Dnlz (DNL-type zinc finger) - Rat Genome Database

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Gene: Dnlz (DNL-type zinc finger) Rattus norvegicus
Analyze
Symbol: Dnlz
Name: DNL-type zinc finger
RGD ID: 1308635
Description: Predicted to enable protein folding chaperone and protein-folding chaperone binding activity. Predicted to be involved in several processes, including chaperone-mediated protein complex assembly; protein import into mitochondrial matrix; and protein stabilization. Predicted to be located in nucleoplasm. Predicted to be active in cytosol; mitochondrion; and nucleus. Orthologous to human DNLZ (DNL-type zinc finger); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC296587; MGC189536; RGD1308635; similar to CG12379-PA
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,568,041 - 29,569,937 (-)NCBIGRCr8
mRatBN7.239,169,948 - 9,171,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,169,793 - 9,180,551 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,223,325 - 12,225,104 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,806,555 - 20,808,334 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,061,892 - 19,063,671 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,796,480 - 3,798,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,796,480 - 3,798,239 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,157,626 - 9,159,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,522,915 - 4,524,662 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,522,914 - 4,524,733 (-)NCBI
Celera33,989,863 - 3,991,610 (-)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytosol  (ISO)
mitochondrion  (IBA,ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:12477932   PMID:18614015  


Genomics

Comparative Map Data
Dnlz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8329,568,041 - 29,569,937 (-)NCBIGRCr8
mRatBN7.239,169,948 - 9,171,727 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl39,169,793 - 9,180,551 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx312,223,325 - 12,225,104 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,806,555 - 20,808,334 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0319,061,892 - 19,063,671 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.033,796,480 - 3,798,467 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl33,796,480 - 3,798,239 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.039,157,626 - 9,159,542 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.434,522,915 - 4,524,662 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.134,522,914 - 4,524,733 (-)NCBI
Celera33,989,863 - 3,991,610 (-)NCBICelera
Cytogenetic Map3p13NCBI
DNLZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,359,483 - 136,363,744 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,359,480 - 136,363,744 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,253,935 - 139,258,196 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,376,173 - 138,378,062 (-)NCBINCBI36Build 36hg18NCBI36
Celera9109,771,288 - 109,773,177 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9108,715,708 - 108,717,619 (-)NCBIHuRef
CHM1_19139,404,548 - 139,406,459 (-)NCBICHM1_1
T2T-CHM13v2.09148,588,818 - 148,593,075 (-)NCBIT2T-CHM13v2.0
Dnlz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,238,130 - 26,242,122 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl226,238,133 - 26,242,122 (-)EnsemblGRCm39 Ensembl
GRCm38226,348,118 - 26,352,110 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,348,121 - 26,352,110 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,203,638 - 26,207,630 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36226,203,643 - 26,207,630 (-)NCBIMGSCv36mm8
Celera226,065,813 - 26,069,805 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.87NCBI
Dnlz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,359,421 - 4,361,081 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,359,421 - 4,361,081 (+)NCBIChiLan1.0ChiLan1.0
DNLZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2113,022,675 - 3,024,687 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan193,025,204 - 3,029,437 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,432,709 - 107,436,360 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,411,832 - 136,416,279 (-)NCBIpanpan1.1PanPan1.1panPan2
DNLZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1949,120,802 - 49,122,789 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl949,120,818 - 49,122,804 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha948,371,497 - 48,373,350 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,997,572 - 49,999,427 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,997,567 - 50,001,581 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,778,121 - 48,779,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0949,072,294 - 49,074,228 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0949,119,821 - 49,121,756 (+)NCBIUU_Cfam_GSD_1.0
Dnlz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947201,935,149 - 201,936,953 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366691,438,227 - 1,439,814 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366691,438,129 - 1,439,909 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNLZ
(Sus scrofa - pig)
No map positions available.
DNLZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,841,598 - 1,846,006 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,841,738 - 1,843,462 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660583,370,130 - 3,374,604 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnlz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247601,531,439 - 1,533,170 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247601,531,439 - 1,533,176 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Dnlz
3 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:87
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000025386
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358357Srcrtb1Stress Responsive Cort Basal QTL 16.360.002blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)3865816227494778Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
1298526Arunc3Aerobic running capacity QTL 32.2exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)3822719433703538Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
70203Gcr2Gastric cancer resistance QTL 22.6stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)3865816227494778Rat
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat

Markers in Region
RH125204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.239,170,008 - 9,170,170 (+)MAPPERmRatBN7.2
mRatBN7.239,170,008 - 9,171,636 (+)MAPPERmRatBN7.2
Rnor_6.033,796,541 - 3,798,168NCBIRnor6.0
Rnor_6.033,796,541 - 3,796,702NCBIRnor6.0
Rnor_5.039,157,688 - 9,159,315UniSTSRnor5.0
Rnor_5.039,157,688 - 9,157,849UniSTSRnor5.0
RGSC_v3.434,522,976 - 4,523,137UniSTSRGSC3.4
RGSC_v3.434,522,976 - 4,524,603UniSTSRGSC3.4
Celera33,989,924 - 3,991,551UniSTS
Celera33,989,924 - 3,990,085UniSTS
Cytogenetic Map3p13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000025386   ⟹   ENSRNOP00000025386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl39,169,793 - 9,180,551 (-)Ensembl
Rnor_6.0 Ensembl33,796,480 - 3,798,177 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076156   ⟹   ENSRNOP00000068367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,796,480 - 3,798,227 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076487   ⟹   ENSRNOP00000068138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl33,796,480 - 3,798,239 (-)Ensembl
RefSeq Acc Id: NM_001130990   ⟹   NP_001124462
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,568,041 - 29,569,820 (-)NCBI
mRatBN7.239,169,948 - 9,171,727 (-)NCBI
Rnor_6.033,796,480 - 3,798,227 (-)NCBI
Rnor_5.039,157,626 - 9,159,542 (-)NCBI
RGSC_v3.434,522,915 - 4,524,662 (-)RGD
Celera33,989,863 - 3,991,610 (-)RGD
Sequence:
RefSeq Acc Id: NR_024073
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,568,041 - 29,569,820 (-)NCBI
mRatBN7.239,169,948 - 9,171,727 (-)NCBI
Rnor_6.033,796,480 - 3,798,227 (-)NCBI
Rnor_5.039,157,626 - 9,159,542 (-)NCBI
RGSC_v3.434,522,915 - 4,524,662 (-)RGD
Celera33,989,863 - 3,991,610 (-)RGD
Sequence:
RefSeq Acc Id: XM_063283470   ⟹   XP_063139540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8329,569,128 - 29,569,937 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001124462 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139540 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93510 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025386.5
RefSeq Acc Id: NP_001124462   ⟸   NM_001130990
- UniProtKB: A6JTD6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025386   ⟸   ENSRNOT00000025386
Ensembl Acc Id: ENSRNOP00000068367   ⟸   ENSRNOT00000076156
Ensembl Acc Id: ENSRNOP00000068138   ⟸   ENSRNOT00000076487
RefSeq Acc Id: XP_063139540   ⟸   XM_063283470
- Peptide Label: isoform X1
Protein Domains
DNL-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZWJ1-F1-model_v2 AlphaFold D3ZWJ1 1-173 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691901
Promoter ID:EPDNEW_R2426
Type:multiple initiation site
Name:Dnlz_1
Description:DNL-type zinc finger
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.033,798,169 - 3,798,229EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308635 AgrOrtholog
BioCyc Gene G2FUF-50387 BioCyc
Ensembl Genes ENSRNOG00000018791 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025386.7 UniProtKB/TrEMBL
InterPro Mt_import_TIM15 UniProtKB/TrEMBL
  Znf_Zim17 UniProtKB/TrEMBL
KEGG Report rno:296587 UniProtKB/TrEMBL
NCBI Gene 296587 ENTREZGENE
PANTHER DNL-TYPE ZINC FINGER PROTEIN UniProtKB/TrEMBL
  Znf_Zim17 UniProtKB/TrEMBL
Pfam zf-DNL UniProtKB/TrEMBL
PhenoGen Dnlz PhenoGen
PROSITE ZF_DNL UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018791 RatGTEx
UniProt A6JTD6 ENTREZGENE, UniProtKB/TrEMBL
  D3ZWJ1_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-22 Dnlz  DNL-type zinc finger  RGD1308635  similar to CG12379-PA   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1308635  similar to CG12379-PA   RGD1308635_predicted  similar to CG12379-PA (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1308635_predicted  similar to CG12379-PA (predicted)  LOC296587_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC296587_predicted  similar to CG12379-PA (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL