Mterf2 (mitochondrial transcription termination factor 2) - Rat Genome Database

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Gene: Mterf2 (mitochondrial transcription termination factor 2) Rattus norvegicus
Analyze
Symbol: Mterf2
Name: mitochondrial transcription termination factor 2
RGD ID: 1311836
Description: Predicted to enable DNA binding activity. Predicted to be involved in termination of mitochondrial transcription. Predicted to be located in mitochondrial nucleoid. Predicted to be active in mitochondrial matrix. Orthologous to human MTERF2 (mitochondrial transcription termination factor 2); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC366856; MGC112659; MTERF domain containing 3; mTERF domain-containing protein 3, mitochondrial; Mterfd3; RGD1311836; similar to transcription termination factor-like protein; transcription termination factor 2, mitochondrial
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8720,485,901 - 20,495,979 (+)NCBIGRCr8
mRatBN7.2718,598,202 - 18,608,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl718,598,103 - 18,620,684 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx720,559,071 - 20,569,113 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0722,721,769 - 22,731,811 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0722,498,731 - 22,508,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0724,638,208 - 24,649,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl724,638,208 - 24,648,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0724,788,242 - 24,798,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,713,326 - 20,723,489 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1720,733,596 - 20,743,756 (+)NCBI
Celera715,826,281 - 15,836,295 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:18614015   PMID:19366608  


Genomics

Comparative Map Data
Mterf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8720,485,901 - 20,495,979 (+)NCBIGRCr8
mRatBN7.2718,598,202 - 18,608,278 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl718,598,103 - 18,620,684 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx720,559,071 - 20,569,113 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0722,721,769 - 22,731,811 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0722,498,731 - 22,508,773 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0724,638,208 - 24,649,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl724,638,208 - 24,648,255 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0724,788,242 - 24,798,742 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4720,713,326 - 20,723,489 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1720,733,596 - 20,743,756 (+)NCBI
Celera715,826,281 - 15,836,295 (+)NCBICelera
Cytogenetic Map7q13NCBI
MTERF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812106,977,277 - 106,987,146 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12106,973,120 - 106,987,163 (-)EnsemblGRCh38hg38GRCh38
GRCh3712107,371,055 - 107,380,924 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612105,895,199 - 105,905,059 (-)NCBINCBI36Build 36hg18NCBI36
Celera12107,036,630 - 107,046,488 (-)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12104,431,573 - 104,441,448 (-)NCBIHuRef
CHM1_112107,336,699 - 107,346,574 (-)NCBICHM1_1
T2T-CHM13v2.012106,940,911 - 106,950,780 (-)NCBIT2T-CHM13v2.0
Mterf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391084,951,092 - 84,963,982 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1084,955,297 - 84,963,891 (-)EnsemblGRCm39 Ensembl
GRCm381085,119,433 - 85,128,027 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1085,119,433 - 85,128,027 (-)EnsemblGRCm38mm10GRCm38
MGSCv371084,582,178 - 84,590,772 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361084,549,235 - 84,557,800 (-)NCBIMGSCv36mm8
Celera1087,095,781 - 87,104,375 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1041.63NCBI
Mterf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540540,870,215 - 40,871,384 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540540,870,002 - 40,871,433 (-)NCBIChiLan1.0ChiLan1.0
MTERF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210115,033,512 - 115,043,169 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112115,028,022 - 115,039,568 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012104,544,783 - 104,554,675 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112107,938,754 - 107,948,648 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12107,939,021 - 107,940,178 (-)Ensemblpanpan1.1panPan2
MTERF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11031,792,889 - 31,794,304 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1031,792,917 - 31,794,074 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1031,765,709 - 31,780,579 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01032,621,587 - 32,636,444 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1032,627,245 - 32,635,702 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11032,357,826 - 32,372,680 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01032,648,303 - 32,663,103 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01032,834,267 - 32,849,133 (+)NCBIUU_Cfam_GSD_1.0
Mterf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494514,987,812 - 15,006,137 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364928,005,944 - 8,007,095 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364927,998,229 - 8,007,103 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MTERF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl513,367,438 - 13,376,642 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1513,374,243 - 13,376,641 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2513,219,978 - 13,228,224 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MTERF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111102,191,842 - 102,200,719 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11102,190,413 - 102,191,567 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037142,851,536 - 142,865,784 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mterf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247502,539,131 - 2,540,312 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247502,535,015 - 2,555,789 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mterf2
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000009135
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat

Markers in Region
RH132121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2718,608,022 - 18,608,226 (+)MAPPERmRatBN7.2
Rnor_6.0724,648,029 - 24,648,232NCBIRnor6.0
Rnor_5.0724,798,487 - 24,798,690UniSTSRnor5.0
RGSC_v3.4720,723,255 - 20,723,458UniSTSRGSC3.4
Celera715,836,061 - 15,836,264UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 8 6 31 12 3
Low 3 43 49 41 13 41 8 11 43 35 29 8 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000009135   ⟹   ENSRNOP00000009135
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,598,103 - 18,608,258 (+)Ensembl
Rnor_6.0 Ensembl724,638,208 - 24,648,255 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113372   ⟹   ENSRNOP00000093657
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,598,103 - 18,620,684 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000118255   ⟹   ENSRNOP00000089858
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl718,598,168 - 18,608,703 (+)Ensembl
RefSeq Acc Id: NM_001014265   ⟹   NP_001014287
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8720,485,901 - 20,495,958 (+)NCBI
mRatBN7.2718,598,202 - 18,608,257 (+)NCBI
Rnor_6.0724,638,208 - 24,648,263 (+)NCBI
Rnor_5.0724,788,242 - 24,798,742 (+)NCBI
RGSC_v3.4720,713,326 - 20,723,489 (+)RGD
Celera715,826,281 - 15,836,295 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079676   ⟹   XP_038935604
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8720,485,902 - 20,495,979 (+)NCBI
mRatBN7.2718,598,203 - 18,608,278 (+)NCBI
RefSeq Acc Id: XM_063264025   ⟹   XP_063120095
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8720,485,921 - 20,495,979 (+)NCBI
RefSeq Acc Id: NP_001014287   ⟸   NM_001014265
- Peptide Label: precursor
- UniProtKB: Q5XIE2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000009135   ⟸   ENSRNOT00000009135
RefSeq Acc Id: XP_038935604   ⟸   XM_039079676
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GHQ6 (UniProtKB/TrEMBL),   A6IFE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093657   ⟸   ENSRNOT00000113372
RefSeq Acc Id: ENSRNOP00000089858   ⟸   ENSRNOT00000118255
RefSeq Acc Id: XP_063120095   ⟸   XM_063264025
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIE2-F1-model_v2 AlphaFold Q5XIE2 1-385 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695097
Promoter ID:EPDNEW_R5622
Type:initiation region
Name:Mterf2_1
Description:mitochondrial transcription termination factor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0724,638,160 - 24,638,220EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311836 AgrOrtholog
BioCyc Gene G2FUF-34629 BioCyc
Ensembl Genes ENSRNOG00000006978 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009135 ENTREZGENE
  ENSRNOT00000009135.5 UniProtKB/TrEMBL
  ENSRNOT00000113372.1 UniProtKB/TrEMBL
  ENSRNOT00000118255 ENTREZGENE
  ENSRNOT00000118255.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.70.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191829 IMAGE-MGC_LOAD
  IMAGE:7386232 IMAGE-MGC_LOAD
InterPro MTERF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MTERF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:366856 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112659 IMAGE-MGC_LOAD
  MGC:94656 IMAGE-MGC_LOAD
NCBI Gene 366856 ENTREZGENE
PANTHER PTHR15437 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRANSCRIPTION TERMINATION FACTOR 2, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam mTERF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mterf2 PhenoGen
RatGTEx ENSRNOG00000006978 RatGTEx
SMART Mterf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6GHQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6IFE3 ENTREZGENE, UniProtKB/TrEMBL
  MTEF2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-10 Mterf2  mitochondrial transcription termination factor 2  Mterfd3  MTERF domain containing 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Mterfd3  MTERF domain containing 3  RGD1311836  similar to transcription termination factor-like protein  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1311836  similar to transcription termination factor-like protein  RGD1311836_predicted  similar to transcription termination factor-like protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1311836_predicted  similar to transcription termination factor-like protein (predicted)  LOC366856_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC366856_predicted  similar to transcription termination factor-like protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL