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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (+)-catechin | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of PHTF2 mRNA | CTD | PMID:24763279 | (-)-demecolcine | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Demecolcine results in decreased expression of PHTF2 mRNA | CTD | PMID:23649840 | 1,1-dichloroethene | increases expression | ISO | Phtf2 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of PHTF2 mRNA | CTD | PMID:26682919 | 1,2-dichloroethane | increases expression | ISO | Phtf2 (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of PHTF2 mRNA | CTD | PMID:28960355 | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of PHTF2 mRNA | CTD | PMID:26496021 | 17beta-estradiol | decreases expression | EXP | | 6480464 | Estradiol results in decreased expression of PHTF2 mRNA | CTD | PMID:32145629 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Phtf2 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PHTF2 mRNA | CTD | PMID:21570461 and PMID:26377647 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PHTF2 mRNA | CTD | PMID:33387578 | 2-hydroxypropanoic acid | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PHTF2 mRNA | CTD | PMID:30851411 | 4-hydroxyphenyl retinamide | decreases expression | ISO | Phtf2 (Mus musculus) | 6480464 | Fenretinide results in decreased expression of PHTF2 mRNA | CTD | PMID:28973697 | acetaldehyde | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Acetaldehyde results in increased expression of PHTF2 mRNA | CTD | PMID:23416264 | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of PHTF2 mRNA | CTD | PMID:28959563 | aflatoxin B1 | decreases methylation | ISO | PHTF2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of PHTF2 gene | CTD | PMID:27153756 | aflatoxin B1 | increases methylation | ISO | PHTF2 (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of PHTF2 intron | CTD | PMID:30157460 | aristolochic acid A | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of PHTF2 mRNA | CTD | PMID:33212167 | arsenite(3-) | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PHTF2 mRNA] | CTD | PMID:32406909 | avobenzone | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | avobenzone results in increased expression of PHTF2 mRNA | CTD | PMID:31016361 | benzo[a]pyrene | multiple interactions | ISO | Phtf2 (Mus musculus) | 6480464 | Benzo(a)pyrene promotes the reaction [AHR protein binds to PHTF2 promoter] | CTD | PMID:19654925 | benzo[a]pyrene | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PHTF2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | increases methylation | ISO | PHTF2 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PHTF2 5' UTR and Benzo(a)pyrene results in increased methylation of PHTF2 promoter | CTD | PMID:27901495 | benzo[a]pyrene | increases expression | ISO | Phtf2 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of PHTF2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene diol epoxide I | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 | benzoates | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Benzoates analog results in decreased expression of PHTF2 mRNA | CTD | PMID:29472718 | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of PHTF2 mRNA | CTD | PMID:26496021 | bisphenol A | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PHTF2 gene | CTD | PMID:31601247 | bisphenol A | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PHTF2 mRNA | CTD | PMID:33670352 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PHTF2 mRNA | CTD | PMID:32145629 | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of PHTF2 mRNA | CTD | PMID:30816183 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PHTF2 gene | CTD | PMID:28505145 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PHTF2 mRNA | CTD | PMID:25181051 | calcitriol | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of PHTF2 mRNA | CTD | PMID:21592394 | calcitriol | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of PHTF2 mRNA | CTD | PMID:21592394 | CGP 52608 | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PHTF2 gene] | CTD | PMID:28238834 | choline | multiple interactions | ISO | Phtf2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PHTF2 mRNA more ... | CTD | PMID:20938992 | cobalt dichloride | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PHTF2 mRNA | CTD | PMID:19376846 | coumestrol | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Coumestrol results in increased expression of PHTF2 mRNA | CTD | PMID:19167446 | cyclosporin A | decreases expression | ISO | Phtf2 (Mus musculus) | 6480464 | Cyclosporine results in decreased expression of PHTF2 mRNA | CTD | PMID:19770486 | dicrotophos | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of PHTF2 mRNA | CTD | PMID:28302478 | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PHTF2 mRNA | CTD | PMID:21551480 | dorsomorphin | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | doxorubicin | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PHTF2 mRNA | CTD | PMID:29803840 | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PHTF2 mRNA | CTD | PMID:29391264 | entinostat | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | entinostat results in decreased expression of PHTF2 mRNA | CTD | PMID:26272509 | entinostat | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHTF2 mRNA | CTD | PMID:27188386 | folic acid | multiple interactions | ISO | Phtf2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PHTF2 mRNA more ... | CTD | PMID:20938992 | fulvestrant | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [bisphenol A co-treated with Fulvestrant] results in decreased methylation of PHTF2 gene | CTD | PMID:31601247 | furan | increases expression | EXP | | 6480464 | furan results in increased expression of PHTF2 mRNA | CTD | PMID:25539665 | geldanamycin | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | geldanamycin results in increased expression of PHTF2 mRNA | CTD | PMID:26705709 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PHTF2 mRNA | CTD | PMID:33387578 | L-methionine | multiple interactions | ISO | Phtf2 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PHTF2 mRNA more ... | CTD | PMID:20938992 | leflunomide | increases expression | ISO | Phtf2 (Mus musculus) | 6480464 | leflunomide results in increased expression of PHTF2 mRNA | CTD | PMID:19751817 | methyl methanesulfonate | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of PHTF2 mRNA | CTD | PMID:23649840 | methylmercury chloride | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of PHTF2 mRNA | CTD | PMID:28001369 | methylmercury chloride | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PHTF2 mRNA | CTD | PMID:28001369 | motexafin gadolinium | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA] | CTD | PMID:16357179 | motexafin gadolinium | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | motexafin gadolinium results in increased expression of PHTF2 mRNA | CTD | PMID:16357179 | panobinostat | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHTF2 mRNA | CTD | PMID:27188386 | paracetamol | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of PHTF2 mRNA | CTD | PMID:22230336 | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PHTF2 mRNA | CTD | PMID:33387578 | pentanal | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | pentanal results in decreased expression of PHTF2 mRNA | CTD | PMID:26079696 | phenylmercury acetate | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PHTF2 mRNA | CTD | PMID:26272509 | phenylmercury acetate | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHTF2 mRNA | CTD | PMID:27188386 | quercetin | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Quercetin results in decreased expression of PHTF2 mRNA | CTD | PMID:21632981 | rac-lactic acid | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of PHTF2 mRNA | CTD | PMID:30851411 | resveratrol | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | resveratrol results in increased expression of PHTF2 mRNA | CTD | PMID:19167446 | resveratrol | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PHTF2 mRNA | CTD | PMID:23557933 | rotenone | decreases expression | EXP | | 6480464 | Rotenone results in decreased expression of PHTF2 mRNA | CTD | PMID:28374803 | SB 431542 | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | testosterone | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of PHTF2 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Testosterone results in decreased expression of PHTF2 mRNA | CTD | PMID:21592394 and PMID:33359661 | tetrachloromethane | affects expression | ISO | Phtf2 (Mus musculus) | 6480464 | Carbon Tetrachloride affects the expression of PHTF2 mRNA | CTD | PMID:17484886 | thimerosal | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of PHTF2 mRNA | CTD | PMID:27188386 | titanium dioxide | decreases expression | ISO | Phtf2 (Mus musculus) | 6480464 | titanium dioxide results in decreased expression of PHTF2 mRNA | CTD | PMID:29264374 | trichostatin A | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of PHTF2 mRNA | CTD | PMID:24935251 | urethane | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Urethane results in increased expression of PHTF2 mRNA | CTD | PMID:28818685 | valproic acid | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of PHTF2 mRNA | CTD | PMID:23179753 more ... | valproic acid | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PHTF2 mRNA | CTD | PMID:27188386 | vincristine | decreases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Vincristine results in decreased expression of PHTF2 mRNA | CTD | PMID:23649840 | zinc acetate | multiple interactions | ISO | PHTF2 (Homo sapiens) | 6480464 | motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA] | CTD | PMID:16357179 | zinc acetate | increases expression | ISO | PHTF2 (Homo sapiens) | 6480464 | Zinc Acetate results in increased expression of PHTF2 mRNA | CTD | PMID:16357179 | |