Cars2 (cysteinyl-tRNA synthetase 2, mitochondrial) - Rat Genome Database

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Gene: Cars2 (cysteinyl-tRNA synthetase 2, mitochondrial) Rattus norvegicus
Analyze
Symbol: Cars2
Name: cysteinyl-tRNA synthetase 2, mitochondrial
RGD ID: 1311612
Description: Predicted to enable ATP binding activity and cysteine-tRNA ligase activity. Predicted to be involved in cysteinyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 27. Orthologous to human CARS2 (cysteinyl-tRNA synthetase 2, mitochondrial); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC361184; LOC361184; probable cysteine--tRNA ligase, mitochondrial; RGD1311612; similar to hypothetical protein FLJ12118; uncharacterized protein LOC361184
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21677,945,468 - 77,987,163 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1677,950,008 - 77,987,772 (+)Ensembl
Rnor_6.01683,288,613 - 83,325,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,288,664 - 83,325,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,756,339 - 82,792,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,801,948 - 82,839,707 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11682,787,426 - 82,825,553 (+)NCBI
Celera1675,748,996 - 75,786,082 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Cars2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21677,945,468 - 77,987,163 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1677,950,008 - 77,987,772 (+)Ensembl
Rnor_6.01683,288,613 - 83,325,706 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1683,288,664 - 83,325,699 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01682,756,339 - 82,792,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41682,801,948 - 82,839,707 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11682,787,426 - 82,825,553 (+)NCBI
Celera1675,748,996 - 75,786,082 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
CARS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813110,641,410 - 110,713,522 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl13110,641,412 - 110,713,603 (-)EnsemblGRCh38hg38GRCh38
GRCh3713111,293,757 - 111,358,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3613110,091,760 - 110,156,464 (-)NCBINCBI36hg18NCBI36
Celera1392,139,805 - 92,204,660 (-)NCBI
Cytogenetic Map13q34NCBI
HuRef1391,893,072 - 91,956,916 (-)NCBIHuRef
CHM1_113111,262,210 - 111,326,592 (-)NCBICHM1_1
T2T-CHM13v2.013109,871,850 - 109,936,733 (-)NCBI
Cars2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39811,564,017 - 11,600,781 (-)NCBIGRCm39mm39
GRCm39 Ensembl811,563,977 - 11,600,783 (-)Ensembl
GRCm38811,514,017 - 11,550,781 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl811,513,977 - 11,550,783 (-)EnsemblGRCm38mm10GRCm38
MGSCv37811,514,017 - 11,550,771 (-)NCBIGRCm37mm9NCBIm37
MGSCv36811,513,947 - 11,555,988 (-)NCBImm8
Celera811,689,324 - 11,725,869 (-)NCBICelera
Cytogenetic Map8A1.1NCBI
Cars2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554041,996,400 - 2,027,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554042,008,980 - 2,027,672 (+)NCBIChiLan1.0ChiLan1.0
CARS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.113110,892,823 - 110,957,000 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13110,892,948 - 110,957,000 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01391,776,774 - 91,843,262 (-)NCBIMhudiblu_PPA_v0panPan3
CARS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12258,891,826 - 58,946,112 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2258,902,293 - 58,947,558 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2258,588,895 - 58,657,725 (-)NCBI
ROS_Cfam_1.02259,501,160 - 59,570,006 (-)NCBI
ROS_Cfam_1.0 Ensembl2259,515,686 - 59,572,338 (-)Ensembl
UMICH_Zoey_3.12259,003,256 - 59,072,169 (-)NCBI
UNSW_CanFamBas_1.02258,995,216 - 59,064,019 (-)NCBI
UU_Cfam_GSD_1.02259,031,097 - 59,100,142 (-)NCBI
Cars2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945193,763,703 - 193,811,975 (-)NCBI
SpeTri2.0NW_0049364722,144,407 - 2,180,431 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CARS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1177,229,971 - 77,265,272 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11177,231,865 - 77,269,936 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21184,746,513 - 84,779,790 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CARS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1388,871,338 - 88,929,454 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl388,871,460 - 88,929,436 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604645,607,271 - 45,700,394 (-)NCBIVero_WHO_p1.0
Cars2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247932,130,608 - 2,148,519 (+)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046247932,126,304 - 2,148,619 (+)NCBIHetGla_female_1.0hetGla2

Position Markers
D16Got94  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,955,152 - 77,955,301 (+)MAPPERmRatBN7.2
Rnor_6.01683,293,805 - 83,293,953NCBIRnor6.0
Rnor_5.01682,761,846 - 82,761,994UniSTSRnor5.0
RGSC_v3.41682,807,083 - 82,807,232RGDRGSC3.4
RGSC_v3.41682,807,084 - 82,807,232UniSTSRGSC3.4
RGSC_v3.11682,792,937 - 82,793,085RGD
Celera1675,754,139 - 75,754,287UniSTS
RH 3.4 Map16756.9UniSTS
RH 3.4 Map16756.9RGD
RH 2.0 Map16871.7RGD
Cytogenetic Map16q12.5UniSTS
RH129391  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,986,194 - 77,986,374 (+)MAPPERmRatBN7.2
Rnor_6.01683,324,738 - 83,324,917NCBIRnor6.0
Rnor_5.01682,791,913 - 82,792,092UniSTSRnor5.0
RGSC_v3.41682,838,739 - 82,838,918UniSTSRGSC3.4
Celera1675,785,118 - 75,785,297UniSTS
RH 3.4 Map16754.1UniSTS
Cytogenetic Map16q12.5UniSTS
RH135208  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21677,971,459 - 77,971,649 (+)MAPPERmRatBN7.2
Rnor_6.01683,310,004 - 83,310,193NCBIRnor6.0
Rnor_5.01682,778,099 - 82,778,288UniSTSRnor5.0
RGSC_v3.41682,823,509 - 82,823,698UniSTSRGSC3.4
Celera1675,770,450 - 75,770,639UniSTS
RH 3.4 Map16759.3UniSTS
Cytogenetic Map16q12.5UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
8694429Bw164Body weight QTL 16450.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)165272646484729064Rat
8694364Abfw7Abdominal fat weight QTL 712.220.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)165272646484729064Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:34
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000019993
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 32 41 25 18 25 1 3 74 35 35 11 1
Low 1 11 16 16 1 16 7 8 6 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000019993   ⟹   ENSRNOP00000019993
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,950,008 - 77,987,156 (+)Ensembl
Rnor_6.0 Ensembl1683,288,664 - 83,325,699 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000096918   ⟹   ENSRNOP00000084040
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1677,950,008 - 77,987,772 (+)Ensembl
RefSeq Acc Id: NM_001177684   ⟹   NP_001171155
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,950,008 - 77,987,159 (+)NCBI
Rnor_6.01683,288,664 - 83,325,702 (+)NCBI
Rnor_5.01682,756,339 - 82,792,881 (+)NCBI
Celera1675,748,996 - 75,786,082 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253460   ⟹   XP_006253522
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,945,468 - 77,987,163 (+)NCBI
Rnor_6.01683,288,613 - 83,325,706 (+)NCBI
Rnor_5.01682,756,339 - 82,792,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253461   ⟹   XP_006253523
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,945,468 - 77,987,163 (+)NCBI
Rnor_6.01683,288,613 - 83,325,706 (+)NCBI
Rnor_5.01682,756,339 - 82,792,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006253462   ⟹   XP_006253524
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,945,468 - 77,987,163 (+)NCBI
Rnor_6.01683,288,614 - 83,325,706 (+)NCBI
Rnor_5.01682,756,339 - 82,792,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094694   ⟹   XP_038950622
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21677,945,468 - 77,987,163 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001171155   ⟸   NM_001177684
- UniProtKB: B2GV57 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253522   ⟸   XM_006253460
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006253523   ⟸   XM_006253461
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006253524   ⟸   XM_006253462
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSRNOP00000019993   ⟸   ENSRNOT00000019993
RefSeq Acc Id: XP_038950622   ⟸   XM_039094694
- Peptide Label: isoform X4
RefSeq Acc Id: ENSRNOP00000084040   ⟸   ENSRNOT00000096918
Protein Domains
tRNA-synt_1e

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2GV57-F1-model_v2 AlphaFold B2GV57 1-550 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700244
Promoter ID:EPDNEW_R10767
Type:initiation region
Name:Cars2_1
Description:cysteinyl-tRNA synthetase 2, mitochondrial
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01683,288,645 - 83,288,705EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
16 83321582 83321583 C G snv SHR/NHsd (RGD)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311612 AgrOrtholog
BioCyc Gene G2FUF-10657 BioCyc
BioCyc Pathway TRNA-CHARGING-PWY [tRNA charging] BioCyc
Ensembl Genes ENSRNOG00000014526 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000019993 ENTREZGENE
  ENSRNOP00000019993.6 UniProtKB/TrEMBL
  ENSRNOP00000084040 ENTREZGENE
  ENSRNOP00000084040.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019993 ENTREZGENE
  ENSRNOT00000019993.7 UniProtKB/TrEMBL
  ENSRNOT00000096918 ENTREZGENE
  ENSRNOT00000096918.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.620 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7191115 IMAGE-MGC_LOAD
InterPro Cys-tRNA-ligase UniProtKB/TrEMBL
  Cys-tRNA/MSH_ligase UniProtKB/TrEMBL
  Rossmann-like_a/b/a_fold UniProtKB/TrEMBL
  tRNA-synt_1_cat_dom UniProtKB/TrEMBL
  tRNAsynth_1a_anticodon-bd UniProtKB/TrEMBL
KEGG Report rno:361184 UniProtKB/TrEMBL
MGC_CLONE MGC:188129 IMAGE-MGC_LOAD
NCBI Gene 361184 ENTREZGENE
PANTHER Cys_tRNA-synt_1a UniProtKB/TrEMBL
Pfam tRNA-synt_1e UniProtKB/TrEMBL
PhenoGen Cars2 PhenoGen
PRINTS TRNASYNTHCYS UniProtKB/TrEMBL
Superfamily-SCOP tRNAsyn_1a_bind UniProtKB/TrEMBL
TIGRFAMs cysS UniProtKB/TrEMBL
UniProt A0A8I5ZXZ9_RAT UniProtKB/TrEMBL
  B2GV57 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary D4A5T2 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-11 Cars2  cysteinyl-tRNA synthetase 2, mitochondrial (putative)  RGD1311612  similar to hypothetical protein FLJ12118  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1311612  similar to hypothetical protein FLJ12118   RGD1311612_predicted  similar to hypothetical protein FLJ12118 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311612_predicted  similar to hypothetical protein FLJ12118 (predicted)  LOC361184_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361184_predicted  similar to hypothetical protein FLJ12118 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL