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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Ints6 | Rat | 1,1-dichloroethene | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | vinylidene chloride results in increased expression of INTS6 mRNA | CTD | PMID:26682919 | Ints6 | Rat | 17alpha-ethynylestradiol | affects expression | ISO | Ints6 (Mus musculus) | 6480464 | Ethinyl Estradiol affects the expression of INTS6 mRNA | CTD | PMID:17555576 | Ints6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of INTS6 mRNA | CTD | PMID:19770486 | Ints6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of INTS6 mRNA | CTD | PMID:32109520 and PMID:33387578 | Ints6 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of INTS6 mRNA | CTD | PMID:19933214 | Ints6 | Rat | 2-methylcholine | affects expression | ISO | INTS6 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of INTS6 mRNA | CTD | PMID:21179406 | Ints6 | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Fenretinide results in increased expression of INTS6 mRNA | CTD | PMID:28973697 | Ints6 | Rat | acrolein | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of INTS6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of INTS6 mRNA | CTD | PMID:32699268 | Ints6 | Rat | aflatoxin B1 | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of INTS6 mRNA | CTD | PMID:19770486 | Ints6 | Rat | alpha-pinene | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of INTS6 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of INTS6 mRNA | CTD | PMID:32699268 | Ints6 | Rat | Aroclor 1254 | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of INTS6 mRNA | CTD | PMID:23650126 | Ints6 | Rat | arsane | affects methylation | ISO | INTS6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of INTS6 gene | CTD | PMID:25304211 | Ints6 | Rat | arsenic atom | affects methylation | ISO | INTS6 (Homo sapiens) | 6480464 | Arsenic affects the methylation of INTS6 gene | CTD | PMID:25304211 | Ints6 | Rat | arsenous acid | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of INTS6 mRNA | CTD | PMID:20458559 | Ints6 | Rat | arsenous acid | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Arsenic Trioxide results in increased expression of INTS6 mRNA | CTD | PMID:35676786 | Ints6 | Rat | benzo[a]pyrene | decreases methylation | ISO | INTS6 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased methylation of INTS6 promoter | CTD | PMID:27901495 | Ints6 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:20018196 | Ints6 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of INTS6 mRNA | CTD | PMID:25181051 and PMID:34947998 | Ints6 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of INTS6 mRNA | CTD | PMID:30816183 | Ints6 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of INTS6 gene | CTD | PMID:28505145 | Ints6 | Rat | casticin | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | casticin results in decreased expression of INTS6 mRNA | CTD | PMID:28444820 | Ints6 | Rat | chlorpyrifos | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of INTS6 mRNA | CTD | PMID:37019170 | Ints6 | Rat | choline | multiple interactions | ISO | Ints6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of INTS6 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of INTS6 gene | CTD | PMID:20938992 | Ints6 | Rat | cisplatin | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Cisplatin co-treated with jinfukang] results in decreased expression of INTS6 mRNA | CTD | PMID:27392435 | Ints6 | Rat | copper(II) sulfate | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of INTS6 mRNA | CTD | PMID:19549813 | Ints6 | Rat | crocidolite asbestos | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Asbestos and Crocidolite results in increased expression of INTS6 mRNA | CTD | PMID:18687144 | Ints6 | Rat | crocidolite asbestos | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of INTS6 mRNA | CTD | PMID:29279043 | Ints6 | Rat | diarsenic trioxide | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Arsenic Trioxide results in increased expression of INTS6 mRNA | CTD | PMID:20458559 | Ints6 | Rat | diarsenic trioxide | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Arsenic Trioxide results in increased expression of INTS6 mRNA | CTD | PMID:35676786 | Ints6 | Rat | Dibutyl phosphate | affects expression | ISO | INTS6 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of INTS6 mRNA | CTD | PMID:37042841 | Ints6 | Rat | dibutyl phthalate | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Dibutyl Phthalate results in increased expression of INTS6 mRNA | CTD | PMID:21266533 | Ints6 | Rat | dicrotophos | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | dicrotophos results in decreased expression of INTS6 mRNA | CTD | PMID:28302478 | Ints6 | Rat | Diisodecyl phthalate | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | diisodecyl phthalate results in decreased expression of INTS6 mRNA | CTD | PMID:25270620 | Ints6 | Rat | dorsomorphin | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Ints6 | Rat | elemental selenium | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Selenium results in decreased expression of INTS6 mRNA | CTD | PMID:19244175 | Ints6 | Rat | elemental selenium | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of INTS6 mRNA | CTD | PMID:19244175 | Ints6 | Rat | endosulfan | increases expression | EXP | | 6480464 | Endosulfan results in increased expression of INTS6 mRNA | CTD | PMID:29391264 | Ints6 | Rat | enzyme inhibitor | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of INTS6 protein | CTD | PMID:23301498 | Ints6 | Rat | folic acid | multiple interactions | ISO | Ints6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of INTS6 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of INTS6 gene | CTD | PMID:20938992 | Ints6 | Rat | formaldehyde | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of INTS6 mRNA | CTD | PMID:20655997 | Ints6 | Rat | gentamycin | increases expression | EXP | | 6480464 | Gentamicins results in increased expression of INTS6 mRNA | CTD | PMID:22061828 and PMID:33387578 | Ints6 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of INTS6 mRNA | CTD | PMID:22061828 | Ints6 | Rat | ivermectin | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of INTS6 protein | CTD | PMID:32959892 | Ints6 | Rat | L-methionine | multiple interactions | ISO | Ints6 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of INTS6 mRNA and [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of INTS6 gene | CTD | PMID:20938992 | Ints6 | Rat | leflunomide | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | leflunomide results in decreased expression of INTS6 mRNA | CTD | PMID:19751817 | Ints6 | Rat | methapyrilene | increases expression | EXP | | 6480464 | Methapyrilene results in increased expression of INTS6 mRNA | CTD | PMID:30467583 | Ints6 | Rat | methylisothiazolinone | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | 2-methyl-4-isothiazolin-3-one results in increased expression of INTS6 mRNA | CTD | PMID:31629900 | Ints6 | Rat | methylmercury chloride | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of INTS6 mRNA | CTD | PMID:28001369 | Ints6 | Rat | N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | N more ... | CTD | PMID:12756304 | Ints6 | Rat | ozone | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of INTS6 mRNA more ... | CTD | PMID:32699268 | Ints6 | Rat | ozone | multiple interactions | ISO | Ints6 (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of Ozone] which results in decreased expression of INTS6 mRNA | CTD | PMID:27106289 | Ints6 | Rat | paracetamol | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of INTS6 mRNA | CTD | PMID:22230336 | Ints6 | Rat | paracetamol | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Acetaminophen results in decreased expression of INTS6 mRNA | CTD | PMID:21420995 | Ints6 | Rat | pentachlorophenol | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Pentachlorophenol results in increased expression of INTS6 mRNA | CTD | PMID:23892564 | Ints6 | Rat | pentanal | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | pentanal results in decreased expression of INTS6 mRNA | CTD | PMID:26079696 | Ints6 | Rat | phenobarbital | affects expression | ISO | Ints6 (Mus musculus) | 6480464 | Phenobarbital affects the expression of INTS6 mRNA | CTD | PMID:23091169 | Ints6 | Rat | phenylmercury acetate | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of INTS6 mRNA | CTD | PMID:26272509 | Ints6 | Rat | phenylmercury acetate | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INTS6 mRNA | CTD | PMID:27188386 | Ints6 | Rat | resveratrol | decreases expression | ISO | Ints6 (Mus musculus) | 6480464 | resveratrol results in decreased expression of INTS6 protein | CTD | PMID:25505154 | Ints6 | Rat | rifampicin | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Rifampin results in decreased expression of INTS6 mRNA | CTD | PMID:24552687 | Ints6 | Rat | SB 431542 | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Ints6 | Rat | selenium atom | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Selenium results in decreased expression of INTS6 mRNA | CTD | PMID:19244175 | Ints6 | Rat | selenium atom | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of INTS6 mRNA | CTD | PMID:19244175 | Ints6 | Rat | silver atom | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Silver results in increased expression of INTS6 mRNA | CTD | PMID:26014281 | Ints6 | Rat | silver(0) | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Silver results in increased expression of INTS6 mRNA | CTD | PMID:26014281 | Ints6 | Rat | sodium arsenate | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | sodium arsenate results in increased expression of INTS6 mRNA | CTD | PMID:21795629 | Ints6 | Rat | sodium arsenite | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of INTS6 mRNA | CTD | PMID:38568856 | Ints6 | Rat | sunitinib | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of INTS6 mRNA | CTD | PMID:31533062 | Ints6 | Rat | tamoxifen | affects expression | ISO | Ints6 (Mus musculus) | 6480464 | Tamoxifen affects the expression of INTS6 mRNA | CTD | PMID:17555576 | Ints6 | Rat | testosterone enanthate | affects expression | ISO | INTS6 (Homo sapiens) | 6480464 | testosterone enanthate affects the expression of INTS6 mRNA | CTD | PMID:17440010 | Ints6 | Rat | thapsigargin | increases expression | ISO | Ints6 (Mus musculus) | 6480464 | Thapsigargin results in increased expression of INTS6 protein | CTD | PMID:24648495 | Ints6 | Rat | thimerosal | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Thimerosal results in increased expression of INTS6 mRNA | CTD | PMID:27188386 | Ints6 | Rat | titanium dioxide | decreases methylation | ISO | Ints6 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of INTS6 gene | CTD | PMID:35295148 | Ints6 | Rat | trichostatin A | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | trichostatin A results in decreased expression of INTS6 mRNA | CTD | PMID:24935251 and PMID:26272509 | Ints6 | Rat | trichostatin A | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INTS6 mRNA | CTD | PMID:27188386 | Ints6 | Rat | triclosan | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Triclosan results in increased expression of INTS6 mRNA | CTD | PMID:30510588 | Ints6 | Rat | triphenyl phosphate | increases expression | EXP | | 6480464 | triphenyl phosphate results in increased expression of INTS6 mRNA | CTD | PMID:30589522 | Ints6 | Rat | urethane | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Urethane results in decreased expression of INTS6 mRNA | CTD | PMID:28818685 | Ints6 | Rat | valproic acid | affects expression | ISO | INTS6 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of INTS6 mRNA | CTD | PMID:25979313 | Ints6 | Rat | valproic acid | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Valproic Acid results in decreased expression of INTS6 mRNA | CTD | PMID:23179753 more ... | Ints6 | Rat | valproic acid | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of INTS6 mRNA | CTD | PMID:27188386 | Ints6 | Rat | vitamin E | decreases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of INTS6 mRNA | CTD | PMID:19244175 | Ints6 | Rat | vitamin E | multiple interactions | ISO | INTS6 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of INTS6 mRNA | CTD | PMID:19244175 | Ints6 | Rat | vorinostat | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | vorinostat results in increased expression of INTS6 mRNA | CTD | PMID:27188386 | Ints6 | Rat | zinc sulfate | increases expression | ISO | INTS6 (Homo sapiens) | 6480464 | Zinc Sulfate results in increased expression of INTS6 mRNA | CTD | PMID:12756304 | |