Snx25 (sorting nexin 25) - Rat Genome Database

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Gene: Snx25 (sorting nexin 25) Rattus norvegicus
Analyze
Symbol: Snx25
Name: sorting nexin 25
RGD ID: 1310150
Description: Predicted to enable phosphatidylinositol binding activity and type I transforming growth factor beta receptor binding activity. Predicted to be involved in negative regulation of transforming growth factor beta receptor signaling pathway and receptor catabolic process. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endosome. Orthologous to human SNX25 (sorting nexin 25); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Previously known as: LOC306471; sorting nexin-25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Snx25Tn(sb-T2/Bart3)2.270Mcwi  
Genetic Models: F344-Snx25Tn(sb-T2/Bart3)2.270Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,867,102 - 52,971,028 (+)NCBIGRCr8
mRatBN7.21646,134,552 - 46,238,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,125,804 - 46,238,440 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01649,328,958 - 49,432,415 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,350,884 - 49,432,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,051,539 - 49,159,381 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,415,658 - 49,518,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,415,438 - 49,518,714 (+)NCBI
Celera1644,133,781 - 44,236,984 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:12477932   PMID:21266196  


Genomics

Comparative Map Data
Snx25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81652,867,102 - 52,971,028 (+)NCBIGRCr8
mRatBN7.21646,134,552 - 46,238,471 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1646,125,804 - 46,238,440 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01649,328,958 - 49,432,415 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1649,350,884 - 49,432,118 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,051,539 - 49,159,381 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41649,415,658 - 49,518,663 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11649,415,438 - 49,518,714 (+)NCBI
Celera1644,133,781 - 44,236,984 (+)NCBICelera
Cytogenetic Map16q11NCBI
SNX25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384185,204,237 - 185,378,642 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4185,204,237 - 185,370,185 (+)EnsemblGRCh38hg38GRCh38
GRCh374186,125,391 - 186,285,120 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364186,368,278 - 186,522,114 (+)NCBINCBI36Build 36hg18NCBI36
Build 344186,506,432 - 186,660,267NCBI
Celera4183,458,214 - 183,611,271 (+)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4181,885,306 - 182,038,630 (+)NCBIHuRef
CHM1_14186,107,800 - 186,261,551 (+)NCBICHM1_1
T2T-CHM13v2.04188,547,948 - 188,721,939 (+)NCBIT2T-CHM13v2.0
Snx25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39846,486,298 - 46,605,535 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl846,486,298 - 46,605,196 (-)EnsemblGRCm39 Ensembl
GRCm38846,033,261 - 46,152,441 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl846,033,261 - 46,152,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv37847,118,615 - 47,209,500 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36847,532,089 - 47,615,519 (-)NCBIMGSCv36mm8
Celera848,716,126 - 48,805,692 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.03NCBI
Snx25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540323,676,002 - 23,787,308 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540323,678,301 - 23,787,256 (-)NCBIChiLan1.0ChiLan1.0
SNX25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23182,919,189 - 183,101,546 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14183,267,470 - 183,449,896 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04177,377,302 - 177,529,601 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14189,631,239 - 189,746,590 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4189,631,239 - 189,746,590 (+)Ensemblpanpan1.1panPan2
SNX25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11645,269,434 - 45,411,890 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1645,269,412 - 45,403,719 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1645,757,002 - 45,899,584 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01647,485,851 - 47,628,628 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1647,485,862 - 47,621,172 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11645,454,112 - 45,588,797 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01646,066,177 - 46,201,210 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01646,197,403 - 46,340,369 (-)NCBIUU_Cfam_GSD_1.0
Snx25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494334,020,358 - 34,127,227 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365543,979,441 - 4,087,162 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365543,982,755 - 4,093,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SNX25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,266,762 - 46,388,324 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,306,967 - 46,388,404 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,105,358 - 53,186,279 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SNX25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17131,171,833 - 131,320,054 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7131,207,046 - 131,313,261 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037111,432,323 - 111,584,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Snx25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476916,058,827 - 16,220,716 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Snx25
554 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:58
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000014828
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
RH133940  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,238,131 - 46,238,328 (+)MAPPERmRatBN7.2
Rnor_6.01649,432,076 - 49,432,272NCBIRnor6.0
Rnor_5.01649,159,058 - 49,159,254UniSTSRnor5.0
RGSC_v3.41649,518,324 - 49,518,520UniSTSRGSC3.4
Celera1644,236,645 - 44,236,841UniSTS
RH 3.4 Map16456.3UniSTS
Cytogenetic Map16q11UniSTS
BI291965  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21646,238,606 - 46,238,751 (+)MAPPERmRatBN7.2
Rnor_6.01649,432,551 - 49,432,695NCBIRnor6.0
Rnor_5.01649,159,533 - 49,159,677UniSTSRnor5.0
RGSC_v3.41649,518,799 - 49,518,943UniSTSRGSC3.4
Celera1644,237,120 - 44,237,264UniSTS
RH 3.4 Map16457.2UniSTS
Cytogenetic Map16q11UniSTS


Genetic Models
This gene Snx25 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 49 41 19 41 2 2 68 35 35 11 2
Low 43 8 6 9 6 6 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000014828   ⟹   ENSRNOP00000014828
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,125,804 - 46,238,440 (+)Ensembl
Rnor_6.0 Ensembl1649,350,884 - 49,432,118 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000099611   ⟹   ENSRNOP00000081215
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,134,499 - 46,238,440 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000106385   ⟹   ENSRNOP00000089441
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1646,134,499 - 46,238,440 (+)Ensembl
RefSeq Acc Id: XM_006253168   ⟹   XP_006253230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,867,114 - 52,971,028 (+)NCBI
mRatBN7.21646,134,552 - 46,238,452 (+)NCBI
Rnor_6.01649,328,958 - 49,432,415 (+)NCBI
Rnor_5.01649,051,539 - 49,159,381 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039094893   ⟹   XP_038950821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,908,007 - 52,971,028 (+)NCBI
mRatBN7.21646,175,425 - 46,238,471 (+)NCBI
RefSeq Acc Id: XM_063275974   ⟹   XP_063132044
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,867,896 - 52,971,028 (+)NCBI
RefSeq Acc Id: XM_224863   ⟹   XP_224863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81652,867,102 - 52,971,028 (+)NCBI
mRatBN7.21646,134,552 - 46,238,452 (+)NCBI
Rnor_6.01649,328,959 - 49,432,415 (+)NCBI
Rnor_5.01649,051,539 - 49,159,381 (+)NCBI
RGSC_v3.41649,415,658 - 49,518,663 (+)RGD
Sequence:
RefSeq Acc Id: XP_224863   ⟸   XM_224863
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZS17 (UniProtKB/TrEMBL),   A6JPP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006253230   ⟸   XM_006253168
- Peptide Label: isoform X2
- UniProtKB: A0A8I6ABR0 (UniProtKB/TrEMBL),   A6JPP4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014828   ⟸   ENSRNOT00000014828
RefSeq Acc Id: XP_038950821   ⟸   XM_039094893
- Peptide Label: isoform X4
- UniProtKB: Q5RJT4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089441   ⟸   ENSRNOT00000106385
RefSeq Acc Id: ENSRNOP00000081215   ⟸   ENSRNOT00000099611
RefSeq Acc Id: XP_063132044   ⟸   XM_063275974
- Peptide Label: isoform X3
Protein Domains
PX   PXA   RGS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M998-F1-model_v2 AlphaFold F1M998 1-840 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310150 AgrOrtholog
BioCyc Gene G2FUF-11336 BioCyc
Ensembl Genes ENSRNOG00000011116 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014828.8 UniProtKB/TrEMBL
  ENSRNOT00000099611.1 UniProtKB/TrEMBL
  ENSRNOT00000106385.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.167.10 UniProtKB/TrEMBL
  3.30.1520.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7132845 IMAGE-MGC_LOAD
InterPro Phox UniProtKB/TrEMBL
  Phox_assoc UniProtKB/TrEMBL
  PX_dom_sf UniProtKB/TrEMBL
  Regulat_G_prot_signal_superfam UniProtKB/TrEMBL
  RGS_sf UniProtKB/TrEMBL
  RGS_subdomain_2 UniProtKB/TrEMBL
  SNX25_PX UniProtKB/TrEMBL
  Sorting_nexin_C UniProtKB/TrEMBL
MGC_CLONE MGC:105891 IMAGE-MGC_LOAD
NCBI Gene 306471 ENTREZGENE
PANTHER PTHR22775:SF29 UniProtKB/TrEMBL
  SORTING NEXIN UniProtKB/TrEMBL
Pfam Nexin_C UniProtKB/TrEMBL
  PF00787 UniProtKB/TrEMBL
  PXA UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
PhenoGen Snx25 PhenoGen
PROSITE PS50195 UniProtKB/TrEMBL
  PXA UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011116 RatGTEx
SMART PXA UniProtKB/TrEMBL
  RGS UniProtKB/TrEMBL
  SM00312 UniProtKB/TrEMBL
Superfamily-SCOP 64268 UniProtKB/TrEMBL
  Regulat_G_prot_signal_superfam UniProtKB/TrEMBL
UniProt A0A8I5ZS17 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ABR0 ENTREZGENE, UniProtKB/TrEMBL
  A6JPP4 ENTREZGENE, UniProtKB/TrEMBL
  F1M998_RAT UniProtKB/TrEMBL
  Q5RJT4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Snx25  sorting nexin 25  Snx25_predicted  sorting nexin 25 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Snx25_predicted  sorting nexin 25 (predicted)      Symbol and Name status set to approved 70820 APPROVED