Osbpl2 (oxysterol binding protein-like 2) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Osbpl2 (oxysterol binding protein-like 2) Rattus norvegicus
Analyze
Symbol: Osbpl2
Name: oxysterol binding protein-like 2
RGD ID: 1311312
Description: Predicted to enable cholesterol binding activity; lipid transfer activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in lipid transport; plasma membrane organization; and protein homotetramerization. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be active in cytosol; intracellular membrane-bounded organelle; and membrane. Predicted to colocalize with lipid droplet. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to human OSBPL2 (oxysterol binding protein like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC296461; MGC108916; oxysterol-binding protein-related protein 2
RGD Orthologs
Human
Pig
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,210,945 - 167,256,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,210,832 - 167,256,219 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,588,135 - 171,633,192 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03180,547,218 - 180,592,280 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03177,211,915 - 177,257,180 (+)NCBIRnor_WKY
Rnor_6.03175,493,650 - 175,538,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,493,698 - 175,538,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,579,718 - 181,624,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,174,367 - 169,219,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,080,402 - 169,125,854 (+)NCBI
Celera3165,323,956 - 165,369,180 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7. Proteomics for Studying the Effects of Ketogenic Diet Against Lithium Chloride/Pilocarpine Induced Epilepsy in Rats. Zheng YQ, etal., Front Neurosci. 2020 Sep 29;14:562853. doi: 10.3389/fnins.2020.562853. eCollection 2020.
Additional References at PubMed
PMID:17428193   PMID:19224871   PMID:30581148  


Genomics

Comparative Map Data
Osbpl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23167,210,945 - 167,256,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,210,832 - 167,256,219 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,588,135 - 171,633,192 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03180,547,218 - 180,592,280 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03177,211,915 - 177,257,180 (+)NCBIRnor_WKY
Rnor_6.03175,493,650 - 175,538,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,493,698 - 175,538,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,579,718 - 181,624,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,174,367 - 169,219,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,080,402 - 169,125,854 (+)NCBI
Celera3165,323,956 - 165,369,180 (-)NCBICelera
Cytogenetic Map3q43NCBI
OSBPL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,238,521 - 62,296,183 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2062,231,922 - 62,296,213 (+)EnsemblGRCh38hg38GRCh38
GRCh372060,813,577 - 60,871,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map20q13.33NCBI
HuRef2057,589,834 - 57,646,867 (+)NCBIHuRef
CHM1_12060,714,603 - 60,772,035 (+)NCBICHM1_1
T2T-CHM13v2.02064,029,614 - 64,087,136 (+)NCBIT2T-CHM13v2.0
OSBPL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,643,377 - 61,685,819 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,643,263 - 61,683,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Osbpl2
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:117
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000010632
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat

Markers in Region
D3Hmgc10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,227,635 - 167,227,846 (+)MAPPERmRatBN7.2
Rnor_6.03175,510,387 - 175,510,597NCBIRnor6.0
Rnor_5.03181,608,086 - 181,608,296UniSTSRnor5.0
RGSC_v3.43169,191,056 - 169,191,266UniSTSRGSC3.4
Celera3165,352,306 - 165,352,506UniSTS
Cytogenetic Map3q43UniSTS
RH133998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,255,731 - 167,255,940 (+)MAPPERmRatBN7.2
Rnor_6.03175,538,478 - 175,538,686NCBIRnor6.0
Rnor_5.03181,579,997 - 181,580,205UniSTSRnor5.0
RGSC_v3.43169,219,333 - 169,219,541UniSTSRGSC3.4
Celera3165,324,235 - 165,324,443UniSTS
RH 3.4 Map31525.1UniSTS
Cytogenetic Map3q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 48 33 19 33 3 74 35 37 11
Low 8 9 8 8 8 8 4 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000087356   ⟹   ENSRNOP00000074937
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,210,928 - 167,256,219 (+)Ensembl
Rnor_6.0 Ensembl3175,493,698 - 175,538,963 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114663   ⟹   ENSRNOP00000092392
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,210,832 - 167,256,219 (+)Ensembl
RefSeq Acc Id: NM_001013079   ⟹   NP_001013097
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,210,945 - 167,256,219 (+)NCBI
Rnor_6.03175,493,698 - 175,538,965 (+)NCBI
Rnor_5.03181,579,718 - 181,624,997 (-)NCBI
RGSC_v3.43169,174,367 - 169,219,820 (+)RGD
Celera3165,323,956 - 165,369,180 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104663   ⟹   XP_038960591
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,221,085 - 167,256,219 (+)NCBI
RefSeq Acc Id: XM_039104664   ⟹   XP_038960592
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.23167,229,323 - 167,256,219 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001013097 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960591 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960592 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91208 (Get FASTA)   NCBI Sequence Viewer  
  EDL88823 (Get FASTA)   NCBI Sequence Viewer  
  EDL88824 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001013097   ⟸   NM_001013079
- UniProtKB: Q5BK47 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074937   ⟸   ENSRNOT00000087356
RefSeq Acc Id: XP_038960591   ⟸   XM_039104663
- Peptide Label: isoform X1
- UniProtKB: Q5BK47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960592   ⟸   XM_039104664
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000092392   ⟸   ENSRNOT00000114663

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK47-F1-model_v2 AlphaFold Q5BK47 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692730
Promoter ID:EPDNEW_R3255
Type:multiple initiation site
Name:Osbpl2_1
Description:oxysterol binding protein-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03175,493,688 - 175,493,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311312 AgrOrtholog
BioCyc Gene G2FUF-46368 BioCyc
Ensembl Genes ENSRNOG00000057756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000074937 ENTREZGENE
  ENSRNOP00000074937.1 UniProtKB/TrEMBL
  ENSRNOP00000092392 ENTREZGENE
  ENSRNOP00000092392.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087356 ENTREZGENE
  ENSRNOT00000087356.2 UniProtKB/TrEMBL
  ENSRNOT00000114663 ENTREZGENE
  ENSRNOT00000114663.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.120 UniProtKB/TrEMBL
  3.30.70.3490 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381353 IMAGE-MGC_LOAD
InterPro OSBP_sf UniProtKB/TrEMBL
  Oxysterol_bd UniProtKB/TrEMBL
  Oxysterol_bd_CS UniProtKB/TrEMBL
KEGG Report rno:296461 UniProtKB/TrEMBL
MGC_CLONE MGC:108916 IMAGE-MGC_LOAD
NCBI Gene 296461 ENTREZGENE
PANTHER OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2 UniProtKB/TrEMBL
  Oxysterol_bd UniProtKB/TrEMBL
Pfam Oxysterol_BP UniProtKB/TrEMBL
PhenoGen Osbpl2 PhenoGen
PROSITE OSBP UniProtKB/TrEMBL
Superfamily-SCOP SSF144000 UniProtKB/TrEMBL
UniProt A0A8I6AI28_RAT UniProtKB/TrEMBL
  Q5BK47 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Osbpl2  oxysterol binding protein-like 2  Osbpl2_predicted  oxysterol binding protein-like 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Osbpl2_predicted  oxysterol binding protein-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED