Osbpl2 (oxysterol binding protein-like 2) - Rat Genome Database

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Gene: Osbpl2 (oxysterol binding protein-like 2) Rattus norvegicus
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Symbol: Osbpl2
Name: oxysterol binding protein-like 2
RGD ID: 1311312
Description: Predicted to enable cholesterol binding activity; lipid transfer activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in several processes, including intracellular cholesterol transport; protein homotetramerization; and regulation of synaptic vesicle priming. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and lipid droplet. Predicted to be active in glutamatergic synapse. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 67. Orthologous to human OSBPL2 (oxysterol binding protein like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; cobalt dichloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC296461; MGC108916; oxysterol-binding protein-related protein 2
RGD Orthologs
Human
Pig
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,585,372 - 187,633,827 (+)NCBIGRCr8
mRatBN7.23167,210,945 - 167,256,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,210,832 - 167,256,219 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,588,135 - 171,633,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,547,218 - 180,592,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,211,915 - 177,257,180 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,493,650 - 175,538,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,493,698 - 175,538,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,579,718 - 181,624,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,174,367 - 169,219,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,080,402 - 169,125,854 (+)NCBI
Celera3165,323,956 - 165,369,180 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
7. Proteomics for Studying the Effects of Ketogenic Diet Against Lithium Chloride/Pilocarpine Induced Epilepsy in Rats. Zheng YQ, etal., Front Neurosci. 2020 Sep 29;14:562853. doi: 10.3389/fnins.2020.562853. eCollection 2020.
Additional References at PubMed
PMID:17428193   PMID:19224871   PMID:30581148  


Genomics

Comparative Map Data
Osbpl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83187,585,372 - 187,633,827 (+)NCBIGRCr8
mRatBN7.23167,210,945 - 167,256,219 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3167,210,832 - 167,256,219 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3171,588,135 - 171,633,192 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03180,547,218 - 180,592,280 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03177,211,915 - 177,257,180 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03175,493,650 - 175,538,965 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3175,493,698 - 175,538,963 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03181,579,718 - 181,624,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43169,174,367 - 169,219,820 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13169,080,402 - 169,125,854 (+)NCBI
Celera3165,323,956 - 165,369,180 (-)NCBICelera
Cytogenetic Map3q43NCBI
OSBPL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382062,238,521 - 62,296,183 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2062,231,922 - 62,296,213 (+)EnsemblGRCh38hg38GRCh38
GRCh372060,813,577 - 60,871,239 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map20q13.33NCBI
HuRef2057,589,834 - 57,646,867 (+)NCBIHuRef
CHM1_12060,714,603 - 60,772,035 (+)NCBICHM1_1
T2T-CHM13v2.02064,029,614 - 64,087,136 (+)NCBIT2T-CHM13v2.0
OSBPL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1761,643,377 - 61,685,819 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11761,643,263 - 61,683,178 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1

Variants

.
Variants in Osbpl2
127 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:167
Count of miRNA genes:117
Interacting mature miRNAs:141
Transcripts:ENSRNOT00000010632
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3122438700167438700Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)398535255168026850Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3127162703168026850Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
2298477Eau4Experimental allergic uveoretinitis QTL 40.0011uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)3137398739169034231Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)398535255168026850Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3149040888168026850Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)398535255168026850Rat

Markers in Region
D3Hmgc10  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83187,605,246 - 187,605,457 (+)Marker Load Pipeline
mRatBN7.23167,227,635 - 167,227,846 (+)MAPPERmRatBN7.2
Rnor_6.03175,510,387 - 175,510,597NCBIRnor6.0
Rnor_5.03181,608,086 - 181,608,296UniSTSRnor5.0
RGSC_v3.43169,191,056 - 169,191,266UniSTSRGSC3.4
Celera3165,352,306 - 165,352,506UniSTS
Cytogenetic Map3q43UniSTS
RH133998  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.23167,255,731 - 167,255,940 (+)MAPPERmRatBN7.2
Rnor_6.03175,538,478 - 175,538,686NCBIRnor6.0
Rnor_5.03181,579,997 - 181,580,205UniSTSRnor5.0
RGSC_v3.43169,219,333 - 169,219,541UniSTSRGSC3.4
Celera3165,324,235 - 165,324,443UniSTS
RH 3.4 Map31525.1UniSTS
Cytogenetic Map3q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000087356   ⟹   ENSRNOP00000074937
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,210,928 - 167,256,219 (+)Ensembl
Rnor_6.0 Ensembl3175,493,698 - 175,538,963 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114663   ⟹   ENSRNOP00000092392
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3167,210,832 - 167,256,219 (+)Ensembl
RefSeq Acc Id: NM_001013079   ⟹   NP_001013097
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,588,562 - 187,633,827 (+)NCBI
mRatBN7.23167,210,945 - 167,256,219 (+)NCBI
Rnor_6.03175,493,698 - 175,538,965 (+)NCBI
Rnor_5.03181,579,718 - 181,624,997 (-)NCBI
RGSC_v3.43169,174,367 - 169,219,820 (+)RGD
Celera3165,323,956 - 165,369,180 (-)RGD
Sequence:
RefSeq Acc Id: XM_039104663   ⟹   XP_038960591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,598,702 - 187,633,827 (+)NCBI
mRatBN7.23167,221,085 - 167,256,219 (+)NCBI
RefSeq Acc Id: XM_039104664   ⟹   XP_038960592
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,606,933 - 187,633,827 (+)NCBI
mRatBN7.23167,229,323 - 167,256,219 (+)NCBI
RefSeq Acc Id: XM_063283422   ⟹   XP_063139492
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,606,933 - 187,633,827 (+)NCBI
RefSeq Acc Id: XM_063283423   ⟹   XP_063139493
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83187,585,372 - 187,633,827 (+)NCBI
RefSeq Acc Id: NP_001013097   ⟸   NM_001013079
- UniProtKB: Q5BK47 (UniProtKB/TrEMBL),   A6KMB6 (UniProtKB/TrEMBL),   A0A0G2K9B7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074937   ⟸   ENSRNOT00000087356
RefSeq Acc Id: XP_038960591   ⟸   XM_039104663
- Peptide Label: isoform X2
- UniProtKB: Q5BK47 (UniProtKB/TrEMBL),   A6KMB6 (UniProtKB/TrEMBL),   A0A0G2K9B7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960592   ⟸   XM_039104664
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000092392   ⟸   ENSRNOT00000114663
RefSeq Acc Id: XP_063139493   ⟸   XM_063283423
- Peptide Label: isoform X2
- UniProtKB: A0A0G2K9B7 (UniProtKB/TrEMBL),   A6KMB6 (UniProtKB/TrEMBL),   Q5BK47 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063139492   ⟸   XM_063283422
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AI28 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK47-F1-model_v2 AlphaFold Q5BK47 1-483 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692730
Promoter ID:EPDNEW_R3255
Type:multiple initiation site
Name:Osbpl2_1
Description:oxysterol binding protein-like 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03175,493,688 - 175,493,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311312 AgrOrtholog
BioCyc Gene G2FUF-46368 BioCyc
Ensembl Genes ENSRNOG00000057756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000087356 ENTREZGENE
  ENSRNOT00000087356.2 UniProtKB/TrEMBL
  ENSRNOT00000114663 ENTREZGENE
  ENSRNOT00000114663.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.160.120 UniProtKB/TrEMBL
  3.30.70.3490 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7381353 IMAGE-MGC_LOAD
InterPro OSBP_sf UniProtKB/TrEMBL
  Oxysterol_bd UniProtKB/TrEMBL
  Oxysterol_bd_CS UniProtKB/TrEMBL
KEGG Report rno:296461 UniProtKB/TrEMBL
MGC_CLONE MGC:108916 IMAGE-MGC_LOAD
NCBI Gene 296461 ENTREZGENE
PANTHER OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 2 UniProtKB/TrEMBL
  Oxysterol_bd UniProtKB/TrEMBL
Pfam Oxysterol_BP UniProtKB/TrEMBL
PhenoGen Osbpl2 PhenoGen
PROSITE OSBP UniProtKB/TrEMBL
RatGTEx ENSRNOG00000057756 RatGTEx
Superfamily-SCOP SSF144000 UniProtKB/TrEMBL
UniProt A0A0G2K9B7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AI28 ENTREZGENE, UniProtKB/TrEMBL
  A6KMB5_RAT UniProtKB/TrEMBL
  A6KMB6 ENTREZGENE, UniProtKB/TrEMBL
  Q5BK47 ENTREZGENE
UniProt Secondary Q5BK47 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Osbpl2  oxysterol binding protein-like 2  Osbpl2_predicted  oxysterol binding protein-like 2 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Osbpl2_predicted  oxysterol binding protein-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED