaction [Dextran Sulfate results in decreased expression of TOLLIP protein] | CTD | PMID:36543318 | neoechinulin A | increases expression | ISO | Tollip (Mus musculus) | 6480464 | neoechinulin A results in increased expression of TOLLIP mRNA | CTD | PMID:19818335 | ozone | multiple interactions | EXP | | 6480464 | [Air Pollutants results in increased abundance of Ozone] which affects the expression of TOLLIP mRNA | CTD | PMID:35430440 | paracetamol | affects expression | ISO | Tollip (Mus musculus) | 6480464 | Acetaminophen affects the expression of TOLLIP mRNA | CTD | PMID:17562736 | paracetamol | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Acetaminophen results in increased expression of TOLLIP mRNA | CTD | PMID:33387578 | paraquat | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Paraquat results in increased expression of TOLLIP protein | CTD | PMID:24521700 | paraquat | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | rhyncophylline promotes the reaction [Paraquat results in increased expression of TOLLIP mRNA] more ... | CTD | PMID:33838153 | paraquat | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Paraquat results in increased expression of TOLLIP mRNA and Paraquat results in increased expression of TOLLIP protein | CTD | PMID:33838153 | PCB138 | decreases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | 2 more ... | CTD | PMID:23829299 | pentanal | decreases expression | EXP | | 6480464 | pentanal results in decreased expression of TOLLIP mRNA | CTD | PMID:26079696 | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of TOLLIP mRNA | CTD | PMID:36331819 | phenobarbital | affects expression | ISO | Tollip (Mus musculus) | 6480464 | Phenobarbital affects the expression of TOLLIP mRNA | CTD | PMID:23091169 | propiconazole | decreases expression | ISO | Tollip (Mus musculus) | 6480464 | propiconazole results in decreased expression of TOLLIP mRNA | CTD | PMID:21278054 | quercetin | increases expression | ISO | Tollip (Mus musculus) | 6480464 | Quercetin results in increased expression of TOLLIP protein | CTD | PMID:23353651 | quercetin | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | TOLLIP protein affects the reaction [Quercetin inhibits the reaction [lipopolysaccharide more ... | CTD | PMID:23353651 | Rhynchophylline | increases expression | ISO | Tollip (Mus musculus) | 6480464 | rhyncophylline results in increased expression of TOLLIP mRNA and rhyncophylline results in increased expression of TOLLIP protein | CTD | PMID:33838153 | Rhynchophylline | multiple interactions | ISO | Tollip (Mus musculus) | 6480464 | rhyncophylline promotes the reaction [Paraquat results in increased expression of TOLLIP mRNA] more ... | CTD | PMID:33838153 | rotenone | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Rotenone results in increased expression of TOLLIP protein | CTD | PMID:35544339 | serpentine asbestos | increases expression | EXP | | 6480464 | Asbestos and Serpentine results in increased expression of TOLLIP mRNA | CTD | PMID:21148743 | silicon dioxide | increases expression | EXP | | 6480464 | Silicon Dioxide results in increased expression of TOLLIP mRNA | CTD | PMID:19428942 | silver atom | increases expression | EXP | | 6480464 | Silver results in increased expression of TOLLIP mRNA | CTD | PMID:22342292 | silver(0) | increases expression | EXP | | 6480464 | Silver results in increased expression of TOLLIP mRNA | CTD | PMID:22342292 | sodium arsenite | decreases expression | ISO | Tollip (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of TOLLIP mRNA | CTD | PMID:21911445 and PMID:31233874 | sunitinib | increases expression | EXP | | 6480464 | Sunitinib results in increased expression of TOLLIP mRNA | CTD | PMID:31533062 | testosterone | decreases expression | ISO | Tollip (Mus musculus) | 6480464 | Testosterone results in decreased expression of TOLLIP mRNA | CTD | PMID:21669218 | thioacetamide | increases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | Thioacetamide results in increased expression of TOLLIP mRNA | CTD | PMID:34492290 | titanium dioxide | decreases expression | EXP | | 6480464 | titanium dioxide results in decreased expression of TOLLIP mRNA | CTD | PMID:22342292 | TMC-120A | increases expression | ISO | Tollip (Mus musculus) | 6480464 | TMC 120A results in increased expression of TOLLIP mRNA | CTD | PMID:19818335 | trimethyltin | increases expression | ISO | Tollip (Mus musculus) | 6480464 | trimethyltin results in increased expression of TOLLIP mRNA | CTD | PMID:21435392 | triptonide | increases expression | ISO | Tollip (Mus musculus) | 6480464 | triptonide results in increased expression of TOLLIP mRNA | CTD | PMID:33045310 | vinclozolin | affects expression | ISO | Tollip (Rattus norvegicus) | 6480464 | vinclozolin affects the expression of TOLLIP mRNA | CTD | PMID:19015723 | zinc protoporphyrin | decreases expression | ISO | Tollip (Rattus norvegicus) | 6480464 | zinc protoporphyrin results in decreased expression of TOLLIP protein | CTD | PMID:25780291 | zoledronic acid | increases expression | EXP | | 6480464 | zoledronic acid results in increased expression of TOLLIP mRNA | CTD | PMID:20977926 | |