Ccrl2 (C-C motif chemokine receptor like 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ccrl2 (C-C motif chemokine receptor like 2) Rattus norvegicus
Analyze
Symbol: Ccrl2
Name: C-C motif chemokine receptor like 2
RGD ID: 1311811
Description: Predicted to enable C-C chemokine binding activity; C-C chemokine receptor activity; and CCR chemokine receptor binding activity. Predicted to be involved in several processes, including calcium-mediated signaling; cell chemotaxis; and positive regulation of cytosolic calcium ion concentration. Predicted to be located in plasma membrane. Predicted to be active in cytoplasm and external side of plasma membrane. Orthologous to human CCRL2 (C-C motif chemokine receptor like 2); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-C chemokine receptor-like 2; chemokine (C-C motif) receptor-like 2; LOC316019
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,912,671 - 119,915,313 (-)NCBIGRCr8
mRatBN7.28111,034,279 - 111,036,914 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8111,034,279 - 111,036,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,648,583 - 116,650,885 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,847,802 - 114,850,104 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,690,634 - 112,692,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,324,298 - 119,326,954 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,324,613 - 119,326,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,666,369 - 118,668,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,451,786 - 115,454,088 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,471,552 - 115,488,476 (-)NCBI
Celera8110,316,626 - 110,318,928 (-)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14530373   PMID:18794339   PMID:20002784  


Genomics

Comparative Map Data
Ccrl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88119,912,671 - 119,915,313 (-)NCBIGRCr8
mRatBN7.28111,034,279 - 111,036,914 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8111,034,279 - 111,036,664 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8116,648,583 - 116,650,885 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08114,847,802 - 114,850,104 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08112,690,634 - 112,692,936 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08119,324,298 - 119,326,954 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8119,324,613 - 119,326,938 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08118,666,369 - 118,668,829 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48115,451,786 - 115,454,088 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18115,471,552 - 115,488,476 (-)NCBI
Celera8110,316,626 - 110,318,928 (-)NCBICelera
Cytogenetic Map8q32NCBI
CCRL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38346,407,259 - 46,409,523 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl346,407,166 - 46,412,997 (+)EnsemblGRCh38hg38GRCh38
GRCh37346,448,750 - 46,451,014 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,423,725 - 46,426,018 (+)NCBINCBI36Build 36hg18NCBI36
Celera346,386,028 - 46,388,321 (+)NCBICelera
Cytogenetic Map3p21.31NCBI
HuRef346,491,076 - 46,493,346 (+)NCBIHuRef
CHM1_1346,398,717 - 46,401,010 (+)NCBICHM1_1
T2T-CHM13v2.0346,422,959 - 46,425,353 (+)NCBIT2T-CHM13v2.0
Ccrl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399110,883,902 - 110,886,586 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9110,883,554 - 110,886,587 (-)EnsemblGRCm39 Ensembl
GRCm389111,054,834 - 111,057,518 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9111,054,486 - 111,057,519 (-)EnsemblGRCm38mm10GRCm38
MGSCv379110,957,339 - 110,959,774 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369110,899,651 - 110,902,086 (-)NCBIMGSCv36mm8
Celera9110,778,403 - 110,780,835 (-)NCBICelera
Cytogenetic Map9F2NCBI
cM Map960.92NCBI
Ccrl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495542025,613,632 - 25,616,770 (-)NCBIChiLan1.0ChiLan1.0
CCRL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2246,366,028 - 46,368,841 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1346,370,796 - 46,373,610 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0346,296,556 - 46,311,246 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1347,413,641 - 47,415,969 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,414,124 - 47,415,562 (+)Ensemblpanpan1.1panPan2
CCRL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12042,270,431 - 42,272,498 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,270,477 - 42,271,526 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,186,582 - 42,190,024 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02042,752,881 - 42,756,323 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2042,752,881 - 42,754,808 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12041,994,143 - 41,997,586 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02042,395,584 - 42,399,027 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02042,676,489 - 42,679,933 (-)NCBIUU_Cfam_GSD_1.0
Ccrl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118200,769,169 - 200,771,820 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936596319,841 - 320,911 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCRL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1329,402,538 - 29,404,607 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,402,488 - 29,410,508 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,566,384 - 32,570,597 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCRL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1227,835,224 - 7,847,762 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl227,846,319 - 7,847,353 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041159,304,481 - 159,318,098 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccrl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473074,671,736 - 74,674,030 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ccrl2
12 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:129
Interacting mature miRNAs:148
Transcripts:ENSRNOT00000044467
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088626Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat

Markers in Region
RH137508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.28111,034,674 - 111,034,812 (+)MAPPERmRatBN7.2
Rnor_6.08119,324,694 - 119,324,831NCBIRnor6.0
Rnor_5.08118,666,765 - 118,666,902UniSTSRnor5.0
RGSC_v3.48115,452,182 - 115,452,319UniSTSRGSC3.4
Celera8110,317,022 - 110,317,159UniSTS
Cytogenetic Map8q32UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 1 11
Low 2 43 53 37 18 37 8 11 14 35 37 8
Below cutoff 4 4 4 58 3

Sequence


RefSeq Acc Id: ENSRNOT00000044467   ⟹   ENSRNOP00000044084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8111,034,279 - 111,036,581 (-)Ensembl
Rnor_6.0 Ensembl8119,324,613 - 119,326,938 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113129   ⟹   ENSRNOP00000081823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8111,034,420 - 111,036,664 (-)Ensembl
RefSeq Acc Id: NM_001108191   ⟹   NP_001101661
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,912,671 - 119,914,973 (-)NCBI
mRatBN7.28111,034,279 - 111,036,581 (-)NCBI
Rnor_6.08119,324,298 - 119,326,600 (-)NCBI
Rnor_5.08118,666,369 - 118,668,829 (-)NCBI
RGSC_v3.48115,451,786 - 115,454,088 (-)RGD
Celera8110,316,626 - 110,318,928 (-)RGD
Sequence:
RefSeq Acc Id: XM_006243966   ⟹   XP_006244028
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,912,902 - 119,915,065 (-)NCBI
mRatBN7.28111,034,510 - 111,036,674 (-)NCBI
Rnor_6.08119,324,529 - 119,326,695 (-)NCBI
Rnor_5.08118,666,369 - 118,668,829 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017595697   ⟹   XP_017451186
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88119,912,902 - 119,915,313 (-)NCBI
mRatBN7.28111,034,510 - 111,036,914 (-)NCBI
Rnor_6.08119,324,529 - 119,326,954 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001101661 (Get FASTA)   NCBI Sequence Viewer  
  XP_006244028 (Get FASTA)   NCBI Sequence Viewer  
  XP_017451186 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77039 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044084
  ENSRNOP00000044084.3
  ENSRNOP00000081823
  ENSRNOP00000081823.1
RefSeq Acc Id: NP_001101661   ⟸   NM_001108191
- UniProtKB: D3ZVM9 (UniProtKB/TrEMBL),   A6I3I8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006244028   ⟸   XM_006243966
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017451186   ⟸   XM_017595697
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZTQ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000044084   ⟸   ENSRNOT00000044467
RefSeq Acc Id: ENSRNOP00000081823   ⟸   ENSRNOT00000113129
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZVM9-F1-model_v2 AlphaFold D3ZVM9 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311811 AgrOrtholog
BioCyc Gene G2FUF-29034 BioCyc
Ensembl Genes ENSRNOG00000033234 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044467 ENTREZGENE
  ENSRNOT00000044467.5 UniProtKB/TrEMBL
  ENSRNOT00000113129.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/TrEMBL
InterPro 7TM_GPCR_Rhodpsn UniProtKB/TrEMBL
  Chmkine_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn_supfam UniProtKB/TrEMBL
KEGG Report rno:316019 UniProtKB/TrEMBL
NCBI Gene 316019 ENTREZGENE
PANTHER C-C CHEMOKINE RECEPTOR-LIKE 2 UniProtKB/TrEMBL
  CELL ADHESION MOLECULE UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/TrEMBL
PhenoGen Ccrl2 PhenoGen
PRINTS CCCHEMOKINER UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033234 RatGTEx
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/TrEMBL
UniProt A0A8I5ZTQ6 ENTREZGENE, UniProtKB/TrEMBL
  A6I3I8 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVM9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccrl2  C-C motif chemokine receptor like 2  Ccrl2  chemokine (C-C motif) receptor-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ccrl2  chemokine (C-C motif) receptor-like 2   Ccrl2_predicted  chemokine (C-C motif) receptor-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ccrl2_predicted  chemokine (C-C motif) receptor-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED