Pglyrp3 (peptidoglycan recognition protein 3) - Rat Genome Database

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Gene: Pglyrp3 (peptidoglycan recognition protein 3) Mus musculus
Analyze
Symbol: Pglyrp3
Name: peptidoglycan recognition protein 3
RGD ID: 1312064
MGI Page MGI
Description: Predicted to enable peptidoglycan binding activity; peptidoglycan immune receptor activity; and protein heterodimerization activity. Acts upstream of or within biological process involved in interaction with host; negative regulation of natural killer cell differentiation involved in immune response; and negative regulation of type II interferon production. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Is expressed in several structures, including adrenal gland; alimentary system; immune system; nervous system; and testis. Orthologous to human PGLYRP3 (peptidoglycan recognition protein 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Gm420; peptidoglycan recognition protein I-alpha; peptidoglycan recognition protein intermediate alpha; PGLYRPIalpha; PGRP-I-alpha
RGD Orthologs
Human
Rat
Bonobo
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39391,919,784 - 91,939,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl391,921,890 - 91,938,889 (+)EnsemblGRCm39 Ensembl
GRCm38392,012,477 - 92,032,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl392,014,583 - 92,031,582 (+)EnsemblGRCm38mm10GRCm38
MGSCv37391,818,505 - 91,835,506 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36392,100,539 - 92,117,511 (+)NCBIMGSCv36mm8
Celera392,058,137 - 92,075,140 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map340.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mouse MP Annotation Import Pipeline RGD automated import pipeline
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11461926   PMID:12477932   PMID:14681479   PMID:15177568   PMID:19218085   PMID:20709292   PMID:21677750   PMID:21873635   PMID:21949809   PMID:22048773   PMID:25114103   PMID:26332373  
PMID:26727498   PMID:33242664  


Genomics

Comparative Map Data
Pglyrp3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39391,919,784 - 91,939,979 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl391,921,890 - 91,938,889 (+)EnsemblGRCm39 Ensembl
GRCm38392,012,477 - 92,032,672 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl392,014,583 - 92,031,582 (+)EnsemblGRCm38mm10GRCm38
MGSCv37391,818,505 - 91,835,506 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36392,100,539 - 92,117,511 (+)NCBIMGSCv36mm8
Celera392,058,137 - 92,075,140 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map340.14NCBI
PGLYRP3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381153,297,116 - 153,312,952 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1153,297,116 - 153,312,952 (-)EnsemblGRCh38hg38GRCh38
GRCh371153,269,592 - 153,285,428 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361151,536,962 - 151,549,818 (-)NCBINCBI36Build 36hg18NCBI36
Build 341150,083,410 - 150,096,267NCBI
Celera1126,341,592 - 126,354,452 (-)NCBICelera
Cytogenetic Map1q21.3NCBI
HuRef1124,633,740 - 124,646,602 (-)NCBIHuRef
CHM1_11154,666,093 - 154,678,953 (-)NCBICHM1_1
T2T-CHM13v2.01152,434,316 - 152,450,166 (-)NCBIT2T-CHM13v2.0
Pglyrp3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82180,174,931 - 180,186,007 (+)NCBIGRCr8
mRatBN7.22177,479,693 - 177,490,769 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2177,477,407 - 177,490,736 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl2176,855,732 - 176,874,162 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2185,048,028 - 185,059,108 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02183,029,793 - 183,040,875 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02177,691,068 - 177,702,156 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02191,903,626 - 192,264,872 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2192,253,629 - 192,264,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02212,601,539 - 212,612,694 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42184,874,939 - 184,884,692 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2172,755,048 - 172,764,801 (-)NCBICelera
Cytogenetic Map2q34NCBI
PGLYRP3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2196,530,820 - 96,547,093 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1196,266,535 - 96,282,804 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01128,642,034 - 128,656,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11132,270,957 - 132,283,860 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1132,270,957 - 132,283,860 (-)Ensemblpanpan1.1panPan2
PGLYRP3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl496,261,775 - 96,277,521 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1496,261,753 - 96,277,521 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24105,188,384 - 105,204,112 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PGLYRP3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12010,445,996 - 10,459,908 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2010,446,660 - 10,459,478 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660389,915,686 - 9,929,417 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Pglyrp3
1205 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:81
Count of miRNA genes:79
Interacting mature miRNAs:80
Transcripts:ENSMUST00000047660
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33265060142405761Mouse
4142399Aec1_mautoimmune exocrinopathy 1 (mouse)Not determined7586174102690034Mouse
26884427Cvht4_mcranial vault height 4, 10 week (mouse)316054164109707316Mouse
13207570Tcq12_mtotal cholesterol QTL 12 (mouse)316504164130163649Mouse
26884422Cvht7_mcranial vault height 7, 16 week (mouse)328954149118893649Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330067588147304689Mouse
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337174862143353183Mouse
13208566Bmiq5_mbody mass index QTL 5 (mouse)340954435115793649Mouse
26884380Skwq1_mskull length QTL 1, 5 week (mouse)343954435101607316Mouse
26884378Skwq6_mskull length QTL 6, 10 week (mouse)351907421102307316Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352207421137205761Mouse
11039519Ltpr3_mLeishmania tropica response 3 (mouse)356704102100464137Mouse
12880419V125Dq4_mvitamin D active form serum level QTL 4 (mouse)35890730792907307Mouse
4141294Bmd24_mbone mineral density 24 (mouse)Not determined36174006195740241Mouse
1301971Cia5_mcollagen induced arthritis QTL 5 (mouse)Not determined366046658100046795Mouse
25314313Syncl1_msynaptonemal complex length 1 (mouse)367907333128393649Mouse
11251721Ewc3_methanol withdrawal and consumption 3 (mouse)369568554103568554Mouse
1301791Char4_mP. chabaudi malaria resistance QTL 4 (mouse)Not determined369625509100655290Mouse
1301422Sle11_msystematic lupus erythematosus susceptibility 11 (mouse)Not determined370208904104209042Mouse
11049572Lmr11c_mleishmaniasis resistance 11c (mouse)372139967106140094Mouse
1300982Lmr11_mleishmaniasis resistance 11 (mouse)Not determined372139967106140094Mouse
1300595Tmevd2_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 2 (mouse)Not determined375463302109463549Mouse
1301392Eae3_msusceptibility to experimental allergic encephalomyelitis 3 (mouse)Not determined379548730113548837Mouse
1301947Pcfm3_mperiosteal circumference and femur length 3 (mouse)Not determined381084652115084797Mouse
1301904Iba2_minduction of brown adipocytes 2 (mouse)Not determined382147043116147184Mouse
11041900Lmr11a_mleishmaniasis resistance 11a (mouse)383463991117464137Mouse
11039510Ltpr3d_mLeishmania tropica response 3d (mouse)383463991117464137Mouse
11039511Ltpr3c_mLeishmania tropica response 3c (mouse)383463991117464137Mouse
11039507Ltpr3g_mLeishmania tropica response 3g (mouse)383463991117464137Mouse
11039508Ltpr3f_mLeishmania tropica response 3f (mouse)383463991117464137Mouse
11039509Ltpr3e_mLeishmania tropica response 3e (mouse)383463991117464137Mouse
11039512Ltpr3b_mLeishmania tropica response 3b (mouse)383463991117464137Mouse
1301272Cfsw1_mcystic fibrosis survival to weaning 1 (mouse)Not determined383882912117883044Mouse
4142099Cq3_mcholesterol QTL 3 (mouse)Not determined384888918118889067Mouse
14746984Manh54_mmandible shape 54 (mouse)385289152119289152Mouse
1357583Sle18_msystematic lupus erythematosus susceptibility 18 (mouse)Not determined387208904125316236Mouse
12738440Twq3_mtestis weight QTL 3 (mouse)387228015121228015Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389139967137453008Mouse
10766455Sle22_msystematic lupus erythematosus susceptibility 22 (mouse)390376936124377072Mouse
14747001Mancz4_mmandible centroid size 4 (mouse)390378017124378017Mouse
1301398Rapop3_mradiation-induced apoptosis 3 (mouse)Not determined390511217100464137Mouse
1302052Etohcta4_methanol conditioned taste aversion 4 (mouse)Not determined391000105125008748Mouse

Markers in Region
Pglyrp3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3F1UniSTS
cM Map340.14UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000047660   ⟹   ENSMUSP00000035737
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl391,921,890 - 91,938,889 (+)Ensembl
GRCm38.p6 Ensembl392,014,583 - 92,031,582 (+)Ensembl
RefSeq Acc Id: NM_207247   ⟹   NP_997130
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39391,921,890 - 91,938,891 (+)NCBI
GRCm38392,014,583 - 92,031,584 (+)NCBI
MGSCv37391,818,505 - 91,835,506 (+)RGD
Celera392,058,137 - 92,075,140 (+)RGD
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006501471   ⟹   XP_006501534
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39391,919,784 - 91,939,979 (+)NCBI
GRCm38392,012,477 - 92,032,672 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_997130 (Get FASTA)   NCBI Sequence Viewer  
  XP_006501534 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein A1A547 (Get FASTA)   NCBI Sequence Viewer  
  AAI28292 (Get FASTA)   NCBI Sequence Viewer  
  AAS49172 (Get FASTA)   NCBI Sequence Viewer  
  EDL15104 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000035737
  ENSMUSP00000035737.5
Reference Protein Sequences
RefSeq Acc Id: NP_997130   ⟸   NM_207247
- Peptide Label: precursor
- UniProtKB: E9QMH8 (UniProtKB/Swiss-Prot),   Q6R1Z2 (UniProtKB/Swiss-Prot),   A1A547 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006501534   ⟸   XM_006501471
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000035737   ⟸   ENSMUST00000047660
Protein Domains
N-acetylmuramoyl-L-alanine amidase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A1A547-F1-model_v2 AlphaFold A1A547 1-347 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2685266 AgrOrtholog
Ensembl Genes ENSMUSG00000042244 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000047660 ENTREZGENE
  ENSMUST00000047660.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.80.10 UniProtKB/Swiss-Prot
InterPro Amidase/PGRP_sf UniProtKB/Swiss-Prot
  Amidase_domain UniProtKB/Swiss-Prot
  PGRP UniProtKB/Swiss-Prot
  PGRP_domain_met/bac UniProtKB/Swiss-Prot
KEGG Report mmu:242100 UniProtKB/Swiss-Prot
MGD MGI:2685266 ENTREZGENE
NCBI Gene 242100 ENTREZGENE
PANTHER PEPTIDOGLYCAN RECOGNITION PROTEIN 3 UniProtKB/Swiss-Prot
  PTHR11022 UniProtKB/Swiss-Prot
Pfam Amidase_2 UniProtKB/Swiss-Prot
PhenoGen Pglyrp3 PhenoGen
SMART Ami_2 UniProtKB/Swiss-Prot
  PGRP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55846 UniProtKB/Swiss-Prot
UniProt A1A547 ENTREZGENE
  E9QMH8 ENTREZGENE
  PGRP3_MOUSE UniProtKB/Swiss-Prot
  Q6R1Z2 ENTREZGENE
UniProt Secondary E9QMH8 UniProtKB/Swiss-Prot
  Q6R1Z2 UniProtKB/Swiss-Prot