Nsun2 (NOP2/Sun RNA methyltransferase 2) - Rat Genome Database

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Gene: Nsun2 (NOP2/Sun RNA methyltransferase 2) Rattus norvegicus
Analyze
Symbol: Nsun2
Name: NOP2/Sun RNA methyltransferase 2
RGD ID: 1311954
Description: Predicted to enable mRNA (cytidine-5-)-methyltransferase activity; tRNA (cytidine-5-)-methyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including RNA methylation; regulation of mRNA export from nucleus; and tRNA stabilization. Predicted to act upstream of or within hair follicle maturation and in utero embryonic development. Predicted to be located in several cellular components, including chromatoid body; extracellular exosome; and nucleolus. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2); INTERACTS WITH (+)-schisandrin B; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361191; NOL1/NOP2/Sun domain family, member 2; NOP2/Sun domain family, member 2; NOP2/Sun RNA methyltransferase family, member 2; RGD1311954; RNA cytosine C(5)-methyltransferase NSUN2; similar to CG6133-PA; tRNA (cytosine(34)-C(5))-methyltransferase; tRNA (cytosine-5-)-methyltransferase NSUN2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,490,583 - 35,514,839 (-)NCBIGRCr8
mRatBN7.2133,662,139 - 33,685,887 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,662,139 - 33,685,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,491,491 - 33,515,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,490,097 - 39,513,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,690,317 - 33,714,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,295,650 - 36,319,906 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,295,650 - 36,319,966 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,692,672 - 37,716,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,820,859 - 3,844,582 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,822,627 - 3,844,539 (-)NCBI
Celera132,266,227 - 32,289,950 (-)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,6-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
all-trans-retinoic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
flutamide  (EXP)
FR900359  (ISO)
hydrogen peroxide  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
menadione  (ISO)
methidathion  (ISO)
methyl methanesulfonate  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
paraquat  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (ISO)
venlafaxine hydrochloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17071714   PMID:22144916   PMID:22395603   PMID:22658674   PMID:22681889   PMID:22885326   PMID:23401851   PMID:23871666   PMID:25340873   PMID:26838785   PMID:27996060   PMID:28341602  
PMID:28418038   PMID:28919411   PMID:30361391   PMID:31276587   PMID:31287866   PMID:31358969  


Genomics

Comparative Map Data
Nsun2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8135,490,583 - 35,514,839 (-)NCBIGRCr8
mRatBN7.2133,662,139 - 33,685,887 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl133,662,139 - 33,685,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx133,491,491 - 33,515,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0139,490,097 - 39,513,799 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0133,690,317 - 33,714,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0136,295,650 - 36,319,906 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl136,295,650 - 36,319,966 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0137,692,672 - 37,716,930 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4173,820,859 - 3,844,582 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1173,822,627 - 3,844,539 (-)NCBI
Celera132,266,227 - 32,289,950 (-)NCBICelera
Cytogenetic Map1p11NCBI
NSUN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3856,599,239 - 6,633,044 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl56,599,239 - 6,633,291 (-)EnsemblGRCh38hg38GRCh38
GRCh3756,599,352 - 6,633,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3656,652,352 - 6,686,157 (-)NCBINCBI36Build 36hg18NCBI36
Build 3456,652,352 - 6,686,157NCBI
Celera56,626,418 - 6,660,533 (-)NCBICelera
Cytogenetic Map5p15.31NCBI
HuRef56,573,722 - 6,608,099 (-)NCBIHuRef
CHM1_156,599,051 - 6,633,433 (-)NCBICHM1_1
T2T-CHM13v2.056,529,664 - 6,563,719 (-)NCBIT2T-CHM13v2.0
Nsun2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391369,760,135 - 69,783,899 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1369,681,865 - 69,783,899 (+)EnsemblGRCm39 Ensembl
GRCm381369,612,016 - 69,635,780 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1369,533,746 - 69,635,780 (+)EnsemblGRCm38mm10GRCm38
MGSCv371369,750,895 - 69,774,658 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361370,079,616 - 70,103,029 (+)NCBIMGSCv36mm8
Celera1371,956,753 - 71,980,601 (+)NCBICelera
Cytogenetic Map13B3NCBI
cM Map1335.55NCBI
Nsun2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555044,338,855 - 4,361,520 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555044,339,044 - 4,360,176 (-)NCBIChiLan1.0ChiLan1.0
NSUN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v246,848,107 - 6,880,920 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan155,001,714 - 5,034,493 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v056,921,073 - 6,953,622 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.156,596,414 - 6,629,121 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl56,596,414 - 6,629,121 (-)Ensemblpanpan1.1panPan2
NSUN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1347,145,176 - 7,172,761 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl347,144,586 - 7,172,335 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3411,653,467 - 11,681,035 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0347,053,243 - 7,080,793 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl347,052,661 - 7,080,668 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1347,100,392 - 7,127,969 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0347,080,917 - 7,108,473 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0347,295,959 - 7,323,555 (+)NCBIUU_Cfam_GSD_1.0
Nsun2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213240,207,658 - 240,234,194 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936634799,176 - 826,852 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936634798,894 - 825,413 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NSUN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1675,335,047 - 75,367,180 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11675,335,565 - 75,414,659 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21681,695,118 - 81,761,793 (+)NCBISscrofa10.2Sscrofa10.2susScr3
NSUN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.146,279,984 - 6,312,737 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl46,280,001 - 6,312,569 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606422,406,642 - 22,439,412 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nsun2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247514,287,249 - 4,309,438 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247514,288,436 - 4,309,172 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nsun2
209 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:436
Count of miRNA genes:250
Interacting mature miRNAs:303
Transcripts:ENSRNOT00000023641
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat

Markers in Region
AI463178  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,663,965 - 33,664,079 (+)MAPPERmRatBN7.2
Rnor_6.0136,297,477 - 36,297,590NCBIRnor6.0
Rnor_5.0137,694,499 - 37,694,612UniSTSRnor5.0
RGSC_v3.4173,822,686 - 3,822,799UniSTSRGSC3.4
Celera132,268,054 - 32,268,167UniSTS
Cytogenetic Map17p14UniSTS
RH132204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,663,923 - 33,664,134 (+)MAPPERmRatBN7.2
Rnor_6.0136,297,435 - 36,297,645NCBIRnor6.0
Rnor_5.0137,694,457 - 37,694,667UniSTSRnor5.0
RGSC_v3.4173,822,644 - 3,822,854UniSTSRGSC3.4
Celera132,268,012 - 32,268,222UniSTS
Cytogenetic Map17p14UniSTS
RH143267  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2133,664,371 - 33,664,557 (+)MAPPERmRatBN7.2
Rnor_6.0136,297,883 - 36,298,068NCBIRnor6.0
Rnor_5.0137,694,905 - 37,695,090UniSTSRnor5.0
RGSC_v3.4173,823,092 - 3,823,277UniSTSRGSC3.4
Celera132,268,460 - 32,268,645UniSTS
Cytogenetic Map17p14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 30 57 41 19 41 7 10 74 35 41 11 7
Low 13 1 1 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000023641   ⟹   ENSRNOP00000023641
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl133,662,139 - 33,685,862 (-)Ensembl
Rnor_6.0 Ensembl136,295,650 - 36,319,896 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090884   ⟹   ENSRNOP00000069129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl133,662,139 - 33,685,862 (-)Ensembl
Rnor_6.0 Ensembl136,297,764 - 36,319,966 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000094155   ⟹   ENSRNOP00000088705
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl133,662,139 - 33,685,862 (-)Ensembl
RefSeq Acc Id: NM_001108403   ⟹   NP_001101873
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,490,583 - 35,514,306 (-)NCBI
mRatBN7.2133,662,139 - 33,685,862 (-)NCBI
Rnor_6.0136,295,650 - 36,319,896 (-)NCBI
Rnor_5.0137,692,672 - 37,716,930 (-)NCBI
RGSC_v3.4173,820,859 - 3,844,582 (-)RGD
Celera132,266,227 - 32,289,950 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006227792   ⟹   XP_006227854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,492,343 - 35,514,334 (-)NCBI
mRatBN7.2133,663,899 - 33,685,887 (-)NCBI
Rnor_6.0136,297,410 - 36,319,906 (-)NCBI
Rnor_5.0137,692,672 - 37,716,930 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063265949   ⟹   XP_063122019
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,492,343 - 35,514,564 (-)NCBI
RefSeq Acc Id: XM_063265950   ⟹   XP_063122020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8135,492,343 - 35,514,839 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001101873   ⟸   NM_001108403
- UniProtKB: D4A3S8 (UniProtKB/TrEMBL),   A6JV18 (UniProtKB/TrEMBL),   A0A0G2JUK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227854   ⟸   XM_006227792
- Peptide Label: isoform X2
- UniProtKB: A0A0G2JUK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023641   ⟸   ENSRNOT00000023641
RefSeq Acc Id: ENSRNOP00000069129   ⟸   ENSRNOT00000090884
RefSeq Acc Id: ENSRNOP00000088705   ⟸   ENSRNOT00000094155
RefSeq Acc Id: XP_063122020   ⟸   XM_063265950
- Peptide Label: isoform X1
- UniProtKB: A6JV18 (UniProtKB/TrEMBL),   D4A3S8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063122019   ⟸   XM_063265949
- Peptide Label: isoform X1
- UniProtKB: A6JV18 (UniProtKB/TrEMBL),   D4A3S8 (UniProtKB/TrEMBL)
Protein Domains
SAM-dependent MTase RsmB/NOP-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A3S8-F1-model_v2 AlphaFold D4A3S8 1-782 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689575
Promoter ID:EPDNEW_R99
Type:multiple initiation site
Name:Nsun2_1
Description:NOP2/Sun RNA methyltransferase family, member 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0136,319,875 - 36,319,935EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311954 AgrOrtholog
BioCyc Gene G2FUF-61870 BioCyc
BioCyc Pathway PWY-6829 [tRNA methylation (yeast)] BioCyc
BioCyc Pathway Image PWY-6829 BioCyc
Ensembl Genes ENSRNOG00000017254 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000023641 ENTREZGENE
  ENSRNOT00000023641.7 UniProtKB/TrEMBL
  ENSRNOT00000090884.2 UniProtKB/TrEMBL
  ENSRNOT00000094155.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
InterPro Fmu/NOL1/Nop2p UniProtKB/TrEMBL
  MeTrfase_RsmB-F_NOP2_cat UniProtKB/TrEMBL
  RCMT UniProtKB/TrEMBL
  RCMT_NCL1 UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:361191 UniProtKB/TrEMBL
NCBI Gene 361191 ENTREZGENE
PANTHER PTHR22808 UniProtKB/TrEMBL
  RNA CYTOSINE C(5)-METHYLTRANSFERASE NSUN2 UniProtKB/TrEMBL
Pfam Nol1_Nop2_Fmu UniProtKB/TrEMBL
PhenoGen Nsun2 PhenoGen
PRINTS RCMTFAMILY UniProtKB/TrEMBL
  RCMTNCL1 UniProtKB/TrEMBL
PROSITE SAM_MT_RSMB_NOP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000017254 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A0G2JUK0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6Q2_RAT UniProtKB/TrEMBL
  A6JV18 ENTREZGENE, UniProtKB/TrEMBL
  D4A3S8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-04 Nsun2  NOP2/Sun RNA methyltransferase 2  Nsun2  NOP2/Sun RNA methyltransferase family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-05 Nsun2  NOP2/Sun RNA methyltransferase family, member 2  Nsun2  NOP2/Sun domain family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Nsun2  NOP2/Sun domain family, member 2  Nsun2  NOL1/NOP2/Sun domain family, member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Nsun2  NOL1/NOP2/Sun domain family, member 2  Nsun2_predicted  NOL1/NOP2/Sun domain family, member 2 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nsun2_predicted  NOL1/NOP2/Sun domain family, member 2 (predicted)  RGD1311954_predicted  similar to CG6133-PA (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1311954_predicted  similar to CG6133-PA (predicted)  LOC361191_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361191_predicted  similar to CG6133-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL