Gene: Cpsf2 (cleavage and polyadenylation specific factor 2) Rattus norvegicus
Analyze
Symbol:
Cpsf2
Name:
cleavage and polyadenylation specific factor 2
Description:
Predicted to have RNA binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage. Predicted to localize to the mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2); PARTICIPATES IN 3'-end pre-mRNA processing pathway; RNA polymerase II transcription termination pathway; mRNA decay pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
cleavage and polyadenylation specific factor 2, 100kDa; cleavage and polyadenylation specificity factor subunit 2; LOC299256
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
CPSF2 (cleavage and polyadenylation specific factor 2) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Cpsf2 (cleavage and polyadenylation specific factor 2) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Cpsf2 (cleavage and polyadenylation specific factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
CPSF2 (cleavage and polyadenylation specific factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
CPSF2 (cleavage and polyadenylation specific factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cpsf2 (cleavage and polyadenylation specific factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
CPSF2 (cleavage and polyadenylation specific factor 2) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
CPSF2 (cleavage and polyadenylation specific factor 2)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cpsf2 (cleavage and polyadenylation specific factor 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
cpsf2 (cleavage and polyadenylation specific factor 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
CFT2
Alliance
DIOPT (Ensembl Compara, Hieranoid, OrthoFinder, PANTHER, PhylomeDB, TreeFam)
Drosophila melanogaster (fruit fly):
Cpsf100
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
cpsf-2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 6 125,870,372 - 125,898,039 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 6 125,870,372 - 125,898,874 (+) Ensembl Rnor_5.0 6 135,081,675 - 135,110,301 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 6 126,246,237 - 126,274,144 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 6 126,255,715 - 126,275,801 (+) NCBI Celera 6 118,620,253 - 118,647,912 (+) NCBI Celera Cytogenetic Map 6 q32 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in increased expression of CPSF2 mRNA CTD PMID:27840820 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:1320167 6480464 Tetrachlorodibenzodioxin results in decreased expression of CPSF2 mRNA CTD PMID:19770486 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1320167 6480464 Tetrachlorodibenzodioxin affects the expression of CPSF2 mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of CPSF2 mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of CPSF2 mRNA CTD PMID:21346803 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of CPSF2 mRNA CTD PMID:19162173 benzo[a]pyrene increases expression ISO RGD:1320167 6480464 Benzo(a)pyrene results in increased expression of CPSF2 mRNA CTD PMID:22228805 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of CPSF2 mRNA CTD PMID:25181051 butanal decreases expression ISO RGD:1320166 6480464 butyraldehyde results in decreased expression of CPSF2 mRNA CTD PMID:26079696 ciguatoxin CTX1B affects expression ISO RGD:1320167 6480464 Ciguatoxins affects the expression of CPSF2 mRNA CTD PMID:18353800 clofibrate decreases expression ISO RGD:1320167 6480464 Clofibrate results in decreased expression of CPSF2 mRNA CTD PMID:17585979 copper(II) sulfate decreases expression ISO RGD:1320166 6480464 Copper Sulfate results in decreased expression of CPSF2 mRNA CTD PMID:19549813 cylindrospermopsin increases expression ISO RGD:1320166 6480464 cylindrospermopsin results in increased expression of CPSF2 mRNA CTD PMID:24921660 dorsomorphin multiple interactions ISO RGD:1320166 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPSF2 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:1320166 6480464 Doxorubicin results in increased expression of CPSF2 mRNA CTD PMID:29803840 flutamide increases expression EXP 6480464 Flutamide results in increased expression of CPSF2 mRNA CTD PMID:24136188 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of CPSF2 mRNA CTD PMID:24793618 formaldehyde decreases expression ISO RGD:1320166 6480464 Formaldehyde results in decreased expression of CPSF2 mRNA CTD PMID:23649840 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of CPSF2 mRNA CTD PMID:22061828 glyphosate increases expression EXP 6480464 glyphosate results in increased expression of CPSF2 mRNA CTD PMID:26302742 hydrogen peroxide affects expression ISO RGD:1320166 6480464 Hydrogen Peroxide affects the expression of CPSF2 mRNA CTD PMID:20044591 lead(0) affects expression ISO RGD:1320166 6480464 Lead affects the expression of CPSF2 mRNA CTD PMID:28903495 lead(2+) affects expression ISO RGD:1320166 6480464 Lead affects the expression of CPSF2 mRNA CTD PMID:28903495 Monobutylphthalate decreases expression EXP 6480464 monobutyl phthalate results in decreased expression of CPSF2 mRNA CTD PMID:29162477 nickel atom decreases expression ISO RGD:1320167 6480464 Nickel results in decreased expression of CPSF2 mRNA CTD PMID:18922574 nickel atom increases expression ISO RGD:1320166 6480464 Nickel results in increased expression of CPSF2 mRNA CTD PMID:24768652 , PMID:25583101 nickel atom decreases expression ISO RGD:1320166 6480464 Nickel results in decreased expression of CPSF2 mRNA CTD PMID:23195993 paracetamol affects expression ISO RGD:1320167 6480464 Acetaminophen affects the expression of CPSF2 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1320166 6480464 Acetaminophen results in decreased expression of CPSF2 mRNA CTD PMID:21420995 pentachlorophenol increases expression ISO RGD:1320167 6480464 Pentachlorophenol results in increased expression of CPSF2 mRNA CTD PMID:23892564 pentanal decreases expression ISO RGD:1320166 6480464 pentanal results in decreased expression of CPSF2 mRNA CTD PMID:26079696 phenobarbital affects expression ISO RGD:1320167 6480464 Phenobarbital affects the expression of CPSF2 mRNA CTD PMID:23091169 SB 431542 multiple interactions ISO RGD:1320166 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPSF2 mRNA CTD PMID:27188386 silver atom decreases expression ISO RGD:1320167 6480464 Silver results in decreased expression of CPSF2 mRNA CTD PMID:27131904 silver(0) decreases expression ISO RGD:1320167 6480464 Silver results in decreased expression of CPSF2 mRNA CTD PMID:27131904 sodium arsenite decreases expression ISO RGD:1320167 6480464 sodium arsenite results in decreased expression of CPSF2 protein CTD PMID:29044176 tetrachloromethane decreases expression ISO RGD:1320167 6480464 Carbon Tetrachloride results in decreased expression of CPSF2 mRNA CTD PMID:17484886 titanium dioxide increases expression ISO RGD:1320167 6480464 titanium dioxide results in increased expression of CPSF2 mRNA CTD PMID:23409001 trichostatin A decreases expression ISO RGD:1320166 6480464 trichostatin A results in decreased expression of CPSF2 mRNA CTD PMID:26272509 trichostatin A affects expression ISO RGD:1320166 6480464 trichostatin A affects the expression of CPSF2 mRNA CTD PMID:28542535 trichostatin A multiple interactions ISO RGD:1320166 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of CPSF2 mRNA CTD PMID:27188386 urethane decreases expression ISO RGD:1320166 6480464 Urethane results in decreased expression of CPSF2 mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1320166 6480464 Valproic Acid affects the expression of CPSF2 mRNA CTD PMID:25979313 valproic acid decreases expression ISO RGD:1320166 6480464 Valproic Acid results in decreased expression of CPSF2 mRNA CTD PMID:23179753 more ... valproic acid decreases methylation ISO RGD:1320166 6480464 Valproic Acid results in decreased methylation of CPSF2 gene CTD PMID:29154799 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of CPSF2 mRNA CTD PMID:23034163
Gene Ontology Annotations
Cellular Component cellular_component ND 1598407 01/2015: no relevant rat data RGD mRNA cleavage and polyadenylation specificity factor complex ISO RGD:1320167 1624291 (MGI:MGI:3619747, PMID:16115198) RGD MGI:MGI:3619747 , PMID:16115198 mRNA cleavage and polyadenylation specificity factor complex IEA UniProtKB:Q9P2I0 , ensembl:ENSP000002988751600115 GO_REF:0000107 Ensembl GO_REF:0000107 mRNA cleavage and polyadenylation specificity factor complex IEA UniProtKB:O35218 , ensembl:ENSMUSP000000477971600115 GO_REF:0000107 Ensembl GO_REF:0000107 mRNA cleavage and polyadenylation specificity factor complex ISO RGD:1320166 1624291 (PMID:18305108), (PMID:21102410) RGD PMID:18305108 , PMID:21102410 Molecular Function molecular_function ND 1598407 01/2015: no relevant rat data RGD protein binding ISO RGD:14271699 1624291 UniProtKB:P21530:PRO_0000038063 (PMID:25010283) RGD PMID:25010283 protein binding ISO RGD:1320166 1624291 UniProtKB:P33240 more ... RGD PMID:18288197 more ... RNA binding IEA UniProtKB-KW:KW-0694 1600115 GO_REF:0000038 UniProt GO_REF:0000038
Molecular Pathway Annotations
724513 Uae14 Urinary albumin excretion QTL 14 6.5 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 88996335 139410483 Rat 724536 Uae7 Urinary albumin excretion QTL 7 3.5 urine albumin amount (VT:0002871) urine albumin level (CMO:0000130) 6 75623277 136143011 Rat 1331725 Bp212 Blood pressure QTL 212 3.52475 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 97949772 133849286 Rat 1298087 Iddm18 Insulin dependent diabetes mellitus QTL 18 0.0001 urine glucose amount (VT:0001758) percentage of study population developing diabetes mellitus during a period of time (CMO:0001114) 6 121224054 135658578 Rat 737976 Pia24 Pristane induced arthritis QTL 24 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 6 117355600 147991367 Rat 1331797 Bp213 Blood pressure QTL 213 3.291 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 108154445 133849286 Rat 1331799 Bp211 Blood pressure QTL 211 3.66407 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 6 75623277 136426962 Rat 1581550 Pur8 Proteinuria QTL 8 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 6 75623393 136142742 Rat 731173 Uae22 Urinary albumin excretion QTL 22 10.1 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 738034 Anxrr5 Anxiety related response QTL 5 5.9 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) 6 88507712 133507712 Rat 1581563 Uae33 Urinary albumin excretion QTL 33 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 75623393 136142742 Rat 2313399 Anxrr28 Anxiety related response QTL 28 aggression-related behavior trait (VT:0015014) tameness/aggressiveness composite score (CMO:0002136) 6 104381930 138066274 Rat 1358355 Srcrt4 Stress Responsive Cort QTL 4 6.39 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 104363890 147991367 Rat 1300076 Glom8 Glomerulus QTL 8 7 0.000000009 kidney glomerulus morphology trait (VT:0005325) count of superficial glomeruli directly contacting the kidney surface (CMO:0001001) 6 91703409 136703409 Rat 2290393 Uae37 Urinary albumin excretion QTL 37 0.0001 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 6 68781170 147991367 Rat 2303624 Vencon5 Ventilatory control QTL 5 4.45 respiration trait (VT:0001943) minute ventilation (VE) (CMO:0000132) 6 92879510 137879510 Rat 61414 Pia3 Pristane induced arthritis QTL 3 4.5 joint integrity trait (VT:0010548) post-insult time to onset of experimental arthritis (CMO:0001450) 6 99273921 144792678 Rat 8552796 Vie3 Viral induced encephalitis QTL 3 2.6 brain integrity trait (VT:0010579) encephalitis incidence/prevalence measurement (CMO:0002361) 6 101207574 147991367 Rat 10054138 Gmadr3 Adrenal mass QTL 3 3.68 0.00045 adrenal gland mass (VT:0010420) both adrenal glands wet weight (CMO:0000164) 6 89631358 134631358 Rat 10054123 Srcrt6 Stress Responsive Cort QTL 6 2.5 0.0043 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 6 89631358 134631358 Rat 4145118 Mcs26 Mammary carcinoma susceptibility QTL 26 0.0001 mammary gland integrity trait (VT:0010552) post-insult time to mammary tumor formation (CMO:0000345) 6 111134524 138065254 Rat 12801411 Schws8 Schwannoma susceptibility QTL 8 nervous system integrity trait (VT:0010566) percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017) 6 99273921 144273921 Rat
Predicted Target Of
Count of predictions: 722 Count of miRNA genes: 307 Interacting mature miRNAs: 405 Transcripts: ENSRNOT00000008612 Prediction methods: Microtar, Miranda, Targetscan Result types: miRGate_prediction
Gene Ontology Annotations
