Tmem68 (transmembrane protein 68) - Rat Genome Database

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Gene: Tmem68 (transmembrane protein 68) Rattus norvegicus
Analyze
Symbol: Tmem68
Name: transmembrane protein 68
RGD ID: 1309006
Description: Predicted to enable acyltransferase activity. Predicted to be located in membrane. Orthologous to human TMEM68 (transmembrane protein 68); INTERACTS WITH (+)-schisandrin B; acrylamide; atrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC312946; RGD1309006; similar to RIKEN cDNA 2010300G19
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,494,054 - 16,524,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,494,276 - 16,524,569 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx518,742,633 - 18,773,416 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0520,341,122 - 20,371,905 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0520,092,601 - 20,123,380 (-)NCBIRnor_WKY
Rnor_6.0516,363,908 - 16,413,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,382,538 - 16,413,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,163,802 - 21,194,571 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4516,787,573 - 16,818,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1516,789,003 - 16,818,154 (-)NCBI
Celera515,860,301 - 15,891,085 (-)NCBICelera
Cytogenetic Map5q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:21873635  


Genomics

Comparative Map Data
Tmem68
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2516,494,054 - 16,524,842 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl516,494,276 - 16,524,569 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx518,742,633 - 18,773,416 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0520,341,122 - 20,371,905 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0520,092,601 - 20,123,380 (-)NCBIRnor_WKY
Rnor_6.0516,363,908 - 16,413,307 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl516,382,538 - 16,413,307 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0521,163,802 - 21,194,571 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4516,787,573 - 16,818,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1516,789,003 - 16,818,154 (-)NCBI
Celera515,860,301 - 15,891,085 (-)NCBICelera
Cytogenetic Map5q12NCBI
TMEM68
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38855,738,758 - 55,773,378 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl855,696,424 - 55,773,407 (-)EnsemblGRCh38hg38GRCh38
GRCh37856,651,317 - 56,685,937 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36856,813,874 - 56,848,439 (-)NCBINCBI36Build 36hg18NCBI36
Celera852,641,534 - 52,677,152 (-)NCBICelera
Cytogenetic Map8q12.1NCBI
HuRef852,119,027 - 52,154,339 (-)NCBIHuRef
CHM1_1856,703,016 - 56,737,479 (-)NCBICHM1_1
T2T-CHM13v2.0856,116,033 - 56,150,430 (-)NCBIT2T-CHM13v2.0
Tmem68
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3943,549,041 - 3,574,853 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl43,549,041 - 3,574,853 (-)EnsemblGRCm39 Ensembl
GRCm3843,549,041 - 3,574,867 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl43,549,041 - 3,574,853 (-)EnsemblGRCm38mm10GRCm38
MGSCv3743,476,188 - 3,501,915 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3643,476,188 - 3,501,915 (-)NCBIMGSCv36mm8
Celera43,493,982 - 3,520,608 (-)NCBICelera
Cytogenetic Map4A1NCBI
Tmem68
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545414,857,396 - 14,895,250 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545414,857,918 - 14,895,250 (-)NCBIChiLan1.0ChiLan1.0
TMEM68
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1849,549,585 - 49,586,260 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl849,549,593 - 49,586,260 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0852,135,766 - 52,214,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TMEM68
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1297,192,130 - 7,241,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl297,160,489 - 7,232,126 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha297,505,747 - 7,553,987 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0297,266,356 - 7,314,648 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl297,266,213 - 7,314,606 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1297,280,929 - 7,329,078 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0297,413,655 - 7,461,856 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0297,690,072 - 7,738,304 (-)NCBIUU_Cfam_GSD_1.0
Tmem68
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530372,300,823 - 72,332,471 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364962,452,990 - 2,485,166 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049364962,453,014 - 2,484,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM68
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl475,969,247 - 76,001,178 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1475,969,201 - 76,003,917 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2482,911,899 - 82,943,871 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM68
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1851,781,021 - 51,819,454 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl851,782,434 - 51,807,062 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603989,984,064 - 90,022,744 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem68
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624965120,911 - 147,945 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624965120,862 - 148,769 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem68
193 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:180
Count of miRNA genes:139
Interacting mature miRNAs:161
Transcripts:ENSRNOT00000012215
Prediction methods:Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331756Rf34Renal function QTL 344.16275kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)5190450412Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1331771Rf35Renal function QTL 354.36965kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)572947086724018Rat
2312562Pur18Proteinuria QTL 182.60.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)5213896532656739Rat
1576314Eutr1Estrogen induced uterine response QTL 1uterus integrity trait (VT:0010575)pyometritis severity score (CMO:0002009)52138965166875058Rat
8662454Vetf3Vascular elastic tissue fragility QTL 327.4artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)5228222669540447Rat
2313085Bss59Bone structure and strength QTL 592.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)5384401826141981Rat
1300117Hrtrt8Heart rate QTL 83.49heart pumping trait (VT:2000009)heart rate (CMO:0000002)5384401847869213Rat
61462Niddm10Non-insulin dependent diabetes mellitus QTL 103.90.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)5511215947171491Rat
631827Alc4Alcohol consumption QTL 43.5consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)5818750118616199Rat
2293666Bmd38Bone mineral density QTL 384.4femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)5894822853948228Rat
7394712Emca13Estrogen-induced mammary cancer QTL 13mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)5982326699753708Rat
1641903Alcrsp3Alcohol response QTL 3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)51268928557689285Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 18 18 6 16 6 74 30 34 11
Low 1 25 39 35 3 35 8 11 5 7 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012215   ⟹   ENSRNOP00000012215
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl516,494,276 - 16,524,569 (-)Ensembl
Rnor_6.0 Ensembl516,382,538 - 16,413,307 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000097725   ⟹   ENSRNOP00000079733
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl516,496,241 - 16,524,535 (-)Ensembl
RefSeq Acc Id: NM_001107903   ⟹   NP_001101373
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,054 - 16,524,825 (-)NCBI
Rnor_6.0516,382,538 - 16,413,307 (-)NCBI
Rnor_5.0521,163,802 - 21,194,571 (-)NCBI
RGSC_v3.4516,787,573 - 16,818,342 (-)RGD
Celera515,860,301 - 15,891,085 (-)RGD
Sequence:
RefSeq Acc Id: XM_006237827   ⟹   XP_006237889
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,842 (-)NCBI
Rnor_6.0516,382,760 - 16,413,302 (-)NCBI
Rnor_5.0521,163,802 - 21,194,571 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006237832   ⟹   XP_006237894
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,842 (-)NCBI
Rnor_6.0516,384,080 - 16,413,302 (-)NCBI
Rnor_5.0521,163,802 - 21,194,571 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039109756   ⟹   XP_038965684
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,519 (-)NCBI
RefSeq Acc Id: XM_039109757   ⟹   XP_038965685
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,564 (-)NCBI
RefSeq Acc Id: XM_039109758   ⟹   XP_038965686
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,069 (-)NCBI
RefSeq Acc Id: XM_039109759   ⟹   XP_038965687
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,539 (-)NCBI
RefSeq Acc Id: XR_005504422
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,842 (-)NCBI
RefSeq Acc Id: XR_005504423
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,494,276 - 16,524,842 (-)NCBI
RefSeq Acc Id: XR_005504424
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,495,616 - 16,524,842 (-)NCBI
RefSeq Acc Id: XR_005504425
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,504,091 - 16,524,842 (-)NCBI
RefSeq Acc Id: XR_005504426
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2516,504,091 - 16,524,842 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001101373   ⟸   NM_001107903
- UniProtKB: D3ZF19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237889   ⟸   XM_006237827
- Peptide Label: isoform X1
- UniProtKB: D3ZF19 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006237894   ⟸   XM_006237832
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000012215   ⟸   ENSRNOT00000012215
RefSeq Acc Id: XP_038965685   ⟸   XM_039109757
- Peptide Label: isoform X1
- UniProtKB: D3ZF19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965687   ⟸   XM_039109759
- Peptide Label: isoform X1
- UniProtKB: D3ZF19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965684   ⟸   XM_039109756
- Peptide Label: isoform X1
- UniProtKB: D3ZF19 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038965686   ⟸   XM_039109758
- Peptide Label: isoform X1
- UniProtKB: D3ZF19 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000079733   ⟸   ENSRNOT00000097725
Protein Domains
PlsC

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZF19-F1-model_v2 AlphaFold D3ZF19 1-329 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693547
Promoter ID:EPDNEW_R4072
Type:initiation region
Name:Tmem68_1
Description:transmembrane protein 68
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0516,413,290 - 16,413,350EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309006 AgrOrtholog
BioCyc Gene G2FUF-42127 BioCyc
Ensembl Genes ENSRNOG00000008872 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012215 ENTREZGENE
  ENSRNOP00000012215.3 UniProtKB/TrEMBL
  ENSRNOP00000079733.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012215 ENTREZGENE
  ENSRNOT00000012215.5 UniProtKB/TrEMBL
  ENSRNOT00000097725.1 UniProtKB/TrEMBL
InterPro Plipid/glycerol_acylTrfase UniProtKB/TrEMBL
KEGG Report rno:312946 UniProtKB/TrEMBL
NCBI Gene 312946 ENTREZGENE
Pfam Acyltransferase UniProtKB/TrEMBL
PhenoGen Tmem68 PhenoGen
UniProt A0A8I5ZND5_RAT UniProtKB/TrEMBL
  D3ZF19 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tmem68  transmembrane protein 68   Tmem68_predicted  transmembrane protein 68 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tmem68_predicted  transmembrane protein 68 (predicted)  RGD1309006_predicted  similar to RIKEN cDNA 2010300G19 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1309006_predicted  similar to RIKEN cDNA 2010300G19 (predicted)  LOC312946_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC312946_predicted  similar to RIKEN cDNA 2010300G19 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL