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Gene: Hddc3 (HD domain containing 3) Rattus norvegicus

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Symbol:

Hddc3

Name:

HD domain containing 3

RGD ID:

1311839

Description:

Predicted to enable guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity. Orthologous to human HDDC3 (HD domain containing 3); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; HD domain-containing protein 3; LOC308758; RGD1311839; similar to RIKEN cDNA 1110033O09

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HDDC3 (HD domain containing 3)	HGNC	EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Hddc3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hddc3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HDDC3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HDDC3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hddc3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HDDC3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HDDC3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hddc3 (HD domain containing 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PRSS41 (serine protease 41)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	HDDC3 (HD domain containing 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Hddc3 (HD domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hddc3 (HD domain containing 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ZK909.3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Mesh1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hddc3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	143,708,703 - 143,711,010 (+)	NCBI		GRCr8
mRatBN7.2	1	134,299,469 - 134,301,757 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	134,299,468 - 134,301,757 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	142,208,351 - 142,210,636 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	149,377,749 - 149,380,034 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	142,295,585 - 142,297,870 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	142,136,428 - 142,138,737 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	142,136,452 - 142,138,737 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	143,088,853 - 143,091,138 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	136,161,425 - 136,163,710 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	136,239,835 - 136,241,412 (+)	NCBI
Celera	1	126,359,496 - 126,361,781 (+)	NCBI		Celera
Cytogenetic Map	1	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Bloom syndrome (ISO)

D-2-hydroxyglutaric aciduria 2 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

acrylamide (ISO)

alpha-pinene (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium dichloride (EXP)

carbamazepine (ISO)

chlorpyrifos (ISO)

cisplatin (ISO)

clofibric acid (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

endosulfan (EXP)

epoxiconazole (ISO)

flutamide (EXP)

folic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

methapyrilene (EXP)

N-nitrosodiethylamine (EXP)

ozone (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

propiconazole (ISO)

rac-lactic acid (ISO)

rotenone (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP)

thioacetamide (EXP)

triazines (ISO)

trichloroethene (EXP)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Molecular Function

guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity (IBA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data

Hddc3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	143,708,703 - 143,711,010 (+)	NCBI		GRCr8
mRatBN7.2	1	134,299,469 - 134,301,757 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	134,299,468 - 134,301,757 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	142,208,351 - 142,210,636 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	149,377,749 - 149,380,034 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	142,295,585 - 142,297,870 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	142,136,428 - 142,138,737 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	142,136,452 - 142,138,737 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	143,088,853 - 143,091,138 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	136,161,425 - 136,163,710 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	136,239,835 - 136,241,412 (+)	NCBI
Celera	1	126,359,496 - 126,361,781 (+)	NCBI		Celera
Cytogenetic Map	1	q31	NCBI

HDDC3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	15	90,929,968 - 90,932,569 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	15	90,929,968 - 90,935,196 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	15	91,473,198 - 91,475,799 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	15	89,275,159 - 89,276,778 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	15	67,883,353 - 67,884,972 (-)	NCBI		Celera
Cytogenetic Map	15	q26.1	NCBI
HuRef	15	67,585,438 - 67,587,057 (-)	NCBI		HuRef
CHM1_1	15	91,315,753 - 91,317,372 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	15	88,689,551 - 88,694,729 (-)	NCBI		T2T-CHM13v2.0

Hddc3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	79,992,864 - 80,000,479 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	79,992,852 - 80,000,295 (+)	Ensembl		GRCm39 Ensembl
GRCm38	7	80,343,075 - 80,346,716 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	80,343,104 - 80,350,547 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	87,488,023 - 87,490,983 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	80,216,650 - 80,219,610 (+)	NCBI		MGSCv36	mm8
Celera	7	77,744,603 - 77,746,179 (+)	NCBI		Celera
Cytogenetic Map	7	D2	NCBI
cM Map	7	45.65	NCBI

Hddc3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955416	14,990,031 - 14,995,818 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955416	14,993,492 - 14,995,818 (-)	NCBI	ChiLan1.0	ChiLan1.0

HDDC3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	16	80,484,407 - 80,488,605 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	15	84,183,061 - 84,187,259 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	15	69,623,932 - 69,628,130 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	15	88,821,307 - 88,822,950 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

HDDC3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	53,310,364 - 53,312,034 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	53,310,404 - 53,311,693 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	55,947,991 - 55,949,662 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	53,726,384 - 53,728,068 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	53,726,427 - 53,727,724 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	53,245,629 - 53,247,302 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	53,456,747 - 53,458,426 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	53,797,243 - 53,798,915 (+)	NCBI		UU_Cfam_GSD_1.0

Hddc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	130,242,697 - 130,244,349 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936483	16,090,063 - 16,097,278 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936483	16,090,191 - 16,092,442 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HDDC3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	53,525,989 - 53,528,004 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	53,525,984 - 53,527,913 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	58,557,178 - 58,559,084 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HDDC3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	8,930,104 - 8,931,824 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	8,929,474 - 8,932,063 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	37,794,213 - 37,795,870 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hddc3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624768	17,318,215 - 17,323,824 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624768	17,313,813 - 17,320,574 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Hddc3
9 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	107
Count of miRNA genes:	86
Interacting mature miRNAs:	95
Transcripts:	ENSRNOT00000016445
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61442	Strs1	Sensitivity to stroke QTL 1	7.4		cerebrum integrity trait (VT:0010549)	post-insult time to onset of cerebrovascular lesion (CMO:0002343)	1	121767634	166767634	Rat
1578780	Cm52	Cardiac mass QTL 52	3.3	0.0001	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	1	81591954	219808434	Rat
1578654	Bss10	Bone structure and strength QTL 10	4		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	1	49393172	159356837	Rat
1598866	Bp287	Blood pressure QTL 287	5.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
1578770	Stresp23	Stress response QTL 23			kidney sympathetic nerve activity (VT:0004050)	stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)	1	123350408	182418476	Rat
9590300	Scort16	Serum corticosterone level QTL 16	4.39	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	1	103111621	148111621	Rat
2298545	Neuinf8	Neuroinflammation QTL 8	4.6		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	1	57336763	151090257	Rat
7794788	Mcs32	Mammary carcinoma susceptibility QTL 32	2.61		mammary gland integrity trait (VT:0010552)	mammary tumor incidence/prevalence measurement (CMO:0000946)	1	115540693	238914717	Rat
631199	Cm23	Cardiac mass QTL 23	4.6	0.0004	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	115585465	172949803	Rat
2313402	Anxrr24	Anxiety related response QTL 24			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	1	48963584	144267916	Rat
1598850	Bp297	Blood pressure QTL 297	2.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121006655	166006655	Rat
631570	Bp94	Blood pressure QTL 94		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123479780	142990467	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	123556856	242907031	Rat
152025232	Bw192	Body weight QTL 192	3.93		body mass (VT:0001259)		1	117917486	196963478	Rat
724521	Uae1	Urinary albumin excretion QTL 1	3.8	0.0001	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	90508614	173018436	Rat
1358902	Bw47	Body weight QTL 47	1.67		body mass (VT:0001259)	body weight (CMO:0000012)	1	90508614	180359386	Rat
61346	Rf2	Renal disease susceptibility QTL 2	3.7		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	1	99267916	144267916	Rat
8655649	Arrd1	Age-related retinal degeneration QTL 1	4.89		retinal layer morphology trait (VT:0003727)	percentage of study population developing retinopathy during a period of time (CMO:0002453)	1	100357752	183970443	Rat
1300153	Bp171	Blood pressure QTL 171	3.37		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	90664883	143200202	Rat
2317833	Alcrsp19	Alcohol response QTL 19	12.4	0.001	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	100979852	145979852	Rat
731168	Bp154	Blood pressure QTL 154	3.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94642644	214537671	Rat
631202	Gluco13	Glucose level QTL 13		0.0001	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	131763437	159756369	Rat
631205	Bp196	Blood pressure QTL 196	4	0.0001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118944897	199050459	Rat
1300158	Bp173	Blood pressure QTL 173	3.48		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	1	115540693	185145286	Rat
1641897	Alcrsp1	Alcohol response QTL 1			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	1	100979852	145979852	Rat
1331749	Hrtrt11	Heart rate QTL 11	2.973		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	1	94494440	198211706	Rat
1331751	Bp199	Blood pressure QTL 199	3.60022		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	1	94494440	181830018	Rat
2293142	Bp314	Blood pressure QTL 314			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	92184926	137184926	Rat
9685799	Bp375	Blood pressure QTL 375			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
2293140	Bp313	Blood pressure QTL 313			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	121833674	166833674	Rat
9685802	Bp376	Blood pressure QTL 376			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	126540680	171540680	Rat
724529	Cm16	Cardiac mass QTL 16	2.7		heart mass (VT:0007028)	calculated heart weight (CMO:0000073)	1	87580395	150700247	Rat
61370	Mcs3	Mammary carcinoma susceptibility QTL 3	2.15		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	102268556	147268556	Rat
1641895	Bp298	Blood pressure QTL 298			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	123350408	182418476	Rat
70209	Niddm23	Non-insulin dependent diabetes mellitus QTL 23	2.82		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	94494440	198324465	Rat
631496	Bp97	Blood pressure QTL 97	3.08		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	106047847	151047847	Rat
634314	Niddm44	Non-insulin dependent diabetes mellitus QTL 44			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	49393289	199050459	Rat
2303591	Gluco41	Glucose level QTL 41	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	102168504	147168504	Rat
1331793	Bp200	Blood pressure QTL 200	3.71601		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	94494440	172949803	Rat
2313060	Bss71	Bone structure and strength QTL 71	2.6	0.0001	long bone metaphysis morphology trait (VT:0000133)	tibia midshaft total cross-sectional area (CMO:0001715)	1	118944747	163944747	Rat
6893347	Bw98	Body weight QTL 98	0.2	0.53	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354591	Cm36	Cardiac mass QTL 36	4.1		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	102813953	201278233	Rat
7421630	Bp362	Blood pressure QTL 362		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	118608292	241799120	Rat
70225	Bp58	Blood pressure QTL 58	3.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32356093	162846471	Rat
10059597	Bp377	Blood pressure QTL 377	3.42	0.025	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	32737458	199368955	Rat
61399	Tcat1	Tongue tumor resistance QTL 1	3.3		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)	1	99267916	144267916	Rat
6893361	Bw104	Body weight QTL 104	0.59	0.27	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
724567	Tcas6	Tongue tumor susceptibility QTL 6	6.85		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	1	92948896	144267916	Rat
738006	Anxrr14	Anxiety related response QTL 14	4	0.00035	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1558645	Bw55	Body weight QTL 55	3.2	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	1	133680936	178680936	Rat
1354615	Cm32	Cardiac mass QTL 32	5.2		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	1	102813953	201278233	Rat
634348	Bp138	Blood pressure QTL 138			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	168883176	Rat
8694370	Bw154	Body weight QTL 154	8.91	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	1	103111621	148111621	Rat
738028	Anxrr12	Anxiety related response QTL 12	4.9	0.00001	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	130636910	175636910	Rat
1354623	Rf46	Renal function QTL 46	3.8		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	1	102813953	151162766	Rat
631654	Bp107	Blood pressure QTL 107			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	125611501	170611501	Rat
631544	Bp84	Blood pressure QTL 84	5.6		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350408	181759564	Rat
152025212	Bw190	Body weight QTL 190	5.7		body mass (VT:0001259)		1	123556856	196963478	Rat
631549	Bp89	Blood pressure QTL 89	5.7		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	123350581	201284552	Rat
1358189	Cstrr1	Cold stress response QTL 1		0.0001	catecholamine amount (VT:0010543)	urine norepinephrine level (CMO:0001629)	1	123350408	182418476	Rat
1354606	Bp246	Blood pressure QTL 246	3.6		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	1	102813953	218753816	Rat

Markers in Region

RH133835

Rat Assembly	Chr	Position (strand)	Source	JBrowse
RH 3.4 Map	1	1070.8	UniSTS
Cytogenetic Map	1	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001107528	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006229431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008759531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC114460	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473980	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016445 ⟹ ENSRNOP00000016445

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	134,299,472 - 134,301,757 (+)	Ensembl
Rnor_6.0 Ensembl	1	142,136,452 - 142,138,737 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000099679 ⟹ ENSRNOP00000080516

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	1	134,299,468 - 134,301,757 (+)	Ensembl

RefSeq Acc Id:

NM_001107528 ⟹ NP_001100998

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	143,708,725 - 143,711,010 (+)	NCBI
mRatBN7.2	1	134,299,472 - 134,301,757 (+)	NCBI
Rnor_6.0	1	142,136,452 - 142,138,737 (+)	NCBI
Rnor_5.0	1	143,088,853 - 143,091,138 (+)	NCBI
RGSC_v3.4	1	136,161,425 - 136,163,710 (+)	RGD
Celera	1	126,359,496 - 126,361,781 (+)	RGD

Sequence:

show sequence

CCCCCGCGCCACCCGCGCGATGGGATCGGAGGCAGCTCAGCTGCTGGAGGCTGCTGACTTCGCC
GCTCAAAAACACCGACAGCAGCGACGGAAAGATCCTGAAGGGACTCCCTACATCAATCACCCCA
TCGGTGTAGCCCGGATCCTAACCCATGAGGCTGGAATCACTGATATTGTGGTGTTGCAGGCGGC
CTTGCTCCATGACACAGTAGAAGACACAGATACTACCCTGGATGAGGTAGAGCTGCACTTTGGA
GCACAGGTTCGACGCTTGGTGGAGGAGGTAACAGATGACAAGACTCTGCCCAAACTGGAAAGAA
AGCGGCAACAGGTGGAACAGGCACCCCACAGCAGCCCAGGGGCCAAACTAGTGAAGCTGGCAGA
CAAGCTACACAATCTAAGGGACCTGAATCGCTGCACCCCTAAAGGCTGGTCAGAACATCGAGTC
CAGGAGTACTTCGAGTGGGCAGCACAGGTGGTAAAAGGGCTTCAAGGAACGAACCAGCAACTGG
AAGAGGCACTAAAACAGCTGTTCGAGGAACGAGGGCTGACTCTCTGAGAGAGCCTCCATGCAGT
CCTGTGGCATGGCTCCAGTAAGGCCCAGGAAAGATAGGATTCTTACTGCATCTCCAAGTGTCCT
CATCTCTCACATTCCTTTATTCAGCCCAGACACCACGGGCTAAAAACTTCTGCCTTTTTTCACA
CAGCTGAGCCCCGGATATGGAAACCAGAAATGCCCATCATACACTAACAGCCTTTCCTTAAGTC
TTGGCTCTGTTTGCTGTTTTGCATGGTGGGACCTCTGGCCCCTTAGGGACCTAAGACTGGATAA
GCCTTGGTTTATAAGTCGTGGAAAATAAAGCATTTAGGGTAAAGGCTTAAACTGCTGTTCCTCC
TTCTCTGGTCTCCCCGAAGAGGACCCACATGCTGGATACTCATTTCCTATGTGTCTTTTGCATC
AGCTCCCCTGGGTTGAAAGCATCGACCCTTGGAGCATGGCGTCCTTATCAACTGAGCTGGACTA
TGTCTTTACGAAGGTCAGATGATGTAGTTGTGGGATGGCAGATATACTGGGAAGGAATGCCATC
ACTTTTTGGCAACTGGCTGGGAAGGACAGAAATCCCAGTAACATGAGAAGGCTAGAAGACCTCA
GTGCCCCAACACCAACTGCAGCAGTTGATTAGTGGCCAATGCCTTGACCCTTAAATTTTATTGG
CTTCCTGGGTTGCTAAGTCACTAGCGCTTCCAAGTAACCGGAAGAGGCCCTGAAGTCGCCCCGC
CCATAGAGGTGGGTGGAATCTGTAGAAAGAAAAAAGCTGTGGAGGTTTGAGTTTGTGTGCGGAA
GTCCCACAGTGTGGGTGTGGCAATCAGAGAGCTTGTGGGGAGTTGGATTTCGCCCTCCATCATG
TAGGTATGGGATATCAAACATAGGTTTGTCAGGCTTGGCGAGCTGATGCCTTTACCCACTCAGC
TATCTCGCCTTCGTTGCCTCTTTTGTTGTTCCGTTTTTGTTTGTTGGAGGGGGATAGGGCCCCC
ACAGCCTTTCTATAATTCTCCTGCCTCTGCGACAAAGCGCAACCAT

hide sequence

RefSeq Acc Id:

XM_006229431 ⟹ XP_006229493

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	143,708,703 - 143,710,311 (+)	NCBI
mRatBN7.2	1	134,299,469 - 134,301,058 (+)	NCBI
Rnor_6.0	1	142,136,464 - 142,138,038 (+)	NCBI
Rnor_5.0	1	143,088,853 - 143,091,138 (+)	NCBI

Sequence:

show sequence

CCGCGCGATGGGATCGGAGGCAGCTCAGCTGCTGGAGGCTGCTGACTTCGCCGCTCAAAAACAC
CGACAGCAGCGACGGAAAGATCCTGAAGGGACTCCCTACATCAATCACCCCATCGGTGGGCGTG
CCGGTTGGGAAGCAGTTCTCTCGGCGGGTGGGGACTGACTGGGACGAGAACACAGAGCGAGTAT
AAATTATTGAGCGCCTTCTTCGAGTCCAAAGCGTTGTATCAACCACTTTTCATGCGTTATGCCG
TGTGTAGCCCGGATCCTAACCCATGAGGCTGGAATCACTGATATTGTGGTGTTGCAGGCGGCCT
TGCTCCATGACACAGTAGAAGACACAGATACTACCCTGGATGAGGTAGAGCTGCACTTTGGAGC
ACAGGTTCGACGCTTGGTGGAGGAGGTAACAGATGACAAGACTCTGCCCAAACTGGAAAGAAAG
CGGCAACAGGTGGAACAGGCACCCCACAGCAGCCCAGGGGCCAAACTAGTGAAGCTGGCAGACA
AGCTACACAATCTAAGGGACCTGAATCGCTGCACCCCTAAAGGCTGGTCAGAACATCGAGTCCA
GGAGTACTTCGAGTGGGCAGCACAGGTGGTAAAAGGGCTTCAAGGAACGAACCAGCAACTGGAA
GAGGCACTAAAACAGCTGTTCGAGGAACGAGGGCTGACTCTCTGAGAGAGCCTCCATGCAGTCC
TGTGGCATGGCTCCAGTAAGGCCCAGGAAAGATAGGATTCTTACTGCATCTCCAAGTGTCCTCA
TCTCTCACATTCCTTTATTCAGCCCAGACACCACGGGCTAAAAACTTCTGCCTTTTTTCACACA
GCTGAGCCCCGGATATGGAAACCAGAAATGCCCATCATACACTAACAGCCTTTCCTTAAGTCTT
GGCTCTGTTTGCTGTTTTGCATGGTGGGACCTCTGGCCCCTTAGGGACCTAAGACTGGATAAGC
CTTGGTTTATAAGTCGTGGAAAATAAAGCATTTAGGGTAAAGGCTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001100998	(Get FASTA)	NCBI Sequence Viewer
	XP_006229493	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM08632	(Get FASTA)	NCBI Sequence Viewer
	EDM08633	(Get FASTA)	NCBI Sequence Viewer
	EDM08634	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016445
	ENSRNOP00000016445.4
	ENSRNOP00000080516.1

RefSeq Acc Id:	NP_001100998 ⟸ NM_001107528
- UniProtKB:	D4A500 (UniProtKB/TrEMBL), A6JCA5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGSEAAQLLEAADFAAQKHRQQRRKDPEGTPYINHPIGVARILTHEAGITDIVVLQAALLHDTV EDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERKRQQVEQAPHSSPGAKLVKLADKLHNLR DLNRCTPKGWSEHRVQEYFEWAAQVVKGLQGTNQQLEEALKQLFEERGLTL hide sequence

RefSeq Acc Id:	XP_006229493 ⟸ XM_006229431
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZQC5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MPCVARILTHEAGITDIVVLQAALLHDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLE RKRQQVEQAPHSSPGAKLVKLADKLHNLRDLNRCTPKGWSEHRVQEYFEWAAQVVKGLQGTNQQ LEEALKQLFEERGLTL hide sequence

Ensembl Acc Id:

ENSRNOP00000016445 ⟸ ENSRNOT00000016445

Ensembl Acc Id:

ENSRNOP00000080516 ⟸ ENSRNOT00000099679

Protein Domains

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D4A500-F1-model_v2	AlphaFold	D4A500	1-179	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690145

Promoter ID:

EPDNEW_R668

Type:

initiation region

Name:

Hddc3_1

Description:

HD domain containing 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	142,136,449 - 142,136,509	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311839	AgrOrtholog
BioCyc Gene	G2FUF-58737	BioCyc
Ensembl Genes	ENSRNOG00000012236	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016445	ENTREZGENE
	ENSRNOT00000016445.6	UniProtKB/TrEMBL
	ENSRNOT00000099679.1	UniProtKB/TrEMBL
Gene3D-CATH	Hypothetical protein af1432	UniProtKB/TrEMBL
InterPro	HD_domain	UniProtKB/TrEMBL
	MESH1	UniProtKB/TrEMBL
	Metal-dep_PHydrolase_HD_dom	UniProtKB/TrEMBL
KEGG Report	rno:308758	UniProtKB/TrEMBL
NCBI Gene	308758	ENTREZGENE
PANTHER	GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1	UniProtKB/TrEMBL
	GUANOSINE-3',5'-BIS(DIPHOSPHATE) 3'-PYROPHOSPHOHYDROLASE MESH1	UniProtKB/TrEMBL
Pfam	HD_4	UniProtKB/TrEMBL
PhenoGen	Hddc3	PhenoGen
PROSITE	PS51831	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012236	RatGTEx
SMART	HDc	UniProtKB/TrEMBL
Superfamily-SCOP	HD-domain/PDEase-like	UniProtKB/TrEMBL
UniProt	A0A8I5ZQC5	ENTREZGENE, UniProtKB/TrEMBL
	A6JCA5	ENTREZGENE, UniProtKB/TrEMBL
	D4A500	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-04-30	Hddc3	HD domain containing 3	Hddc3_predicted	HD domain containing 3 (predicted)	'predicted' is removed	2292626	APPROVED
2006-03-30	Hddc3_predicted	HD domain containing 3 (predicted)	RGD1311839_predicted	similar to RIKEN cDNA 1110033O09 (predicted)	Symbol and Name updated	1299863	APPROVED
2005-01-20	RGD1311839_predicted	similar to RIKEN cDNA 1110033O09 (predicted)	LOC308758_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC308758_predicted	similar to RIKEN cDNA 1110033O09 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar