Loxl2 (lysyl oxidase-like 2) - Rat Genome Database

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Gene: Loxl2 (lysyl oxidase-like 2) Rattus norvegicus
Analyze
Symbol: Loxl2
Name: lysyl oxidase-like 2
RGD ID: 1308435
Description: Predicted to enable metal ion binding activity; oligosaccharide binding activity; and protein-lysine 6-oxidase activity. Predicted to be involved in several processes, including collagen fibril organization; peptidyl-lysine oxidation; and positive regulation of cell differentiation. Located in basement membrane. Orthologous to human LOXL2 (lysyl oxidase like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290350; lysyl oxidase homolog 2; lysyl oxidase-like protein 2; MGC189171
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,091,547 - 51,182,843 (+)NCBIGRCr8
mRatBN7.21544,683,449 - 44,773,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,683,880 - 44,773,067 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,801,847 - 48,888,730 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01549,913,342 - 50,000,223 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,772,671 - 46,859,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,276,022 - 51,365,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,303,909 - 51,365,234 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,005,461 - 55,092,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41549,982,103 - 50,068,902 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,024,097 - 50,084,571 (+)NCBI
Celera1544,366,507 - 44,453,187 (+)NCBICelera
Cytogenetic Map15p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcipotriol  (ISO)
carbon nanotube  (ISO)
chloroprene  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
D-penicillamine  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dopamine  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenoldopam  (EXP)
fentanyl  (EXP)
fenvalerate  (EXP)
fipronil  (EXP)
folic acid  (ISO)
glyphosate  (EXP)
graphene oxide  (ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
methapyrilene  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentane-2,3-dione  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (EXP)
progesterone  (ISO)
rotenone  (EXP,ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
topotecan  (ISO)
tributylstannane  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
basement membrane  (IDA,IEA)
chromatin  (IEA,ISO,ISS)
chromosome  (IEA)
collagen-containing extracellular matrix  (IBA)
endoplasmic reticulum  (IEA,ISO,ISS)
extracellular space  (IBA,IEA,ISO,ISS)
membrane  (IEA)
nucleoplasm  (IEA,ISO)
nucleus  (IEA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane. Bignon M, etal., Blood. 2011 Oct 6;118(14):3979-89. doi: 10.1182/blood-2010-10-313296. Epub 2011 Aug 11.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16096638   PMID:21071451   PMID:22204712   PMID:23319596   PMID:23979707   PMID:24006456   PMID:24239292   PMID:24414204   PMID:25959397   PMID:27735137   PMID:28332555  
PMID:29581294   PMID:29966587   PMID:34426599  


Genomics

Comparative Map Data
Loxl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81551,091,547 - 51,182,843 (+)NCBIGRCr8
mRatBN7.21544,683,449 - 44,773,067 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1544,683,880 - 44,773,067 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1548,801,847 - 48,888,730 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01549,913,342 - 50,000,223 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01546,772,671 - 46,859,556 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01551,276,022 - 51,365,238 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1551,303,909 - 51,365,234 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01555,005,461 - 55,092,980 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41549,982,103 - 50,068,902 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11550,024,097 - 50,084,571 (+)NCBI
Celera1544,366,507 - 44,453,187 (+)NCBICelera
Cytogenetic Map15p11NCBI
LOXL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38823,296,897 - 23,404,120 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl823,296,897 - 23,425,328 (-)EnsemblGRCh38hg38GRCh38
GRCh37823,154,410 - 23,261,633 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36823,210,355 - 23,317,667 (-)NCBINCBI36Build 36hg18NCBI36
Build 34823,210,640 - 23,317,575NCBI
Celera822,116,981 - 22,224,289 (-)NCBICelera
Cytogenetic Map8p21.3NCBI
HuRef821,700,441 - 21,807,111 (-)NCBIHuRef
CHM1_1823,356,541 - 23,463,832 (-)NCBICHM1_1
T2T-CHM13v2.0823,571,770 - 23,679,001 (-)NCBIT2T-CHM13v2.0
Loxl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391469,846,085 - 69,933,283 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1469,846,517 - 69,933,283 (+)EnsemblGRCm39 Ensembl
GRCm381469,608,692 - 69,695,834 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1469,609,068 - 69,695,834 (+)EnsemblGRCm38mm10GRCm38
MGSCv371470,009,283 - 70,095,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361468,344,556 - 68,428,775 (+)NCBIMGSCv36mm8
Celera1467,164,771 - 67,231,456 (+)NCBICelera
Cytogenetic Map14D2NCBI
cM Map1436.06NCBI
Loxl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540346,504,440 - 46,584,016 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540346,503,226 - 46,583,807 (-)NCBIChiLan1.0ChiLan1.0
LOXL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2741,802,508 - 41,909,114 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1817,529,707 - 17,636,058 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0822,547,303 - 22,653,676 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1819,483,331 - 19,589,522 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl819,483,335 - 19,589,522 (-)Ensemblpanpan1.1panPan2
LOXL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12534,095,858 - 34,186,775 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2534,126,335 - 34,185,969 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2534,684,511 - 34,775,173 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02534,303,470 - 34,394,384 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2534,303,481 - 34,394,388 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12534,249,922 - 34,341,273 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02534,104,318 - 34,195,732 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02534,259,681 - 34,351,266 (+)NCBIUU_Cfam_GSD_1.0
Loxl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494311,704,822 - 11,789,837 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365556,781,321 - 6,865,768 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365556,781,563 - 6,865,662 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOXL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl147,435,867 - 7,540,704 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1147,435,861 - 7,540,699 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOXL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1821,416,821 - 21,516,923 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl821,416,787 - 21,516,854 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605220,707,763 - 20,805,731 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Loxl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475818,568,607 - 18,621,785 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475818,567,367 - 18,644,528 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Loxl2
204 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:82
Count of miRNA genes:68
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000058663
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)152788577486257085Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154063126846187442Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154028990149308583Rat

Markers in Region
D15Mgh11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,759,391 - 44,759,533 (+)MAPPERmRatBN7.2
Rnor_6.01551,353,605 - 51,353,746NCBIRnor6.0
Rnor_5.01555,081,347 - 55,081,488UniSTSRnor5.0
RGSC_v3.41550,057,446 - 50,057,588RGDRGSC3.4
RGSC_v3.41550,057,447 - 50,057,588UniSTSRGSC3.4
RGSC_v3.11550,073,226 - 50,073,368RGD
Celera1544,441,732 - 44,441,873UniSTS
FHH x ACI Map1546.36RGD
FHH x ACI Map1546.36UniSTS
Cytogenetic Map15p11UniSTS
D15Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,759,312 - 44,759,531 (+)MAPPERmRatBN7.2
Rnor_6.01551,353,526 - 51,353,744NCBIRnor6.0
Rnor_5.01555,081,268 - 55,081,486UniSTSRnor5.0
RGSC_v3.41550,057,367 - 50,057,586RGDRGSC3.4
RGSC_v3.41550,057,368 - 50,057,586UniSTSRGSC3.4
RGSC_v3.11550,073,147 - 50,073,366RGD
Celera1544,441,653 - 44,441,871UniSTS
Cytogenetic Map15p11UniSTS
D15Wox4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,759,329 - 44,759,531 (+)MAPPERmRatBN7.2
Rnor_6.01551,353,543 - 51,353,744NCBIRnor6.0
Rnor_5.01555,081,285 - 55,081,486UniSTSRnor5.0
RGSC_v3.41550,057,385 - 50,057,586UniSTSRGSC3.4
Celera1544,441,670 - 44,441,871UniSTS
Cytogenetic Map15p11UniSTS
RH124140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21544,766,673 - 44,767,926 (+)MAPPERmRatBN7.2
mRatBN7.24115,555,823 - 115,556,054 (+)MAPPERmRatBN7.2
Rnor_6.04113,882,579 - 113,882,809NCBIRnor6.0
Rnor_6.01551,361,065 - 51,362,317NCBIRnor6.0
Rnor_5.01555,088,807 - 55,090,059UniSTSRnor5.0
Rnor_5.04178,567,679 - 178,567,909UniSTSRnor5.0
RGSC_v3.44117,261,114 - 117,261,344UniSTSRGSC3.4
RGSC_v3.41550,064,728 - 50,065,980UniSTSRGSC3.4
Celera1544,449,013 - 44,450,265UniSTS
Celera4104,550,500 - 104,550,730UniSTS
Cytogenetic Map4q34UniSTS
Cytogenetic Map15p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000058663   ⟹   ENSRNOP00000055457
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1544,719,957 - 44,773,067 (+)Ensembl
Rnor_6.0 Ensembl1551,304,059 - 51,365,124 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085237   ⟹   ENSRNOP00000073118
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1544,683,880 - 44,773,064 (+)Ensembl
Rnor_6.0 Ensembl1551,303,909 - 51,365,234 (+)Ensembl
RefSeq Acc Id: NM_001106047   ⟹   NP_001099517
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,738 - 51,180,624 (+)NCBI
mRatBN7.21544,683,944 - 44,770,848 (+)NCBI
Rnor_6.01551,276,022 - 51,365,238 (+)NCBI
Rnor_5.01555,005,461 - 55,092,980 (+)NCBI
RGSC_v3.41549,982,103 - 50,068,902 (+)RGD
Celera1544,366,507 - 44,453,187 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093148   ⟹   XP_038949076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,279 - 51,182,843 (+)NCBI
mRatBN7.21544,683,475 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093149   ⟹   XP_038949077
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,279 - 51,182,843 (+)NCBI
mRatBN7.21544,683,475 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093150   ⟹   XP_038949078
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,352 - 51,182,843 (+)NCBI
mRatBN7.21544,683,477 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093151   ⟹   XP_038949079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,654 - 51,182,843 (+)NCBI
mRatBN7.21544,683,839 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093152   ⟹   XP_038949080
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,653 - 51,182,843 (+)NCBI
mRatBN7.21544,683,838 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093153   ⟹   XP_038949081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,251 - 51,182,843 (+)NCBI
mRatBN7.21544,683,449 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093154   ⟹   XP_038949082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,352 - 51,182,843 (+)NCBI
mRatBN7.21544,683,479 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_039093155   ⟹   XP_038949083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,091,547 - 51,182,843 (+)NCBI
mRatBN7.21544,683,481 - 44,773,067 (+)NCBI
RefSeq Acc Id: XM_063274138   ⟹   XP_063130208
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81551,093,564 - 51,182,843 (+)NCBI
RefSeq Acc Id: NP_001099517   ⟸   NM_001106047
- Peptide Label: precursor
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot),   A0A0G2K4P0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073118   ⟸   ENSRNOT00000085237
Ensembl Acc Id: ENSRNOP00000055457   ⟸   ENSRNOT00000058663
RefSeq Acc Id: XP_038949081   ⟸   XM_039093153
- Peptide Label: isoform X4
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949076   ⟸   XM_039093148
- Peptide Label: isoform X1
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949077   ⟸   XM_039093149
- Peptide Label: isoform X2
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949078   ⟸   XM_039093150
- Peptide Label: isoform X3
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949082   ⟸   XM_039093154
- Peptide Label: isoform X5
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949083   ⟸   XM_039093155
- Peptide Label: isoform X6
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949080   ⟸   XM_039093152
- Peptide Label: isoform X4
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038949079   ⟸   XM_039093151
- Peptide Label: isoform X4
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063130208   ⟸   XM_063274138
- Peptide Label: isoform X7
- UniProtKB: F1LPM2 (UniProtKB/Swiss-Prot),   B5DF27 (UniProtKB/Swiss-Prot),   A0A0G2K4P0 (UniProtKB/TrEMBL)
Protein Domains
SRCR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B5DF27-F1-model_v2 AlphaFold B5DF27 1-776 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308435 AgrOrtholog
BioCyc Gene G2FUF-13255 BioCyc
Ensembl Genes ENSRNOG00000016758 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000058663.5 UniProtKB/TrEMBL
  ENSRNOT00000085237.2 UniProtKB/TrEMBL
Gene3D-CATH 3.10.250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro LOX-like_protein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lysyl_oxidase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290350 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 290350 ENTREZGENE
PANTHER LYSYL OXIDASE HOMOLOG 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSYL OXIDASE-LIKE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Lysyl_oxidase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Loxl2 PhenoGen
PRINTS LYSYLOXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPERACTRCPTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LYSYL_OXIDASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000016758 RatGTEx
SMART SM00202 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K4P0 ENTREZGENE, UniProtKB/TrEMBL
  B5DF27 ENTREZGENE
  F1LPM2 ENTREZGENE
  J3QTE1_RAT UniProtKB/TrEMBL
  LOXL2_RAT UniProtKB/Swiss-Prot
UniProt Secondary F1LPM2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Loxl2  lysyl oxidase-like 2   Loxl2_predicted  lysyl oxidase-like 2 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Loxl2_predicted  lysyl oxidase-like 2 (predicted)      Symbol and Name status set to approved 70820 APPROVED