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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | 17alpha-ethynylestradiol | affects expression | ISO | RGD:1317515 | 6480464 | Ethinyl Estradiol affects the expression of PLAGL2 mRNA | CTD | PMID:17555576 | 17beta-estradiol | increases expression | ISO | RGD:1317514 | 6480464 | Estradiol results in increased expression of PLAGL2 mRNA | CTD | PMID:23019147 | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | RGD:1317515 | 6480464 | Tetrachlorodibenzodioxin affects the expression of PLAGL2 mRNA | CTD | PMID:21570461 | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PLAGL2 mRNA | CTD | PMID:33387578 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLAGL2 mRNA | CTD | PMID:32109520 | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | RGD:1317515 | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PLAGL2 mRNA | CTD | PMID:19465110 | 2,3,7,8-Tetrachlorodibenzofuran | increases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | 2-methylcholine | affects expression | ISO | RGD:1317514 | 6480464 | beta-methylcholine affects the expression of PLAGL2 mRNA | CTD | PMID:21179406 | 4,4'-diaminodiphenylmethane | decreases expression | ISO | RGD:1317515 | 6480464 | 4, 4'-diaminodiphenylmethane results in decreased expression of PLAGL2 mRNA | CTD | PMID:18648102 | 4-hydroxynon-2-enal | decreases expression | ISO | RGD:1317515 | 6480464 | 4-hydroxy-2-nonenal results in decreased expression of PLAGL2 mRNA | CTD | PMID:19191707 | 4-hydroxyphenyl retinamide | increases expression | ISO | RGD:1317515 | 6480464 | Fenretinide results in increased expression of PLAGL2 mRNA | CTD | PMID:28973697 | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of PLAGL2 mRNA | CTD | PMID:28959563 | acrylamide | increases expression | ISO | RGD:1317514 | 6480464 | Acrylamide results in increased expression of PLAGL2 mRNA | CTD | PMID:32763439 | aflatoxin B1 | increases expression | ISO | RGD:1317514 | 6480464 | Aflatoxin B1 results in increased expression of PLAGL2 mRNA | CTD | PMID:22100608 | aflatoxin B1 | decreases methylation | ISO | RGD:1317514 | 6480464 | Aflatoxin B1 results in decreased methylation of PLAGL2 gene | CTD | PMID:27153756 | aflatoxin B1 | increases expression | ISO | RGD:1317515 | 6480464 | Aflatoxin B1 results in increased expression of PLAGL2 mRNA | CTD | PMID:19770486 | all-trans-retinoic acid | increases expression | ISO | RGD:1317514 | 6480464 | Tretinoin results in increased expression of PLAGL2 mRNA | CTD | PMID:33167477 | arsenite(3-) | increases methylation | ISO | RGD:1317514 | 6480464 | arsenite results in increased methylation of PLAGL2 promoter | CTD | PMID:23974009 | arsenous acid | increases expression | ISO | RGD:1317514 | 6480464 | Arsenic Trioxide results in increased expression of PLAGL2 mRNA | CTD | PMID:20458559 | benzo[a]pyrene | decreases expression | ISO | RGD:1317515 | 6480464 | Benzo(a)pyrene results in decreased expression of PLAGL2 mRNA | CTD | PMID:22228805 | benzo[a]pyrene | increases expression | ISO | RGD:1317514 | 6480464 | Benzo(a)pyrene results in increased expression of PLAGL2 mRNA | CTD | PMID:32234424 | benzo[a]pyrene | affects methylation | ISO | RGD:1317514 | 6480464 | Benzo(a)pyrene affects the methylation of PLAGL2 5' UTR | CTD | PMID:27901495 | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PLAGL2 mRNA | CTD | PMID:25181051, PMID:34947998 | bisphenol A | increases methylation | ISO | RGD:1317515 | 6480464 | bisphenol A results in increased methylation of PLAGL2 promoter | CTD | PMID:27312807 | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PLAGL2 gene | CTD | PMID:28505145 | bisphenol A | affects methylation | ISO | RGD:1317515 | 6480464 | bisphenol A affects the methylation of PLAGL2 promoter | CTD | PMID:27334623 | buta-1,3-diene | decreases expression | ISO | RGD:1317515 | 6480464 | 1, 3-butadiene results in decreased expression of PLAGL2 mRNA | CTD | PMID:29038090 | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of PLAGL2 mRNA | CTD | PMID:19167457 | cadmium atom | multiple interactions | ISO | RGD:1317514 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PLAGL2 mRNA | CTD | PMID:35301059 | cadmium dichloride | multiple interactions | ISO | RGD:1317514 | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PLAGL2 mRNA | CTD | PMID:35301059 | CGP 52608 | multiple interactions | ISO | RGD:1317514 | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PLAGL2 gene] | CTD | PMID:28238834 | chrysene | increases expression | ISO | RGD:1317515 | 6480464 | chrysene results in increased expression of PLAGL2 mRNA | CTD | PMID:26377693 | cisplatin | decreases expression | ISO | RGD:1317514 | 6480464 | Cisplatin results in decreased expression of PLAGL2 mRNA | CTD | PMID:27594783 | cobalt dichloride | increases expression | EXP | | 6480464 | cobaltous chloride results in increased expression of PLAGL2 mRNA | CTD | PMID:24386269 | copper atom | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLAGL2 mRNA | CTD | PMID:26033743 | copper(0) | increases expression | EXP | | 6480464 | Copper deficiency results in increased expression of PLAGL2 mRNA | CTD | PMID:26033743 | copper(II) sulfate | decreases expression | ISO | RGD:1317514 | 6480464 | Copper Sulfate results in decreased expression of PLAGL2 mRNA | CTD | PMID:19549813 | coumarin | decreases phosphorylation | ISO | RGD:1317514 | 6480464 | coumarin results in decreased phosphorylation of PLAGL2 protein | CTD | PMID:35688186 | Cuprizon | increases expression | EXP | | 6480464 | Cuprizone results in increased expression of PLAGL2 mRNA | CTD | PMID:26577399 | cyclosporin A | decreases expression | ISO | RGD:1317514 | 6480464 | Cyclosporine results in decreased expression of PLAGL2 mRNA | CTD | PMID:25562108 | desferrioxamine B | multiple interactions | ISO | RGD:1317515 | 6480464 | Deferoxamine results in increased expression of and affects the localization of PLAGL2 protein | CTD | PMID:11832486 | diarsenic trioxide | increases expression | ISO | RGD:1317514 | 6480464 | Arsenic Trioxide results in increased expression of PLAGL2 mRNA | CTD | PMID:20458559 | dicrotophos | increases expression | ISO | RGD:1317514 | 6480464 | dicrotophos results in increased expression of PLAGL2 mRNA | CTD | PMID:28302478 | dieldrin | affects expression | EXP | | 6480464 | Dieldrin affects the expression of PLAGL2 mRNA | CTD | PMID:22546817 | dorsomorphin | multiple interactions | ISO | RGD:1317514 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | fenthion | increases expression | ISO | RGD:1317515 | 6480464 | Fenthion results in increased expression of PLAGL2 mRNA | CTD | PMID:34813904 | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PLAGL2 mRNA | CTD | PMID:33387578 | lead(0) | affects expression | ISO | RGD:1317514 | 6480464 | Lead affects the expression of PLAGL2 mRNA | CTD | PMID:28903495 | leflunomide | decreases expression | ISO | RGD:1317514 | 6480464 | leflunomide results in decreased expression of PLAGL2 mRNA | CTD | PMID:28988120 | menadione | affects expression | ISO | RGD:1317514 | 6480464 | Vitamin K 3 affects the expression of PLAGL2 mRNA | CTD | PMID:20044591 | methylmercury chloride | decreases expression | ISO | RGD:1317514 | 6480464 | methylmercuric chloride results in decreased expression of PLAGL2 mRNA | CTD | PMID:28001369 | nickel atom | increases expression | ISO | RGD:1317514 | 6480464 | Nickel results in increased expression of PLAGL2 mRNA | CTD | PMID:25583101 | protein kinase inhibitor | multiple interactions | ISO | RGD:1317514 | 6480464 | Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of PLAGL2 mRNA] | CTD | PMID:28003376 | rotenone | increases expression | ISO | RGD:1317515 | 6480464 | Rotenone results in increased expression of PLAGL2 mRNA | CTD | PMID:32937126 | SB 431542 | multiple interactions | ISO | RGD:1317514 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | succimer | multiple interactions | ISO | RGD:1317515 | 6480464 | [Succimer binds to Magnetite Nanoparticles] which results in increased expression of PLAGL2 mRNA, [Succimer co-treated with Magnetite Nanoparticles] results in increased expression of PLAGL2 mRNA | CTD | PMID:21641980, PMID:26378955 | sunitinib | increases expression | ISO | RGD:1317514 | 6480464 | Sunitinib results in increased expression of PLAGL2 mRNA | CTD | PMID:31533062 | temozolomide | decreases expression | ISO | RGD:1317514 | 6480464 | Temozolomide results in decreased expression of PLAGL2 mRNA | CTD | PMID:31758290 | testosterone | increases expression | ISO | RGD:1317515 | 6480464 | Testosterone deficiency results in increased expression of PLAGL2 mRNA | CTD | PMID:33848595 | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PLAGL2 mRNA | CTD | PMID:34492290 | trichostatin A | decreases expression | ISO | RGD:1317514 | 6480464 | trichostatin A results in decreased expression of PLAGL2 mRNA | CTD | PMID:24935251, PMID:26272509 | trichostatin A | multiple interactions | ISO | RGD:1317514 | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAGL2 mRNA | CTD | PMID:27188386 | triptonide | decreases expression | ISO | RGD:1317515 | 6480464 | triptonide results in decreased expression of PLAGL2 mRNA | CTD | PMID:33045310 | valproic acid | decreases methylation | ISO | RGD:1317514 | 6480464 | Valproic Acid results in decreased methylation of PLAGL2 gene | CTD | PMID:29154799 | valproic acid | multiple interactions | ISO | RGD:1317514 | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PLAGL2 mRNA | CTD | PMID:27188386 | valproic acid | decreases expression | ISO | RGD:1317514 | 6480464 | Valproic Acid results in decreased expression of PLAGL2 mRNA | CTD | PMID:23179753 more ... | zinc atom | multiple interactions | ISO | RGD:1317514 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PLAGL2 mRNA | CTD | PMID:18593933 | zinc(0) | multiple interactions | ISO | RGD:1317514 | 6480464 | [PCI 5002 co-treated with Zinc] results in increased expression of PLAGL2 mRNA | CTD | PMID:18593933 | |