Cracd (capping protein inhibiting regulator of actin dynamics) - Rat Genome Database

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Gene: Cracd (capping protein inhibiting regulator of actin dynamics) Rattus norvegicus
Analyze
Symbol: Cracd
Name: capping protein inhibiting regulator of actin dynamics
RGD ID: 1311575
Description: Predicted to be involved in maintenance of gastrointestinal epithelium and negative regulation of barbed-end actin filament capping. Orthologous to human CRACD (capping protein inhibiting regulator of actin dynamics); INTERACTS WITH 17beta-estradiol; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: capping protein-inhibiting regulator of actin dynamics; hypothetical LOC289568; LOC289568; RGD1311575; uncharacterized protein KIAA1211 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,638,328 - 31,874,391 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,638,328 - 31,683,987 (-)EnsemblGRCr8
mRatBN7.21431,284,066 - 31,520,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,284,184 - 31,522,431 (-)EnsemblmRatBN7.2
Rnor_6.01433,649,989 - 33,783,794 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,649,637 - 33,677,031 (-)Ensemblrn6Rnor6.0
Rnor_5.01433,440,443 - 33,572,091 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,579,288 - 33,607,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,598,428 - 30,835,727 (-)NCBICelera
RGSC_v3.11433,580,497 - 33,603,246 (-)NCBI
Cytogenetic Map14p11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:30361697  


Genomics

Comparative Map Data
Cracd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81431,638,328 - 31,874,391 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1431,638,328 - 31,683,987 (-)EnsemblGRCr8
mRatBN7.21431,284,066 - 31,520,103 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1431,284,184 - 31,522,431 (-)EnsemblmRatBN7.2
Rnor_6.01433,649,989 - 33,783,794 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1433,649,637 - 33,677,031 (-)Ensemblrn6Rnor6.0
Rnor_5.01433,440,443 - 33,572,091 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41433,579,288 - 33,607,176 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1430,598,428 - 30,835,727 (-)NCBICelera
RGSC_v3.11433,580,497 - 33,603,246 (-)NCBI
Cytogenetic Map14p11NCBI
CRACD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38456,049,098 - 56,330,609 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl456,049,098 - 56,330,609 (+)Ensemblhg38GRCh38
GRCh37456,915,264 - 57,196,775 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36456,731,118 - 56,891,647 (+)NCBIBuild 36Build 36hg18NCBI36
Celera454,542,821 - 54,703,255 (+)NCBICelera
Cytogenetic Map4q12NCBI
HuRef452,990,321 - 53,150,672 (+)NCBIHuRef
CHM1_1457,071,533 - 57,232,004 (+)NCBICHM1_1
T2T-CHM13v2.0459,537,287 - 59,818,577 (+)NCBIT2T-CHM13v2.0
Cracd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39576,803,225 - 77,021,393 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl576,804,359 - 77,021,392 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38576,657,629 - 76,873,554 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl576,656,512 - 76,873,554 (+)Ensemblmm10GRCm38
MGSCv37577,269,624 - 77,302,579 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36577,915,374 - 77,948,329 (+)NCBIMGSCv36mm8
Celera574,119,956 - 74,149,740 (+)NCBICelera
Cytogenetic Map5C3.3NCBI
cM Map541.34NCBI
Cracd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544714,650,035 - 14,672,593 (-)Ensembl
ChiLan1.0NW_00495544714,650,035 - 14,672,593 (-)NCBIChiLan1.0ChiLan1.0
CRACD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2373,455,101 - 73,736,550 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1473,660,618 - 73,942,052 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0467,598,880 - 67,880,269 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1474,167,488 - 74,317,354 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl474,167,488 - 74,199,802 (-)EnsemblpanPan2panpan1.1
CRACD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha1348,186,323 - 48,464,898 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01348,908,991 - 49,188,758 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1349,053,638 - 49,185,780 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11348,582,034 - 48,860,708 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01348,274,278 - 48,389,682 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01349,055,345 - 49,335,630 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Cracd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528527,740,917 - 27,989,201 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648218,527,088 - 18,551,262 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_00493648218,464,273 - 18,557,330 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648218,309,078 - 18,557,335 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRACD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl855,537,546 - 55,600,939 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1855,336,363 - 55,600,931 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2857,919,085 - 57,976,199 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRACD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1712,293,366 - 12,570,793 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl712,296,214 - 12,325,965 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366606612,963,771 - 13,241,119 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cracd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476113,065,318 - 13,367,504 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Cracd
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11133,595,740 - 33,624,139 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cracd
1637 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1222
Count of miRNA genes:319
Interacting mature miRNAs:432
Transcripts:ENSRNOT00000002908, ENSRNOT00000074534
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631528Scl11Serum cholesterol level QTL 114.9blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)141787564536079022Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
731183Pia20Pristane induced arthritis QTL 203.55joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)14939329839411170Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143123808072970315Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143067446985041098Rat
2324617Coatc2Coat color QTL 20.001coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)143112133339507682Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14862139853621398Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141891545442433608Rat
7387267Uae42Urinary albumin excretion QTL 420.61urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)142252151767521517Rat
631839Niddm37Non-insulin dependent diabetes mellitus QTL 373.37blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1411334716100078267Rat
2313397Coatc1Coat color QTL1coat/hair pigmentation trait (VT:0010463)coat/hair color measurement (CMO:0001808)141889519263895192Rat
631262Tcas4Tongue tumor susceptibility QTL 47.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)141790672654251504Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat
2302045Pia39Pristane induced arthritis QTL 394.90.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G2a level (CMO:0002116)14862139853621398Rat

Markers in Region
RH132249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,284,264 - 31,284,467 (+)MAPPERmRatBN7.2
Rnor_6.01433,649,731 - 33,649,933NCBIRnor6.0
Rnor_5.01433,440,644 - 33,440,846UniSTSRnor5.0
RGSC_v3.41433,577,884 - 33,578,086UniSTSRGSC3.4
Celera1430,598,170 - 30,598,372UniSTS
RH 3.4 Map14425.9UniSTS
Cytogenetic Map14p11UniSTS
RH141277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21431,286,266 - 31,286,482 (+)MAPPERmRatBN7.2
Rnor_6.01433,651,733 - 33,651,948NCBIRnor6.0
Rnor_5.01433,442,646 - 33,442,861UniSTSRnor5.0
RGSC_v3.41433,579,886 - 33,580,101UniSTSRGSC3.4
Celera1430,600,172 - 30,600,387UniSTS
RH 3.4 Map14381.98UniSTS
Cytogenetic Map14p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 67 162 89 88 57 92 57 6 350 191 11 141 78 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221709 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765226 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765232 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765235 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770114 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770115 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770118 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039092927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000002908   ⟹   ENSRNOP00000002908
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,638,328 - 31,683,987 (-)Ensembl
mRatBN7.2 Ensembl1431,284,184 - 31,522,431 (-)Ensembl
Rnor_6.0 Ensembl1433,649,637 - 33,677,031 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000153116   ⟹   ENSRNOP00000099078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,638,328 - 31,683,987 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000169487   ⟹   ENSRNOP00000111597
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1431,638,328 - 31,668,042 (-)Ensembl
RefSeq Acc Id: NM_001427853   ⟹   NP_001414782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,638,328 - 31,874,391 (-)NCBI
RefSeq Acc Id: XM_039092919   ⟹   XP_038948847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,638,440 - 31,667,914 (-)NCBI
mRatBN7.21431,284,066 - 31,313,653 (-)NCBI
RefSeq Acc Id: XM_039092920   ⟹   XP_038948848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,638,440 - 31,667,914 (-)NCBI
mRatBN7.21431,284,066 - 31,313,653 (-)NCBI
RefSeq Acc Id: XM_039092927   ⟹   XP_038948855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,638,440 - 31,667,699 (-)NCBI
mRatBN7.21431,284,066 - 31,313,458 (-)NCBI
RefSeq Acc Id: XM_063272905   ⟹   XP_063128975
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81431,638,440 - 31,683,947 (-)NCBI
Ensembl Acc Id: ENSRNOP00000002908   ⟸   ENSRNOT00000002908
RefSeq Acc Id: XP_038948848   ⟸   XM_039092920
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038948847   ⟸   XM_039092919
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038948855   ⟸   XM_039092927
- Peptide Label: isoform X4
RefSeq Acc Id: NP_001414782   ⟸   NM_001427853
- UniProtKB: D4A5F4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128975   ⟸   XM_063272905
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000099078   ⟸   ENSRNOT00000153116
Ensembl Acc Id: ENSRNOP00000111597   ⟸   ENSRNOT00000169487
Protein Domains
DUF4592

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A5F4-F1-model_v2 AlphaFold D4A5F4 1-1290 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311575 AgrOrtholog
BioCyc Gene G2FUF-15956 BioCyc
Ensembl Genes ENSRNOG00000002139 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000002908 ENTREZGENE
  ENSRNOT00000002908.9 UniProtKB/TrEMBL
  ENSRNOT00000153116 ENTREZGENE
  ENSRNOT00000153116.1 UniProtKB/TrEMBL
  ENSRNOT00000169487 ENTREZGENE
  ENSRNOT00000169487.1 UniProtKB/TrEMBL
InterPro Actin_dynamics_regulator UniProtKB/TrEMBL
  DUF4592 UniProtKB/TrEMBL
NCBI Gene 289568 ENTREZGENE
PANTHER CANCER-RELATED REGULATOR OF ACTIN DYNAMICS UniProtKB/TrEMBL
  CAPPING PROTEIN-INHIBITING REGULATOR OF ACTIN DYNAMICS UniProtKB/TrEMBL
Pfam DUF4592 UniProtKB/TrEMBL
PhenoGen Cracd PhenoGen
RatGTEx ENSRNOG00000002139 RatGTEx
UniProt A0ABK0LCY4_RAT UniProtKB/TrEMBL
  A0ABK0M389_RAT UniProtKB/TrEMBL
  D4A5F4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-13 Cracd  capping protein inhibiting regulator of actin dynamics  RGD1311575  hypothetical LOC289568  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1311575  hypothetical LOC289568   RGD1311575_predicted  hypothetical LOC289568 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311575_predicted  hypothetical LOC289568 (predicted)  LOC289568_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC289568_predicted  hypothetical LOC289568 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL