Kif26a (kinesin family member 26A) - Rat Genome Database

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Gene: Kif26a (kinesin family member 26A) Rattus norvegicus
Analyze
Symbol: Kif26a
Name: kinesin family member 26A
RGD ID: 1307957
Description: Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including nervous system development; regulation of cell growth by extracellular stimulus; and regulation of neuron migration. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations. Orthologous to human KIF26A (kinesin family member 26A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; atrazine; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: hypothetical protein LOC688273; kinesin-like protein KIF26A; LOC314473
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,035,986 - 137,072,027 (+)NCBIGRCr8
mRatBN7.26131,214,839 - 131,250,874 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,387,882 - 131,422,402 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,684,848 - 131,719,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,044,396 - 131,078,929 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,720,254 - 136,755,515 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,720,266 - 136,754,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06145,729,938 - 145,764,803 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,947,394 - 137,007,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,951,582 - 137,013,355 (+)NCBI
Celera6128,767,372 - 128,829,093 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytoskeleton  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19914172  


Genomics

Comparative Map Data
Kif26a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86137,035,986 - 137,072,027 (+)NCBIGRCr8
mRatBN7.26131,214,839 - 131,250,874 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6131,387,882 - 131,422,402 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06131,684,848 - 131,719,368 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06131,044,396 - 131,078,929 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06136,720,254 - 136,755,515 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6136,720,266 - 136,754,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06145,729,938 - 145,764,803 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46136,947,394 - 137,007,168 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16136,951,582 - 137,013,355 (+)NCBI
Celera6128,767,372 - 128,829,093 (+)NCBICelera
Cytogenetic Map6q32NCBI
KIF26A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814104,138,587 - 104,180,894 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14104,136,454 - 104,180,894 (+)EnsemblGRCh38hg38GRCh38
GRCh3714104,604,924 - 104,647,231 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614103,674,813 - 103,716,988 (+)NCBINCBI36Build 36hg18NCBI36
Build 3414103,675,216 - 103,716,984NCBI
Celera1484,659,257 - 84,701,440 (+)NCBICelera
Cytogenetic Map14q32.33NCBI
HuRef1484,784,732 - 84,827,340 (+)NCBIHuRef
CHM1_114104,543,544 - 104,585,776 (+)NCBICHM1_1
T2T-CHM13v2.01498,375,914 - 98,418,495 (+)NCBIT2T-CHM13v2.0
Kif26a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912112,109,378 - 112,148,181 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12112,112,642 - 112,148,181 (+)EnsemblGRCm39 Ensembl
GRCm3812112,143,974 - 112,181,747 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12112,146,208 - 112,181,747 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712113,384,419 - 113,419,958 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612112,594,016 - 112,629,557 (+)NCBIMGSCv36mm8
Celera12113,348,968 - 113,387,126 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1261.14NCBI
Kif26a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555382,800,385 - 2,832,936 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555382,801,706 - 2,832,888 (+)NCBIChiLan1.0ChiLan1.0
KIF26A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v215105,295,997 - 105,340,531 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan114104,514,424 - 104,557,032 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01484,762,903 - 84,807,440 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.114104,569,947 - 104,612,348 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl14104,570,327 - 104,611,245 (+)Ensemblpanpan1.1panPan2
KIF26A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1871,789,024 - 71,827,794 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl871,788,821 - 71,827,804 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha871,298,277 - 71,336,515 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0872,064,940 - 72,103,193 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl872,062,687 - 72,103,195 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1871,753,370 - 71,791,509 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0871,794,017 - 71,831,774 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0872,192,632 - 72,230,872 (+)NCBIUU_Cfam_GSD_1.0
Kif26a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244086402,256,000 - 2,290,375 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366211,085,964 - 1,119,369 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366211,084,957 - 1,119,619 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KIF26A
(Sus scrofa - pig)		 No map positions available.
KIF26A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12482,072,506 - 82,115,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2482,074,837 - 82,114,589 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605369,401,444 - 69,442,786 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kif26a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624734885,863 - 915,403 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624734884,922 - 917,393 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Kif26a
140 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:161
Count of miRNA genes:110
Interacting mature miRNAs:118
Transcripts:ENSRNOT00000018278
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 12 2 2 2 47 10 24 10
Low 2 31 35 19 19 19 8 11 27 25 17 1 8
Below cutoff 1 20 20 20

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000018278   ⟹   ENSRNOP00000018278
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)Ensembl
Rnor_6.0 Ensembl6136,720,266 - 136,754,802 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086868   ⟹   ENSRNOP00000069901
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6131,214,861 - 131,250,320 (+)Ensembl
Rnor_6.0 Ensembl6136,720,582 - 136,754,926 (+)Ensembl
RefSeq Acc Id: NM_001170348   ⟹   NP_001163819
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,036,010 - 137,072,022 (+)NCBI
mRatBN7.26131,214,861 - 131,250,874 (+)NCBI
Rnor_6.06136,720,266 - 136,754,802 (+)NCBI
Rnor_5.06145,729,938 - 145,764,803 (+)NCBI
RGSC_v3.46136,947,394 - 137,007,168 (+)RGD
Celera6128,767,372 - 128,829,093 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001414931   ⟹   NP_001401860
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,036,010 - 137,072,022 (+)NCBI
mRatBN7.26131,214,861 - 131,250,874 (+)NCBI
RefSeq Acc Id: XM_006240635   ⟹   XP_006240697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,035,986 - 137,072,027 (+)NCBI
mRatBN7.26131,214,839 - 131,250,874 (+)NCBI
Rnor_6.06136,720,254 - 136,755,515 (+)NCBI
Rnor_5.06145,729,938 - 145,764,803 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039112423   ⟹   XP_038968351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86137,051,221 - 137,072,027 (+)NCBI
mRatBN7.26131,230,065 - 131,250,874 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_001163819   ⟸   NM_001170348
- Peptide Label: isoform 2
- UniProtKB: D3ZUT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240697   ⟸   XM_006240635
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JWJ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018278   ⟸   ENSRNOT00000018278
RefSeq Acc Id: ENSRNOP00000069901   ⟸   ENSRNOT00000086868
RefSeq Acc Id: XP_038968351   ⟸   XM_039112423
- Peptide Label: isoform X2
RefSeq Acc Id: NP_001401860   ⟸   NM_001414931
- Peptide Label: isoform 1
Protein Domains
Kinesin motor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUT0-F1-model_v2 AlphaFold D3ZUT0 1-1873 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694849
Promoter ID:EPDNEW_R5373
Type:initiation region
Name:Kif26a_1
Description:kinesin family member 26A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06136,720,266 - 136,720,326EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307957 AgrOrtholog
BioCyc Gene G2FUF-35800 BioCyc
Ensembl Genes ENSRNOG00000013661 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018278 ENTREZGENE
  ENSRNOT00000018278.8 UniProtKB/TrEMBL
  ENSRNOT00000086868.2 UniProtKB/TrEMBL
Gene3D-CATH 3.40.850.10 UniProtKB/TrEMBL
InterPro Kinesin-like_fam UniProtKB/TrEMBL
  Kinesin_motor_dom UniProtKB/TrEMBL
  Kinesin_motor_dom_sf UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report rno:314473 UniProtKB/TrEMBL
NCBI Gene 314473 ENTREZGENE
PANTHER KINESIN-LIKE PROTEIN KIF26A UniProtKB/TrEMBL
  UNCHARACTERIZED UniProtKB/TrEMBL
Pfam Kinesin UniProtKB/TrEMBL
PhenoGen Kif26a PhenoGen
PRINTS KINESINHEAVY UniProtKB/TrEMBL
PROSITE KINESIN_MOTOR_DOMAIN2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013661 RatGTEx
SMART KISc UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/TrEMBL
UniProt A0A0G2JWJ1 ENTREZGENE, UniProtKB/TrEMBL
  D3ZUT0 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Kif26a  kinesin family member 26A  LOC688273  hypothetical protein LOC688273  Data merged from RGD:1591153 1643240 APPROVED
2013-05-24 Kif26a  kinesin family member 26A  LOC684940  similar to CG14535-PA  Data merged from RGD:1584416 1643240 APPROVED
2008-04-30 Kif26a  kinesin family member 26A   Kif26a_predicted  kinesin family member 26A (predicted)  'predicted' is removed 2292626 APPROVED
2006-11-20 LOC688273  hypothetical protein LOC688273      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-11-19 LOC684940  similar to CG14535-PA      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-12 Kif26a_predicted  kinesin family member 26A (predicted)      Symbol and Name status set to approved 70820 APPROVED