Rspry1 (ring finger and SPRY domain containing 1) - Rat Genome Database

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Gene: Rspry1 (ring finger and SPRY domain containing 1) Rattus norvegicus
Analyze
Symbol: Rspry1
Name: ring finger and SPRY domain containing 1
RGD ID: 1308847
Description: Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be active in cytoplasm. Orthologous to human RSPRY1 (ring finger and SPRY domain containing 1); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; chlormequat chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC291860; LOC689249; MGC156751; RGD1308847; RING finger and SPRY domain-containing protein 1; similar to F16A11.1; similar to SPla/RYanodine receptor SPRY (1J970)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21910,352,449 - 10,403,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,353,821 - 10,401,102 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,317,054 - 10,364,193 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01911,083,903 - 11,131,050 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01910,370,850 - 10,418,001 (-)NCBIRnor_WKY
Rnor_6.01910,770,572 - 10,826,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,770,574 - 10,826,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,764,829 - 10,820,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,794,160 - 10,843,023 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,798,033 - 10,847,998 (-)NCBI
Celera1910,243,223 - 10,290,488 (-)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15632090  


Genomics

Comparative Map Data
Rspry1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21910,352,449 - 10,403,015 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,353,821 - 10,401,102 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,317,054 - 10,364,193 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01911,083,903 - 11,131,050 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01910,370,850 - 10,418,001 (-)NCBIRnor_WKY
Rnor_6.01910,770,572 - 10,826,895 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1910,770,574 - 10,826,895 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01910,764,829 - 10,820,883 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41910,794,160 - 10,843,023 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11910,798,033 - 10,847,998 (-)NCBI
Celera1910,243,223 - 10,290,488 (-)NCBICelera
Cytogenetic Map19p13NCBI
RSPRY1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381657,186,152 - 57,240,469 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1657,186,137 - 57,240,469 (+)EnsemblGRCh38hg38GRCh38
GRCh371657,220,241 - 57,274,381 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,777,742 - 55,830,451 (+)NCBINCBI36Build 36hg18NCBI36
Celera1641,720,063 - 41,772,638 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1643,089,815 - 43,142,600 (+)NCBIHuRef
CHM1_11658,627,738 - 58,681,196 (+)NCBICHM1_1
T2T-CHM13v2.01662,982,600 - 63,036,458 (+)NCBIT2T-CHM13v2.0
Rspry1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,328,569 - 95,386,905 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,328,565 - 95,386,903 (+)EnsemblGRCm39 Ensembl
GRCm38894,601,941 - 94,660,276 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,601,937 - 94,660,275 (+)EnsemblGRCm38mm10GRCm38
MGSCv37897,125,841 - 97,184,176 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,491,109 - 97,548,982 (+)NCBIMGSCv36mm8
Celera898,935,623 - 98,988,663 (+)NCBICelera
Cytogenetic Map8C5NCBI
Rspry1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,843,671 - 14,884,742 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,843,521 - 14,884,083 (+)NCBIChiLan1.0ChiLan1.0
RSPRY1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11656,596,843 - 56,648,085 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,596,851 - 56,648,085 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01637,464,158 - 37,515,481 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RSPRY1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,139,908 - 59,186,340 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,141,107 - 59,186,724 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha255,768,089 - 55,814,514 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,678,215 - 59,724,611 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,678,192 - 59,724,597 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,509,629 - 56,555,927 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,516,879 - 57,563,294 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,410,958 - 58,457,378 (-)NCBIUU_Cfam_GSD_1.0
Rspry1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,250,412 - 50,294,665 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,294,340 - 9,340,268 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049364759,294,421 - 9,338,372 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RSPRY1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl619,154,417 - 19,204,826 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1619,154,413 - 19,204,827 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2617,159,489 - 17,195,780 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RSPRY1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1543,137,942 - 43,187,327 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl543,155,963 - 43,188,765 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,131,948 - 33,181,777 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rspry1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474628,808,364 - 28,862,113 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474628,808,364 - 28,862,125 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rspry1
217 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:24
Count of miRNA genes:21
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000023988
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat

Markers in Region
AI608258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,352,649 - 10,352,794 (+)MAPPERmRatBN7.2
Rnor_6.01910,769,403 - 10,769,547NCBIRnor6.0
Rnor_5.01910,763,660 - 10,763,804UniSTSRnor5.0
RGSC_v3.41910,792,991 - 10,793,135UniSTSRGSC3.4
Celera1910,242,054 - 10,242,198UniSTS
Cytogenetic Map19p12UniSTS
BF390149  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,362,533 - 10,362,700 (+)MAPPERmRatBN7.2
Rnor_6.01910,779,287 - 10,779,453NCBIRnor6.0
Rnor_5.01910,773,731 - 10,773,897UniSTSRnor5.0
RGSC_v3.41910,803,598 - 10,803,764UniSTSRGSC3.4
Celera1910,251,963 - 10,252,129UniSTS
RH 3.4 Map1995.52UniSTS
Cytogenetic Map19p12UniSTS
RH138519  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,353,125 - 10,353,263 (+)MAPPERmRatBN7.2
Rnor_6.01910,769,879 - 10,770,016NCBIRnor6.0
Rnor_5.01910,764,136 - 10,764,273UniSTSRnor5.0
RGSC_v3.41910,793,467 - 10,793,604UniSTSRGSC3.4
Celera1910,242,530 - 10,242,667UniSTS
RH 3.4 Map19104.7UniSTS
Cytogenetic Map19p12UniSTS
AI009640  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,352,489 - 10,352,674 (+)MAPPERmRatBN7.2
Rnor_6.01910,769,243 - 10,769,427NCBIRnor6.0
Rnor_5.01910,763,500 - 10,763,684UniSTSRnor5.0
RGSC_v3.41910,792,831 - 10,793,015UniSTSRGSC3.4
Celera1910,241,894 - 10,242,078UniSTS
RH 3.4 Map19104.6UniSTS
Cytogenetic Map19p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 22 39 23 19 23 1 1 74 35 41 11 1
Low 21 18 18 18 7 10 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000090217   ⟹   ENSRNOP00000071830
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,353,821 - 10,401,102 (-)Ensembl
Rnor_6.0 Ensembl1910,770,574 - 10,826,895 (-)Ensembl
RefSeq Acc Id: NM_001100945   ⟹   NP_001094415
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21910,353,819 - 10,401,102 (-)NCBI
Rnor_6.01910,770,572 - 10,826,895 (-)NCBI
Rnor_5.01910,764,829 - 10,820,883 (-)NCBI
RGSC_v3.41910,794,160 - 10,843,023 (-)RGD
Celera1910,243,223 - 10,290,488 (-)RGD
Sequence:
RefSeq Acc Id: XM_039097997   ⟹   XP_038953925
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21910,352,449 - 10,403,015 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001094415 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953925 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI29113 (Get FASTA)   NCBI Sequence Viewer  
  EDL87335 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001094415   ⟸   NM_001100945
- Peptide Label: precursor
- UniProtKB: A1L1K9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071830   ⟸   ENSRNOT00000090217
RefSeq Acc Id: XP_038953925   ⟸   XM_039097997
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K1G4 (UniProtKB/TrEMBL)
Protein Domains
B30.2/SPRY   RING-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K1G4-F1-model_v2 AlphaFold A0A0G2K1G4 1-578 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308847 AgrOrtholog
BioCyc Gene G2FUF-6502 BioCyc
Ensembl Genes ENSRNOG00000060931 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000071830 ENTREZGENE
  ENSRNOP00000071830.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000090217 ENTREZGENE
  ENSRNOT00000090217.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/TrEMBL
  3.30.40.10 UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/TrEMBL
  B302/SPRY UniProtKB/TrEMBL
  ConA-like_dom UniProtKB/TrEMBL
  RNF123/RSPRY1-like UniProtKB/TrEMBL
  SPRY_rcpt UniProtKB/TrEMBL
  SPRY_RSPRY1 UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:689249 UniProtKB/TrEMBL
NCBI Gene 689249 ENTREZGENE
PANTHER PTHR13363 UniProtKB/TrEMBL
Pfam SPRY UniProtKB/TrEMBL
PhenoGen Rspry1 PhenoGen
PROSITE B302_SPRY UniProtKB/TrEMBL
  ZF_RING_2 UniProtKB/TrEMBL
SMART RING UniProtKB/TrEMBL
  SPRY UniProtKB/TrEMBL
Superfamily-SCOP ConA_like_lec_gl UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
UniProt A0A0G2K1G4 ENTREZGENE, UniProtKB/TrEMBL
  A1L1K9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-22 Rspry1  ring finger and SPRY domain containing 1  LOC689249  similar to F16A11.1  Data Merged 737654 APPROVED
2008-09-05 Rspry1  ring finger and SPRY domain containing 1  RGD1308847  similar to SPla/RYanodine receptor SPRY (1J970)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308847  similar to SPla/RYanodine receptor SPRY (1J970)   RGD1308847_predicted  similar to SPla/RYanodine receptor SPRY (1J970) (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC689249  similar to F16A11.1      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 RGD1308847_predicted  similar to SPla/RYanodine receptor SPRY (1J970) (predicted)  LOC291860_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC291860_predicted  similar to SPla/RYanodine receptor SPRY (1J970) (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL