Igsf8 (immunoglobulin superfamily, member 8) - Rat Genome Database

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Gene: Igsf8 (immunoglobulin superfamily, member 8) Rattus norvegicus
Analyze
Symbol: Igsf8
Name: immunoglobulin superfamily, member 8
RGD ID: 1311500
Description: Predicted to act upstream of or within regulation of cell motility. Predicted to be located in axon; intracellular membrane-bounded organelle; and synapse. Predicted to be active in membrane. Orthologous to human IGSF8 (immunoglobulin superfamily member 8); INTERACTS WITH 3,3',4,4',5-pentachlorobiphenyl; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: immunoglobulin superfamily member 8; LOC304979; MGC105805
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,770,348 - 84,781,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,770,279 - 84,778,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,273,715 - 87,281,889 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01388,673,987 - 88,682,165 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01385,858,305 - 85,866,459 (+)NCBIRnor_WKY
Rnor_6.01390,692,590 - 90,703,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,692,666 - 90,700,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,193,429 - 95,221,983 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,301,142 - 88,309,250 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,490,025 - 88,498,134 (+)NCBI
Celera1384,380,746 - 84,388,864 (+)NCBICelera
Cytogenetic Map13q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:11504738   PMID:11673522   PMID:17634366   PMID:19199708   PMID:19946888   PMID:20458337   PMID:21700703   PMID:22687584   PMID:23376485  


Genomics

Comparative Map Data
Igsf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,770,348 - 84,781,534 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,770,279 - 84,778,576 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1387,273,715 - 87,281,889 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01388,673,987 - 88,682,165 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01385,858,305 - 85,866,459 (+)NCBIRnor_WKY
Rnor_6.01390,692,590 - 90,703,262 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,692,666 - 90,700,789 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01395,193,429 - 95,221,983 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41388,301,142 - 88,309,250 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11388,490,025 - 88,498,134 (+)NCBI
Celera1384,380,746 - 84,388,864 (+)NCBICelera
Cytogenetic Map13q24NCBI
IGSF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,091,339 - 160,099,468 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1160,091,340 - 160,098,943 (-)EnsemblGRCh38hg38GRCh38
GRCh371160,061,129 - 160,068,618 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,327,754 - 158,335,032 (-)NCBINCBI36Build 36hg18NCBI36
Build 341156,874,203 - 156,881,481NCBI
Celera1133,129,914 - 133,137,192 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,418,244 - 131,425,733 (-)NCBIHuRef
CHM1_11161,456,514 - 161,464,003 (-)NCBICHM1_1
T2T-CHM13v2.01159,228,416 - 159,235,905 (-)NCBIT2T-CHM13v2.0
Igsf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,139,934 - 172,147,410 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,089,208 - 172,147,408 (+)EnsemblGRCm39 Ensembl
GRCm381172,312,367 - 172,319,843 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,261,641 - 172,319,841 (+)EnsemblGRCm38mm10GRCm38
MGSCv371174,242,538 - 174,249,968 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361174,149,082 - 174,156,512 (+)NCBIMGSCv36mm8
Celera1175,165,962 - 175,173,390 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.59NCBI
Igsf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,877,369 - 11,883,962 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546811,877,369 - 11,883,962 (-)NCBIChiLan1.0ChiLan1.0
IGSF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,366,220 - 139,370,711 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,366,228 - 139,374,732 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,445,180 - 135,452,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IGSF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,093,463 - 22,100,009 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3822,062,591 - 22,100,020 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,166,225 - 22,173,180 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03822,209,636 - 22,216,585 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,180,129 - 22,216,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13822,114,099 - 22,121,044 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03822,510,596 - 22,517,560 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03822,920,492 - 22,927,445 (+)NCBIUU_Cfam_GSD_1.0
Igsf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,218,735 - 6,225,650 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740528,821 - 535,776 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936740528,826 - 535,776 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IGSF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,393,624 - 90,401,369 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,393,614 - 90,401,380 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,335,001 - 98,342,777 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IGSF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,845,767 - 3,853,077 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,848,946 - 3,852,609 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660382,903,087 - 2,910,432 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Igsf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,155,270 - 1,164,960 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247941,155,452 - 1,162,191 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Igsf8
39 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:38
Count of miRNA genes:32
Interacting mature miRNAs:36
Transcripts:ENSRNOT00000010028
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)131101056920Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)133124133193395974Rat
70181BpQTLcluster11Blood pressure QTL cluster 116.922arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)133124133193395974Rat
12879444Bp397Blood pressure QTL 397arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134504940490049404Rat
12879471Bp398Blood pressure QTL 398arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134551471990514719Rat
12879441Bp396Blood pressure QTL 396arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134569998390699983Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134608804691088046Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)135987440885581182Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)136906051986800898Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)136906051986800898Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)136906051986800898Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)137486211785581182Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1302791Stl29Serum triglyceride level QTL 293.30.0011blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)138473078886800898Rat

Markers in Region
AA033172  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,777,522 - 84,777,602 (+)MAPPERmRatBN7.2
Rnor_6.01390,699,742 - 90,699,821NCBIRnor6.0
Rnor_5.01395,220,926 - 95,221,005UniSTSRnor5.0
Celera1384,387,811 - 84,387,890UniSTS
Cytogenetic Map13q24UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 6 7 2 12 2 74 20 35 5
Low 37 50 39 7 39 8 11 15 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000010028   ⟹   ENSRNOP00000010028
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,773,771 - 84,778,576 (+)Ensembl
Rnor_6.0 Ensembl1390,692,666 - 90,700,789 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099941   ⟹   ENSRNOP00000076903
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,773,487 - 84,778,576 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102622   ⟹   ENSRNOP00000095607
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1384,770,279 - 84,778,570 (+)Ensembl
RefSeq Acc Id: NM_001014787   ⟹   NP_001014787
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,770,447 - 84,778,576 (+)NCBI
Rnor_6.01390,692,666 - 90,700,795 (+)NCBI
Rnor_5.01395,193,429 - 95,221,983 (+)NCBI
RGSC_v3.41388,301,142 - 88,309,250 (+)RGD
Celera1384,380,746 - 84,388,864 (+)RGD
Sequence:
RefSeq Acc Id: XM_006250289   ⟹   XP_006250351
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,770,364 - 84,778,580 (+)NCBI
Rnor_6.01390,692,597 - 90,700,799 (+)NCBI
Rnor_5.01395,193,429 - 95,221,983 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017598830   ⟹   XP_017454319
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,770,348 - 84,781,534 (+)NCBI
Rnor_6.01390,692,590 - 90,703,262 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039090796   ⟹   XP_038946724
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21384,771,047 - 84,778,580 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001014787   ⟸   NM_001014787
- Peptide Label: precursor
- UniProtKB: A0A140TAA1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250351   ⟸   XM_006250289
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017454319   ⟸   XM_017598830
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ANQ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000010028   ⟸   ENSRNOT00000010028
RefSeq Acc Id: XP_038946724   ⟸   XM_039090796
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000076903   ⟸   ENSRNOT00000099941
RefSeq Acc Id: ENSRNOP00000095607   ⟸   ENSRNOT00000102622
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A140TAA1-F1-model_v2 AlphaFold A0A140TAA1 1-611 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311500 AgrOrtholog
BioCyc Gene G2FUF-17325 BioCyc
Ensembl Genes ENSRNOG00000007604 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000010028.7 UniProtKB/TrEMBL
  ENSRNOP00000076903 ENTREZGENE
  ENSRNOP00000076903.1 UniProtKB/TrEMBL
  ENSRNOP00000095607 ENTREZGENE
  ENSRNOP00000095607.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010028.8 UniProtKB/TrEMBL
  ENSRNOT00000099941 ENTREZGENE
  ENSRNOT00000099941.1 UniProtKB/TrEMBL
  ENSRNOT00000102622 ENTREZGENE
  ENSRNOT00000102622.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7312924 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:304979 UniProtKB/TrEMBL
MGC_CLONE MGC:105805 IMAGE-MGC_LOAD
NCBI Gene 304979 ENTREZGENE
Pfam V-set UniProtKB/TrEMBL
PhenoGen Igsf8 PhenoGen
PROSITE IG_LIKE UniProtKB/TrEMBL
SMART SM00409 UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0A140TAA1 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5YBJ3_RAT UniProtKB/TrEMBL
  A0A8I6ANQ3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Igsf8  immunoglobulin superfamily, member 8  Igsf8_predicted  immunoglobulin superfamily, member 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Igsf8_predicted  immunoglobulin superfamily, member 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED