Cts7 (cathepsin 7) - Rat Genome Database

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Gene: Cts7 (cathepsin 7) Rattus norvegicus
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Symbol: Cts7
Name: cathepsin 7
RGD ID: 1309226
Description: Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to act upstream of or within negative regulation of mitotic cell cycle and trophoblast giant cell differentiation. Predicted to be located in several cellular components, including Golgi apparatus; endosome; and extracellular region. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L); INTERACTS WITH bisphenol A; trichloroethene; 2,3,7,8-tetrachlorodibenzodioxine (ortholog).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290970
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,393,930 - 3,430,291 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,393,930 - 3,399,070 (+)EnsemblGRCr8
mRatBN7.2173,388,299 - 3,424,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,388,299 - 3,393,439 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx173,407,814 - 3,412,954 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0174,949,488 - 4,954,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,404,271 - 3,409,411 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,280,311 - 3,285,451 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,280,311 - 3,285,451 (+)Ensemblrn6Rnor6.0
Rnor_5.0175,492,909 - 5,498,049 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,092,366 - 9,097,506 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,519,200 - 3,524,340 (+)NCBICelera
RGSC_v3.1179,090,456 - 9,097,240 (+)NCBI
Cytogenetic Map17p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Cts7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8173,393,930 - 3,430,291 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl173,393,930 - 3,399,070 (+)EnsemblGRCr8
mRatBN7.2173,388,299 - 3,424,664 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl173,388,299 - 3,393,439 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx173,407,814 - 3,412,954 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0174,949,488 - 4,954,628 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0173,404,271 - 3,409,411 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,280,311 - 3,285,451 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,280,311 - 3,285,451 (+)Ensemblrn6Rnor6.0
Rnor_5.0175,492,909 - 5,498,049 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4179,092,366 - 9,097,506 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera173,519,200 - 3,524,340 (+)NCBICelera
RGSC_v3.1179,090,456 - 9,097,240 (+)NCBI
Cytogenetic Map17p14NCBI
Cts7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391361,500,275 - 61,506,010 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1361,500,275 - 61,506,011 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381361,352,461 - 61,358,196 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1361,352,461 - 61,358,197 (-)Ensemblmm10GRCm38
MGSCv371361,453,822 - 61,459,531 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361361,362,084 - 61,367,793 (-)NCBIMGSCv36mm8
Celera1362,402,826 - 62,408,541 (-)NCBICelera
Cytogenetic Map13B2NCBI
cM Map1332.71NCBI

Variants

.
Variants in Cts7
65 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:136
Count of miRNA genes:120
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000043686
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131706603Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17136045694Rat
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17143999106Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17143999106Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17143999106Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17212084322087569Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17121499218Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17212084342054133Rat
1549900Iddm20Insulin dependent diabetes mellitus QTL 203.7pancreas integrity trait (VT:0010560)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)17122181410Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122877318Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17138037084Rat

Markers in Region
Cts7-ps  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2173,391,420 - 3,392,072 (+)MAPPERmRatBN7.2
Rnor_6.0173,287,226 - 3,287,877NCBIRnor6.0
Rnor_6.0173,283,433 - 3,284,084NCBIRnor6.0
Rnor_5.0175,496,031 - 5,496,682UniSTSRnor5.0
Rnor_5.0175,499,872 - 5,500,523UniSTSRnor5.0
RGSC_v3.4179,095,488 - 9,096,139UniSTSRGSC3.4
Celera173,522,322 - 3,522,973UniSTS
Cytogenetic Map17p14UniSTS


Expression

RNA-SEQ Expression

ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
4 2 3 1 1 1 2 1 4 8 2

Sequence


Ensembl Acc Id: ENSRNOT00000043686   ⟹   ENSRNOP00000051349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl173,393,930 - 3,399,070 (+)Ensembl
mRatBN7.2 Ensembl173,388,299 - 3,393,439 (+)Ensembl
Rnor_6.0 Ensembl173,280,311 - 3,285,451 (+)Ensembl
RefSeq Acc Id: NM_001106099   ⟹   NP_001099569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,393,930 - 3,399,070 (+)NCBI
mRatBN7.2173,388,299 - 3,393,439 (+)NCBI
Rnor_6.0173,280,311 - 3,285,451 (+)NCBI
Rnor_5.0175,492,909 - 5,498,049 (+)NCBI
RGSC_v3.4179,092,366 - 9,097,506 (+)RGD
Celera173,519,200 - 3,524,340 (+)RGD
Sequence:
RefSeq Acc Id: XM_039095445   ⟹   XP_038951373
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8173,395,020 - 3,430,291 (+)NCBI
mRatBN7.2173,389,389 - 3,424,664 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001099569 (Get FASTA)   NCBI Sequence Viewer  
  XP_038951373 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein D3ZZ07 (Get FASTA)   NCBI Sequence Viewer  
  EDL93846 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000051349
  ENSRNOP00000051349.2
RefSeq Acc Id: NP_001099569   ⟸   NM_001106099
- Peptide Label: precursor
- UniProtKB: D3ZZ07 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000051349   ⟸   ENSRNOT00000043686
RefSeq Acc Id: XP_038951373   ⟸   XM_039095445
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZZ07-F1-model_v2 AlphaFold D3ZZ07 1-331 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309226 AgrOrtholog
BioCyc Gene G2FUF-10486 BioCyc
Ensembl Genes ENSRNOG00000033540 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000043686 ENTREZGENE
  ENSRNOT00000043686.3 UniProtKB/Swiss-Prot
Gene3D-CATH Cysteine proteinases UniProtKB/Swiss-Prot
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
  Peptidase_C1A_papain-like UniProtKB/Swiss-Prot
  Prot_inhib_I29 UniProtKB/Swiss-Prot
KEGG Report rno:290970 UniProtKB/Swiss-Prot
NCBI Gene 290970 ENTREZGENE
PANTHER CYSTEINE PROTEASE FAMILY C1-RELATED UniProtKB/Swiss-Prot
Pfam Inhibitor_I29 UniProtKB/Swiss-Prot
  Peptidase_C1 UniProtKB/Swiss-Prot
PhenoGen Cts7 PhenoGen
PRINTS PAPAIN UniProtKB/Swiss-Prot
PROSITE THIOL_PROTEASE_CYS UniProtKB/Swiss-Prot
  THIOL_PROTEASE_HIS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033540 RatGTEx
SMART Inhibitor_I29 UniProtKB/Swiss-Prot
  Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
UniProt CAT7_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Cts7  cathepsin 7   Cts7_predicted  cathepsin 7 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Cts7_predicted  cathepsin 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED