Iars2 (isoleucyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Gene: Iars2 (isoleucyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Iars2
Name: isoleucyl-tRNA synthetase 2, mitochondrial
RGD ID: 1311857
Description: Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation and mitochondrial translation. Predicted to be active in mitochondrion. Orthologous to human IARS2 (isoleucyl-tRNA synthetase 2, mitochondrial); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: isoleucine--tRNA ligase, mitochondrial; isoleucine-tRNA synthetase 2, mitochondrial; isoleucyl-tRNA synthetase, mitochondrial; LOC364070; mitochondrial isoleucine tRNA synthetase; RGD1311857; similar to hypothetical protein FLJ10326
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81399,363,035 - 99,397,068 (-)NCBIGRCr8
mRatBN7.21396,831,484 - 96,865,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,831,484 - 96,865,501 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1399,330,620 - 99,364,644 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,736,584 - 100,770,617 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,912,874 - 97,946,903 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013103,229,868 - 103,265,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13103,231,387 - 103,264,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,904,738 - 107,938,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,289,607 - 101,337,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,481,932 - 101,526,405 (-)NCBI
Celera1396,346,977 - 96,378,913 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (IEA)
mitochondrion  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14651853   PMID:15632090   PMID:18614015  


Genomics

Comparative Map Data
Iars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81399,363,035 - 99,397,068 (-)NCBIGRCr8
mRatBN7.21396,831,484 - 96,865,518 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1396,831,484 - 96,865,501 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1399,330,620 - 99,364,644 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013100,736,584 - 100,770,617 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01397,912,874 - 97,946,903 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013103,229,868 - 103,265,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13103,231,387 - 103,264,906 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013107,904,738 - 107,938,042 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413101,289,607 - 101,337,461 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113101,481,932 - 101,526,405 (-)NCBI
Celera1396,346,977 - 96,378,913 (-)NCBICelera
Cytogenetic Map13q26NCBI
IARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381220,094,132 - 220,148,041 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1220,094,132 - 220,148,041 (+)EnsemblGRCh38hg38GRCh38
GRCh371220,267,474 - 220,321,383 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,334,078 - 218,388,006 (+)NCBINCBI36Build 36hg18NCBI36
Celera1193,486,662 - 193,540,592 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1190,941,806 - 190,995,804 (+)NCBIHuRef
CHM1_11221,540,260 - 221,593,871 (+)NCBICHM1_1
T2T-CHM13v2.01219,333,406 - 219,387,315 (+)NCBIT2T-CHM13v2.0
Iars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391185,018,839 - 185,061,615 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1185,016,923 - 185,061,593 (-)EnsemblGRCm39 Ensembl
GRCm381185,286,642 - 185,329,419 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1185,284,726 - 185,329,396 (-)EnsemblGRCm38mm10GRCm38
MGSCv371187,110,541 - 187,153,280 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361186,987,450 - 187,030,189 (-)NCBIMGSCv36mm8
Celera1192,244,078 - 192,279,032 (-)NCBICelera
Cytogenetic Map1H5NCBI
cM Map189.48NCBI
Iars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555203,485,816 - 3,520,549 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555203,485,816 - 3,521,035 (-)NCBIChiLan1.0ChiLan1.0
IARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2129,265,349 - 29,319,096 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1129,227,709 - 29,281,454 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01195,666,995 - 195,720,661 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11200,703,860 - 200,756,849 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1200,703,711 - 200,757,648 (+)Ensemblpanpan1.1panPan2
IARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13814,864,004 - 14,925,684 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3814,863,998 - 14,925,635 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3814,906,454 - 14,968,937 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03814,899,113 - 14,961,588 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3814,898,983 - 14,962,667 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13814,909,808 - 14,971,917 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03815,255,376 - 15,317,833 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03815,543,643 - 15,606,062 (+)NCBIUU_Cfam_GSD_1.0
Iars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934456,808,716 - 56,864,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366502,056,921 - 2,112,767 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366502,056,921 - 2,112,487 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl109,685,678 - 9,737,159 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1109,685,641 - 9,739,816 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21011,767,633 - 11,807,380 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1259,414,316 - 9,485,542 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl259,414,711 - 9,485,429 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660559,713,779 - 9,791,538 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248353,725,132 - 3,766,284 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248353,725,233 - 3,763,279 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iars2
97 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:79
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000057395
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat

Markers in Region
RH130522  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,831,070 - 96,831,263 (+)MAPPERmRatBN7.2
Rnor_6.013103,230,555 - 103,230,747NCBIRnor6.0
Rnor_5.013107,904,050 - 107,904,242UniSTSRnor5.0
RGSC_v3.413101,291,707 - 101,291,899UniSTSRGSC3.4
Celera1396,346,047 - 96,346,239UniSTS
RH 3.4 Map13657.2UniSTS
Cytogenetic Map13q26UniSTS
RH141729  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,830,590 - 96,830,799 (+)MAPPERmRatBN7.2
Rnor_6.013103,230,075 - 103,230,283NCBIRnor6.0
Rnor_5.013107,903,570 - 107,903,778UniSTSRnor5.0
RGSC_v3.413101,291,227 - 101,291,435UniSTSRGSC3.4
Celera1396,345,567 - 96,345,775UniSTS
RH 3.4 Map13654.9UniSTS
Cytogenetic Map13q26UniSTS
AU049946  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21396,844,976 - 96,845,164 (+)MAPPERmRatBN7.2
Rnor_6.013103,244,387 - 103,244,574NCBIRnor6.0
Rnor_5.013107,918,205 - 107,918,392UniSTSRnor5.0
RGSC_v3.413101,306,258 - 101,306,445UniSTSRGSC3.4
Celera1396,360,176 - 96,360,363UniSTS
Cytogenetic Map13q26UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 39 11 8
Low 2
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000057395   ⟹   ENSRNOP00000054206
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1396,853,326 - 96,865,501 (-)Ensembl
Rnor_6.0 Ensembl13103,249,794 - 103,264,906 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000085211   ⟹   ENSRNOP00000071701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl13103,239,602 - 103,264,906 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090786   ⟹   ENSRNOP00000072118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1396,831,484 - 96,865,501 (-)Ensembl
Rnor_6.0 Ensembl13103,231,387 - 103,264,906 (-)Ensembl
RefSeq Acc Id: NM_001398608   ⟹   NP_001385537
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81399,363,035 - 99,397,068 (-)NCBI
mRatBN7.21396,831,484 - 96,865,518 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001385537 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL94911 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054206.5
  ENSRNOP00000072118
  ENSRNOP00000072118.2
RefSeq Acc Id: ENSRNOP00000054206   ⟸   ENSRNOT00000057395
RefSeq Acc Id: ENSRNOP00000071701   ⟸   ENSRNOT00000085211
RefSeq Acc Id: ENSRNOP00000072118   ⟸   ENSRNOT00000090786
RefSeq Acc Id: NP_001385537   ⟸   NM_001398608
- UniProtKB: A0A0G2K261 (UniProtKB/TrEMBL)
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K261-F1-model_v2 AlphaFold A0A0G2K261 1-1011 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699092
Promoter ID:EPDNEW_R9615
Type:multiple initiation site
Name:Iars2_1
Description:isoleucyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013103,265,001 - 103,265,061EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311857 AgrOrtholog
BioCyc Gene G2FUF-16985 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
BioCyc Pathway Image TRNA-CHARGING-PWY BioCyc
Ensembl Genes ENSRNOG00000002368 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057395.5 UniProtKB/TrEMBL
  ENSRNOT00000090786 ENTREZGENE
  ENSRNOT00000090786.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.730.20 UniProtKB/TrEMBL
  3.40.50.620 UniProtKB/TrEMBL
  3.90.740.10 UniProtKB/TrEMBL
  Ile-tRNA synthetase CP2 domain-like UniProtKB/TrEMBL
InterPro aa-tRNA-synth_I_CS UniProtKB/TrEMBL
  aa-tRNA-synth_Ia UniProtKB/TrEMBL
  Anticodon_Ile_BEm UniProtKB/TrEMBL
  Ile-tRNA-ligase UniProtKB/TrEMBL
  Ile-tRNA-ligase_type1 UniProtKB/TrEMBL
  M/V/L/I-tRNA-synth_anticd-bd UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  tRNAsynth_1a_anticodon-bd UniProtKB/TrEMBL
  Val/Leu/Ile-tRNA-synth_edit UniProtKB/TrEMBL
NCBI Gene 364070 ENTREZGENE
PANTHER ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL UniProtKB/TrEMBL
  SOLEUCYL-TRNA SYNTHETASE UniProtKB/TrEMBL
Pfam Anticodon_1 UniProtKB/TrEMBL
  tRNA-synt_1 UniProtKB/TrEMBL
PhenoGen Iars2 PhenoGen
PRINTS TRNASYNTHILE UniProtKB/TrEMBL
PROSITE AA_TRNA_LIGASE_I UniProtKB/TrEMBL
RatGTEx ENSRNOG00000002368 RatGTEx
Superfamily-SCOP Nucleotidylyl transferase UniProtKB/TrEMBL
  SSF47323 UniProtKB/TrEMBL
  ValRS_IleRS_edit UniProtKB/TrEMBL
UniProt A0A0G2K261 ENTREZGENE, UniProtKB/TrEMBL
  D4A8P9_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Iars2  isoleucyl-tRNA synthetase 2, mitochondrial  Iars2  isoleucine-tRNA synthetase 2, mitochondrial   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Iars2  isoleucine-tRNA synthetase 2, mitochondrial   Iars2_predicted  isoleucine-tRNA synthetase 2, mitochondrial (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Iars2_predicted  isoleucine-tRNA synthetase 2, mitochondrial (predicted)  RGD1311857_predicted  similar to hypothetical protein FLJ10326 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1311857_predicted  similar to hypothetical protein FLJ10326 (predicted)  LOC364070_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC364070_predicted  similar to hypothetical protein FLJ10326 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL