Fkbp8 (FKBP prolyl isomerase 8) - Rat Genome Database

Name: Fkbp8
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Fkbp8 (FKBP prolyl isomerase 8) Rattus norvegicus

Analyze

Symbol:

Fkbp8

Name:

FKBP prolyl isomerase 8

RGD ID:

1308670

Description:

Predicted to enable disordered domain specific binding activity; identical protein binding activity; and protein folding chaperone. Predicted to be involved in negative regulation of protein phosphorylation and positive regulation by host of viral transcription. Predicted to act upstream of or within several processes, including dorsal/ventral neural tube patterning; positive regulation of BMP signaling pathway; and smoothened signaling pathway. Predicted to be located in cytosol; endoplasmic reticulum; and mitochondrial envelope. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of protein-containing complex. Orthologous to human FKBP8 (FKBP prolyl isomerase 8); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 4-amino-2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

FK506 binding protein 8; FK506 binding protein 8, 38kDa; FK506-binding protein 8; FKBP-8; LOC290652; MGC125185; peptidyl-prolyl cis-trans isomerase; peptidyl-prolyl cis-trans isomerase FKBP8; PPIase; PPIase FKBP8; rotamase

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FKBP8 (FKBP prolyl isomerase 8)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Fkbp8 (FK506 binding protein 8)	HGNC	NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Fkbp8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FKBP8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FKBP8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fkbp8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FKBP8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FKBP8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fkbp8 (FKBP prolyl isomerase 8)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	FKBP8 (FKBP prolyl isomerase 8)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Mus musculus (house mouse):	Fkbp8 (FK506 binding protein 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Danio rerio (zebrafish):	fkbp8 (FKBP prolyl isomerase 8)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	zda	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	18,895,608 - 18,902,648 (-)	NCBI
Rnor_6.0 Ensembl	16	20,645,957 - 20,652,889 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	20,645,956 - 20,652,890 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	20,501,665 - 20,508,369 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,401,883 - 19,407,192 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	19,401,881 - 19,408,527 (-)	NCBI
Celera	16	19,087,049 - 19,094,012 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

clubfoot (ISS)

Marfanoid Mental Retardation Syndrome, Autosomal (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,6-trinitrotoluene (EXP)

3,4-methylenedioxymethamphetamine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-amino-2,6-dinitrotoluene (EXP)

all-trans-4-oxoretinoic acid (ISO)

all-trans-retinoic acid (ISO)

atrazine (ISO)

bisphenol A (EXP)

cadmium dichloride (EXP)

chlorpyrifos (ISO)

chromium(6+) (ISO)

ciguatoxin CTX1B (ISO)

clofibrate (ISO)

doxorubicin (ISO)

ethanol (ISO)

fenofibrate (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

isotretinoin (ISO)

methotrexate (ISO)

N-methyl-4-phenylpyridinium (ISO)

ochratoxin A (ISO)

paracetamol (ISO)

pentachlorophenol (ISO)

pioglitazone (ISO)

quercetin (ISO)

rotenone (ISO)

sodium arsenite (EXP)

tert-butyl hydroperoxide (ISO)

testosterone enanthate (ISO)

tetrahydropalmatine (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IEA)

camera-type eye development (ISO)

cell fate specification (ISO)

dorsal/ventral neural tube patterning (ISO)

dorsal/ventral pattern formation (ISO)

multicellular organism growth (ISO)

negative regulation of apoptotic process (ISO)

negative regulation of protein phosphorylation (ISO)

neural tube development (ISO)

positive regulation by host of viral transcription (ISO)

positive regulation of BMP signaling pathway (ISO)

protein folding (ISO)

protein peptidyl-prolyl isomerization (IEA)

regulation of BMP signaling pathway (ISO)

regulation of gene expression (ISO)

smoothened signaling pathway (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

endoplasmic reticulum (ISO)

integral component of endoplasmic reticulum membrane (ISO)

mitochondrial envelope (ISO)

mitochondrial membrane (IEA)

mitochondrion (ISO)

protein-containing complex (ISO)

Molecular Function

disordered domain specific binding (ISO)

identical protein binding (ISO)

peptidyl-prolyl cis-trans isomerase activity (IEA)

protein binding (ISO)

protein folding chaperone (ISO)

References

References - curated


1.	GOA data from the GO Consortium
2.	MGD data from the GO Consortium
3.	RGD automated data pipeline
4.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:15105374	PMID:15733859	PMID:17024179	PMID:18003640	PMID:18590716	PMID:18614015	PMID:19946888	PMID:26748656	PMID:29916806	PMID:31505169

Genomics

Comparative Map Data

Fkbp8
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	16	18,895,608 - 18,902,648 (-)	NCBI
Rnor_6.0 Ensembl	16	20,645,957 - 20,652,889 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	16	20,645,956 - 20,652,890 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	16	20,501,665 - 20,508,369 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	19,401,883 - 19,407,192 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	16	19,401,881 - 19,408,527 (-)	NCBI
Celera	16	19,087,049 - 19,094,012 (-)	NCBI		Celera
Cytogenetic Map	16	p14	NCBI

FKBP8
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	19	18,531,751 - 18,544,077 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	19	18,531,763 - 18,543,573 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	19	18,642,573 - 18,654,383 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	18,503,568 - 18,515,383 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	19	18,503,567 - 18,515,383	NCBI
Celera	19	18,544,773 - 18,556,588 (-)	NCBI
Cytogenetic Map	19	p13.11	NCBI
HuRef	19	18,205,047 - 18,217,230 (-)	NCBI		HuRef
CHM1_1	19	18,643,053 - 18,654,863 (-)	NCBI		CHM1_1

Fkbp8
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	70,980,371 - 70,987,978 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	8	70,980,374 - 70,987,978 (+)	Ensembl
GRCm38	8	70,527,721 - 70,535,328 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	70,527,724 - 70,535,328 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	73,051,642 - 73,059,227 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	73,458,516 - 73,464,312 (+)	NCBI			mm8
Celera	8	73,084,164 - 73,091,753 (+)	NCBI		Celera
Cytogenetic Map	8	B3.3	NCBI

Fkbp8
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955524	3,036,953 - 3,044,296 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955524	3,037,825 - 3,044,296 (+)	NCBI	ChiLan1.0	ChiLan1.0

FKBP8
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	19	18,980,269 - 18,992,170 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	18,980,269 - 18,992,170 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	19	18,009,505 - 18,021,772 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

FKBP8
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	44,494,856 - 44,504,084 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	44,489,219 - 44,598,497 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	44,409,560 - 44,418,774 (+)	NCBI
ROS_Cfam_1.0	20	44,981,067 - 44,990,281 (+)	NCBI
UMICH_Zoey_3.1	20	44,218,433 - 44,227,646 (+)	NCBI
UNSW_CanFamBas_1.0	20	44,628,579 - 44,637,790 (+)	NCBI
UU_Cfam_GSD_1.0	20	44,904,032 - 44,913,247 (+)	NCBI

Fkbp8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	203,177,956 - 203,186,579 (+)	NCBI
SpeTri2.0	NW_004936596	2,728,089 - 2,735,718 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FKBP8
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	59,252,073 - 59,267,165 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	59,256,546 - 59,267,171 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	59,035,636 - 59,046,247 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FKBP8
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	17,007,764 - 17,018,409 (-)	NCBI
ChlSab1.1 Ensembl	6	17,007,390 - 17,017,714 (-)	Ensembl
Vero_WHO_p1.0	NW_023666074	2,321,762 - 2,332,880 (+)	NCBI

Fkbp8
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624908	1,713,590 - 1,720,709 (-)	NCBI

Position Markers

RH128354

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	18,895,671 - 18,895,853 (+)	MAPPER
Rnor_6.0	16	20,646,020 - 20,646,201	NCBI	Rnor6.0
Rnor_5.0	16	20,501,729 - 20,501,910	UniSTS	Rnor5.0
RGSC_v3.4	16	19,401,947 - 19,402,128	UniSTS	RGSC3.4
Celera	16	19,087,113 - 19,087,294	UniSTS
RH 3.4 Map	16	214.6	UniSTS
Cytogenetic Map	16	p14	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	24228366	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	27556253	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	27556253	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	27556253	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	31816439	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	33160624	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	34465490	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	41240937	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	41240937	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		hepatic copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	41240957	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	244593	45244593	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	1090054	86162972	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1340741	46340741	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	1550187	49247447	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	1550187	63210301	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1550187	63210301	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	1550187	63210301	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	1550187	63210301	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1728297	46728297	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	4136355	23105837	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4136355	45905331	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	5013802	45905331	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	5013802	45905331	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	5013802	45905331	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	5013802	50013802	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	5013802	50169318	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	5013802	52144919	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	5013802	64012784	Rat
631517	Scl9	Serum cholesterol level QTL 9	3.3		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	16	17309396	22744540	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor depth of invasion (CMO:0001888)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	19398187	70590230	Rat
70205	Gcr3	Gastric cancer resistance QTL 3	2.3		stomach morphology trait (VT:0000470)	stomach tumor diameter (CMO:0001889)	16	19398187	70590230	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	76
Count of miRNA genes:	62
Interacting mature miRNAs:	68
Transcripts:	ENSRNOT00000027040
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	43	57	41	19	41	8	11	74	35	41	11	8
Low
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001037180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094322	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094323	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094325	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094327	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039094328	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC107454	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ216680	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219623	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000275	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000077756 ⟹ ENSRNOP00000074539

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	20,645,957 - 20,652,889 (-)	Ensembl

RefSeq Acc Id:

NM_001037180 ⟹ NP_001032257

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,570 (-)	NCBI
Rnor_6.0	16	20,645,956 - 20,652,890 (-)	NCBI
Rnor_5.0	16	20,501,665 - 20,508,369 (-)	NCBI
RGSC_v3.4	16	19,401,883 - 19,407,192 (-)	RGD
Celera	16	19,087,049 - 19,094,012 (-)	RGD

Sequence:

show sequence

CTGGGGGTGGGGAGGGGGGCACAGGACCCCAAGCGGGGTCCCCAAGCCGCAGGGCCAGTTCCTG
ATCCCCCAGCAGCATGGCGTCTTGGGCCGAGCCCTCTGAGCCTGCTGCCCAGCTACTTTGTGGG
GCCCCACTCCTGGAGGGCTTTGAGGTGCTTGATGGGGTTGATGATGCAGAGGAGGAAGATGACC
TAAGTGGGTTGCCACCACTAGAGGATATGGGACAGCCTACGGTGGAGGAGGCTGAGCAGCCTGG
AGCCCTAGCTCGGGAGTTCCTGGCAGCCACAGAGCCTGAGCCAGCCCCAGCCCCCGCCCCGGAA
GAGTGGCTGGACATTCTGGGGAACGGATTGCTGCGTAAGAAGACACTGGTCCCAGGCCCAACAG
GCTCTAGCCGCCCACTCAAGGGCCAGGTGGTGACCGTACACCTGCAGATGTCCCTGGAGAATGG
CACCCGTGTGCAAGAGGAGCCCGAACTGGCTTTCACGCTTGGAGACTGCGATGTTATCCAGGCC
CTGGACCTCAGCGTCCCGCTCATGCATGTGGGCGAGACAGCAATGGTCACCGCTGACTCCAAGT
ACTGCTACGGTCCCCAGGGCAGCAGGAGCCCATACATCCCCCCCCATGCAGCCCTGTGCCTGGA
AGTCACCCTGAAGACAGCAGAGGATGGACCTGACCTGGAGATGCTGAGTGGGCAGGAGCGCGTG
GCCCTGGCCAACCGCAAGCGGGAGTGTGGCAATGCCCACTACCAGCGTGCTGACTTTGTGCTGG
CTGCCAACTCCTATGACCTGGCCATCAAGGCCATCACCTCCAACGCCAAAGTGGACATGACTTG
TGAGGAGGAGGAGGAGCTGCTACAGCTGAAGGTCAAGTGTCTGAACAACCTTGCGGCATCGCAG
CTAAAGCTGGACCACTACCGAGCAGCACTGCGCTCCTGTAGCCAGGTGCTGGAGCACCAGCCAG
ACAACATCAAGGCACTGTTCCGCAAGGGCAAGGTGCTGGCTCAGCAGGGTGAATACAGTGAGGC
CATCCCCATCCTGAGGGCGGCCCTGAAGCTGGAGCCTTCCAACAAGACGATCCATGCGGAGCTC
TCAAAGCTGGTAAAGAAGCGTGCTGCACAGCGGAGCACAGAGACTGCCCTGTACCGAAAGATGC
TAGGCAACCCCAGCCGGCTGCCTGCCAAGTGTCCGGGCAAGGGTGCCTGGTCCATCCCGTGGAA
ATGGCTGTTTGGGGCAACTGCCGTGGCCCTGGGGGGCGTGGCTCTCTCTGTGGTCATTGCTGCC
AGGAACTGACTGTCCCCCTGCATACCTGGACCCCAACCTGTGCTCCCCAACTCCCCCAGGCTCC
CTGTCCACTGCCCTCCCTGGCCGAGACACCTCCTATGGGTTGGGGGAGCAAGGATTGAGGGTCG
CACACCCCAACAAGCAGGAAAGACTGAGACCCTGAAAGGGGGCATGGGGTACAGCCCAGAGGGA
GGGGCCCTGTTCCTCCAGACCCAGTTGTCTCTCTCCCACAACCCTGTTGTCCTCTGGGGTCAGG
CCTCAGCTGGGGCAGCCTCAGTTTTCCCTCAGTAGGCCTGGGGGCAGCACTACCATTCCTTCCT
GCCCGCCTGCACCCTCTGTCCAGGCTTCCCCACAGTGATTTAAATAAAGCCTCACCCCACACCC
TAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039094321 ⟹ XP_038950249

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,648 (-)	NCBI

RefSeq Acc Id:

XM_039094322 ⟹ XP_038950250

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,452 (-)	NCBI

RefSeq Acc Id:

XM_039094323 ⟹ XP_038950251

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,600 (-)	NCBI

RefSeq Acc Id:

XM_039094324 ⟹ XP_038950252

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,301 (-)	NCBI

RefSeq Acc Id:

XM_039094325 ⟹ XP_038950253

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,648 (-)	NCBI

RefSeq Acc Id:

XM_039094326 ⟹ XP_038950254

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,452 (-)	NCBI

RefSeq Acc Id:

XM_039094327 ⟹ XP_038950255

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,648 (-)	NCBI

RefSeq Acc Id:

XM_039094328 ⟹ XP_038950256

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	16	18,895,608 - 18,902,600 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001032257	(Get FASTA)	NCBI Sequence Viewer
	XP_038950249	(Get FASTA)	NCBI Sequence Viewer
	XP_038950250	(Get FASTA)	NCBI Sequence Viewer
	XP_038950251	(Get FASTA)	NCBI Sequence Viewer
	XP_038950252	(Get FASTA)	NCBI Sequence Viewer
	XP_038950253	(Get FASTA)	NCBI Sequence Viewer
	XP_038950254	(Get FASTA)	NCBI Sequence Viewer
	XP_038950255	(Get FASTA)	NCBI Sequence Viewer
	XP_038950256	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI07455	(Get FASTA)	NCBI Sequence Viewer
	EDL90703	(Get FASTA)	NCBI Sequence Viewer
	EDL90704	(Get FASTA)	NCBI Sequence Viewer
	EDL90705	(Get FASTA)	NCBI Sequence Viewer
	EDL90706	(Get FASTA)	NCBI Sequence Viewer
	EDL90707	(Get FASTA)	NCBI Sequence Viewer
	EDL90708	(Get FASTA)	NCBI Sequence Viewer
	Q3B7U9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001032257 ⟸ NM_001037180

- UniProtKB:

Q3B7U9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MASWAEPSEPAAQLLCGAPLLEGFEVLDGVDDAEEEDDLSGLPPLEDMGQPTVEEAEQPGALAR
EFLAATEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPTGSSRPLKGQVVTVHLQMSLENGTRVQ
EEPELAFTLGDCDVIQALDLSVPLMHVGETAMVTADSKYCYGPQGSRSPYIPPHAALCLEVTLK
TAEDGPDLEMLSGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAITSNAKVDMTCEEEE
ELLQLKVKCLNNLAASQLKLDHYRAALRSCSQVLEHQPDNIKALFRKGKVLAQQGEYSEAIPIL
RAALKLEPSNKTIHAELSKLVKKRAAQRSTETALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFG
ATAVALGGVALSVVIAARN

hide sequence

RefSeq Acc Id:

ENSRNOP00000074539 ⟸ ENSRNOT00000077756

RefSeq Acc Id:	XP_038950255 ⟸ XM_039094327
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038950253 ⟸ XM_039094325
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038950249 ⟸ XM_039094321
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038950256 ⟸ XM_039094328
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038950251 ⟸ XM_039094323
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038950254 ⟸ XM_039094326
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038950250 ⟸ XM_039094322
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038950252 ⟸ XM_039094324
- Peptide Label:	isoform X1

Protein Domains

PPIase FKBP-type

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700026

Promoter ID:

EPDNEW_R10549

Type:

multiple initiation site

Name:

Fkbp8_1

Description:

FK506 binding protein 8

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	20,652,925 - 20,652,985	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308670	AgrOrtholog
Ensembl Genes	ENSRNOG00000058359	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000074539	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000077756	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	1.25.40.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7378812	IMAGE-MGC_LOAD
InterPro	PPIase_FKBP_dom	UniProtKB/Swiss-Prot
	TPR-contain_dom	UniProtKB/Swiss-Prot
	TPR-like_helical_dom_sf	UniProtKB/Swiss-Prot
	TPR_repeat	UniProtKB/Swiss-Prot
KEGG Report	rno:290652	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:125185	IMAGE-MGC_LOAD
NCBI Gene	290652	ENTREZGENE
Pfam	FKBP_C	UniProtKB/Swiss-Prot
PhenoGen	Fkbp8	PhenoGen
PROSITE	FKBP_PPIASE	UniProtKB/Swiss-Prot
	TPR	UniProtKB/Swiss-Prot
	TPR_REGION	UniProtKB/Swiss-Prot
SMART	TPR	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48452	UniProtKB/Swiss-Prot
UniProt	FKBP8_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-11-09	Fkbp8	FKBP prolyl isomerase 8	Fkbp8	FK506 binding protein 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2009-10-22	Fkbp8	FK506 binding protein 8	Fkbp8	FK506 binding protein 8, 38kDa	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-09-24	Fkbp8	FK506 binding protein 8, 38kDa	Fkbp8	FK506 binding protein 8	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Fkbp8	FK506 binding protein 8	Fkbp8_predicted	FK506 binding protein 8 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Fkbp8_predicted	FK506 binding protein 8 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI