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Gene: Rbks (ribokinase) Rattus norvegicus
Analyze
Symbol:
Rbks
Name:
ribokinase
RGD ID:
1310064
Description:
Predicted to have identical protein binding activity. Predicted to be involved in D-ribose catabolic process and carbohydrate phosphorylation. Predicted to localize to cytoplasm and nucleus. Orthologous to human RBKS (ribokinase); PARTICIPATES IN pentose phosphate pathway; ribose 5-phosphate isomerase deficiency pathway; transaldolase deficiency pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; all-trans-retinoic acid.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC362706
RGD Orthologs
Alliance Genes
More Info
more info ...
More Info
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
RBKS (ribokinase)
HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Rbks (ribokinase)
HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Rbks (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
RBKS (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
RBKS (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Rbks (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
RBKS (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
RBKS (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Rbks (ribokinase)
Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
RBKS (ribokinase)
Alliance
DIOPT (Ensembl Compara|HGNC|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Mus musculus (house mouse):
Rbks (ribokinase)
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Danio rerio (zebrafish):
rbks (ribokinase)
Alliance
DIOPT (PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
CG13369
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Caenorhabditis elegans (roundworm):
F07A11.5
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Saccharomyces cerevisiae (baker's yeast):
RBK1
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Drosophila melanogaster (fruit fly):
CG17010
Alliance
DIOPT (Ensembl Compara|Hieranoid|InParanoid|OMA|OrthoFinder|OrthoInspector|PANTHER|PhylomeDB|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl mRatBN7.2 6 24,747,651 - 24,824,290 (+) NCBI Rnor_6.0 Ensembl 6 26,051,396 - 26,128,906 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_6.0 6 26,051,568 - 26,128,762 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 6 35,875,881 - 35,953,018 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 24,792,303 - 24,868,759 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 24,795,240 - 24,871,665 (+) NCBI Celera 6 24,241,936 - 24,318,495 (+) NCBI Celera Cytogenetic Map 6 q14 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of RBKS mRNA] CTD PMID:31150632 1,2-dimethylhydrazine multiple interactions ISO RGD:1320752 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RBKS mRNA CTD PMID:22206623 1,2-dimethylhydrazine decreases expression ISO RGD:1320752 6480464 1, 2-Dimethylhydrazine results in decreased expression of RBKS mRNA CTD PMID:22206623 17alpha-ethynylestradiol multiple interactions ISO RGD:1320752 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBKS mRNA CTD PMID:17942748 17beta-estradiol decreases expression ISO RGD:1320751 6480464 Estradiol results in decreased expression of RBKS mRNA CTD PMID:23019147 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1320752 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of RBKS mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1320752 6480464 Tetrachlorodibenzodioxin affects the expression of RBKS mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of RBKS mRNA CTD PMID:21215274 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1320752 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of RBKS mRNA CTD PMID:18648102 afimoxifene decreases response to substance ISO RGD:1320751 6480464 RBKS results in decreased susceptibility to afimoxifene CTD PMID:21233418 aflatoxin B1 affects expression ISO RGD:1320751 6480464 Aflatoxin B1 affects the expression of RBKS protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:1320751 6480464 Aflatoxin B1 results in decreased methylation of RBKS gene CTD PMID:27153756 aflatoxin B1 decreases expression ISO RGD:1320751 6480464 Aflatoxin B1 results in decreased expression of RBKS mRNA CTD PMID:22100608 aflatoxin B1 decreases expression ISO RGD:1320752 6480464 Aflatoxin B1 results in decreased expression of RBKS mRNA CTD PMID:19770486 aflatoxin B2 decreases methylation ISO RGD:1320751 6480464 aflatoxin B2 results in decreased methylation of RBKS intron CTD PMID:30157460 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of RBKS mRNA CTD PMID:20488242 amiodarone increases expression ISO RGD:1320751 6480464 Amiodarone results in increased expression of RBKS mRNA CTD PMID:19774075 benzo[a]pyrene increases expression ISO RGD:1320751 6480464 Benzoapyrene results in increased expression of RBKS mRNA CTD PMID:20106945 more ... benzo[a]pyrene decreases expression ISO RGD:1320751 6480464 Benzoapyrene results in decreased expression of RBKS mRNA CTD PMID:32234424 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of RBKS mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of RBKS mRNA CTD PMID:30816183 bisphenol A decreases expression ISO RGD:1320751 6480464 bisphenol A results in decreased expression of RBKS mRNA CTD PMID:31121516 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of RBKS gene CTD PMID:28505145 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of RBKS promoter CTD PMID:22457795 chlorohydrocarbon decreases expression EXP 6480464 Hydrocarbons, Chlorinated results in decreased expression of RBKS mRNA CTD PMID:18077114 copper(II) sulfate decreases expression ISO RGD:1320751 6480464 Copper Sulfate results in decreased expression of RBKS mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1320752 6480464 Cyclosporine results in decreased expression of RBKS mRNA CTD PMID:19770486 cyclosporin A decreases expression ISO RGD:1320751 6480464 Cyclosporine results in decreased expression of RBKS mRNA CTD PMID:25562108 dicrotophos decreases expression ISO RGD:1320751 6480464 dicrotophos results in decreased expression of RBKS mRNA CTD PMID:28302478 dinophysistoxin 1 decreases expression ISO RGD:1320751 6480464 dinophysistoxin 1 results in decreased expression of RBKS mRNA CTD PMID:28939011 folic acid multiple interactions ISO RGD:1320752 6480464 [1, 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RBKS mRNA CTD PMID:22206623 hydrogen peroxide affects expression ISO RGD:1320751 6480464 Hydrogen Peroxide affects the expression of RBKS mRNA CTD PMID:20044591 isotretinoin decreases expression ISO RGD:1320751 6480464 Isotretinoin results in decreased expression of RBKS mRNA CTD PMID:20436886 methylmercury chloride decreases expression ISO RGD:1320751 6480464 methylmercuric chloride results in decreased expression of RBKS mRNA CTD PMID:28001369 paracetamol affects expression ISO RGD:1320752 6480464 Acetaminophen affects the expression of RBKS mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1320751 6480464 Acetaminophen results in decreased expression of RBKS mRNA CTD PMID:21420995 , PMID:29067470 perfluorooctanoic acid multiple interactions ISO RGD:1320752 6480464 Dietary Fats, Unsaturated inhibits the reaction [perfluorooctanoic acid results in increased expression of RBKS mRNA] CTD PMID:23626681 quercetin decreases expression ISO RGD:1320751 6480464 Quercetin results in decreased expression of RBKS mRNA CTD PMID:21632981 quercitrin decreases expression ISO RGD:1320751 6480464 quercitrin results in decreased expression of RBKS mRNA CTD PMID:25193878 silver atom increases expression ISO RGD:1320752 6480464 Silver results in increased expression of RBKS mRNA CTD PMID:27131904 silver(0) increases expression ISO RGD:1320752 6480464 Silver results in increased expression of RBKS mRNA CTD PMID:27131904 sunitinib increases expression ISO RGD:1320751 6480464 Sunitinib results in increased expression of RBKS mRNA CTD PMID:31533062 T-2 toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of RBKS mRNA CTD PMID:26141394 tetrachloromethane affects expression ISO RGD:1320752 6480464 Carbon Tetrachloride affects the expression of RBKS mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of RBKS mRNA] CTD PMID:31150632 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of RBKS mRNA CTD PMID:31150632 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of RBKS mRNA CTD PMID:23411599 Triptolide decreases expression EXP 6480464 triptolide results in decreased expression of RBKS protein CTD PMID:32519852 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1320751 6480464 tris2-butoxyethyl phosphate affects the expression of RBKS mRNA CTD PMID:29024780 urethane decreases expression ISO RGD:1320751 6480464 Urethane results in decreased expression of RBKS mRNA CTD PMID:28818685
Cellular Component
cytoplasm IEA UniProtKB-SubCell:SL-0086 1600115 GO_REF:0000044 UniProt GO_REF:0000044 cytoplasm located_in IEA UniProtKB-SubCell:SL-0086 1600115 GO_REF:0000044 UniProt GO_REF:0000044 nucleus IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000044 UniProt GO_REF:0000044 nucleus located_in IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000044 UniProt GO_REF:0000044
Imported Annotations - SMPDB
Imported Annotations - KEGG (archival)
References
Additional References at PubMed
Genomics
QTLs in Region (Rnor_6.0)
738023 Alc17 Alcohol consumption QTL 17 3.1 0.003 consumption behavior trait (VT:0002069) ethanol drink intake rate to body weight ratio (CMO:0001616) 6 1 35623029 Rat 1354616 Despr12 Despair related QTL 12 0.0012 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 6 1 35623029 Rat 1549905 Stresp10 Stress response QTL 10 6.83 0.0066 stress-related behavior trait (VT:0010451) number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960) 6 1 35623029 Rat 2300176 Bmd51 Bone mineral density QTL 51 11.7 0.0001 femur mineral mass (VT:0010011) bone mineral density (CMO:0001226) 6 1 35623029 Rat 2300190 Bmd52 Bone mineral density QTL 52 11.2 0.0001 femur mineral mass (VT:0010011) volumetric bone mineral density (CMO:0001553) 6 1 35623029 Rat 1331743 Uae28 Urinary albumin excretion QTL 28 4.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 1 41917988 Rat 9589048 Scfw3 Subcutaneous fat weight QTL 3 4.57 0.001 subcutaneous adipose mass (VT:1000472) abdominal subcutaneous fat pad weight (CMO:0002069) 6 1 42388212 Rat 9589129 Insul24 Insulin level QTL 24 19.06 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 6 1 42388212 Rat 7411603 Foco13 Food consumption QTL 13 5.5 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 42388212 Rat 7411542 Bw127 Body weight QTL 127 5.5 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 6 1 42388212 Rat 8552962 Pigfal16 Plasma insulin-like growth factor 1 level QTL 16 9.4 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 1 42388212 Rat 2293709 Bss23 Bone structure and strength QTL 23 5.18 0.0001 femur morphology trait (VT:0000559) femur cross-sectional area (CMO:0001661) 6 1 43665660 Rat 2293650 Bss31 Bone structure and strength QTL 31 5.05 0.0001 femur strength trait (VT:0010010) femur midshaft polar moment of inertia (CMO:0001669) 6 1 43665660 Rat 2293656 Bss28 Bone structure and strength QTL 28 6.79 0.0001 femur morphology trait (VT:0000559) femur midshaft cortical cross-sectional area (CMO:0001663) 6 1 43665660 Rat 7411584 Foco4 Food consumption QTL 4 4.3 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 6 1 44015370 Rat 738024 Sach5 Saccharine consumption QTL 5 3.9 0.00039 consumption behavior trait (VT:0002069) saccharin intake volume to total fluid intake volume ratio (CMO:0001601) 6 1 44570292 Rat 2301972 Bp325 Blood pressure QTL 325 4.8 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 6 1 75623393 Rat 1359023 Bp272 Blood pressure QTL 272 2.5 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 1120393 28706721 Rat 2292589 Emca10 Estrogen-induced mammary cancer QTL 10 0.048 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 1120393 46120393 Rat 1354664 Slep2 Serum leptin concentration QTL 2 4.49 blood leptin amount (VT:0005667) serum leptin level (CMO:0000780) 6 1120393 75023446 Rat 1576309 Emca7 Estrogen-induced mammary cancer QTL 7 4 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 6 2537030 111715717 Rat 1578665 Bss16 Bone structure and strength QTL 16 4.4 femur morphology trait (VT:0000559) bone trabecular cross-sectional area (CMO:0002311) 6 6161722 76002731 Rat 1578668 Bmd14 Bone mineral density QTL 14 3.8 femur mineral mass (VT:0010011) total volumetric bone mineral density (CMO:0001728) 6 6161722 76002731 Rat 4145119 Mcs25 Mammary carcinoma susceptibility QTL 25 0.0001 mammary gland integrity trait (VT:0010552) ratio of deaths to total study population during a period of time (CMO:0001023) 6 7009971 115379601 Rat 634322 Bw12 Body weight QTL 12 0 body mass (VT:0001259) body weight (CMO:0000012) 7 10173862 55173862 Rat 1300128 Rf16 Renal function QTL 16 3.89 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 34367603 Rat 1300164 Rf15 Renal function QTL 15 3.12 renal blood flow trait (VT:2000006) absolute change in renal blood flow rate (CMO:0001168) 6 13122958 57516539 Rat 10401812 Kidm54 Kidney mass QTL 54 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 10401800 Kidm49 Kidney mass QTL 49 kidney mass (VT:0002707) both kidneys wet weight (CMO:0000085) 6 16810107 61810107 Rat 8552910 Pigfal5 Plasma insulin-like growth factor 1 level QTL 5 4.3 blood insulin-like growth factor amount (VT:0010479) plasma insulin-like growth factor 1 level (CMO:0001299) 6 19417887 64417887 Rat 1641898 Colcr4 Colorectal carcinoma resistance QTL4 3.71 0.0007 intestine integrity trait (VT:0010554) well differentiated malignant colorectal tumor surface area measurement (CMO:0002077) 6 21515302 65784818 Rat 2293839 Kiddil2 Kidney dilation QTL 2 4.8 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat 2293841 Kiddil4 Kidney dilation QTL 4 4.4 kidney pelvis morphology trait (VT:0004194) hydronephrosis severity score (CMO:0001208) 6 22042854 84763421 Rat