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Gene: Spast (spastin) Rattus norvegicus
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Symbol: Spast
Name: spastin
Description: Predicted to have microtubule-severing ATPase activity and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule cytoskeleton organization; and protein complex oligomerization. Predicted to colocalize with the endoplasmic reticulum; endosome; and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LOC362700; spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant); spastic paraplegia 4 (autosomal dominant, spastin); Spg4
Orthologs:
Homo sapiens (human) : SPAST (spastin)  HGNC  Alliance
Mus musculus (house mouse) : Spast (spastin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Spast (spastin)
Pan paniscus (bonobo/pygmy chimpanzee) : SPAST (spastin)
Canis lupus familiaris (dog) : SPAST (spastin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Spast (spastin)
Sus scrofa (pig) : SPAST (spastin)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0622,230,067 - 22,282,166 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0632,118,321 - 32,168,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4620,990,083 - 21,048,692 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1620,995,867 - 21,051,815 (-)NCBI
Celera620,614,184 - 20,664,224 (-)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
 
More on Spast
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308494
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.