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Gene: Ldah (lipid droplet associated hydrolase) Rattus norvegicus

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Symbol:

Ldah

Name:

lipid droplet associated hydrolase

RGD ID:

1311648

Description:

Predicted to enable sterol ester esterase activity. Predicted to be involved in cholesterol homeostasis; intracellular triglyceride homeostasis; and lipid storage. Predicted to act upstream of with a positive effect on lipid droplet fusion. Predicted to be located in endoplasmic reticulum. Predicted to be active in lipid droplet. Orthologous to human LDAH (lipid droplet associated hydrolase); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hypothetical protein LOC313949; lipid droplet-associated hydrolase; lipid droplet-associated serine hydrolase; LOC313949; RGD1311648; similar to hypothetical protein FLJ21820; UPF0554 protein C2orf43 homolog

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LDAH (lipid droplet associated hydrolase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ldah (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ldah (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LDAH (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LDAH (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ldah (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LDAH (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LDAH (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ldah (lipid droplet associated hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ldah (lipid droplet associated hydrolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	LDAH (lipid droplet associated hydrolase)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ldah (lipid droplet associated hydrolase)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	F11C1.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG9186	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	YPR147C	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F26A3.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	ldah	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	36,801,359 - 36,885,929 (+)	NCBI		GRCr8
mRatBN7.2	6	31,082,045 - 31,166,625 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	31,082,055 - 31,166,618 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	31,374,145 - 31,458,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	31,690,068 - 31,774,640 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	31,164,591 - 31,249,149 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	33,407,223 - 33,491,726 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,407,248 - 33,491,725 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	43,191,256 - 43,259,692 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	6	43,274,971 - 43,276,852 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	31,758,976 - 31,845,613 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	31,761,928 - 31,848,566 (+)	NCBI
Celera	6	30,533,370 - 30,616,806 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Prostatic Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-tribromophenol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

4-hydroxyphenyl retinamide (ISO)

Aflatoxin B2 alpha (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-lapachone (ISO)

bisphenol A (EXP,ISO)

bisphenol F (EXP)

cadmium dichloride (EXP)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

decabromodiphenyl ether (EXP,ISO)

dicrotophos (ISO)

flutamide (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gallic acid (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

lead diacetate (EXP)

methyl methanesulfonate (ISO)

nitrates (ISO)

ozone (ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

potassium chromate (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

temozolomide (ISO)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

triphenyl phosphate (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cholesterol homeostasis (IEA,ISO,ISS)

intracellular triglyceride homeostasis (IEA,ISO,ISS)

lipid droplet fusion (IEA,ISO,ISS)

lipid storage (IBA,IEA)

Cellular Component

endoplasmic reticulum (IEA,ISO,ISS)

lipid droplet (IBA,IEA,ISO,ISS)

Molecular Function

hydrolase activity (IEA)

lipase activity (IEA)

sterol ester esterase activity (IEA,ISO,ISS)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:24357060

Genomics

Comparative Map Data

Ldah
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	36,801,359 - 36,885,929 (+)	NCBI		GRCr8
mRatBN7.2	6	31,082,045 - 31,166,625 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	31,082,055 - 31,166,618 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	31,374,145 - 31,458,719 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	31,690,068 - 31,774,640 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	31,164,591 - 31,249,149 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	33,407,223 - 33,491,726 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	33,407,248 - 33,491,725 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	43,191,256 - 43,259,692 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	6	43,274,971 - 43,276,852 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	31,758,976 - 31,845,613 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	6	31,761,928 - 31,848,566 (+)	NCBI
Celera	6	30,533,370 - 30,616,806 (+)	NCBI		Celera
Cytogenetic Map	6	q14	NCBI

LDAH
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	2	20,682,489 - 20,823,101 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	2	20,684,014 - 20,823,130 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	2	20,883,791 - 21,022,861 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	20,748,299 - 20,886,308 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	2	20,747,203 - 20,885,172 (-)	NCBI		Celera
Cytogenetic Map	2	p24.1	NCBI
HuRef	2	20,641,762 - 20,779,692 (-)	NCBI		HuRef
CHM1_1	2	20,814,201 - 20,952,135 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	2	20,711,570 - 20,856,339 (-)	NCBI		T2T-CHM13v2.0

Ldah
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	8,258,095 - 8,350,811 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	8,258,107 - 8,335,759 (+)	Ensembl		GRCm39 Ensembl
GRCm38	12	8,208,095 - 8,300,811 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	8,208,107 - 8,285,759 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	8,214,913 - 8,292,565 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	8,234,131 - 8,311,760 (+)	NCBI		MGSCv36	mm8
Celera	12	8,602,897 - 8,679,608 (+)	NCBI		Celera
Cytogenetic Map	12	A1.1	NCBI
cM Map	12	3.85	NCBI

Ldah
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955469	3,160,497 - 3,272,643 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955469	3,161,691 - 3,277,018 (-)	NCBI	ChiLan1.0	ChiLan1.0

LDAH
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	12	105,703,307 - 105,845,490 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	2A	105,707,429 - 105,858,390 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	2A	20,668,816 - 20,808,519 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	2A	20,784,999 - 20,922,673 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2A	20,785,002 - 20,923,390 (-)	Ensembl	panpan1.1		panPan2

LDAH
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	17	15,642,809 - 15,747,652 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	17	15,644,678 - 15,747,607 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	17	15,607,516 - 15,712,405 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	17	15,794,902 - 15,899,697 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	17	15,794,900 - 15,899,636 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	17	15,648,732 - 15,753,469 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	17	15,655,810 - 15,760,735 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	17	15,687,903 - 15,792,689 (-)	NCBI		UU_Cfam_GSD_1.0

Ldah
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024406292	60,044,414 - 60,133,107 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936493	10,706,489 - 10,795,446 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936493	10,706,501 - 10,795,151 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LDAH
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	117,463,809 - 117,571,899 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	117,463,795 - 117,575,422 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	125,415,972 - 125,534,850 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LDAH
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	14	86,843,370 - 87,008,966 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	14	86,866,459 - 87,010,009 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	25,197,376 - 25,351,166 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ldah
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624738	3,302,237 - 3,412,901 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624738	3,303,520 - 3,428,598 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ldah
172 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	164
Count of miRNA genes:	124
Interacting mature miRNAs:	144
Transcripts:	ENSRNOT00000030244
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
8552962	Pigfal16	Plasma insulin-like growth factor 1 level QTL 16	9.4		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	6	1	41223769	Rat
10401812	Kidm54	Kidney mass QTL 54			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1331743	Uae28	Urinary albumin excretion QTL 28	4.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	6	1	34235784	Rat
2292589	Emca10	Estrogen-induced mammary cancer QTL 10		0.048	mammary gland integrity trait (VT:0010552)	post-insult time to mammary tumor formation (CMO:0000345)	6	16536140	61536140	Rat
10401800	Kidm49	Kidney mass QTL 49			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	6	14368788	59368788	Rat
1300164	Rf15	Renal function QTL 15	3.12		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	54641141	Rat
9589129	Insul24	Insulin level QTL 24	19.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	6	1	41223769	Rat
1578758	Tcas9	Tongue tumor susceptibility QTL 9	3.29		tongue integrity trait (VT:0010553)	number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)	6	1	37618905	Rat
4145119	Mcs25	Mammary carcinoma susceptibility QTL 25		0.0001	mammary gland integrity trait (VT:0010552)	ratio of deaths to total study population during a period of time (CMO:0001023)	6	10894415	110548006	Rat
7411603	Foco13	Food consumption QTL 13	5.5	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	41223769	Rat
1598843	Cm63	Cardiac mass QTL 63	2.6		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	6	1	39036266	Rat
738024	Sach5	Saccharine consumption QTL 5	3.9	0.00039	consumption behavior trait (VT:0002069)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	6	1	43394190	Rat
7411542	Bw127	Body weight QTL 127	5.5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	1	41223769	Rat
9589048	Scfw3	Subcutaneous fat weight QTL 3	4.57	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	6	1	41223769	Rat
2293839	Kiddil2	Kidney dilation QTL 2	4.8		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1576309	Emca7	Estrogen-induced mammary cancer QTL 7	4		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	6	15107216	107351382	Rat
2293709	Bss23	Bone structure and strength QTL 23	5.18	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	6	1	42487980	Rat
2293650	Bss31	Bone structure and strength QTL 31	5.05	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	6	1	42487980	Rat
7411584	Foco4	Food consumption QTL 4	4.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	6	1	42838846	Rat
1578665	Bss16	Bone structure and strength QTL 16	4.4		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	6	11735669	72593685	Rat
2293841	Kiddil4	Kidney dilation QTL 4	4.4		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	6	20866422	81133036	Rat
1300128	Rf16	Renal function QTL 16	3.89		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	6	5074497	34434305	Rat
1641898	Colcr4	Colorectal carcinoma resistance QTL4	3.71	0.0007	intestine integrity trait (VT:0010554)	well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)	6	20338777	62613667	Rat
1578668	Bmd14	Bone mineral density QTL 14	3.8		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	6	11735669	72593685	Rat
2301972	Bp325	Blood pressure QTL 325	4.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	6	1	72227641	Rat
2293656	Bss28	Bone structure and strength QTL 28	6.79	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	6	1	42487980	Rat
1354664	Slep2	Serum leptin concentration QTL 2	4.49		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	6	16536140	71636405	Rat

Markers in Region

RH131008

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	31,082,144 - 31,082,335 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	33,407,334 - 33,407,524	NCBI	Rnor6.0
Rnor_5.0	6	43,191,326 - 43,191,516	UniSTS	Rnor5.0
RGSC_v3.4	6	31,759,046 - 31,759,236	UniSTS	RGSC3.4
Celera	6	30,533,440 - 30,533,630	UniSTS
Cytogenetic Map	6	q14	UniSTS

AU048419

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	6	31,108,285 - 31,108,468 (+)	MAPPER	mRatBN7.2
Rnor_6.0	6	33,433,478 - 33,433,660	NCBI	Rnor6.0
Rnor_5.0	6	43,217,399 - 43,217,581	UniSTS	Rnor5.0
RGSC_v3.4	6	31,785,119 - 31,785,301	UniSTS	RGSC3.4
Celera	6	30,559,550 - 30,559,732	UniSTS
Cytogenetic Map	6	q14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014075	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001394269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008764592	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261882	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261883	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063261884	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010052083	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010052084	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC142360	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473947	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210061	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000030244 ⟹ ENSRNOP00000033708

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	31,082,055 - 31,166,618 (+)	Ensembl
Rnor_6.0 Ensembl	6	33,407,248 - 33,491,725 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000096109 ⟹ ENSRNOP00000089371

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	31,082,073 - 31,164,760 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115305 ⟹ ENSRNOP00000088267

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	6	31,082,073 - 31,166,450 (+)	Ensembl

RefSeq Acc Id:

NM_001014075 ⟹ NP_001014097

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,801,359 - 36,885,929 (+)	NCBI
mRatBN7.2	6	31,082,049 - 31,166,625 (+)	NCBI
Rnor_6.0	6	33,407,264 - 33,491,726 (+)	NCBI
Rnor_5.0	6	43,191,256 - 43,259,692 (+)	NCBI
Rnor_5.0	6	43,274,971 - 43,276,852 (+)	NCBI
RGSC_v3.4	6	31,758,976 - 31,845,613 (+)	RGD
Celera	6	30,533,370 - 30,616,806 (+)	RGD

Sequence:

show sequence

TGAAGCTTTGACAAGAGGTCCGCGGACGACCCCGATACTTTGTGGATGGGCAGAAATGGCCTCA
GAAGTTGAGGATGGAGTCCCTGTGCATGAGGAATTCTTTCTCTGTGGTGGAGTTGAAACCCAGA
TCATTAAATGTGGGCCCTGGACTAACCTCTTTGATAAACAAGGTGTCAGCAAGCCAAAACATCT
TATCTTCGTCATTCCCGGTAACCCAGGCCTTTCCCCCTTCTACGTGCCATTTGCAAAGGCCTTG
TACTCTTTGGTGAAGGGCCACTTCCCAGTATGGATCATCTCGCATGCTGGGTTTTGCTTGACTC
CCAAGGACAAGAAGATTCTCACTGCACCACAGGAACCAAATGCTCAAGAAATTGAGGACATCTA
TGGTCTGAATGGTCAAATAGAGCACAAAATAGCTTTTCTGAGAGCTCACGTACCGAAGGATGTG
AAGCTTATATTCATTGGCCATTCCGTAGGCAGCTATATTGCTCTTCACGTGATGAACCGTGCCC
CGGAGCTGCCGGTCGTCCACACCTTTCTGCTGTTTCCAACTATCGAGCGAATGTCCGAATCGCC
CAACGGCAAGTTTGCCACTCCATTTTTGTGCCGGTTTCGATATATGCTCTATGCTGCCAGCTAC
TTAATTTTTAAGCCATGTCCTGAAATGATAAAGTCCTTCATAGTCCAAAAAGTCCTGGAAAAAA
TGAGCTTTAAATCCGAACTTCGTTTGACGGATCTTCTTCAACCATTCTGCCTTGCTAATGCTGC
CTACCTCGGGGGCCAAGAAATGATCCATGTGGTGAAGAGAGATGATGGAATCATAAAGGAACTT
TTACCTAAGCTTACATTTTACTATGGTAAAACAGATGGCTGGTGTCCAGTAAACTACTATGAAG
ACATGAAGAGAGATTTTCCAGAAGCCAATCTTCACCTCTGTGAGAAAGGAATACCCCATGCTTT
TGTTCTCGGTTTTAGCCAGGAGATGGCTGCCATGGTTGCTGACTGGATAAACAATAGACTGCCC
AAAAAATAAGTACTGTCCCAAGGGGGAACAAGAGCACCCACAGGCAACACATAGAAGCTGTAGG
TGTGCTCTGCTTAGGGGTAAATGTTTAATCTTAATGCTTGAAAGAAAAATTGAGACCCTCTTGT
CTTAGAGATTACCAGCTCCCAGGCCCTGTGTTAAGACTAAAGTGAACACAGCTAATGACTCATT
CCATGGAAGAGCAATAAGCAGAGGATGCTGACGGTGCACTTTGGAGAAACCCAGTTCAGGGGAA
ACCATTTCAGACTTCATACAGGTCCTGGCTGAGATCATCAGCAGGATCTTCGTGGTCCACCTGC
AGTACACCAAACATCAGGTTTGCCCGACACTCCTCTACTAACCAGACAGGGTTGCTGGAAGATC
CTGACTCTATCCTGCCACAGGATAGCTAACAGGCTGCTCCTGACCCCTGAAATGCCAGGTCCCT
GCAGGCTCTTCCAGAGCGAGAAGGGAGGGATGAAGAGTCCACATCGGATTTGTATGGGCATGGG
ATTTCTTGCCAGTGCAATCCGCCAGTGACGCTCCATGGACAGGAAGCAGTGAGCCACCCTAGCC
ATTCACGATGCCGTTAGCTACCTTGTGACTCTTCCCTTCTCAAAATCTCCTAGAACATAAATTT
GGAAAGGTGTTTTAAATTGTTAAGTAAAACACTAGCATAATTTCATTCCCCACGTGCCTAAACT
TTATTGATCGGAAAGAAATGATTTTTCAAATGAACAGAATCCTGCAAGCCATTAAATTTTTATT
ACTTCACTTCTGAAAGCATCAAAGTCGAGTAGAAAAGCATATTCCTGACTAAGAAGCAGAGGGG
TGCATCCTCCAAACACACTGAACAGCTATGCGGCCTTACCTTAACTGACTCAATCCTGAGATCT
CGGAGGCCAGTTAAACCCAGCCGTCTGTAGTAACAGTTGAACAGTTAGTTGGAAGCATTCCATT
TTCTTGTAGAAAAAAAGCTCTCATAACAGTATCATTCCTCAAGGGCAGTGAGATGGTCCTTCCT
CTCAAAGACCTAAGGCACTGATGAAAGATTTGGCTCTGGTGTGCTGCCAGCCCAGTGGTGAGAG
AGGAGTAGTTCTCATCGCTCGGCATGGCTTCCACATAGGAGCTCAGCTTCTCCAGACAAGGAGT
GCTCTCAGTCCAGGAAGACACCGTGAGGGTCCTTACTGTGTTTGCACAAGGAGGCCTCCTGCAG
AGCTGACCTGGGAAGCCAGGATTCTTGCTCTGAGTGCCCCGCTTATAGAACAGGCTTGATCAGT
AGTGGGAATCAGTACATAGAAACAAATCCTGGGGGGGCTGGAGAGGTGGCTCAGCGGTTAAGAG
CACTGACTGCTCTTCCAGAGGTCCTGAGTTCAAATCCCAGCAACCACATGGTGGCTCACAACCA
TCTGTAATGAGATCTGATGCCCTCTTCTGGTGTGTCTGAAGACAGCTACAATGTACTCATATAT
AATAAATAAATAAATAAATAAATAAAAAGAAAGAAACAAATCCTGGTAAATCAGACCTAGTGGA
ACAAAAGAGTAGCATTCGTAGCTCTCTCTTAGAAATTATTTTACATTACTCTTTGTTTCCCAAA
TCCTGTTTAAAAGGCCCTGGTTCCTCATTCCTACTCCTCACCTAATCACCAAACAATATTTTAT
AATAAATTTCTCACCCGCAGTCAAAAAAAAAAAAAAAAAAAAAAAAAAGG

hide sequence

RefSeq Acc Id:

NM_001394269 ⟹ NP_001381198

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,801,359 - 36,885,929 (+)	NCBI
mRatBN7.2	6	31,082,049 - 31,166,625 (+)	NCBI

RefSeq Acc Id:

XM_063261882 ⟹ XP_063117952

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,812,687 - 36,885,929 (+)	NCBI

RefSeq Acc Id:

XM_063261883 ⟹ XP_063117953

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,801,359 - 36,885,929 (+)	NCBI

RefSeq Acc Id:

XM_063261884 ⟹ XP_063117954

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,801,382 - 36,885,929 (+)	NCBI

RefSeq Acc Id:

XR_010052083

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,801,364 - 36,884,179 (+)	NCBI

RefSeq Acc Id:

XR_010052084

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	6	36,801,364 - 36,861,407 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014097	(Get FASTA)	NCBI Sequence Viewer
	NP_001381198	(Get FASTA)	NCBI Sequence Viewer
	XP_063117952	(Get FASTA)	NCBI Sequence Viewer
	XP_063117953	(Get FASTA)	NCBI Sequence Viewer
	XP_063117954	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH88848	(Get FASTA)	NCBI Sequence Viewer
	EDM03067	(Get FASTA)	NCBI Sequence Viewer
	EDM03068	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000033708
	ENSRNOP00000033708.5
	ENSRNOP00000088267.1
	ENSRNOP00000089371
	ENSRNOP00000089371.1
GenBank Protein	Q5HZX7	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014097 ⟸ NM_001014075

- UniProtKB:

Q5HZX7 (UniProtKB/Swiss-Prot), A0A8L2QK08 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MASEVEDGVPVHEEFFLCGGVETQIIKCGPWTNLFDKQGVSKPKHLIFVIPGNPGLSPFYVPFA
KALYSLVKGHFPVWIISHAGFCLTPKDKKILTAPQEPNAQEIEDIYGLNGQIEHKIAFLRAHVP
KDVKLIFIGHSVGSYIALHVMNRAPELPVVHTFLLFPTIERMSESPNGKFATPFLCRFRYMLYA
ASYLIFKPCPEMIKSFIVQKVLEKMSFKSELRLTDLLQPFCLANAAYLGGQEMIHVVKRDDGII
KELLPKLTFYYGKTDGWCPVNYYEDMKRDFPEANLHLCEKGIPHAFVLGFSQEMAAMVADWINN
RLPKK

hide sequence

Ensembl Acc Id:

ENSRNOP00000033708 ⟸ ENSRNOT00000030244

Ensembl Acc Id:

ENSRNOP00000089371 ⟸ ENSRNOT00000096109

Ensembl Acc Id:

ENSRNOP00000088267 ⟸ ENSRNOT00000115305

RefSeq Acc Id:	NP_001381198 ⟸ NM_001394269
- UniProtKB:	Q5HZX7 (UniProtKB/Swiss-Prot), A0A8L2QK08 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117953 ⟸ XM_063261883
- Peptide Label:	isoform X2
- UniProtKB:	A0A8I6ABK2 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063117954 ⟸ XM_063261884
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063117952 ⟸ XM_063261882
- Peptide Label:	isoform X1
- UniProtKB:	Q5HZX7 (UniProtKB/Swiss-Prot), A0A8L2QK08 (UniProtKB/TrEMBL)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5HZX7-F1-model_v2	AlphaFold	Q5HZX7	1-325	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13694483

Promoter ID:

EPDNEW_R5006

Type:

multiple initiation site

Name:

Ldah_1

Description:

lipid droplet associated hydrolase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	6	33,407,250 - 33,407,310	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311648	AgrOrtholog
BioCyc Gene	G2FUF-38199	BioCyc
Ensembl Genes	ENSRNOG00000021475	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000030244	ENTREZGENE
	ENSRNOT00000030244.7	UniProtKB/TrEMBL
	ENSRNOT00000096109	ENTREZGENE
	ENSRNOT00000096109.1	UniProtKB/TrEMBL
	ENSRNOT00000115305.1	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.1820	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7314294	IMAGE-MGC_LOAD
InterPro	AB_hydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	LDAH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:313949	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105595	IMAGE-MGC_LOAD
NCBI Gene	313949	ENTREZGENE
PANTHER	LIPID DROPLET-ASSOCIATED HYDROLASE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR13390	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	LIDHydrolase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ldah	PhenoGen
PROSITE	LIPASE_SER	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000021475	RatGTEx
Superfamily-SCOP	SSF53474	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6ABK2	ENTREZGENE, UniProtKB/TrEMBL
	A0A8L2QK08	ENTREZGENE, UniProtKB/TrEMBL
	LDAH_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-04-03	Ldah	lipid droplet associated hydrolase	RGD1311648	similar to hypothetical protein FLJ21820	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1311648	similar to hypothetical protein FLJ21820	RGD1311648_predicted	similar to hypothetical protein FLJ21820 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1311648_predicted	similar to hypothetical protein FLJ21820 (predicted)	LOC313949_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC313949_predicted	similar to hypothetical protein FLJ21820 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD