Arhgef18 (Rho/Rac guanine nucleotide exchange factor 18) - Rat Genome Database

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Gene: Arhgef18 (Rho/Rac guanine nucleotide exchange factor 18) Rattus norvegicus
Analyze
Symbol: Arhgef18
Name: Rho/Rac guanine nucleotide exchange factor 18
RGD ID: 1311448
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in negative regulation of stress fiber assembly and protein localization to cell-cell junction. Predicted to act upstream of or within actin cytoskeleton organization; regulation of cell shape; and small GTPase mediated signal transduction. Predicted to be located in apical part of cell; cytosol; and plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC304193; rho guanine nucleotide exchange factor 18; rho/rac guanine nucleotide exchange factor (GEF) 18
RGD Orthologs
Human
Mouse
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,395,035 - 1,503,081 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,395,088 - 1,503,081 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,058,113 - 2,167,374 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0122,681,667 - 2,790,942 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0121,453,728 - 1,562,982 (+)NCBIRnor_WKY
Rnor_6.0121,889,252 - 1,998,128 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,889,331 - 1,998,127 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,056,145 - 4,161,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,712,198 - 2,855,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,713,997 - 2,740,671 (-)NCBI
Celera123,250,654 - 3,359,236 (+)NCBICelera
Cytogenetic Map12p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14512443   PMID:18570454   PMID:22006950   PMID:25753039  


Genomics

Comparative Map Data
Arhgef18
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2121,395,035 - 1,503,081 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl121,395,088 - 1,503,081 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx122,058,113 - 2,167,374 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0122,681,667 - 2,790,942 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0121,453,728 - 1,562,982 (+)NCBIRnor_WKY
Rnor_6.0121,889,252 - 1,998,128 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl121,889,331 - 1,998,127 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,056,145 - 4,161,174 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4122,712,198 - 2,855,137 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1122,713,997 - 2,740,671 (-)NCBI
Celera123,250,654 - 3,359,236 (+)NCBICelera
Cytogenetic Map12p12NCBI
ARHGEF18
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,348,937 - 7,479,989 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl197,348,937 - 7,472,485 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,413,842 - 7,537,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,351,866 - 7,443,371 (+)NCBINCBI36Build 36hg18NCBI36
Build 34197,351,865 - 7,443,370NCBI
Celera197,331,115 - 7,409,876 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,128,031 - 7,179,714 (+)NCBIHuRef
HuRef197,186,895 - 7,208,106 (+)NCBIHuRef
CHM1_1197,459,437 - 7,537,381 (+)NCBICHM1_1
T2T-CHM13v2.0197,341,415 - 7,473,145 (+)NCBIT2T-CHM13v2.0
Arhgef18
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3983,403,339 - 3,506,601 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl83,403,415 - 3,506,601 (+)EnsemblGRCm39 Ensembl
GRCm3883,353,338 - 3,456,601 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl83,353,415 - 3,456,601 (+)EnsemblGRCm38mm10GRCm38
MGSCv3783,393,008 - 3,456,600 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3683,393,008 - 3,456,600 (+)NCBIMGSCv36mm8
Celera83,618,863 - 3,682,398 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
Arhgef18
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,746,838 - 1,772,772 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,745,202 - 1,823,411 (-)NCBIChiLan1.0ChiLan1.0
ARHGEF18
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,196,670 - 52,281,491 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,201,007 - 52,283,000 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,001,555 - 52,087,194 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02052,726,796 - 52,812,572 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2052,726,780 - 52,812,567 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12051,930,590 - 52,016,159 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,374,118 - 52,459,723 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,604,731 - 52,690,664 (+)NCBIUU_Cfam_GSD_1.0
Arhgef18
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,262,232 - 213,334,821 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,514,691 - 4,572,518 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365884,522,517 - 4,572,551 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ARHGEF18
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,651,100 - 71,747,409 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,651,096 - 71,747,513 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2272,176,541 - 72,198,429 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ARHGEF18
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,846,595 - 6,972,701 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,869,318 - 6,973,989 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081898,649 - 1,027,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Arhgef18
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828536,926 - 605,119 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828529,529 - 604,996 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Arhgef18
959 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:267
Count of miRNA genes:170
Interacting mature miRNAs:213
Transcripts:ENSRNOT00000066281
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat

Markers in Region
D12Got218  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,472,333 - 1,472,460 (+)MAPPERmRatBN7.2
Rnor_6.0121,967,808 - 1,967,934NCBIRnor6.0
Rnor_5.0124,130,854 - 4,130,980UniSTSRnor5.0
RGSC_v3.4122,742,743 - 2,742,869UniSTSRGSC3.4
Celera123,328,176 - 3,328,302UniSTS
Cytogenetic Map12p12UniSTS
RH131614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,502,850 - 1,503,054 (+)MAPPERmRatBN7.2
Rnor_6.0121,997,897 - 1,998,100NCBIRnor6.0
Rnor_5.0124,160,943 - 4,161,146UniSTSRnor5.0
RGSC_v3.4122,712,225 - 2,712,428UniSTSRGSC3.4
Celera123,359,006 - 3,359,209UniSTS
Cytogenetic Map12p12UniSTS
RH131442  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,479,254 - 1,479,534 (+)MAPPERmRatBN7.2
Rnor_6.0121,974,728 - 1,975,007NCBIRnor6.0
Rnor_5.0124,137,774 - 4,138,053UniSTSRnor5.0
RGSC_v3.4122,735,670 - 2,735,949UniSTSRGSC3.4
Celera123,335,095 - 3,335,313UniSTS
Cytogenetic Map12p12UniSTS
RH143508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2121,484,736 - 1,484,868 (+)MAPPERmRatBN7.2
Rnor_6.0121,980,209 - 1,980,340NCBIRnor6.0
Rnor_5.0124,143,255 - 4,143,386UniSTSRnor5.0
RGSC_v3.4122,730,337 - 2,730,468UniSTSRGSC3.4
Celera123,340,515 - 3,340,646UniSTS
Cytogenetic Map12p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 2 19 3 19 3 66 35 35 11
Low 41 38 38 38 8 11 8 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000066281   ⟹   ENSRNOP00000062255
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,395,088 - 1,503,081 (+)Ensembl
Rnor_6.0 Ensembl121,889,331 - 1,998,127 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000100968   ⟹   ENSRNOP00000089688
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,395,088 - 1,503,081 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110862   ⟹   ENSRNOP00000078753
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl121,395,088 - 1,503,081 (+)Ensembl
RefSeq Acc Id: NM_001107115   ⟹   NP_001100585
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2121,395,088 - 1,503,081 (+)NCBI
Rnor_6.0121,889,331 - 1,998,127 (+)NCBI
Rnor_5.0124,056,145 - 4,161,174 (+)NCBI
RGSC_v3.4122,712,198 - 2,855,137 (-)RGD
Celera123,250,654 - 3,359,236 (+)RGD
Sequence:
RefSeq Acc Id: XM_017598309   ⟹   XP_017453798
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2121,395,035 - 1,501,457 (+)NCBI
Rnor_6.0121,889,252 - 1,998,128 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089307   ⟹   XP_038945235
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2121,473,919 - 1,501,281 (+)NCBI
RefSeq Acc Id: XM_039089308   ⟹   XP_038945236
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2121,395,035 - 1,501,457 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001100585   ⟸   NM_001107115
- Sequence:
RefSeq Acc Id: XP_017453798   ⟸   XM_017598309
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000062255   ⟸   ENSRNOT00000066281
RefSeq Acc Id: XP_038945236   ⟸   XM_039089308
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038945235   ⟸   XM_039089307
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000078753   ⟸   ENSRNOT00000110862
RefSeq Acc Id: ENSRNOP00000089688   ⟸   ENSRNOT00000100968
Protein Domains
C2H2-type   DH   PH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LT94-F1-model_v2 AlphaFold F1LT94 1-1184 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698364
Promoter ID:EPDNEW_R8889
Type:multiple initiation site
Name:Arhgef18_1
Description:Rho/Rac guanine nucleotide exchange factor 18
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0121,889,335 - 1,889,395EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311448 AgrOrtholog
BioCyc Gene G2FUF-20405 BioCyc
Ensembl Genes ENSRNOG00000028090 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000062255.2 UniProtKB/TrEMBL
  ENSRNOP00000078753.1 UniProtKB/TrEMBL
  ENSRNOP00000089688.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000066281.3 UniProtKB/TrEMBL
  ENSRNOT00000100968.1 UniProtKB/TrEMBL
  ENSRNOT00000110862.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.900.10 UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/TrEMBL
InterPro ARHGEF18_PH UniProtKB/TrEMBL
  DBL_dom_sf UniProtKB/TrEMBL
  DH-domain UniProtKB/TrEMBL
  PH_16 UniProtKB/TrEMBL
  PH_type UniProtKB/TrEMBL
  Pleckstrin_homology UniProtKB/TrEMBL
  Znf_C2H2_type UniProtKB/TrEMBL
KEGG Report rno:304193 UniProtKB/TrEMBL
NCBI Gene 304193 ENTREZGENE
PANTHER RHO/RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR 18 UniProtKB/TrEMBL
  RIKEN CDNA A430078G23 GENE UniProtKB/TrEMBL
Pfam PH_16 UniProtKB/TrEMBL
  RhoGEF UniProtKB/TrEMBL
PhenoGen Arhgef18 PhenoGen
PROSITE DH_2 UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/TrEMBL
  ZINC_FINGER_C2H2_2 UniProtKB/TrEMBL
SMART RhoGEF UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP DH-domain UniProtKB/TrEMBL
  PH domain-like UniProtKB/TrEMBL
UniProt A0A8I5ZLL3_RAT UniProtKB/TrEMBL
  A0A8I6ALJ4_RAT UniProtKB/TrEMBL
  F1LT94_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Arhgef18  Rho/Rac guanine nucleotide exchange factor 18  Arhgef18  rho/rac guanine nucleotide exchange factor (GEF) 18  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Arhgef18  rho/rac guanine nucleotide exchange factor (GEF) 18   Arhgef18_predicted  rho/rac guanine nucleotide exchange factor (GEF) 18 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Arhgef18_predicted  rho/rac guanine nucleotide exchange factor (GEF) 18 (predicted)      Symbol and Name status set to approved 70820 APPROVED