Tasp1 (taspase 1) - Rat Genome Database
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Gene: Tasp1 (taspase 1) Rattus norvegicus
Analyze
Symbol: Tasp1
Name: taspase 1
RGD ID: 1308591
Description: Predicted to have identical protein binding activity and threonine-type endopeptidase activity. Predicted to be involved in positive regulation of transcription, DNA-templated; protein maturation; and proteolysis. Predicted to localize to cytoplasm. Orthologous to human TASP1 (taspase 1); INTERACTS WITH 2,4-dinitrotoluene; acrylamide; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC311468; MGC125209; RGD1308591; similar to 4930485D02Rik protein; taspase, threonine aspartase 1; threonine aspartase 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Tasp1Tn(sb-T2/Bart3)2.219Mcwi  
Genetic Models: F344-Tasp1Tn(sb-T2/Bart3)2.219Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03132,888,785 - 133,131,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3132,888,772 - 133,131,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03139,347,611 - 139,588,372 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43128,002,479 - 128,228,127 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13127,907,732 - 128,133,709 (-)NCBI
Celera3125,825,868 - 126,047,420 (-)NCBICelera
Cytogenetic Map3q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:14636557   PMID:16216576   PMID:22829979  


Genomics

Comparative Map Data
Tasp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.03132,888,785 - 133,131,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3132,888,772 - 133,131,192 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03139,347,611 - 139,588,372 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43128,002,479 - 128,228,127 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13127,907,732 - 128,133,709 (-)NCBI
Celera3125,825,868 - 126,047,420 (-)NCBICelera
Cytogenetic Map3q36NCBI
TASP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2013,389,392 - 13,638,932 (-)EnsemblGRCh38hg38GRCh38
GRCh382013,104,760 - 13,638,932 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372013,370,036 - 13,619,583 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362013,318,036 - 13,567,583 (-)NCBINCBI36hg18NCBI36
Build 342013,318,038 - 13,558,799NCBI
Celera2013,440,107 - 13,689,648 (-)NCBI
Cytogenetic Map20p12.1NCBI
HuRef2013,324,503 - 13,574,057 (-)NCBIHuRef
CHM1_12013,370,132 - 13,618,116 (-)NCBICHM1_1
Tasp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392139,675,399 - 139,908,767 (-)NCBIGRCm39mm39
GRCm382139,833,479 - 140,066,847 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2139,833,480 - 140,066,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv372139,659,216 - 139,892,521 (-)NCBIGRCm37mm9NCBIm37
MGSCv362139,525,027 - 139,758,201 (-)NCBImm8
Celera2141,009,953 - 141,252,432 (-)NCBICelera
Cytogenetic Map2F3NCBI
Tasp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541522,855,822 - 23,091,732 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541522,856,382 - 23,091,732 (-)NCBIChiLan1.0ChiLan1.0
TASP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12013,335,443 - 13,584,376 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2013,335,443 - 13,584,378 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02013,350,135 - 13,599,861 (-)NCBIMhudiblu_PPA_v0panPan3
TASP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl249,001,246 - 9,324,695 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1249,001,175 - 9,314,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Tasp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364856,163,809 - 6,460,361 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TASP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1721,964,431 - 22,357,476 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11721,963,369 - 22,358,444 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21724,534,792 - 24,918,068 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TASP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1242,284,264 - 42,529,551 (-)NCBI
ChlSab1.1 Ensembl242,283,687 - 42,529,488 (-)Ensembl
Tasp1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474114,341,076 - 14,633,441 (-)NCBI

Position Markers
RH140780  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03132,913,832 - 132,914,035NCBIRnor6.0
Rnor_6.01238,095,882 - 38,096,063NCBIRnor6.0
Rnor_5.01239,967,088 - 39,967,269UniSTSRnor5.0
Rnor_5.03139,372,508 - 139,372,711UniSTSRnor5.0
RGSC_v3.43128,028,504 - 128,028,707UniSTSRGSC3.4
RGSC_v3.41233,797,460 - 33,797,641UniSTSRGSC3.4
Celera3125,849,602 - 125,849,805UniSTS
Celera1234,350,265 - 34,350,446UniSTS
Cytogenetic Map12q15UniSTS
Cytogenetic Map3q36-q41UniSTS
RH 3.4 Map12574.12UniSTS
AI396692  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.03133,106,044 - 133,106,776NCBIRnor6.0
Rnor_5.03139,563,633 - 139,564,365UniSTSRnor5.0
RGSC_v3.43128,211,460 - 128,212,192UniSTSRGSC3.4
Celera3126,030,852 - 126,031,584UniSTS
Cytogenetic Map3q36-q41UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)330846101172879276Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)339248391140271184Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)343295930163640485Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)343295930163640485Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)345406058177699992Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)348561928155263151Rat
1581568Rf53Renal function QTL 53total urine protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)358204463170534769Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)361241033165369047Rat
1581546Pur13Proteinuria QTL 132.930.0335total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)381136227154416635Rat
7387306Bw124Body weight QTL 1243.20.0003body mass (VT:0001259)body weight (CMO:0000012)388910015133910015Rat
631649Bp123Blood pressure QTL 1233.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)394788365139788365Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)397009185142009185Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)399465522168732722Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3101058963146058963Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3102152812155263151Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3102466149147466149Rat
2312659Slep7Serum leptin concentration QTL 70.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)3103141814176418101Rat
2312670Bw94Body weight QTL 940.01inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)3103141814176418101Rat
2312673Scl63Serum cholesterol level QTL 630.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3103141814176418101Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3103141944170934860Rat
619618Rf3Renal disease susceptibility QTL 36.50.001urine albumin amount (VT:0002871)urine albumin excretion rate to body weight ratio (CMO:0001270)3114376250159376250Rat
1331758Bp207Blood pressure QTL 2072.848arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3117303473141971336Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3119471263164471263Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)3120917788141971336Rat
1358204Insglur1Insulin/glucose ratio QTL 13.8blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)3120917788141971336Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3125848628170848628Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3126575595153412619Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3126575595165355668Rat
1598877Bp285Blood pressure QTL 2851.50.03arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3128986468173986468Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3129787213177699992Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3130006659175006659Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3132875075176418101Rat


Genetic Models
This gene Tasp1 is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:66
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000055630
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 20 5
Low 3 43 57 41 19 41 8 11 54 35 36 11 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001044243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591759 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07053891 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07053892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07053893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07053894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07053895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025374 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025375 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025377 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025378 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025380 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01025381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC105618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000055630   ⟹   ENSRNOP00000052492
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3132,888,772 - 133,131,192 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083637   ⟹   ENSRNOP00000075239
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3132,889,661 - 133,122,691 (-)Ensembl
RefSeq Acc Id: NM_001044243   ⟹   NP_001037708
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03132,889,059 - 133,122,755 (-)NCBI
Rnor_5.03139,347,611 - 139,588,372 (-)NCBI
RGSC_v3.43128,002,479 - 128,228,127 (-)RGD
Celera3125,825,868 - 126,047,420 (-)RGD
Sequence:
RefSeq Acc Id: XM_017591759   ⟹   XP_017447248
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03132,888,785 - 133,131,139 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017591760   ⟹   XP_017447249
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03132,965,567 - 133,131,213 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001037708 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447248 (Get FASTA)   NCBI Sequence Viewer  
  XP_017447249 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI05619 (Get FASTA)   NCBI Sequence Viewer  
  EDL80319 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001037708   ⟸   NM_001044243
- UniProtKB: Q0VGK5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017447248   ⟸   XM_017591759
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447249   ⟸   XM_017591760
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000052492   ⟸   ENSRNOT00000055630
RefSeq Acc Id: ENSRNOP00000075239   ⟸   ENSRNOT00000083637

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692469
Promoter ID:EPDNEW_R2994
Type:multiple initiation site
Name:Tasp1_1
Description:taspase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03133,131,175 - 133,131,235EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
3 128030776 128030777 C T snv ACI/EurMcwi (MCW), FHH/EurMcwi (MCW), SS/JrHsdMcwi (MCW), SR/JrHsd (MCW), FHL/EurMcwi (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308591 AgrOrtholog
Ensembl Genes ENSRNOG00000004493 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000052492 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000075239 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000055630 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000083637 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453153 IMAGE-MGC_LOAD
InterPro Ntn_hydrolases_N UniProtKB/TrEMBL
  Peptidase_T2 UniProtKB/TrEMBL
  Taspase1 UniProtKB/TrEMBL
KEGG Report rno:311468 UniProtKB/TrEMBL
MGC_CLONE MGC:125209 IMAGE-MGC_LOAD
NCBI Gene 311468 ENTREZGENE
PANTHER Peptidase_T2 UniProtKB/TrEMBL
Pfam Asparaginase_2 UniProtKB/TrEMBL
PhenoGen Tasp1 PhenoGen
Superfamily-SCOP SSF56235 UniProtKB/TrEMBL
UniGene Rn.22314 ENTREZGENE
UniProt Q0VGK5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tasp1  taspase, threonine aspartase 1   Tasp1_predicted  taspase, threonine aspartase 1 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Tasp1_predicted  taspase, threonine aspartase 1 (predicted)  RGD1308591_predicted  similar to 4930485D02Rik protein (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1308591_predicted  similar to 4930485D02Rik protein (predicted)  LOC311468_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311468_predicted  similar to 4930485D02Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL