Ipo11 (importin 11) - Rat Genome Database

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Gene: Ipo11 (importin 11) Rattus norvegicus
Analyze
Symbol: Ipo11
Name: importin 11
RGD ID: 1311133
Description: Predicted to enable small GTPase binding activity. Predicted to be involved in intracellular protein transport. Predicted to be located in cytoplasm. Orthologous to human IPO11 (importin 11).
Type: protein-coding
RefSeq Status: MODEL
Previously known as: importin-11; LOC310056; similar to importin 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Ipo11-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8239,903,316 - 40,076,485 (-)NCBIGRCr8
mRatBN7.2238,169,688 - 38,342,929 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.0237,952,982 - 38,120,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl237,954,161 - 38,110,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0257,049,753 - 57,215,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4238,006,409 - 38,054,430 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1237,926,777 - 37,974,871 (-)NCBI
Celera234,041,416 - 34,210,706 (-)NCBICelera
Cytogenetic Map2q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:11809816   PMID:12477932  


Genomics

Comparative Map Data
Ipo11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8239,903,316 - 40,076,485 (-)NCBIGRCr8
mRatBN7.2238,169,688 - 38,342,929 (-)NCBImRatBN7.2mRatBN7.2
Rnor_6.0237,952,982 - 38,120,451 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl237,954,161 - 38,110,567 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0257,049,753 - 57,215,181 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4238,006,409 - 38,054,430 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1237,926,777 - 37,974,871 (-)NCBI
Celera234,041,416 - 34,210,706 (-)NCBICelera
Cytogenetic Map2q13NCBI
IPO11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38562,578,735 - 62,628,589 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl562,403,972 - 62,628,582 (+)EnsemblGRCh38hg38GRCh38
GRCh37561,874,562 - 61,924,416 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36561,744,351 - 61,960,165 (+)NCBINCBI36Build 36hg18NCBI36
Build 34561,744,350 - 61,960,164NCBI
Celera558,704,531 - 58,921,350 (+)NCBICelera
Cytogenetic Map5q12.1NCBI
HuRef558,830,947 - 58,880,547 (+)NCBIHuRef
CHM1_1561,874,345 - 61,924,070 (+)NCBICHM1_1
T2T-CHM13v2.0563,398,374 - 63,448,302 (+)NCBIT2T-CHM13v2.0
Ipo11-lrrc70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3913106,930,947 - 106,972,810 (-)NCBIGRCm39GRCm39mm39
GRCm3813106,794,439 - 106,836,302 (-)NCBIGRCm38GRCm38mm10GRCm38
Cytogenetic Map13D1NCBI
Ipo11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554466,034,277 - 6,225,640 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554466,034,277 - 6,225,627 (-)NCBIChiLan1.0ChiLan1.0
IPO11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2451,287,365 - 51,499,916 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1549,440,997 - 49,653,546 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0551,370,503 - 51,584,256 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1553,013,430 - 53,226,598 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl553,013,430 - 53,226,598 (-)Ensemblpanpan1.1panPan2
Ipo11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213197,168,763 - 197,374,904 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364806,104,333 - 6,304,413 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364806,105,237 - 6,311,335 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IPO11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1458,602,143 - 58,827,120 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660497,121,956 - 7,352,145 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ipo11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248157,254,909 - 7,478,569 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248157,255,803 - 7,492,289 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ipo11
1086 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:77
Count of miRNA genes:40
Interacting mature miRNAs:41
Transcripts:ENSRNOT00000060904, ENSRNOT00000072212, ENSRNOT00000074971
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat
731179Mamtr3Mammary tumor resistance QTL 30.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)23237377043665178Rat
10755436Coatc8Coat color QTL 80.02431coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23502311780023117Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat

Markers in Region
RH142483  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2238,300,022 - 38,300,176 (+)MAPPERmRatBN7.2
Rnor_6.0238,077,021 - 38,077,173NCBIRnor6.0
Rnor_5.0257,171,754 - 57,171,906UniSTSRnor5.0
RGSC_v3.4238,011,590 - 38,011,742UniSTSRGSC3.4
Celera234,167,835 - 34,167,987UniSTS
RH 3.4 Map2174.8UniSTS
Cytogenetic Map2q14UniSTS
AA945067  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2238,216,234 - 38,216,442 (+)MAPPERmRatBN7.2
Rnor_6.0237,998,569 - 37,998,776NCBIRnor6.0
Rnor_5.0257,095,340 - 57,095,547UniSTSRnor5.0
Celera234,087,854 - 34,088,061UniSTS
RH 3.4 Map2174.8UniSTS
Cytogenetic Map2q14UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 27 37 21 18 21 8 9 74 30 38 10 8
Low 2 16 20 20 1 20 2 5 3 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000072212   ⟹   ENSRNOP00000065744
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl237,954,161 - 38,110,567 (-)Ensembl
RefSeq Acc Id: XM_063282682   ⟹   XP_063138752
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282683   ⟹   XP_063138753
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282684   ⟹   XP_063138754
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282685   ⟹   XP_063138755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,903,316 - 40,076,485 (-)NCBI
RefSeq Acc Id: XM_063282686   ⟹   XP_063138756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8239,949,640 - 40,076,485 (-)NCBI
RefSeq Acc Id: ENSRNOP00000065744   ⟸   ENSRNOT00000072212
RefSeq Acc Id: XP_063138754   ⟸   XM_063282684
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063138755   ⟸   XM_063282685
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138753   ⟸   XM_063282683
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063138752   ⟸   XM_063282682
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063138756   ⟸   XM_063282686
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R8E8-F1-model_v2 AlphaFold M0R8E8 1-976 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311133 AgrOrtholog
BioCyc Gene G2FUF-54527 BioCyc
Ensembl Genes ENSRNOG00000039717 Ensembl
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7316678 IMAGE-MGC_LOAD
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
MGC_CLONE MGC:109371 IMAGE-MGC_LOAD
NCBI Gene 310056 ENTREZGENE
PANTHER IMPORTIN-11 UniProtKB/TrEMBL
  IMPORTIN-7, 8, 11 UniProtKB/TrEMBL
PhenoGen Ipo11 PhenoGen
RatGTEx ENSRNOG00000039717 RatGTEx
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt Q562A4_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Ipo11  importin 11  LOC683676  similar to importin 11  Data merged from RGD:1584477 1643240 APPROVED
2008-04-30 Ipo11  importin 11   Ipo11_predicted  importin 11 (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-19 LOC683676  similar to importin 11      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Ipo11_predicted  importin 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED