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Gene: Setdb1 (SET domain bifurcated histone lysine methyltransferase 1) Rattus norvegicus
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Symbol: Setdb1
Name: SET domain bifurcated histone lysine methyltransferase 1
Description: Predicted to have DNA binding activity; histone methyltransferase activity (H3-K9 specific); and promoter-specific chromatin binding activity. Involved in response to ethanol and response to vitamin. Predicted to colocalize with the nuclear chromatin. Human ortholog(s) of this gene implicated in autistic disorder and lung cancer. Orthologous to human SETDB1 (SET domain bifurcated histone lysine methyltransferase 1); PARTICIPATES IN homocysteine metabolic pathway; methionine cycle/metabolic pathway; Wnt signaling, non-canonical pathway; INTERACTS WITH bisphenol A; copper atom; copper(0).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: histone-lysine N-methyltransferase SETDB1; LOC310668; LOC689883; SET domain, bifurcated 1; similar to Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (SET domain bifurcated 1) (ERG-associated protein with SET domain) (ESET)
Orthologs:
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02196,495,867 - 196,527,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2196,495,867 - 196,527,127 (-)Ensembl
Rnor_5.02215,994,295 - 216,025,842 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42190,232,228 - 190,264,309 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12190,195,015 - 190,227,043 (-)NCBI
Celera2175,432,236 - 175,463,195 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Setdb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1308370
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.