Tekt4 (tektin 4) - Rat Genome Database

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Gene: Tekt4 (tektin 4) Rattus norvegicus
Analyze
Symbol: Tekt4
Name: tektin 4
RGD ID: 1308075
Description: Predicted to be involved in cilium assembly and cilium movement involved in cell motility. Predicted to act upstream of with a positive effect on regulation of brood size. Predicted to be located in axonemal microtubule; sperm midpiece; and sperm principal piece. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. Orthologous to human TEKT4 (tektin 4); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC302991; RGD1308075; similar to hypothetical protein MGC27019; Tek4; tektin-4; Tektin4
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,992,284 - 14,997,460 (+)NCBIGRCr8
mRatBN7.21014,487,760 - 14,492,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,487,760 - 14,492,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,228,280 - 19,233,448 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,717,151 - 18,722,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,216,324 - 14,221,492 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,828,642 - 14,833,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,828,597 - 14,833,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,644,898 - 14,650,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,721,884 - 14,727,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,721,883 - 14,727,060 (+)NCBI
Celera1014,158,676 - 14,163,852 (+)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:15948161   PMID:16596631   PMID:17244819   PMID:18247331   PMID:18951373   PMID:20108326   PMID:21630459  


Genomics

Comparative Map Data
Tekt4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81014,992,284 - 14,997,460 (+)NCBIGRCr8
mRatBN7.21014,487,760 - 14,492,936 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1014,487,760 - 14,492,936 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1019,228,280 - 19,233,448 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01018,717,151 - 18,722,319 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01014,216,324 - 14,221,492 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01014,828,642 - 14,833,818 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1014,828,597 - 14,833,827 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01014,644,898 - 14,650,074 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,721,884 - 14,727,060 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11014,721,883 - 14,727,060 (+)NCBI
Celera1014,158,676 - 14,163,852 (+)NCBICelera
Cytogenetic Map10q12NCBI
TEKT4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38294,871,430 - 94,876,823 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl294,871,430 - 94,876,823 (+)EnsemblGRCh38hg38GRCh38
GRCh37295,537,175 - 95,542,568 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36294,900,959 - 94,906,295 (+)NCBINCBI36Build 36hg18NCBI36
Celera289,887,633 - 89,892,969 (+)NCBICelera
Cytogenetic Map2q11.1NCBI
HuRef289,566,262 - 89,571,598 (+)NCBIHuRef
CHM1_1295,541,540 - 95,546,876 (+)NCBICHM1_1
T2T-CHM13v2.0295,377,957 - 95,383,351 (+)NCBIT2T-CHM13v2.0
Tekt4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,673,511 - 25,695,576 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1725,673,515 - 25,695,576 (+)EnsemblGRCm39 Ensembl
GRCm381725,454,549 - 25,476,602 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,454,615 - 25,476,602 (+)EnsemblGRCm38mm10GRCm38
MGSCv371725,608,535 - 25,613,539 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361725,199,181 - 25,204,200 (+)NCBIMGSCv36mm8
Celera1726,000,231 - 26,005,233 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1712.6NCBI
LOC117978981
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21234,080,917 - 34,086,217 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A34,083,728 - 34,088,976 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A104,533,252 - 104,538,659 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
TEKT4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,590,912 - 39,596,672 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,857,097 - 40,862,854 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0639,935,527 - 39,941,285 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl639,935,448 - 39,941,725 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1639,611,991 - 39,617,745 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0639,584,633 - 39,590,380 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0640,063,330 - 40,069,088 (+)NCBIUU_Cfam_GSD_1.0
Tekt4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344111,944,656 - 111,949,974 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650142,686 - 47,771 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650142,686 - 47,771 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC110259951
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl340,738,135 - 40,744,248 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1340,738,065 - 40,744,248 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TEKT4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.112108,535,947 - 108,543,823 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl12108,535,895 - 108,541,359 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603896,935,169 - 96,940,598 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Tekt4
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:80
Count of miRNA genes:77
Interacting mature miRNAs:80
Transcripts:ENSRNOT00000025434
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10124158324Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10476552719816042Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402717245662Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10514402719233348Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10615418215990232Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat

Markers in Region
D10Mit6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,487,011 - 14,487,201 (+)MAPPERmRatBN7.2
Rnor_6.01014,827,894 - 14,828,083NCBIRnor6.0
Rnor_5.01014,644,150 - 14,644,339UniSTSRnor5.0
RGSC_v3.41014,721,135 - 14,721,325RGDRGSC3.4
RGSC_v3.41014,721,136 - 14,721,325UniSTSRGSC3.4
RGSC_v3.11014,721,056 - 14,721,447RGD
Celera1014,157,928 - 14,158,117UniSTS
Cytogenetic Map10q12UniSTS
RH130246  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,492,712 - 14,492,919 (+)MAPPERmRatBN7.2
Rnor_6.01014,833,595 - 14,833,801NCBIRnor6.0
Rnor_5.01014,649,851 - 14,650,057UniSTSRnor5.0
RGSC_v3.41014,726,837 - 14,727,043UniSTSRGSC3.4
Celera1014,163,629 - 14,163,835UniSTS
Cytogenetic Map10q12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 9 2
Low 1 14 1 1 1 1 64 11 9 1
Below cutoff 2 22 17 3 10 3 3 5 10 32 19 3

Sequence


RefSeq Acc Id: ENSRNOT00000025434   ⟹   ENSRNOP00000025434
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1014,487,760 - 14,492,936 (+)Ensembl
Rnor_6.0 Ensembl1014,828,597 - 14,833,827 (+)Ensembl
RefSeq Acc Id: NM_001013965   ⟹   NP_001013987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81014,992,284 - 14,997,460 (+)NCBI
mRatBN7.21014,487,760 - 14,492,936 (+)NCBI
Rnor_6.01014,828,642 - 14,833,818 (+)NCBI
Rnor_5.01014,644,898 - 14,650,074 (+)NCBI
RGSC_v3.41014,721,884 - 14,727,060 (+)RGD
Celera1014,158,676 - 14,163,852 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001013987 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH79304 (Get FASTA)   NCBI Sequence Viewer  
  BAD93477 (Get FASTA)   NCBI Sequence Viewer  
  EDM03933 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025434
  ENSRNOP00000025434.3
  ENSRNOP00055032385
  ENSRNOP00060012116
  ENSRNOP00065011258
GenBank Protein Q6AXV2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001013987   ⟸   NM_001013965
- UniProtKB: Q6AXV2 (UniProtKB/Swiss-Prot),   A6HD28 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000025434   ⟸   ENSRNOT00000025434

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6AXV2-F1-model_v2 AlphaFold Q6AXV2 1-447 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697051
Promoter ID:EPDNEW_R7576
Type:initiation region
Name:Tekt4_1
Description:tektin 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,828,647 - 14,828,707EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308075 AgrOrtholog
BioCyc Gene G2FUF-25777 BioCyc
Ensembl Genes ENSRNOG00000018792 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055023219 UniProtKB/Swiss-Prot
  ENSRNOG00060009207 UniProtKB/Swiss-Prot
  ENSRNOG00065009410 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025434 ENTREZGENE
  ENSRNOT00000025434.6 UniProtKB/Swiss-Prot
  ENSRNOT00055039910 UniProtKB/Swiss-Prot
  ENSRNOT00060015522 UniProtKB/Swiss-Prot
  ENSRNOT00065015053 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7134598 IMAGE-MGC_LOAD
InterPro Tektin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tektin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302991 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94442 IMAGE-MGC_LOAD
NCBI Gene 302991 ENTREZGENE
PANTHER PTHR19960 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TEKTIN-4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Tektin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tekt4 PhenoGen
PRINTS TEKTIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018792 RatGTEx
  ENSRNOG00055023219 RatGTEx
  ENSRNOG00060009207 RatGTEx
  ENSRNOG00065009410 RatGTEx
UniProt A6HD28 ENTREZGENE, UniProtKB/TrEMBL
  Q6AXV2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Tekt4  tektin 4  RGD1308075  similar to hypothetical protein MGC27019  Symbol and Name updated 1299863 APPROVED
2005-12-06 RGD1308075  similar to hypothetical protein MGC27019  RGD1308075_predicted  similar to hypothetical protein MGC27019 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308075_predicted  similar to hypothetical protein MGC27019 (predicted)  LOC302991_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC302991_predicted  similar to hypothetical protein MGC27019 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL