Fastk (Fas-activated serine/threonine kinase) - Rat Genome Database

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Gene: Fastk (Fas-activated serine/threonine kinase) Rattus norvegicus
Analyze
Symbol: Fastk
Name: Fas-activated serine/threonine kinase
RGD ID: 1311601
Description: Predicted to enable RNA binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitochondrial RNA processing; protein phosphorylation; and regulation of gene expression. Predicted to be located in mitochondrion and nuclear speck. Predicted to be active in mitochondrial matrix and ribonucleoprotein granule. Orthologous to human FASTK (Fas activated serine/threonine kinase); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296741
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,624,697 - 11,628,769 (+)NCBIGRCr8
mRatBN7.2410,732,273 - 10,736,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,732,256 - 10,737,430 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,878,512 - 15,882,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,698,703 - 11,702,756 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,050,487 - 10,054,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,260,521 - 7,264,590 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,260,575 - 7,264,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,271,900 - 7,275,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,096,675 - 6,100,690 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,096,674 - 6,100,689 (+)NCBI
Celera46,346,824 - 6,350,893 (+)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP)
bisphenol F  (EXP)
bortezomib  (ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glafenine  (EXP)
hydroxytyrosol  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
isotretinoin  (ISO)
methidathion  (ISO)
methimazole  (EXP)
ochratoxin A  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
resveratrol  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloroethene  (ISO)
tetraphene  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7544399   PMID:12477932   PMID:17135269   PMID:17592127   PMID:18614015   PMID:34800366  


Genomics

Comparative Map Data
Fastk
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8411,624,697 - 11,628,769 (+)NCBIGRCr8
mRatBN7.2410,732,273 - 10,736,332 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl410,732,256 - 10,737,430 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx415,878,512 - 15,882,565 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0411,698,703 - 11,702,756 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0410,050,487 - 10,054,540 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.047,260,521 - 7,264,590 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl47,260,575 - 7,264,589 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.047,271,900 - 7,275,954 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.446,096,675 - 6,100,690 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.146,096,674 - 6,100,689 (+)NCBI
Celera46,346,824 - 6,350,893 (+)NCBICelera
Cytogenetic Map4q11NCBI
FASTK
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387151,076,624 - 151,080,809 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7151,076,624 - 151,080,866 (-)EnsemblGRCh38hg38GRCh38
GRCh377150,773,711 - 150,777,896 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,404,641 - 150,408,884 (-)NCBINCBI36Build 36hg18NCBI36
Celera7145,331,040 - 145,335,283 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,586,082 - 144,590,344 (-)NCBIHuRef
CHM1_17150,782,105 - 150,786,367 (-)NCBICHM1_1
T2T-CHM13v2.07152,249,742 - 152,253,931 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27150,103,248 - 150,107,510 (-)NCBI
Fastk
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39524,646,036 - 24,650,280 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl524,643,438 - 24,650,285 (-)EnsemblGRCm39 Ensembl
GRCm38524,441,038 - 24,445,295 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl524,438,440 - 24,445,287 (-)EnsemblGRCm38mm10GRCm38
MGSCv37523,946,858 - 23,951,053 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36523,951,105 - 23,955,300 (-)NCBIMGSCv36mm8
Celera521,390,838 - 21,394,107 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map511.78NCBI
Fastk
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,513,580 - 5,516,679 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554915,513,482 - 5,516,681 (-)NCBIChiLan1.0ChiLan1.0
FASTK
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,498,571 - 187,502,861 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,508,833 - 39,513,109 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,663,470 - 142,667,730 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,816,011 - 154,820,266 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,816,011 - 154,820,266 (-)Ensemblpanpan1.1panPan2
FASTK
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11615,126,540 - 15,130,959 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1615,124,704 - 15,130,917 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1615,734,967 - 15,739,161 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01616,848,913 - 16,853,330 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,848,516 - 16,853,313 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,221,399 - 15,225,593 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,802,793 - 15,806,994 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,853,529 - 15,857,724 (-)NCBIUU_Cfam_GSD_1.0
Fastk
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,399,222 - 6,403,438 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,499,934 - 6,504,241 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,499,991 - 6,504,214 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FASTK
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,145,184 - 6,149,365 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1186,145,189 - 6,149,367 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,509,321 - 6,513,473 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FASTK
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121119,259,012 - 119,263,257 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21119,259,115 - 119,263,193 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607215,229,804 - 15,234,050 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fastk
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248005,541,145 - 5,545,271 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fastk
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:154
Count of miRNA genes:111
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000064893
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat

Markers in Region
RH128009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2410,731,773 - 10,731,968 (+)MAPPERmRatBN7.2
Rnor_6.047,260,032 - 7,260,226NCBIRnor6.0
Rnor_5.047,271,396 - 7,271,590UniSTSRnor5.0
RGSC_v3.446,096,132 - 6,096,326UniSTSRGSC3.4
Celera46,346,335 - 6,346,529UniSTS
Cytogenetic Map4q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001371289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006235895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775649 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775650 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008775652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592938 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602735 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285695 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215763 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226623 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000064893   ⟹   ENSRNOP00000063396
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,732,317 - 10,736,331 (+)Ensembl
Rnor_6.0 Ensembl47,260,575 - 7,264,589 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000093879   ⟹   ENSRNOP00000086402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,732,256 - 10,737,430 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107208   ⟹   ENSRNOP00000096270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,732,326 - 10,736,329 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118434   ⟹   ENSRNOP00000093199
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl410,732,376 - 10,736,331 (+)Ensembl
RefSeq Acc Id: NM_001371289   ⟹   NP_001358218
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,727 - 11,628,769 (+)NCBI
mRatBN7.2410,732,290 - 10,736,332 (+)NCBI
RefSeq Acc Id: XM_006235894   ⟹   XP_006235956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,752 - 11,628,769 (+)NCBI
mRatBN7.2410,732,308 - 10,736,332 (+)NCBI
Rnor_6.047,260,523 - 7,264,590 (+)NCBI
Rnor_5.047,271,900 - 7,275,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006235895   ⟹   XP_006235957
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,752 - 11,628,769 (+)NCBI
mRatBN7.2410,732,308 - 10,736,332 (+)NCBI
Rnor_6.047,260,523 - 7,264,590 (+)NCBI
Rnor_5.047,271,900 - 7,275,954 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017592938   ⟹   XP_017448427
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,772 - 11,628,769 (+)NCBI
mRatBN7.2410,732,319 - 10,736,332 (+)NCBI
Rnor_6.047,260,628 - 7,264,590 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107220   ⟹   XP_038963148
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,697 - 11,628,769 (+)NCBI
mRatBN7.2410,732,274 - 10,736,332 (+)NCBI
RefSeq Acc Id: XM_039107223   ⟹   XP_038963151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,626,568 - 11,628,769 (+)NCBI
mRatBN7.2410,732,342 - 10,736,332 (+)NCBI
RefSeq Acc Id: XM_063285694   ⟹   XP_063141764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,772 - 11,628,769 (+)NCBI
RefSeq Acc Id: XM_063285695   ⟹   XP_063141765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8411,624,713 - 11,627,881 (+)NCBI
RefSeq Acc Id: XP_006235957   ⟸   XM_006235895
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AQA7 (UniProtKB/TrEMBL),   A6K549 (UniProtKB/TrEMBL),   A0A8I6A5X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006235956   ⟸   XM_006235894
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AQA7 (UniProtKB/TrEMBL),   A6K549 (UniProtKB/TrEMBL),   A0A8I6A5X4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017448427   ⟸   XM_017592938
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AQA7 (UniProtKB/TrEMBL),   A6K549 (UniProtKB/TrEMBL),   A0A8I6A5X4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063396   ⟸   ENSRNOT00000064893
RefSeq Acc Id: XP_038963148   ⟸   XM_039107220
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A5X4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001358218   ⟸   NM_001371289
- UniProtKB: A0A8I6A5X4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963151   ⟸   XM_039107223
- Peptide Label: isoform X5
Ensembl Acc Id: ENSRNOP00000086402   ⟸   ENSRNOT00000093879
Ensembl Acc Id: ENSRNOP00000093199   ⟸   ENSRNOT00000118434
Ensembl Acc Id: ENSRNOP00000096270   ⟸   ENSRNOT00000107208
RefSeq Acc Id: XP_063141765   ⟸   XM_063285695
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063141764   ⟸   XM_063285694
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A5X4 (UniProtKB/TrEMBL)
Protein Domains
FAST kinase leucine-rich   FAST kinase-like protein subdomain   RAP

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5XIG7-F1-model_v2 AlphaFold Q5XIG7 1-395 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692792
Promoter ID:EPDNEW_R3313
Type:initiation region
Name:Fastk_1
Description:Fas-activated serine/threonine kinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.047,260,595 - 7,260,655EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311601 AgrOrtholog
BioCyc Gene G2FUF-46044 BioCyc
Ensembl Genes ENSRNOG00000011667 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000064893.2 UniProtKB/TrEMBL
  ENSRNOT00000093879.1 UniProtKB/TrEMBL
  ENSRNOT00000107208.1 UniProtKB/TrEMBL
  ENSRNOT00000118434.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190690 IMAGE-MGC_LOAD
InterPro FAST_2 UniProtKB/TrEMBL
  FAST_kinase UniProtKB/TrEMBL
  FAST_Leu-rich UniProtKB/TrEMBL
  RAP UniProtKB/TrEMBL
MGC_CLONE MGC:94606 IMAGE-MGC_LOAD
NCBI Gene 296741 ENTREZGENE
PANTHER FAST LEU-RICH DOMAIN-CONTAINING UniProtKB/TrEMBL
  PTHR21228:SF4 UniProtKB/TrEMBL
Pfam FAST_1 UniProtKB/TrEMBL
  FAST_2 UniProtKB/TrEMBL
  RAP UniProtKB/TrEMBL
PhenoGen Fastk PhenoGen
PROSITE RAP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011667 RatGTEx
SMART RAP UniProtKB/TrEMBL
UniProt A0A8I6A5X4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AJU9_RAT UniProtKB/TrEMBL
  A0A8I6AQA7 ENTREZGENE, UniProtKB/TrEMBL
  A6K549 ENTREZGENE, UniProtKB/TrEMBL
  Q5XIG7_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Fastk  Fas-activated serine/threonine kinase  Fastk_predicted  Fas-activated serine/threonine kinase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fastk_predicted  Fas-activated serine/threonine kinase (predicted)      Symbol and Name status set to approved 70820 APPROVED