Twsg1 (twisted gastrulation BMP signaling modulator 1) - Rat Genome Database

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Gene: Twsg1 (twisted gastrulation BMP signaling modulator 1) Rattus norvegicus
Analyze
Symbol: Twsg1
Name: twisted gastrulation BMP signaling modulator 1
RGD ID: 1311215
Description: Predicted to enable heparin binding activity and transforming growth factor beta binding activity. Predicted to be involved in negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of cytokine production; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including BMP signaling pathway; negative regulation of osteoblast differentiation; and regulation of BMP signaling pathway. Predicted to be active in extracellular space. Orthologous to human TWSG1 (twisted gastrulation BMP signaling modulator 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; dibutyl phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC363294; twisted gastrulation homolog 1; twisted gastrulation homolog 1 (Drosophila); twisted gastrulation protein homolog 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89112,979,972 - 113,014,315 (-)NCBIGRCr8
mRatBN7.29105,533,116 - 105,567,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,533,136 - 105,567,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9113,944,806 - 113,973,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,054,620 - 119,083,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,410,654 - 117,439,487 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,699,151 - 113,732,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,699,170 - 113,732,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09113,230,657 - 113,264,099 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49104,694,731 - 104,729,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19104,907,180 - 104,938,570 (-)NCBI
Celera9102,911,360 - 102,940,263 (-)NCBICelera
Cytogenetic Map9q37NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12665593   PMID:14681194   PMID:15013800   PMID:15780974   PMID:15843411   PMID:16289463   PMID:17164348   PMID:23376485  


Genomics

Comparative Map Data
Twsg1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89112,979,972 - 113,014,315 (-)NCBIGRCr8
mRatBN7.29105,533,116 - 105,567,460 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl9105,533,136 - 105,567,479 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9113,944,806 - 113,973,639 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09119,054,620 - 119,083,679 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09117,410,654 - 117,439,487 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09113,699,151 - 113,732,601 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9113,699,170 - 113,732,622 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09113,230,657 - 113,264,099 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.49104,694,731 - 104,729,090 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.19104,907,180 - 104,938,570 (-)NCBI
Celera9102,911,360 - 102,940,263 (-)NCBICelera
Cytogenetic Map9q37NCBI
TWSG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38189,334,773 - 9,402,420 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl189,334,767 - 9,402,420 (+)EnsemblGRCh38hg38GRCh38
GRCh37189,334,771 - 9,402,418 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36189,324,851 - 9,392,418 (+)NCBINCBI36Build 36hg18NCBI36
Build 34189,324,850 - 9,392,417NCBI
Celera189,219,304 - 9,286,615 (+)NCBICelera
Cytogenetic Map18p11.22NCBI
HuRef189,298,467 - 9,364,729 (+)NCBIHuRef
CHM1_1189,334,596 - 9,402,161 (+)NCBICHM1_1
T2T-CHM13v2.0189,497,987 - 9,565,608 (+)NCBIT2T-CHM13v2.0
Twsg1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391766,230,060 - 66,258,198 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1766,228,967 - 66,258,221 (-)EnsemblGRCm39 Ensembl
GRCm381765,923,065 - 65,951,187 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1765,921,972 - 65,951,226 (-)EnsemblGRCm38mm10GRCm38
MGSCv371766,272,405 - 66,300,527 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361765,822,609 - 65,850,673 (-)NCBIMGSCv36mm8
Celera1770,231,747 - 70,259,874 (-)NCBICelera
Cytogenetic Map17E1.1NCBI
cM Map1735.26NCBI
Twsg1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554022,652,020 - 2,686,117 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554022,652,020 - 2,685,350 (-)NCBIChiLan1.0ChiLan1.0
TWSG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21729,048,226 - 29,115,502 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11814,740,820 - 14,808,080 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0184,883,688 - 4,950,963 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1187,164,091 - 7,229,271 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl187,164,091 - 7,229,271 (-)Ensemblpanpan1.1panPan2
TWSG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1775,337,347 - 75,397,485 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl775,335,235 - 75,398,325 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha774,725,544 - 74,790,454 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0775,385,087 - 75,451,743 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl775,385,019 - 75,452,636 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0775,106,123 - 75,167,742 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0775,411,428 - 75,477,211 (+)NCBIUU_Cfam_GSD_1.0
Twsg1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049442,673,370 - 2,720,055 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366261,901,680 - 1,946,460 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366261,901,686 - 1,946,554 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TWSG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl698,625,505 - 98,678,258 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1698,629,116 - 98,678,322 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2691,965,863 - 92,015,046 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TWSG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11868,225,350 - 68,289,458 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1868,225,343 - 68,290,969 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605043,175,298 - 43,240,621 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Twsg1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477018,047,810 - 18,081,761 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477018,047,790 - 18,081,559 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Twsg1
159 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:594
Count of miRNA genes:294
Interacting mature miRNAs:360
Transcripts:ENSRNOT00000017915
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat

Markers in Region
RH133016  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29105,560,202 - 105,560,402 (-)MAPPERmRatBN7.2
mRatBN7.29105,560,202 - 105,560,402 (+)MAPPERmRatBN7.2
Rnor_6.09113,706,234 - 113,706,433NCBIRnor6.0
Rnor_6.09113,796,009 - 113,796,208NCBIRnor6.0
Rnor_5.09113,325,201 - 113,325,400UniSTSRnor5.0
Rnor_5.09113,237,728 - 113,237,927UniSTSRnor5.0
RGSC_v3.49104,721,822 - 104,722,021UniSTSRGSC3.4
Celera9102,935,242 - 102,935,441UniSTS
Cytogenetic Map9q37UniSTS
RH133800  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29105,534,350 - 105,534,535 (-)MAPPERmRatBN7.2
Rnor_6.09113,731,182 - 113,731,366NCBIRnor6.0
Rnor_5.09113,262,676 - 113,262,860UniSTSRnor5.0
RGSC_v3.49104,695,970 - 104,696,154UniSTSRGSC3.4
Celera9102,909,398 - 102,909,582UniSTS
Cytogenetic Map9q37UniSTS
RH141244  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.29105,533,226 - 105,533,444 (-)MAPPERmRatBN7.2
Rnor_6.09113,732,273 - 113,732,490NCBIRnor6.0
Rnor_5.09113,263,767 - 113,263,984UniSTSRnor5.0
RGSC_v3.49104,694,846 - 104,695,063UniSTSRGSC3.4
Celera9102,908,083 - 102,908,491UniSTS
RH 3.4 Map81156.49UniSTS
Cytogenetic Map9q37UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017915   ⟹   ENSRNOP00000017915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl9105,533,136 - 105,567,479 (-)Ensembl
Rnor_6.0 Ensembl9113,699,170 - 113,732,622 (+)Ensembl
RefSeq Acc Id: NM_001108811   ⟹   NP_001102281
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89112,979,972 - 113,014,315 (-)NCBI
mRatBN7.29105,533,116 - 105,567,460 (-)NCBI
Rnor_6.09113,701,476 - 113,729,404 (+)NCBI
Rnor_5.09113,230,657 - 113,264,099 (+)NCBI
RGSC_v3.49104,694,731 - 104,729,090 (-)RGD
Celera9102,911,360 - 102,940,263 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001412824   ⟹   NP_001399753
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89112,979,972 - 113,014,315 (-)NCBI
mRatBN7.29105,533,116 - 105,567,460 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001102281 (Get FASTA)   NCBI Sequence Viewer  
  NP_001399753 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL91800 (Get FASTA)   NCBI Sequence Viewer  
  EDL91801 (Get FASTA)   NCBI Sequence Viewer  
  EDL91802 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017915.3
RefSeq Acc Id: NP_001102281   ⟸   NM_001108811
- Peptide Label: precursor
- UniProtKB: D4A9T2 (UniProtKB/TrEMBL),   A6JRD5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017915   ⟸   ENSRNOT00000017915
RefSeq Acc Id: NP_001399753   ⟸   NM_001412824
- Peptide Label: precursor
- UniProtKB: D4A9T2 (UniProtKB/TrEMBL),   A6JRD5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A9T2-F1-model_v2 AlphaFold D4A9T2 1-222 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696905
Promoter ID:EPDNEW_R7429
Type:multiple initiation site
Name:Twsg1_1
Description:twisted gastrulation BMP signaling modulator 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09113,699,173 - 113,699,233EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311215 AgrOrtholog
BioCyc Gene G2FUF-26476 BioCyc
Ensembl Genes ENSRNOG00000013340 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017915.6 UniProtKB/TrEMBL
InterPro Tsg UniProtKB/TrEMBL
KEGG Report rno:363294 UniProtKB/TrEMBL
NCBI Gene 363294 ENTREZGENE
PANTHER Tsg UniProtKB/TrEMBL
  TWISTED GASTRULATION PROTEIN HOMOLOG 1 UniProtKB/TrEMBL
Pfam Tsg UniProtKB/TrEMBL
PhenoGen Twsg1 PhenoGen
RatGTEx ENSRNOG00000013340 RatGTEx
UniProt A6JRD5 ENTREZGENE, UniProtKB/TrEMBL
  D4A9T2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-11-11 Twsg1  twisted gastrulation BMP signaling modulator 1  Twsg1  twisted gastrulation homolog 1 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Twsg1  twisted gastrulation homolog 1 (Drosophila)   Twsg1_predicted  twisted gastrulation homolog 1 (Drosophila) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Twsg1_predicted  twisted gastrulation homolog 1 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED