Mmp25 (matrix metallopeptidase 25) - Rat Genome Database

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Gene: Mmp25 (matrix metallopeptidase 25) Rattus norvegicus
Analyze
Symbol: Mmp25
Name: matrix metallopeptidase 25
RGD ID: 1308298
Description: Predicted to enable metalloendopeptidase activity and zinc ion binding activity. Predicted to be involved in proteolysis. Predicted to act upstream of or within hard palate development. Predicted to be located in plasma membrane. Orthologous to human MMP25 (matrix metallopeptidase 25); INTERACTS WITH 6-propyl-2-thiouracil; amphetamine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302963; matrix metalloproteinase 25; matrix metalloproteinase-25
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,164,974 - 13,180,503 (-)NCBIGRCr8
mRatBN7.21012,661,297 - 12,676,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,661,208 - 12,675,871 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01012,962,214 - 12,966,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01012,775,579 - 12,790,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,894,707 - 12,907,837 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,894,706 - 12,907,338 (-)NCBI
Celera1012,357,848 - 12,372,315 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20809987  


Genomics

Comparative Map Data
Mmp25
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81013,164,974 - 13,180,503 (-)NCBIGRCr8
mRatBN7.21012,661,297 - 12,676,119 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1012,661,208 - 12,675,871 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01012,962,214 - 12,966,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01012,775,579 - 12,790,270 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41012,894,707 - 12,907,837 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11012,894,706 - 12,907,338 (-)NCBI
Celera1012,357,848 - 12,372,315 (-)NCBICelera
Cytogenetic Map10q12NCBI
MMP25
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38163,046,561 - 3,060,726 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl163,046,062 - 3,060,729 (+)EnsemblGRCh38hg38GRCh38
GRCh37163,096,562 - 3,110,727 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36163,036,683 - 3,050,728 (+)NCBINCBI36Build 36hg18NCBI36
Build 34163,036,682 - 3,050,607NCBI
Celera163,302,227 - 3,316,272 (+)NCBICelera
Cytogenetic Map16p13.3NCBI
HuRef163,068,244 - 3,082,289 (+)NCBIHuRef
CHM1_1163,096,556 - 3,110,601 (+)NCBICHM1_1
T2T-CHM13v2.0163,073,131 - 3,087,328 (+)NCBIT2T-CHM13v2.0
Mmp25
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391723,847,289 - 23,864,006 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1723,847,285 - 23,864,251 (-)EnsemblGRCm39 Ensembl
GRCm381723,628,315 - 23,645,269 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1723,628,311 - 23,645,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv371723,766,425 - 23,782,236 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361723,357,080 - 23,372,891 (-)NCBIMGSCv36mm8
Celera1724,135,036 - 24,151,429 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1711.87NCBI
Mmp25
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544214,286,615 - 14,300,737 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544214,288,139 - 14,302,154 (-)NCBIChiLan1.0ChiLan1.0
MMP25
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2183,591,056 - 3,605,376 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1167,369,678 - 7,383,749 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0161,988,340 - 2,002,417 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1163,160,866 - 3,171,884 (+)NCBIpanpan1.1PanPan1.1panPan2
MMP25
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1638,128,585 - 38,139,882 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl638,130,092 - 38,140,007 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha639,370,770 - 39,380,151 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0638,440,808 - 38,450,193 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl638,439,215 - 38,450,914 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1638,126,846 - 38,136,229 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0638,099,404 - 38,108,766 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0638,575,110 - 38,584,486 (-)NCBIUU_Cfam_GSD_1.0
Mmp25
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344105,580,820 - 105,590,821 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366941,118,670 - 1,128,261 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366941,118,432 - 1,128,315 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MMP25
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl339,130,777 - 39,142,303 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1339,129,452 - 39,143,621 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2340,556,364 - 40,569,663 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MMP25
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.152,792,249 - 2,806,357 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl52,792,389 - 2,804,728 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606828,021,466 - 28,036,807 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mmp25
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624824791,236 - 804,591 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624824787,159 - 803,765 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mmp25
62 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:23
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000046876
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129497586Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000097998   ⟹   ENSRNOP00000090645
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1012,661,208 - 12,675,871 (-)Ensembl
RefSeq Acc Id: NM_001427286   ⟹   NP_001414215
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,164,977 - 13,180,503 (-)NCBI
RefSeq Acc Id: XM_039087061   ⟹   XP_038942989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81013,164,974 - 13,171,493 (-)NCBI
mRatBN7.21012,661,297 - 12,666,881 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001414215 (Get FASTA)   NCBI Sequence Viewer  
  XP_038942989 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000090645.1
RefSeq Acc Id: XP_038942989   ⟸   XM_039087061
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000090645   ⟸   ENSRNOT00000097998
RefSeq Acc Id: NP_001414215   ⟸   NM_001427286
- UniProtKB: A0A8I6ABC2 (UniProtKB/TrEMBL)
Protein Domains
Peptidase metallopeptidase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308298 AgrOrtholog
BioCyc Gene G2FUF-25921 BioCyc
Ensembl Genes ENSRNOG00000071032 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097998.1 UniProtKB/TrEMBL
Gene3D-CATH 2.110.10.10 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
InterPro Hemopexin-like_dom UniProtKB/TrEMBL
  Hemopexin-like_dom_sf UniProtKB/TrEMBL
  Hemopexin-like_repeat UniProtKB/TrEMBL
  M10A_MMP UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Pept_M10_metallopeptidase UniProtKB/TrEMBL
  Pept_M10A UniProtKB/TrEMBL
  Peptidase_Metallo UniProtKB/TrEMBL
  Peptidoglycan-bd-like UniProtKB/TrEMBL
  PGBD-like_sf UniProtKB/TrEMBL
NCBI Gene 302963 ENTREZGENE
PANTHER MATRIX METALLOPROTEINASE UniProtKB/TrEMBL
  MATRIX METALLOPROTEINASE-25 UniProtKB/TrEMBL
Pfam Hemopexin UniProtKB/TrEMBL
  Peptidase_M10 UniProtKB/TrEMBL
  PG_binding_1 UniProtKB/TrEMBL
PhenoGen Mmp25 PhenoGen
PIRSF Peptidase_M10A_matrix UniProtKB/TrEMBL
PRINTS MATRIXIN UniProtKB/TrEMBL
PROSITE HEMOPEXIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000071032 RatGTEx
SMART SM00120 UniProtKB/TrEMBL
  ZnMc UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF47090 UniProtKB/TrEMBL
  SSF50923 UniProtKB/TrEMBL
UniProt A0A8I6ABC2 ENTREZGENE, UniProtKB/TrEMBL
  A6HCK0_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Mmp25  matrix metallopeptidase 25  Mmp25  matrix metallopeptidase 25  Data merged from RGD:149736504 737654 PROVISIONAL
2021-08-09 Mmp25  matrix metallopeptidase 25      Symbol and Name status set to provisional 45752 PROVISIONAL
2012-10-05 Mmp25  matrix metallopeptidase 25  Mmp25  matrix metalloproteinase 25  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Mmp25  matrix metalloproteinase 25   Mmp25_predicted  matrix metalloproteinase 25 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Mmp25_predicted  matrix metalloproteinase 25 (predicted)      Symbol and Name status set to approved 70820 APPROVED