Wdr77 (WD repeat domain 77) - Rat Genome Database

Name: Wdr77
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Wdr77 (WD repeat domain 77) Rattus norvegicus

Analyze

Symbol:

Wdr77

Name:

WD repeat domain 77

RGD ID:

1310479

Description:

Predicted to have methyl-CpG binding activity and nuclear receptor coactivator activity. Predicted to be involved in several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; regulation of transcription by RNA polymerase II; and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development. Predicted to localize to several cellular components, including Golgi apparatus; methylosome; and nucleoplasm. Orthologous to human WDR77 (WD repeat domain 77); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

Ac2-269; LOC310769; MEP-50; methylosome protein 50; RGD1310479; similar to Ac2-269; WD repeat-containing protein 77

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WDR77 (WD repeat domain 77)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Wdr77 (WD repeat domain 77)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Wdr77 (WD repeat domain 77)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WDR77 (WD repeat domain 77)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC479902 (methylosome protein 50)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wdr77 (WD repeat domain 77)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WDR77 (WD repeat domain 77)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	WDR77 (WD repeat domain 77)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wdr77 (WD repeat domain 77)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	WDR77 (WD repeat domain 77)	Alliance	DIOPT (Ensembl Compara\|HGNC\|OMA)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	193,435,465 - 193,445,534 (+)	NCBI
Rnor_6.0 Ensembl	2	208,420,309 - 208,587,260 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	208,577,292 - 208,587,263 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	227,998,508 - 228,008,479 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	201,206,860 - 201,216,573 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	201,169,461 - 201,178,632 (+)	NCBI
Celera	2	186,138,007 - 186,147,978 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Ovarian Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

carbon nanotube (ISO)

celastrol (ISO)

cisplatin (ISO)

cobalt dichloride (ISO)

copper(II) sulfate (ISO)

diarsenic trioxide (ISO)

dibutyl phthalate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

endosulfan (EXP)

enzyme inhibitor (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

flutamide (EXP)

formaldehyde (ISO)

gedunin (ISO)

methyl methanesulfonate (ISO)

nefazodone (EXP)

nickel atom (ISO)

nickel dichloride (ISO)

pentachlorophenol (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium dichromate (EXP)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

trimellitic anhydride (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell population proliferation (ISO)

negative regulation of epithelial cell proliferation involved in prostate gland development (IBA,ISO)

pole plasm assembly (IBA)

positive regulation of cell population proliferation (IBA,ISO)

positive regulation of transcription, DNA-templated (IEA)

regulation of transcription by RNA polymerase II (IBA,ISO)

secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development (IBA,ISO)

Cellular Component

cytoplasm (ISO,ISS)

cytosol (IBA,ISO,ISS)

Golgi apparatus (ISO)

methylosome (IBA,ISO,ISS)

nucleoplasm (IBA,ISO)

nucleus (ISO,ISS)

pole plasm (IBA)

Molecular Function

methyl-CpG binding (IBA,ISO,ISS)

nuclear receptor coactivator activity (IBA,ISO)

protein binding (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8889548	PMID:12477932	PMID:12972618	PMID:17032745	PMID:18356297	PMID:18984161	PMID:19188445	PMID:21081503	PMID:25284789

Genomics

Comparative Map Data

Wdr77
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	193,435,465 - 193,445,534 (+)	NCBI
Rnor_6.0 Ensembl	2	208,420,309 - 208,587,260 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	2	208,577,292 - 208,587,263 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	2	227,998,508 - 228,008,479 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	201,206,860 - 201,216,573 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	2	201,169,461 - 201,178,632 (+)	NCBI
Celera	2	186,138,007 - 186,147,978 (+)	NCBI		Celera
Cytogenetic Map	2	q34	NCBI

WDR77
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	111,439,890 - 111,449,256 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	111,439,890 - 111,449,256 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	111,982,512 - 111,991,878 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	111,784,035 - 111,793,353 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	1	110,229,435 - 110,238,753 (-)	NCBI
Cytogenetic Map	1	p13.2	NCBI
HuRef	1	109,853,961 - 109,863,279 (-)	NCBI		HuRef
CHM1_1	1	112,097,521 - 112,106,939 (-)	NCBI		CHM1_1

Wdr77
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	105,866,814 - 105,877,076 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	3	105,866,685 - 105,877,353 (+)	Ensembl
GRCm38	3	105,959,498 - 105,969,760 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	105,959,369 - 105,970,037 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	105,762,416 - 105,772,678 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	3	106,087,554 - 106,097,816 (+)	NCBI			mm8
Celera	3	108,149,918 - 108,160,180 (+)	NCBI		Celera
Cytogenetic Map	3	F2.2	NCBI

Wdr77
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955435	14,933,243 - 14,940,438 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955435	14,929,202 - 14,940,439 (-)	NCBI	ChiLan1.0	ChiLan1.0

WDR77
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	126,236,409 - 126,245,444 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	126,236,409 - 126,249,996 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	114,101,570 - 114,110,634 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LOC479902
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	6	40,624,886 - 40,635,200 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	6	40,626,219 - 40,634,521 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Wdr77
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936690	112,337 - 120,478 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WDR77
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	4	108,907,332 - 108,941,037 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	4	108,907,192 - 108,915,594 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	4	119,090,107 - 119,098,520 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WDR77
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	22,162,605 - 22,171,495 (+)	NCBI
ChlSab1.1 Ensembl	20	22,162,692 - 22,172,171 (+)	Ensembl

Wdr77
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624772	7,158,530 - 7,167,034 (-)	NCBI

Position Markers

RH128703

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	2	208,429,989 - 208,430,187	NCBI	Rnor6.0
Rnor_6.0	2	208,586,969 - 208,587,167	NCBI	Rnor6.0
Rnor_5.0	2	228,008,185 - 228,008,383	UniSTS	Rnor5.0
Rnor_5.0	2	227,851,479 - 227,851,677	UniSTS	Rnor5.0
RGSC_v3.4	2	201,216,488 - 201,216,686	UniSTS	RGSC3.4
Celera	2	186,147,684 - 186,147,882	UniSTS
Cytogenetic Map	2	q34	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	pulse pressure (CMO:0000292)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	140566078	217498545	Rat
70175	BpQTLCluster3	Blood pressure QTL cluster 3	4.128		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	140566078	217498545	Rat
71113	Cari2	Carrageenan-induced inflammation QTL 2	2.7	0.009	hypodermis integrity trait (VT:0010550)	inflammatory exudate volume (CMO:0001429)	2	147522550	217498710	Rat
631266	Bp132	Blood pressure QTL 132		0.0005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	46537589	217498710	Rat
61458	Bp10	Blood pressure QTL 10	3.42		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	204003742	231132207	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	43133606	217498545	Rat
61467	Bp14	Blood pressure QTL 14	2.2		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	43133606	217498545	Rat
61469	Bp16	Blood pressure QTL 16	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	184730446	229730446	Rat
70162	Bp63	Blood pressure QTL 63	5.64		arterial blood pressure trait (VT:2000000)	blood pressure measurement (CMO:0000003)	2	184730446	229730446	Rat
724568	Uae13	Urinary albumin excretion QTL 13	4.4		urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	2	149114878	225501939	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	181990297	240020001	Rat
1331745	Bp203	Blood pressure QTL 203	4.377		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	204585642	235290110	Rat
1331760	Bp206	Blood pressure QTL 206	3.62454		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	56244671	217498710	Rat
1298074	Bp164	Blood pressure QTL 164		0.003	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1298076	Bp166	Blood pressure QTL 166		0.0009	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141583337	217498710	Rat
1298080	Bp163	Blood pressure QTL 163		0.02	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828049	217498710	Rat
1298083	Bp158	Blood pressure QTL 158	2.62		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	204003742	231132207	Rat
1298085	Bp165	Blood pressure QTL 165		0.0006	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	42776916	217498710	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	147122993	240020001	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	147122993	240020001	Rat
2307174	Activ3	Activity QTL 3	4.83	0.000058	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	2	183984665	228984665	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	204585642	243689611	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	199380312	244380312	Rat
631501	Bp101	Blood pressure QTL 101	2.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	157914409	217498545	Rat
631507	Bp105	Blood pressure QTL 105		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	116075644	228737869	Rat
1302793	Bw16	Body weight QTL 16	5	0.0001	body mass (VT:0001259)	body weight (CMO:0000012)	2	169852800	217498545	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	254121739	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	155965557	237742948	Rat
1598838	Bp290	Blood pressure QTL 290	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	181522444	226522444	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	205583921	243562243	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	194378622	239378622	Rat
634308	Sach6	Saccharin preference QTL 6	4.9		taste sensitivity trait (VT:0001986)	saccharin intake volume to total fluid intake volume ratio (CMO:0001601)	2	116075644	228737869	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	175403337	239166203	Rat
1578648	Bss11	Bone structure and strength QTL 11	4.7		femur morphology trait (VT:0000559)	femoral neck cortical cross-sectional area (CMO:0001702)	2	118446646	227707979	Rat
1300165	Rf9	Renal function QTL 9	3.28		kidney glomerulus integrity trait (VT:0010546)	index of glomerular damage (CMO:0001135)	2	138901276	217498710	Rat
1354605	Rf48	Renal function QTL 48	2.9		blood creatinine amount (VT:0005328)	plasma creatinine level (CMO:0000537)	2	75687495	221880419	Rat
1354609	Niddm62	Non-insulin dependent diabetes mellitus QTL 62	4.72	0.000006	insulin secretion trait (VT:0003564)	plasma insulin level (CMO:0000342)	2	158159186	217498710	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	83819608	239166203	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66828236	243550655	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	83819608	243901375	Rat
2301966	Bp322	Blood pressure QTL 322	3.58		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	158159186	217498710	Rat
1359022	Ppulsi1	Prepulse inhibition QTL 1	3.63		prepulse inhibition trait (VT:0003088)	acoustic startle response measurement (CMO:0001519)	2	142053350	228984665	Rat
1554319	Bmd2	Bone mineral density QTL 2	13.4	0.0001	lumbar vertebra area (VT:0010570)	lumbar vertebra cross-sectional area (CMO:0001689)	2	118446793	228582621	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	177680772	243901375	Rat
1358913	Cm41	Cardiac mass QTL 41	2.73		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1358917	Cm42	Cardiac mass QTL 42	2.82		heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	2	23837491	218957222	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	200453324	236318668	Rat
1359031	Bp275	Blood pressure QTL 275			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	200453324	236318668	Rat
2293084	Iddm26	Insulin dependent diabetes mellitus QTL 26	2.9		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	188838511	228984665	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	204585642	249585642	Rat
61374	Edpm2	Estrogen-dependent pituitary mass QTL 2	4.42	0.86	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	2	78321410	217498710	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	204585642	249585642	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	194998627	239998627	Rat
4889834	Pur24	Proteinuria QTL 24	5.8	0.014	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	2	198704357	217498710	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	197253963	242253963	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	197253963	242253963	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	197253963	242253963	Rat
7488925	Bp364	Blood pressure QTL 364		0.001	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	174160958	219160958	Rat
7488927	Bp365	Blood pressure QTL 365		0.008	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	177339806	222339806	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	169852670	243026643	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	83754907	237610852	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	197253963	242253963	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	16679272	245624402	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	185
Count of miRNA genes:	148
Interacting mature miRNAs:	164
Transcripts:	ENSRNOT00000022571
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	nervous system	reproductive system	respiratory system
High
Medium
Low
Below cutoff	3	5	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001008771	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102417	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY321348	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC097367	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB581439	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK842118	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213175	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ226328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000077	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

NM_001008771 ⟹ NP_001008771

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	193,435,563 - 193,445,534 (+)	NCBI
Rnor_6.0	2	208,577,292 - 208,587,263 (+)	NCBI
Rnor_5.0	2	227,998,508 - 228,008,479 (+)	NCBI
RGSC_v3.4	2	201,206,860 - 201,216,573 (+)	RGD
Celera	2	186,138,007 - 186,147,978 (+)	NCBI

Sequence:

show sequence

GGGGCGGATGCGCAGAGGTGCACCACGTGTGGTGTTCCTCCAGCGCAGTCAGGATCTCGTCTAG
TTTGGGTCTAGGTTAGATTTGGAATCGTGGAGATGCGGAAGGAAAGCCCACCTCCGCTCGTGCC
CCCGGCGGCCCGCGAGTGGAACCTGCCCCCCAATGCGCCCGCCTGCATGGAACGGCAGTTGGAA
GCTGCACGGTACCGCTCTGATGGTTCCCTTCTGCTCGGGGCTTCCAGTCTGAGTGGTCGCTGCT
GGGCAGGATCTCTGTGGTTTTTCAAGGATCCTAGTGCGGCCCCCAACGAAGGTTTCTGCTCTGC
TGGCGTCCAGACGGAGGCTGGAGTAGCTGACCTCACTTGGGTTGGGGACAAAGGTATCTTAGTG
GCTTCTGATTCAGGTGCTGTTGAATTGTGGGAGCTAGATGAGAACGAGACACTTATTGTCAGCA
AGTTCTGCAAGTATGAGCATGATGACATTGTGTCTACTGTCACTGTCCTGAGCTCCGGCACACA
GGCTGTCAGTGGTAGCAAAGACTTCTGCATCAAAATTTGGGACCTGGCTCAGCAGATGTCGCTG
AATTCATACCGAGCTCATGCGGGACAGGTCACCTGTGTTGCTGCCTCTCCCCACAGAGAAACTG
TGTTTCTTTCATGCAGTGAGGACAGTAGAATTTTGCTCTGGGATACCCGCTGTCCCAAGCCGGC
ATCACAGATGGGCTGCAATGCCTCTGGCTACCTCCCTACCTCCCTGGCTTGGCATCCTCAGCAG
AGTGAAATCTTTGTCTTTGGTGATGAGAATGGATCTGTCTCCCTTGTGGACACCAAGAATGCAA
GCTGCACCCTCAGCTCAGCTGTGCACTCGCAGTGTGTCACTAGACTGGTGTTCTCTCCACACAG
TGTTCCCTTCCTGGCCTCTCTCAGTGAAGACTGTTCACTTGCTGTGCTGGATTCAAGCTTTTCT
GAGGTGTTTAGAAGTCGAGCCCACAGAGACTTTGTGAGAGATGCTACATGGTCTCCACTCAATC
ACTCCCTTCTTACCACAGTTGGCTGGGACCATCAGGTCATCCACCATGTTGTGCCGTTAGAGCC
TCTCCCAGCCCCTGGACCTGACAGTGTTGTGGAGTAGAATGGATTGCAGAAGAAAAGAGCCTTC
TGTCTGCAAGTGTCGACTCGCTTGCCCCTGCCTTCCATTTGTGAGAGAGAGAGCACAGGAGCCT
TGTAGAGCATGATTACTCCCTAGTCCCGTGCAGTAACTAGTCAGATTCTCAGCCTGAGGGAGGC
TGCATCCCATAGTGACTTGGAGGAAAAAGCTTCCTTTATAAATGGATGTATGTGTGAGTACACG
TGTGAGTGCAGTGTATAGTTTGGAGTGGAGAAAATTATCCTTCAGCTTTCCCAAAGCAATGCTC
TTTACCCCCGACAAAATGACCAGAGGATTTTATGCTTCCCATGTCTGGGGGCTGACTATGTTGT
TAGGGATATGGAGTGTGGGTATCCCTGGATGCTTGGGAATACTTCACATTACTCAGAGGTGCGT
AACTTATTTTTATATAGAGTTTAATTCACTATATGGGAATTACTTCCCATATACAAAAGTCTAG
CCAGACTACCTTGAGAAGACAGAACAGTTTTGTACGAATGCCTGTTAAATGGAATCAAATCCAC
TTTCTGGGTGAATCAATTTGGCCCTTGGAGTTCGCGCTCGCTCACCCTGTGTTCCTTCTTTTGT
GTTGTGTATGAGAGATGAGTGCTTTCCTGTCCTAGATTTCACAGTTTTAGGGATGATGGAGTAC
TTAAATTAAAAGTGTTTCAGTGAAGCGAGAAGATTGACATGGATTGTTACAGAGAAATCTGTCA
TTGTCATTTTTCCCACCTAAAAATTCCCTGAGGACTGATCTGGGTACTTTGCTCTGGAGAGCTG
AAGTCTGAGCGCTGTATATTTGGACTCCTAAGATTGAAGATCCGGCATCAGAGAAACTGTCAAA
AATACTGGAAGGTGAAATAAAGACTTATCCTTTCATCTTTCCTCCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039102417 ⟹ XP_038958345

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	193,435,465 - 193,445,534 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001008771	(Get FASTA)	NCBI Sequence Viewer
	XP_038958345	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97367	(Get FASTA)	NCBI Sequence Viewer
	AAP86280	(Get FASTA)	NCBI Sequence Viewer
	EDL81829	(Get FASTA)	NCBI Sequence Viewer
	Q4QR85	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001008771 ⟸ NM_001008771

- UniProtKB:

Q4QR85 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MRKESPPPLVPPAAREWNLPPNAPACMERQLEAARYRSDGSLLLGASSLSGRCWAGSLWFFKDP
SAAPNEGFCSAGVQTEAGVADLTWVGDKGILVASDSGAVELWELDENETLIVSKFCKYEHDDIV
STVTVLSSGTQAVSGSKDFCIKIWDLAQQMSLNSYRAHAGQVTCVAASPHRETVFLSCSEDSRI
LLWDTRCPKPASQMGCNASGYLPTSLAWHPQQSEIFVFGDENGSVSLVDTKNASCTLSSAVHSQ
CVTRLVFSPHSVPFLASLSEDCSLAVLDSSFSEVFRSRAHRDFVRDATWSPLNHSLLTTVGWDH
QVIHHVVPLEPLPAPGPDSVVE

hide sequence

RefSeq Acc Id:	XP_038958345 ⟸ XM_039102417
- Peptide Label:	isoform X1

Protein Domains

WD_REPEATS_REGION

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1310479	AgrOrtholog
Ensembl Genes	ENSRNOG00000016394	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00000046022	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000022571	UniProtKB/TrEMBL
	ENSRNOP00000064692	UniProtKB/TrEMBL
	ENSRNOP00000068002	UniProtKB/Swiss-Prot
	ENSRNOP00000068445	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOP00000074936	UniProtKB/TrEMBL
	ENSRNOP00000075656	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000022571	UniProtKB/TrEMBL
	ENSRNOT00000073644	UniProtKB/TrEMBL
	ENSRNOT00000076065	UniProtKB/Swiss-Prot
	ENSRNOT00000076654	ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOT00000086279	UniProtKB/Swiss-Prot
	ENSRNOT00000090500	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7443204	IMAGE-MGC_LOAD
InterPro	WD40/YVTN_repeat-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD40_repeat_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD40_repeat_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:100911453	UniProtKB/Swiss-Prot
	rno:310769	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:114400	IMAGE-MGC_LOAD
NCBI Gene	310769	ENTREZGENE
Pfam	WD40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Wdr77	PhenoGen
PROSITE	WD_REPEATS_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD_REPEATS_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	WD_REPEATS_REGION	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	WD40	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	MEP50_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q7TPI7_RAT	UniProtKB/TrEMBL
UniProt Secondary	M0R5M2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Wdr77	WD repeat domain 77	RGD1310479	similar to Ac2-269	Symbol and Name updated	1299863	APPROVED
2005-12-06	RGD1310479	similar to Ac2-269	RGD1310479_predicted	similar to Ac2-269 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1310479_predicted	similar to Ac2-269 (predicted)	LOC310769_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC310769_predicted	similar to Ac2-269 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD