Mpv17 (mitochondrial inner membrane protein MPV17) - Rat Genome Database
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Gene: Mpv17 (mitochondrial inner membrane protein MPV17) Rattus norvegicus
Analyze
Symbol: Mpv17
Name: mitochondrial inner membrane protein MPV17
RGD ID: 1310512
Description: Predicted to have channel activity. Predicted to be involved in several processes, including glomerular basement membrane development; regulation of mitochondrial DNA metabolic process; and sensory perception of sound. Predicted to localize to mitochondrial inner membrane and peroxisome. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2EE and mitochondrial DNA depletion syndrome 6. Orthologous to human MPV17 (mitochondrial inner membrane protein MPV17); INTERACTS WITH bisphenol A; (+)-catechin (ortholog); 1,2-dimethylhydrazine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC360463; MpV17 mitochondrial inner membrane protein; MPV17 mitochondrial membrane protein-like; Mpv17 transgene, kidney disease mutant-like; Mpv17l
Orthologs:
Homo sapiens (human) : MPV17 (mitochondrial inner membrane protein MPV17)  HGNC  Alliance
Mus musculus (house mouse) : Mpv17 (MpV17 mitochondrial inner membrane protein)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mpv17 (mitochondrial inner membrane protein MPV17)
Pan paniscus (bonobo/pygmy chimpanzee) : MPV17 (mitochondrial inner membrane protein MPV17)
Canis lupus familiaris (dog) : MPV17 (mitochondrial inner membrane protein MPV17)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mpv17 (mitochondrial inner membrane protein MPV17)
Sus scrofa (pig) : MPV17 (mitochondrial inner membrane protein MPV17)
Chlorocebus sabaeus (African green monkey) : MPV17 (mitochondrial inner membrane protein MPV17)
Heterocephalus glaber (naked mole-rat) : Mpv17 (mitochondrial inner membrane protein MPV17)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0626,585,713 - 26,600,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,587,443 - 26,599,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,403,896 - 36,416,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,200,452 - 25,214,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1101,655,564 - 1,672,677 (+)NCBI
Celera624,714,225 - 24,727,365 (+)NCBICelera
Cytogenetic Map6q14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
channel activity  (IEA,ISO,ISS)
protein binding  (ISO)

References

Additional References at PubMed
PMID:7957077   PMID:12477932   PMID:16041630   PMID:16582910   PMID:18614015   PMID:25861990   PMID:26123482   PMID:26760297  


Genomics

Comparative Map Data
Mpv17
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0626,585,713 - 26,600,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl626,587,443 - 26,599,511 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0636,403,896 - 36,416,645 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4625,200,452 - 25,214,909 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1101,655,564 - 1,672,677 (+)NCBI
Celera624,714,225 - 24,727,365 (+)NCBICelera
Cytogenetic Map6q14NCBI
MPV17
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl227,309,492 - 27,325,680 (-)EnsemblGRCh38hg38GRCh38
GRCh38227,309,492 - 27,323,097 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37227,532,360 - 27,545,969 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36227,385,864 - 27,399,473 (-)NCBINCBI36hg18NCBI36
Build 34227,444,012 - 27,457,082NCBI
Celera227,379,464 - 27,393,076 (-)NCBI
Cytogenetic Map2p23.3NCBI
HuRef227,274,582 - 27,288,152 (-)NCBIHuRef
CHM1_1227,462,306 - 27,475,919 (-)NCBICHM1_1
Mpv17
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39531,298,007 - 31,311,595 (-)NCBI
GRCm38531,140,663 - 31,154,251 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl531,140,654 - 31,154,251 (-)EnsemblGRCm38mm10GRCm38
MGSCv37531,443,033 - 31,456,615 (-)NCBIGRCm37mm9NCBIm37
MGSCv36531,417,529 - 31,430,812 (-)NCBImm8
Celera528,619,571 - 28,633,245 (-)NCBICelera
Cytogenetic Map5B1NCBI
Mpv17
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554699,279,540 - 9,291,954 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554699,279,540 - 9,292,012 (-)NCBIChiLan1.0ChiLan1.0
MPV17
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A27,399,258 - 27,412,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A27,399,258 - 27,414,090 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A27,311,551 - 27,325,249 (-)NCBIMhudiblu_PPA_v0panPan3
MPV17
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1721,281,361 - 21,290,339 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11721,280,523 - 21,290,967 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mpv17
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364935,246,803 - 5,258,147 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MPV17
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3111,821,690 - 111,835,663 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13111,823,075 - 111,833,929 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MPV17
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11480,289,285 - 80,302,838 (+)NCBI
Mpv17
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247389,395,315 - 9,411,904 (-)NCBI


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6135623029Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6135623029Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6135623029Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6135623029Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6135623029Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6141917988Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6142388212Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6142388212Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142388212Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6142388212Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6142388212Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6143665660Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6143665660Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6143665660Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6144015370Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6144570292Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6175623393Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6112039328706721Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112039346120393Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)6112039375023446Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)62537030111715717Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)6616172276002731Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6616172276002731Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)percentage of deaths in a study population during a period of time (CMO:0001024)67009971115379601Rat
634322Bw12Body weight QTL 120body mass (VT:0001259)body weight (CMO:0000012)71017386255173862Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295834367603Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)61312295857516539Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61681010761810107Rat
8552910Pigfal5Plasma insulin-like growth factor 1 level QTL 54.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)61941788764417887Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62151530265784818Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62204285484763421Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000034207
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 7 10 74 35 39 11 7
Low 1 1 2 1
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001098240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764516 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008764519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594209 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07063281 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01042326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01042327 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC091193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000034207   ⟹   ENSRNOP00000037647
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl626,587,443 - 26,599,511 (+)Ensembl
RefSeq Acc Id: NM_001098240   ⟹   NP_001091710
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,587,192 - 26,600,265 (+)NCBI
Rnor_5.0636,403,896 - 36,416,645 (+)NCBI
RGSC_v3.4625,200,452 - 25,214,909 (+)RGD
Celera624,714,225 - 24,727,365 (+)RGD
Sequence:
RefSeq Acc Id: XM_008764515   ⟹   XP_008762737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,595,116 - 26,597,367 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764516   ⟹   XP_008762738
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,595,116 - 26,597,366 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764517   ⟹   XP_008762739
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,587,433 - 26,597,368 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008764519   ⟹   XP_008762741
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,587,438 - 26,597,367 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594206   ⟹   XP_017449695
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,366 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594207   ⟹   XP_017449696
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,366 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594208   ⟹   XP_017449697
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,366 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594209   ⟹   XP_017449698
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,366 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594210   ⟹   XP_017449699
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,365 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594211   ⟹   XP_017449700
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,365 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017594212   ⟹   XP_017449701
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,585,713 - 26,597,366 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001091710   ⟸   NM_001098240
- UniProtKB: Q5BK62 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008762741   ⟸   XM_008764519
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_008762739   ⟸   XM_008764517
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_008762737   ⟸   XM_008764515
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008762738   ⟸   XM_008764516
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017449695   ⟸   XM_017594206
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449701   ⟸   XM_017594212
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_017449697   ⟸   XM_017594208
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449698   ⟸   XM_017594209
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449696   ⟸   XM_017594207
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017449699   ⟸   XM_017594210
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_017449700   ⟸   XM_017594211
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: ENSRNOP00000037647   ⟸   ENSRNOT00000034207

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694445
Promoter ID:EPDNEW_R4969
Type:single initiation site
Name:Mpv17_1
Description:MpV17 mitochondrial inner membrane protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0626,587,428 - 26,587,488EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310512 AgrOrtholog
Ensembl Genes ENSRNOG00000049430 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000037647 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000034207 ENTREZGENE, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7373705 IMAGE-MGC_LOAD
InterPro Mpv17_PMP22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:360463 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108867 IMAGE-MGC_LOAD
NCBI Gene 360463 ENTREZGENE
PANTHER PTHR11266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Mpv17_PMP22 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mpv17 PhenoGen
UniGene Rn.207192 ENTREZGENE
UniProt F1LNG8_RAT UniProtKB/TrEMBL
  MPV17_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-27 Mpv17  mitochondrial inner membrane protein MPV17  Mpv17  MpV17 mitochondrial inner membrane protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-08-29 Mpv17  MpV17 mitochondrial inner membrane protein  Mpv17l  MPV17 mitochondrial membrane protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Mpv17l  MPV17 mitochondrial membrane protein-like  Mpv17l  Mpv17 transgene, kidney disease mutant-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-11 Mpv17l  Mpv17 transgene, kidney disease mutant-like  Mpv17l  MPV17 mitochondrial membrane protein-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Mpv17l  MPV17 mitochondrial membrane protein-like  Mpv17l  Mpv17 transgene, kidney disease mutant-like   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mpv17l  Mpv17 transgene, kidney disease mutant-like   Mpv17l_predicted  Mpv17 transgene, kidney disease mutant-like (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mpv17l_predicted  Mpv17 transgene, kidney disease mutant-like (predicted)      Symbol and Name status set to approved 70820 APPROVED