Piwil4 (piwi-like RNA-mediated gene silencing 4) - Rat Genome Database

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Gene: Piwil4 (piwi-like RNA-mediated gene silencing 4) Rattus norvegicus
Analyze
Symbol: Piwil4
Name: piwi-like RNA-mediated gene silencing 4
RGD ID: 1311015
Description: Predicted to enable RNA endonuclease activity and piRNA binding activity. Involved in regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in mitochondrion; nucleoplasm; and piP-body. Predicted to be active in P granule and nucleus. Orthologous to human PIWIL4 (piwi like RNA-mediated gene silencing 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC315432; LOC689972; piwi-like 4; piwi-like 4 (Drosophila); piwi-like protein 4; similar to piwi-like 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,817,985 - 19,861,327 (-)NCBIGRCr8
mRatBN7.2811,536,520 - 11,579,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,536,520 - 11,579,761 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,521,749 - 15,564,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,819,492 - 13,862,295 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,795,101 - 11,837,796 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,208,774 - 13,251,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,208,774 - 13,251,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,150,647 - 13,192,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,491,035 - 11,534,564 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,491,034 - 11,534,564 (-)NCBI
Celera813,007,375 - 13,049,493 (-)NCBICelera
Cytogenetic Map8q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO,ISS)
mitochondrion  (IEA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,ISO,ISS)
P granule  (IBA,IEA,ISO,ISS)
piP-body  (ISO,ISS)

Molecular Function
piRNA binding  (IBA,IEA,ISO,ISS)
protein binding  (ISO)
RNA endonuclease activity  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. PIWI-interacting RNAs as novel regulators of pancreatic beta cell function. Henaoui IS, etal., Diabetologia. 2017 Oct;60(10):1977-1986. doi: 10.1007/s00125-017-4368-2. Epub 2017 Jul 16.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:17395546   PMID:18381894   PMID:18922463   PMID:20011505   PMID:20059948   PMID:22020280   PMID:25038252   PMID:25503965   PMID:26669262   PMID:28025795  


Genomics

Comparative Map Data
Piwil4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,817,985 - 19,861,327 (-)NCBIGRCr8
mRatBN7.2811,536,520 - 11,579,883 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,536,520 - 11,579,761 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,521,749 - 15,564,552 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,819,492 - 13,862,295 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,795,101 - 11,837,796 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,208,774 - 13,251,970 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,208,774 - 13,251,812 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,150,647 - 13,192,599 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,491,035 - 11,534,564 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,491,034 - 11,534,564 (-)NCBI
Celera813,007,375 - 13,049,493 (-)NCBICelera
Cytogenetic Map8q12NCBI
PIWIL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,567,368 - 94,621,421 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,543,840 - 94,621,421 (+)EnsemblGRCh38hg38GRCh38
GRCh371194,300,534 - 94,354,587 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,940,182 - 93,994,234 (+)NCBINCBI36Build 36hg18NCBI36
Build 341193,940,181 - 93,994,234NCBI
Celera1191,588,283 - 91,642,396 (+)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,365,674 - 90,419,786 (+)NCBIHuRef
CHM1_11194,183,460 - 94,237,568 (+)NCBICHM1_1
T2T-CHM13v2.01194,574,415 - 94,628,468 (+)NCBIT2T-CHM13v2.0
Piwil4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,613,072 - 14,651,968 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,607,526 - 14,652,036 (-)EnsemblGRCm39 Ensembl
GRCm38914,701,776 - 14,740,672 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,696,230 - 14,740,733 (-)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl914,696,230 - 14,740,740 (-)EnsemblGRCm38mm10GRCm38
MGSCv37914,506,802 - 14,545,177 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,452,751 - 14,491,126 (-)NCBIMGSCv36mm8
Celera911,982,833 - 12,021,209 (-)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.25NCBI
Piwil4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955605331,633 - 398,528 (-)NCBIChiLan1.0ChiLan1.0
PIWIL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,414,340 - 95,468,649 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,504,084 - 96,560,116 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,572,252 - 89,628,251 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11193,098,926 - 93,151,404 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1193,097,709 - 93,150,981 (+)Ensemblpanpan1.1panPan2
PIWIL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,319,986 - 6,391,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,319,987 - 6,366,787 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,330,852 - 6,377,361 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,500,351 - 6,547,075 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,500,352 - 6,547,201 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,287,775 - 6,334,256 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,350,835 - 6,397,206 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,399,353 - 6,446,079 (-)NCBIUU_Cfam_GSD_1.0
Piwil4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,489,052 - 79,535,015 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936674355,302 - 402,388 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIWIL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,703,340 - 26,751,854 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,679,960 - 26,751,856 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,436,750 - 30,505,677 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIWIL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,768,124 - 85,817,426 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,768,287 - 85,817,000 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604339,958,043 - 40,009,359 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Piwil4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473539,220,242 - 39,285,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Piwil4
340 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:69
Interacting mature miRNAs:87
Transcripts:ENSRNOT00000049724
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat

Markers in Region
D8Got10  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2811,549,508 - 11,549,776 (+)MAPPERmRatBN7.2
Rnor_6.0813,221,757 - 13,222,024NCBIRnor6.0
Rnor_5.0813,163,630 - 13,163,897UniSTSRnor5.0
RGSC_v3.4811,503,884 - 11,504,151RGDRGSC3.4
RGSC_v3.4811,503,885 - 11,504,152UniSTSRGSC3.4
RGSC_v3.1811,503,884 - 11,504,150RGD
Celera813,020,358 - 13,020,627UniSTS
RH 3.4 Map8107.5UniSTS
RH 3.4 Map8107.5RGD
Cytogenetic Map8q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 11 11
Low 2 11 3 8 3 2 2 4 29 28 10 2
Below cutoff 40 43 35 35 6 8 64 6 2 1 6

Sequence


RefSeq Acc Id: ENSRNOT00000049724   ⟹   ENSRNOP00000039460
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,536,520 - 11,579,761 (-)Ensembl
Rnor_6.0 Ensembl813,208,774 - 13,251,812 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078117   ⟹   ENSRNOP00000072452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl811,536,520 - 11,579,761 (-)Ensembl
Rnor_6.0 Ensembl813,209,384 - 13,251,812 (-)Ensembl
RefSeq Acc Id: NM_001271133   ⟹   NP_001258062
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,817,986 - 19,861,220 (-)NCBI
mRatBN7.2811,536,520 - 11,579,761 (-)NCBI
Rnor_6.0813,208,774 - 13,251,812 (-)NCBI
Rnor_5.0813,150,647 - 13,192,599 (-)NCBI
Celera813,007,375 - 13,049,493 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765980   ⟹   XP_008764202
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8819,817,985 - 19,861,327 (-)NCBI
mRatBN7.2811,536,520 - 11,579,883 (-)NCBI
Rnor_6.0813,208,776 - 13,251,970 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001258062 (Get FASTA)   NCBI Sequence Viewer  
  XP_008764202 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98798 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039460
  ENSRNOP00000039460.5
  ENSRNOP00000072452
  ENSRNOP00000072452.2
GenBank Protein Q4G033 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001258062   ⟸   NM_001271133
- UniProtKB: Q4G033 (UniProtKB/Swiss-Prot),   F1LQ32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008764202   ⟸   XM_008765980
- Peptide Label: isoform X1
- UniProtKB: Q4G033 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072452   ⟸   ENSRNOT00000078117
RefSeq Acc Id: ENSRNOP00000039460   ⟸   ENSRNOT00000049724
Protein Domains
PAZ   Piwi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4G033-F1-model_v2 AlphaFold Q4G033 1-848 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311015 AgrOrtholog
BioCyc Gene G2FUF-31689 BioCyc
Ensembl Genes ENSRNOG00000009043 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049724 ENTREZGENE
  ENSRNOT00000049724.6 UniProtKB/TrEMBL
  ENSRNOT00000078117.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.420.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.2300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  paz domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7375953 IMAGE-MGC_LOAD
InterPro PAZ_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PAZ_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNaseH_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:689972 UniProtKB/TrEMBL
MGC_CLONE MGC:112840 IMAGE-MGC_LOAD
NCBI Gene Piwil4 ENTREZGENE
PANTHER EUKARYOTIC TRANSLATION INITIATION FACTOR 2C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIWI-LIKE PROTEIN 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Piwil4 PhenoGen
PROSITE PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIWI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009043 RatGTEx
SMART PAZ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Piwi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF101690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53098 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K303_RAT UniProtKB/TrEMBL
  F1LQ32 ENTREZGENE, UniProtKB/TrEMBL
  PIWL4_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-02-27 Piwil4  piwi-like RNA-mediated gene silencing 4  Piwil4  piwi-like 4 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-19 Piwil4  piwi-like 4 (Drosophila)  LOC689972  similar to piwi-like 4  Data merged from RGD:1586328 737654 APPROVED
2006-11-19 LOC689972  similar to piwi-like 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-12-06 Piwil4  piwi-like 4 (Drosophila)  Piwil4_predicted  piwi-like 4 (Drosophila) (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Piwil4_predicted  piwi-like 4 (Drosophila) (predicted)      Symbol and Name status set to approved 70820 APPROVED