Spast (spastin) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Spast (spastin) Rattus norvegicus
Analyze
Symbol: Spast
Name: spastin
RGD ID: 1308494
Description: Predicted to enable microtubule severing ATPase activity and tubulin binding activity. Predicted to be involved in several processes, including axonal transport; microtubule cytoskeleton organization; and protein complex oligomerization. Predicted to be located in several cellular components, including endoplasmic reticulum tubular network; microtubule cytoskeleton; and nucleus. Predicted to be active in microtubule cytoskeleton. Predicted to colocalize with endoplasmic reticulum; endosome; and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 4. Orthologous to human SPAST (spastin); INTERACTS WITH 2,4-dinitrotoluene; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC362700; spastic paraplegia 4 (autosomal dominant; spastic paraplegia 4 (autosomal dominant); spastic paraplegia 4 (autosomal dominant, spastin); Spg4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8626,807,220 - 26,858,456 (-)NCBIGRCr8
mRatBN7.2621,055,349 - 21,106,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,055,349 - 21,107,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,386,251 - 21,436,870 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0621,702,093 - 21,752,711 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,182,545 - 21,233,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,230,067 - 22,282,166 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,230,928 - 22,281,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0632,118,321 - 32,168,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4620,990,083 - 21,048,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1620,995,867 - 21,051,815 (-)NCBI
Celera620,614,184 - 20,664,224 (-)NCBICelera
Cytogenetic Map6q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO,ISS)
axon cytoplasm  (IEA)
centrosome  (IEA,ISO)
cytoplasm  (ISO)
cytoplasmic vesicle  (ISO)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA,ISO,ISS)
endoplasmic reticulum tubular network  (ISO)
endosome  (IEA,ISO,ISS)
membrane  (IEA)
microtubule  (IEA)
microtubule cytoskeleton  (IBA,ISO,ISS)
midbody  (IEA,ISO,ISS)
nuclear membrane  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)
perinuclear region of cytoplasm  (IEA,ISO)
spindle  (IEA)
spindle pole  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A large family with hereditary spastic paraparesis due to a frame shift mutation of the spastin (SPG4) gene: association with multiple sclerosis in two affected siblings and epilepsy in other affected family members. Mead SH, etal., J Neurol Neurosurg Psychiatry 2001 Dec;71(6):788-91.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12490534   PMID:15716377   PMID:16026783   PMID:16219033   PMID:17389232   PMID:18997780   PMID:19000169   PMID:19056867   PMID:19453301   PMID:20530212   PMID:21310966  
PMID:21545838   PMID:23745751   PMID:23969831   PMID:25390646   PMID:26040712   PMID:26875866   PMID:31963385   PMID:36587525  


Genomics

Comparative Map Data
Spast
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8626,807,220 - 26,858,456 (-)NCBIGRCr8
mRatBN7.2621,055,349 - 21,106,586 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl621,055,349 - 21,107,954 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx621,386,251 - 21,436,870 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0621,702,093 - 21,752,711 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0621,182,545 - 21,233,162 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0622,230,067 - 22,282,166 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl622,230,928 - 22,281,886 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0632,118,321 - 32,168,698 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4620,990,083 - 21,048,692 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1620,995,867 - 21,051,815 (-)NCBI
Celera620,614,184 - 20,664,224 (-)NCBICelera
Cytogenetic Map6q13NCBI
SPAST
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38232,063,556 - 32,157,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl232,063,556 - 32,157,637 (+)EnsemblGRCh38hg38GRCh38
GRCh37232,288,625 - 32,382,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36232,142,184 - 32,236,210 (+)NCBINCBI36Build 36hg18NCBI36
Build 34232,200,330 - 32,294,356NCBI
Celera232,133,566 - 32,227,549 (+)NCBICelera
Cytogenetic Map2p22.3NCBI
HuRef232,027,230 - 32,121,818 (+)NCBIHuRef
CHM1_1232,218,851 - 32,312,626 (+)NCBICHM1_1
T2T-CHM13v2.0232,111,981 - 32,206,198 (+)NCBIT2T-CHM13v2.0
Spast
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391774,643,805 - 74,698,110 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1774,645,982 - 74,698,110 (+)EnsemblGRCm39 Ensembl
GRCm381774,337,923 - 74,391,115 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1774,338,987 - 74,391,115 (+)EnsemblGRCm38mm10GRCm38
MGSCv371774,738,327 - 74,790,453 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361774,243,969 - 74,293,468 (+)NCBIMGSCv36mm8
Celera1778,633,795 - 78,686,156 (+)NCBICelera
Cytogenetic Map17E2NCBI
cM Map1745.64NCBI
Spast
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955441485,815 - 520,452 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955441471,609 - 521,920 (+)NCBIChiLan1.0ChiLan1.0
SPAST
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21294,335,723 - 94,425,719 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A94,339,698 - 94,429,694 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A32,085,245 - 32,175,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A32,150,514 - 32,888,168 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A32,150,792 - 32,885,029 (+)Ensemblpanpan1.1panPan2
SPAST
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11725,393,169 - 25,447,686 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1725,393,422 - 25,446,539 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1725,185,513 - 25,240,078 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01725,955,733 - 26,010,638 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1725,955,693 - 26,011,753 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11725,255,491 - 25,310,582 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01725,327,446 - 25,381,966 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01725,426,764 - 25,481,606 (+)NCBIUU_Cfam_GSD_1.0
Spast
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629269,496,954 - 69,555,811 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364931,283,729 - 1,343,390 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364931,283,754 - 1,342,592 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPAST
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3107,439,813 - 107,508,926 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13107,439,810 - 107,508,915 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23114,454,182 - 114,524,375 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap3q21-q27NCBI
SPAST
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11475,343,437 - 75,429,196 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1475,343,327 - 75,429,139 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604536,643,431 - 36,733,159 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Spast
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473813,721,136 - 13,780,530 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Spast
449 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:703
Count of miRNA genes:294
Interacting mature miRNAs:377
Transcripts:ENSRNOT00000039375
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
1359023Bp272Blood pressure QTL 2722.5arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)61653614027261739Rat
2292589Emca10Estrogen-induced mammary cancer QTL 100.048mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)61653614061536140Rat
1354664Slep2Serum leptin concentration QTL 24.49blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)61653614071636405Rat
1641898Colcr4Colorectal carcinoma resistance QTL43.710.0007intestine integrity trait (VT:0010554)well differentiated malignant colorectal tumor surface area measurement (CMO:0002077)62033877762613667Rat
2293839Kiddil2Kidney dilation QTL 24.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat
2293841Kiddil4Kidney dilation QTL 44.4kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)62086642281133036Rat

Markers in Region
RH132989  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2621,054,936 - 21,055,134 (+)MAPPERmRatBN7.2
Rnor_6.0622,230,516 - 22,230,713NCBIRnor6.0
Rnor_5.0632,117,909 - 32,118,106UniSTSRnor5.0
RGSC_v3.4620,989,764 - 20,989,961UniSTSRGSC3.4
Celera620,613,772 - 20,613,969UniSTS
Cytogenetic Map6q12UniSTS
RH139397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2621,055,653 - 21,055,746 (+)MAPPERmRatBN7.2
Rnor_6.0622,231,233 - 22,231,325NCBIRnor6.0
Rnor_5.0632,118,626 - 32,118,718UniSTSRnor5.0
RGSC_v3.4620,990,481 - 20,990,573UniSTSRGSC3.4
Celera620,614,489 - 20,614,581UniSTS
Cytogenetic Map6q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 32 16 19 16 3 4 74 22 41 11 3
Low 25 25 25 25 5 7 13 5
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000039375   ⟹   ENSRNOP00000033763
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl621,055,349 - 21,106,312 (-)Ensembl
Rnor_6.0 Ensembl622,230,928 - 22,281,886 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000079137   ⟹   ENSRNOP00000073338
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl621,055,349 - 21,106,312 (-)Ensembl
Rnor_6.0 Ensembl622,231,455 - 22,281,724 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105595   ⟹   ENSRNOP00000085299
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl621,055,349 - 21,107,954 (-)Ensembl
RefSeq Acc Id: NM_001108702   ⟹   NP_001102172
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,446 (-)NCBI
mRatBN7.2621,055,349 - 21,106,579 (-)NCBI
Rnor_6.0622,230,928 - 22,281,886 (-)NCBI
Rnor_5.0632,118,321 - 32,168,698 (-)NCBI
RGSC_v3.4620,990,083 - 21,048,692 (-)RGD
Celera620,614,184 - 20,664,224 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001414954   ⟹   NP_001401883
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,446 (-)NCBI
mRatBN7.2621,055,349 - 21,106,579 (-)NCBI
RefSeq Acc Id: XM_008764486   ⟹   XP_008762708
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,456 (-)NCBI
mRatBN7.2621,055,349 - 21,106,585 (-)NCBI
Rnor_6.0622,230,067 - 22,282,165 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008764488   ⟹   XP_008762710
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8626,807,220 - 26,858,416 (-)NCBI
mRatBN7.2621,055,349 - 21,106,586 (-)NCBI
Rnor_6.0622,230,067 - 22,282,166 (-)NCBI
Sequence:
RefSeq Acc Id: NP_001102172   ⟸   NM_001108702
- Peptide Label: isoform 2
- UniProtKB: B2RYN7 (UniProtKB/Swiss-Prot),   A0A8L2QK18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762710   ⟸   XM_008764488
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3R4 (UniProtKB/TrEMBL),   A0A8L2QK18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008762708   ⟸   XM_008764486
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QK18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000073338   ⟸   ENSRNOT00000079137
RefSeq Acc Id: ENSRNOP00000033763   ⟸   ENSRNOT00000039375
RefSeq Acc Id: ENSRNOP00000085299   ⟸   ENSRNOT00000105595
RefSeq Acc Id: NP_001401883   ⟸   NM_001414954
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K590 (UniProtKB/TrEMBL),   A0A8L2QK18 (UniProtKB/TrEMBL)
Protein Domains
AAA+ ATPase   MIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RYN7-F1-model_v2 AlphaFold B2RYN7 1-581 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694422
Promoter ID:EPDNEW_R4938
Type:initiation region
Name:Spast_1
Description:spastin
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0622,281,725 - 22,281,785EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308494 AgrOrtholog
BioCyc Gene G2FUF-38441 BioCyc
Ensembl Genes ENSRNOG00000027136 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000039375 ENTREZGENE
  ENSRNOT00000039375.6 UniProtKB/TrEMBL
  ENSRNOT00000079137 ENTREZGENE
  ENSRNOT00000079137.2 UniProtKB/TrEMBL
  ENSRNOT00000105595.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Phosphotransferase system, lactose/cellobiose-type IIA subunit UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9030077 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spastin_chordate UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vps4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:362700 UniProtKB/Swiss-Prot
MGC_CLONE MGC:188738 IMAGE-MGC_LOAD
NCBI Gene 362700 ENTREZGENE
PANTHER AAA DOMAIN-CONTAINING UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPASTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Vps4_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Spast PhenoGen
PIRSF Spastin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000027136 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K590 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A3R4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QK18 ENTREZGENE, UniProtKB/TrEMBL
  B2RYN7 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Spast  spastin   Spast_predicted  spastin (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Spast_predicted  spastin (predicted)  Spg4_predicted  spastic paraplegia 4 (autosomal dominant; spastin) (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-12 Spg4_predicted  spastic paraplegia 4 (autosomal dominant; spastin) (predicted)      Symbol and Name status set to approved 70820 APPROVED