Message Center
{{ messageCount }} Messages
Watched Genes
{{$index + 1}}. {{ watchedObject.symbol }} (RGD ID:{{watchedObject.rgdId}})
Watched Ontology Terms
{{$index + 1}}. {{ watchedTerm.term }} ({{watchedTerm.accId}})
{{gene.symbol}}: {{ gene.description }}
Save what matters to you
{{ loginError }}
Sign in with your RGD account
Gene: Efr3b (EFR3 homolog B) Rattus norvegicus
Analyze
Symbol:
Efr3b
Name:
EFR3 homolog B
RGD ID:
1310845
Description:
Predicted to be involved in phosphatidylinositol phosphorylation and protein localization to plasma membrane. Predicted to localize to actin cytoskeleton; cytosol; and plasma membrane. Orthologous to human EFR3B (EFR3 homolog B); INTERACTS WITH bisphenol A; tetrachloromethane; (-)-epigallocatechin 3-gallate (ortholog).
Type:
protein-coding
RefSeq Status:
MODEL
Also known as:
EFR3 homolog B (S. cerevisiae); LOC313928; protein EFR3 homolog B; RGD1310845; similar to KIAA0953 protein
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
EFR3B (EFR3 homolog B) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):
Efr3b (EFR3 homolog B) HGNC
Treefam, EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Efr3b (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
EFR3B (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
EFR3B (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Efr3b (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
EFR3B (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
EFR3B (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Efr3b (EFR3 homolog B) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
EFR3B (EFR3 homolog B)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Efr3b (EFR3 homolog B)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
efr3bb (EFR3 homolog Bb (S. cerevisiae))
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
efr3ba (EFR3 homolog Ba (S. cerevisiae))
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
EFR3
Alliance
DIOPT (Ensembl Compara|OrthoFinder|OrthoInspector)
Caenorhabditis elegans (roundworm):
efr-3
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB)
Drosophila melanogaster (fruit fly):
stmA
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 28,390,541 - 28,464,174 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 28,393,016 - 28,464,118 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 6 38,199,581 - 38,273,364 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 26,943,439 - 27,015,602 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 26,946,381 - 27,015,675 (-) NCBI Celera 6 26,423,314 - 26,496,653 (-) NCBI Celera Cytogenetic Map 6 q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1602224 6480464 [potassium chromateVI co-treated with epigallocatechin gallate] results in decreased expression of EFR3B mRNA CTD PMID:22079256 17beta-estradiol multiple interactions ISO RGD:1602224 6480464 [Estradiol co-treated with TGFB1 protein] results in increased expression of EFR3B mRNA, EGF protein inhibits the reaction [Estradiol results in decreased expression of EFR3B mRNA] CTD PMID:24758408 , PMID:30165855 17beta-estradiol decreases expression ISO RGD:1602224 6480464 Estradiol results in decreased expression of EFR3B mRNA CTD PMID:24758408 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1623354 6480464 Tetrachlorodibenzodioxin results in decreased expression of EFR3B mRNA CTD PMID:19465110 2-hydroxypropanoic acid decreases expression ISO RGD:1602224 6480464 Lactic Acid results in decreased expression of EFR3B mRNA CTD PMID:30851411 4-hydroxyphenyl retinamide increases expression ISO RGD:1623354 6480464 Fenretinide results in increased expression of EFR3B mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine affects expression ISO RGD:1602224 6480464 Decitabine affects the expression of EFR3B mRNA CTD PMID:23300844 aflatoxin B1 decreases expression ISO RGD:1602224 6480464 Aflatoxin B1 results in decreased expression of EFR3B mRNA CTD PMID:21641981 aflatoxin B1 increases methylation ISO RGD:1602224 6480464 Aflatoxin B1 results in increased methylation of EFR3B gene, Aflatoxin B1 results in increased methylation of EFR3B intron CTD PMID:27153756 , PMID:30157460 aflatoxin B2 affects methylation ISO RGD:1602224 6480464 aflatoxin B2 affects the methylation of EFR3B intron CTD PMID:30157460 benzo[a]pyrene decreases expression ISO RGD:1602224 6480464 Benzoapyrene results in decreased expression of EFR3B mRNA CTD PMID:20064835 more ... benzo[a]pyrene affects methylation ISO RGD:1602224 6480464 Benzoapyrene affects the methylation of EFR3B intron CTD PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:1602224 6480464 Benzoapyrene results in increased methylation of EFR3B promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:1623354 6480464 Benzoapyrene results in decreased expression of EFR3B mRNA CTD PMID:32417428 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1602224 6480464 7 more ... CTD PMID:26238291 benzo[e]pyrene increases methylation ISO RGD:1602224 6480464 benzoepyrene results in increased methylation of EFR3B intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1602224 6480464 Diethylhexyl Phthalate results in decreased expression of EFR3B mRNA CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of EFR3B mRNA CTD PMID:25181051 butanal increases expression ISO RGD:1602224 6480464 butyraldehyde results in increased expression of EFR3B mRNA CTD PMID:26079696 carbon nanotube increases expression ISO RGD:1623354 6480464 Nanotubes more ... CTD PMID:25554681 choline multiple interactions ISO RGD:1623354 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFR3B gene CTD PMID:20938992 chromium(6+) affects expression ISO RGD:1623354 6480464 chromium hexavalent ion affects the expression of EFR3B mRNA CTD PMID:28472532 cisplatin affects expression ISO RGD:1602224 6480464 Cisplatin affects the expression of EFR3B mRNA CTD PMID:23300844 dichloroacetic acid decreases expression ISO RGD:1623354 6480464 Dichloroacetic Acid results in decreased expression of EFR3B mRNA CTD PMID:28962523 dioxygen multiple interactions ISO RGD:1623354 6480464 [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of EFR3B mRNA CTD PMID:30529165 dorsomorphin multiple interactions ISO RGD:1602224 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 ethanol affects splicing ISO RGD:1623354 6480464 Ethanol affects the splicing of EFR3B mRNA CTD PMID:30319688 folic acid multiple interactions ISO RGD:1623354 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFR3B gene CTD PMID:20938992 L-methionine multiple interactions ISO RGD:1623354 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EFR3B gene CTD PMID:20938992 lead(0) affects expression ISO RGD:1602224 6480464 Lead affects the expression of EFR3B mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1602224 6480464 Lead affects the expression of EFR3B mRNA CTD PMID:28903495 methapyrilene increases methylation ISO RGD:1602224 6480464 Methapyrilene results in increased methylation of EFR3B intron CTD PMID:30157460 paracetamol increases expression ISO RGD:1602224 6480464 Acetaminophen results in increased expression of EFR3B mRNA CTD PMID:26497421 phenylmercury acetate decreases expression ISO RGD:1602224 6480464 Phenylmercuric Acetate results in decreased expression of EFR3B mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1602224 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EFR3B mRNA CTD PMID:27188386 potassium chromate decreases expression ISO RGD:1602224 6480464 potassium chromateVI results in decreased expression of EFR3B mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1602224 6480464 [potassium chromateVI co-treated with epigallocatechin gallate] results in decreased expression of EFR3B mRNA CTD PMID:22079256 propanal increases expression ISO RGD:1602224 6480464 propionaldehyde results in increased expression of EFR3B mRNA CTD PMID:26079696 rac-lactic acid decreases expression ISO RGD:1602224 6480464 Lactic Acid results in decreased expression of EFR3B mRNA CTD PMID:30851411 SB 431542 multiple interactions ISO RGD:1602224 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-5-benzo1 more ... CTD PMID:27188386 silicon dioxide increases expression ISO RGD:1602224 6480464 Silicon Dioxide analog results in increased expression of EFR3B mRNA CTD PMID:25895662 sulforaphane decreases expression ISO RGD:1602224 6480464 sulforafan results in decreased expression of EFR3B mRNA CTD PMID:31838189 tamoxifen increases expression ISO RGD:1623354 6480464 Tamoxifen results in increased expression of EFR3B mRNA CTD PMID:25123088 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of EFR3B mRNA CTD PMID:31150632 trichostatin A decreases expression ISO RGD:1602224 6480464 trichostatin A results in decreased expression of EFR3B mRNA CTD PMID:24935251 urethane increases expression ISO RGD:1602224 6480464 Urethane results in increased expression of EFR3B mRNA CTD PMID:28818685 valproic acid increases expression ISO RGD:1602224 6480464 Valproic Acid results in increased expression of EFR3B mRNA CTD PMID:23179753 valproic acid decreases expression ISO RGD:1602224 6480464 Valproic Acid results in decreased expression of EFR3B mRNA CTD PMID:23179753 more ... valproic acid multiple interactions ISO RGD:1602224 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EFR3B mRNA CTD PMID:27188386 vorinostat multiple interactions ISO RGD:1602224 6480464 [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-5-benzo1, 3dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-ylbenzamide] results in decreased expression of EFR3B mRNA CTD PMID:27188386
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
738023 Alc17 Alcohol consumption QTL 17 3.1 0.003 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) 6 1 35623029 Rat 1354616 Despr12 Despair related QTL 12 0.0012 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 6 1 35623029 Rat 1549905 Stresp10 Stress response QTL 10 6.83 0.0066 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 6 1 35623029 Rat 2300176 Bmd51 Bone mineral density QTL 51 11.7 0.0001 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) 6 1 35623029 Rat 2300190 Bmd52 Bone mineral density QTL 52 11.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 6 1 35623029 Rat 1331743 Uae28 Urinary albumin excretion QTL 28 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 1 41917988 Rat 9589048 Scfw3 Subcutaneous fat weight QTL 3 4.57 0.001 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) 6 1 42388212 Rat 9589129 Insul24 Insulin level QTL 24 19.06 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 6 1 42388212 Rat 7411603 Foco13 Food consumption QTL 13 5.5 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 42388212 Rat 7411542 Bw127 Body weight QTL 127 5.5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 6 1 42388212 Rat 8552962 Pigfal16 Plasma insulin-like growth factor 1 level QTL 16 9.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 1 42388212 Rat 2293709 Bss23 Bone structure and strength QTL 23 5.18 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 6 1 43665660 Rat 2293650 Bss31 Bone structure and strength QTL 31 5.05 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 6 1 43665660 Rat 2293656 Bss28 Bone structure and strength QTL 28 6.79 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 6 1 43665660 Rat 7411584 Foco4 Food consumption QTL 4 4.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 44015370 Rat 738024 Sach5 Saccharine consumption QTL 5 3.9 0.00039 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) 6 1 44570292 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 1 75623393 Rat 1359023 Bp272 Blood pressure QTL 272 2.5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 1120393 28706721 Rat 2292589 Emca10 Estrogen-induced mammary cancer QTL 10 0.048 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 1120393 46120393 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 6 1120393 75023446 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 2537030 111715717 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 6 6161722 76002731 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 6 6161722 76002731 Rat 4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) 6 7009971 115379601 Rat 634322 Bw12 Body weight QTL 12 0 body mass (VT:0001259) body weight (CMO:0000012) 7 10173862 55173862 Rat 1300128 Rf16 Renal function QTL 16 3.89 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 34367603 Rat 1300164 Rf15 Renal function QTL 15 3.12 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 57516539 Rat 10401812 Kidm54 Kidney mass QTL 54 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 10401800 Kidm49 Kidney mass QTL 49 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 8552910 Pigfal5 Plasma insulin-like growth factor 1 level QTL 5 4.3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 19417887 64417887 Rat 1641898 Colcr4 Colorectal carcinoma resistance QTL4 3.71 0.0007 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) 6 21515302 65784818 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat
