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Gene: FEM1B (fem-1 homolog B) Homo sapiens
Symbol: FEM1B
Name: fem-1 homolog B
Description: This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp451E0710; F1A-ALPHA; F1AA; fem-1 homolog b (C. elegans); FEM-1-like death receptor binding protein; fem-1-like death receptor-binding protein alpha; fem-1-like in apoptotic pathway protein alpha; FEM1-beta; FIAA; protein fem-1 homolog B
Mus musculus (house mouse) : Fem1b (feminization 1 homolog b (C. elegans))  MGI  Alliance
Rattus norvegicus (Norway rat) : Fem1b (fem-1 homolog B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fem1b (fem-1 homolog B)
Pan paniscus (bonobo/pygmy chimpanzee) : FEM1B (fem-1 homolog B)
Canis lupus familiaris (dog) : FEM1B (fem-1 homolog B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fem1b (fem-1 homolog B)
Sus scrofa (pig) : FEM1B (fem-1 homolog B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381568,277,803 - 68,295,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371568,570,141 - 68,583,640 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361566,357,195 - 66,370,694 (+)NCBINCBI36hg18NCBI36
Build 341566,357,194 - 66,370,693NCBI
Celera1545,455,064 - 45,468,563 (+)NCBI
Cytogenetic Map15q23NCBI
HuRef1545,400,895 - 45,414,396 (+)NCBIHuRef
CHM1_11568,688,084 - 68,706,153 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FEM1B
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1312083
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.