Gene: Tmc2 (transmembrane channel-like 2) Rattus norvegicus
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Symbol: Tmc2
Name: transmembrane channel-like 2
Description: ENCODES a protein that exhibits mechanosensitive ion channel activity (ortholog); voltage-gated calcium channel activity (ortholog); INVOLVED IN calcium ion transmembrane transport (ortholog); detection of mechanical stimulus involved in sensory perception of sound (ortholog); regulation of calcium ion transmembrane transport (ortholog); FOUND IN stereocilium tip (ortholog); INTERACTS WITH bisphenol A; C60 fullerene; aflatoxin B1 (ortholog)
AGR Description: Predicted to have mechanosensitive ion channel activity and voltage-gated calcium channel activity; predicted to be involved in several processes, including calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, and regulation of calcium ion transmembrane transport; predicted to localize to the stereocilium tip; orthologous to human TMC2 (transmembrane channel like 2).
Merged Description: Predicted to have mechanosensitive ion channel activity and voltage-gated calcium channel activity; predicted to be involved in several processes, including calcium ion transmembrane transport, detection of mechanical stimulus involved in sensory perception of sound, and regulation of calcium ion transmembrane transport; predicted to localize to the stereocilium tip; orthologous to human TMC2 (transmembrane channel like 2); INTERACTS WITH bisphenol A; C60 fullerene; aflatoxin B1 (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC296153; transmembrane channel-like gene family 2; transmembrane channel-like protein 2
Orthologs:
Homo sapiens (human) : TMC2 (transmembrane channel like 2)  HGNC  Alliance
Mus musculus (house mouse) : Tmc2 (transmembrane channel-like gene family 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tmc2 (transmembrane channel like 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TMC2 (transmembrane channel like 2)
Canis lupus familiaris (dog) : TMC2 (transmembrane channel like 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tmc2 (transmembrane channel like 2)
Sus scrofa (pig) : TMC2 (transmembrane channel like 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03122,720,769 - 122,790,100 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03129,221,627 - 129,289,966 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43117,795,111 - 117,874,361 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13117,741,777 - 117,779,934 (+)NCBI
Celera3116,211,915 - 116,280,083 (+)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Tmc2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1310073
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.