Clybl (citrate lyase beta like) - Rat Genome Database

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Gene: Clybl (citrate lyase beta like) Mus musculus
Analyze
Symbol: Clybl
Name: citrate lyase beta like
RGD ID: 1312157
MGI Page MGI
Description: Enables (S)-citramalyl-CoA lyase activity. Involved in positive regulation of cobalamin metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human CLYBL (citramalyl-CoA lyase); INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: (3S)-malyl-CoA thioesterase; 0610033J05Rik; 2310014M14Rik; AI256068; beta-methylmalate synthase; citramalyl-CoA lyase, mitochondrial; citrate lyase beta-like; citrate lyase subunit beta-like protein, mitochondrial; Cl; Clb; malate synthase
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,408,289 - 122,639,646 (+)NCBIGRCm39mm39
GRCm39 Ensembl14122,419,116 - 122,639,646 (+)Ensembl
GRCm3814122,170,994 - 122,402,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,181,704 - 122,402,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714122,580,916 - 122,801,456 (+)NCBIGRCm37mm9NCBIm37
MGSCv3614121,316,901 - 121,537,408 (+)NCBImm8
Celera14120,744,413 - 120,964,342 (+)NCBICelera
Cytogenetic Map14E5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
4-hydroxyphenyl retinamide  (EXP)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
aristolochic acid  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (ISO)
cadmium dichloride  (EXP,ISO)
chlordecone  (EXP)
choline  (EXP)
ciguatoxin CTX1B  (EXP)
cisplatin  (EXP,ISO)
clobetasol  (EXP)
clofibric acid  (ISO)
cocaine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclosporin A  (EXP,ISO)
daunorubicin  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
dorsomorphin  (ISO)
endosulfan  (ISO)
folic acid  (EXP)
glyphosate  (ISO)
hydralazine  (ISO)
indole-3-methanol  (ISO)
L-methionine  (EXP)
lipopolysaccharide  (ISO)
MeIQx  (ISO)
methyl methanesulfonate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (EXP)
pirinixic acid  (EXP)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium fluoride  (EXP)
sulforaphane  (EXP)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11741334   PMID:12477932   PMID:12520002   PMID:14610273   PMID:14681479   PMID:16141072   PMID:16141073   PMID:16919269  
PMID:17062627   PMID:17967808   PMID:18614015   PMID:18799693   PMID:21267068   PMID:21873635   PMID:24194600   PMID:29056341   PMID:32325033  


Genomics

Comparative Map Data
Clybl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914122,408,289 - 122,639,646 (+)NCBIGRCm39mm39
GRCm39 Ensembl14122,419,116 - 122,639,646 (+)Ensembl
GRCm3814122,170,994 - 122,402,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14122,181,704 - 122,402,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv3714122,580,916 - 122,801,456 (+)NCBIGRCm37mm9NCBIm37
MGSCv3614121,316,901 - 121,537,408 (+)NCBImm8
Celera14120,744,413 - 120,964,342 (+)NCBICelera
Cytogenetic Map14E5NCBI
CLYBL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1399,606,669 - 99,897,134 (+)EnsemblGRCh38hg38GRCh38
GRCh381399,606,690 - 99,909,444 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3713100,258,918 - 100,561,698 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361399,056,937 - 99,342,825 (+)NCBINCBI36hg18NCBI36
Build 341399,056,936 - 99,342,824NCBI
Celera1381,103,446 - 81,393,885 (+)NCBI
Cytogenetic Map13q32.3NCBI
HuRef1380,853,642 - 81,143,528 (+)NCBIHuRef
CHM1_113100,228,927 - 100,519,376 (+)NCBICHM1_1
Clybl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21599,283,644 - 99,505,697 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1599,283,650 - 99,505,695 (+)Ensembl
Rnor_6.015108,608,203 - 108,838,222 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15108,608,204 - 108,838,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015111,996,327 - 112,224,036 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415107,313,924 - 107,539,458 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.115107,403,371 - 107,555,046 (+)NCBI
Celera1598,056,530 - 98,276,073 (+)NCBICelera
Cytogenetic Map15q25NCBI
Clybl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540410,814,307 - 11,034,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540410,813,161 - 11,016,687 (-)NCBIChiLan1.0ChiLan1.0
CLYBL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11399,912,758 - 100,198,856 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1399,912,773 - 100,195,417 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01380,774,572 - 81,066,375 (+)NCBIMhudiblu_PPA_v0panPan3
CLYBL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12249,608,997 - 49,893,766 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2249,608,358 - 49,871,572 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2249,389,904 - 49,674,862 (+)NCBI
ROS_Cfam_1.02250,050,746 - 50,335,889 (+)NCBI
UMICH_Zoey_3.12249,702,099 - 50,000,006 (+)NCBI
UNSW_CanFamBas_1.02249,735,357 - 50,033,523 (+)NCBI
UU_Cfam_GSD_1.02249,772,072 - 50,070,593 (+)NCBI
Clybl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945185,032,471 - 185,285,822 (+)NCBI
SpeTri2.0NW_00493647210,666,345 - 10,919,694 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLYBL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1168,507,877 - 68,767,546 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11168,507,828 - 68,768,322 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21175,887,675 - 76,025,089 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CLYBL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1378,258,096 - 78,574,515 (+)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604634,754,124 - 35,069,782 (+)NCBIVero_WHO_p1.0
Clybl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479311,240,495 - 11,479,386 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
BB357638  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,365,325 - 122,365,454UniSTSGRCm38
MGSCv3714122,764,547 - 122,764,676UniSTSGRCm37
Celera14120,927,427 - 120,927,556UniSTS
Cytogenetic Map14E5UniSTS
Whitehead/MRC_RH141278.17UniSTS
AI256068  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,384,204 - 122,384,289UniSTSGRCm38
MGSCv3714122,783,426 - 122,783,511UniSTSGRCm37
Celera14120,946,306 - 120,946,391UniSTS
Cytogenetic Map14E5UniSTS
Whitehead/MRC_RH141278.05UniSTS
Clybl  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map14E5UniSTS
cM Map14 UniSTS
UniSTS:224844  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,292,877 - 122,292,993UniSTSGRCm38
MGSCv3714122,692,099 - 122,692,215UniSTSGRCm37
Celera14120,855,429 - 120,855,545UniSTS
Cytogenetic Map14E5UniSTS
D15Rat157  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3814122,381,415 - 122,381,593UniSTSGRCm38
MGSCv3714122,780,637 - 122,780,815UniSTSGRCm37
Celera14120,943,517 - 120,943,695UniSTS
Cytogenetic Map14E5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755523Hgb2_mhemoglobin 2 (mouse)14105647242124902244Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:142
Count of miRNA genes:136
Interacting mature miRNAs:140
Transcripts:ENSMUST00000026625
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000026625   ⟹   ENSMUSP00000026625
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,419,116 - 122,639,646 (+)Ensembl
GRCm38.p6 Ensembl14122,181,704 - 122,402,234 (+)Ensembl
RefSeq Acc Id: ENSMUST00000226136
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl14122,495,453 - 122,639,639 (+)Ensembl
GRCm38.p6 Ensembl14122,258,041 - 122,402,227 (+)Ensembl
RefSeq Acc Id: NM_029556   ⟹   NP_083832
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,419,106 - 122,639,646 (+)NCBI
GRCm3814122,181,694 - 122,402,234 (+)NCBI
MGSCv3714122,580,916 - 122,801,456 (+)RGD
Celera14120,744,413 - 120,964,342 (+)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030247994   ⟹   XP_030103854
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,517,503 - 122,639,640 (+)NCBI
GRCm3814122,280,091 - 122,402,228 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247996   ⟹   XP_030103856
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,612,830 - 122,639,646 (+)NCBI
GRCm3814122,375,418 - 122,402,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030247997   ⟹   XP_030103857
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,610,106 - 122,639,646 (+)NCBI
GRCm3814122,375,218 - 122,402,234 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158840   ⟹   XP_036014733
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3914122,408,289 - 122,639,640 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_083832   ⟸   NM_029556
- Peptide Label: precursor
- UniProtKB: Q8R4N0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030103854   ⟸   XM_030247994
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030103857   ⟸   XM_030247997
- Peptide Label: isoform X3
RefSeq Acc Id: XP_030103856   ⟸   XM_030247996
- Peptide Label: isoform X3
RefSeq Acc Id: ENSMUSP00000026625   ⟸   ENSMUST00000026625
RefSeq Acc Id: XP_036014733   ⟸   XM_036158840
- Peptide Label: isoform X1

Promoters
RGD ID:8683268
Promoter ID:EPDNEW_M19664
Type:multiple initiation site
Name:Clybl_1
Description:Mus musculus citrate lyase beta like , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3814122,181,716 - 122,181,776EPDNEW
RGD ID:6824784
Promoter ID:MM_KWN:17860
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:NM_029556
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3614122,580,619 - 122,581,119 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1916884 AgrOrtholog
Ensembl Genes ENSMUSG00000025545 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000026625 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000026625 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.60 UniProtKB/Swiss-Prot
InterPro Aldolase/citrate-lyase_domain UniProtKB/Swiss-Prot
  Citramalyl-CoA_lyase UniProtKB/Swiss-Prot
  Citrate_lyase_beta/mcl1/mcl2 UniProtKB/Swiss-Prot
  Pyrv/PenolPyrv_Kinase-like_dom UniProtKB/Swiss-Prot
  Pyrv_Kinase-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report mmu:69634 UniProtKB/Swiss-Prot
MGD MGI:1916884 ENTREZGENE
NCBI Gene 69634 ENTREZGENE
PANTHER PTHR11105 UniProtKB/Swiss-Prot
Pfam HpcH_HpaI UniProtKB/Swiss-Prot
PhenoGen Clybl PhenoGen
PIRSF Cit_lyase_B UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51621 UniProtKB/Swiss-Prot
UniProt CLYBL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9D7D0 UniProtKB/Swiss-Prot