Wbp11 (WW domain binding protein 11) - Rat Genome Database

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Gene: Wbp11 (WW domain binding protein 11) Rattus norvegicus
Analyze
Symbol: Wbp11
Name: WW domain binding protein 11
RGD ID: 1307911
Description: Predicted to enable WW domain binding activity and protein phosphatase regulator activity. Predicted to be involved in mRNA processing and rRNA processing. Predicted to act upstream of or within RNA splicing and regulation of catalytic activity. Predicted to be located in cytosol and nuclear speck. Orthologous to human WBP11 (WW domain binding protein 11); PARTICIPATES IN spliceosome pathway; INTERACTS WITH 2,6-dinitrotoluene; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC297695; MGC94547; splicing factor that interacts with PQBP-1 and PP1; wbp-11; WW domain-binding protein 11
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Wbp11-ps1   Wbp11-ps3  
Candidate Gene For: Kidm48
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24169,680,984 - 169,694,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,680,983 - 169,694,443 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4175,975,711 - 175,989,125 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04171,757,453 - 171,770,900 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04170,381,374 - 170,394,788 (-)NCBIRnor_WKY
Rnor_6.04170,772,166 - 170,785,613 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,154,227 - 170,186,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,772,163 - 170,810,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04234,414,445 - 234,427,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,823,936 - 173,837,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,069,061 - 174,082,432 (-)NCBI
Celera4158,264,513 - 158,277,960 (-)NCBICelera
Cytogenetic Map4q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:14640981   PMID:15489334   PMID:19592703   PMID:22681889   PMID:24912190  


Genomics

Comparative Map Data
Wbp11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.24169,680,984 - 169,694,431 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4169,680,983 - 169,694,443 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4175,975,711 - 175,989,125 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.04171,757,453 - 171,770,900 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.04170,381,374 - 170,394,788 (-)NCBIRnor_WKY
Rnor_6.04170,772,166 - 170,785,613 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,154,227 - 170,186,942 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl4170,772,163 - 170,810,080 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04234,414,445 - 234,427,903 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44173,823,936 - 173,837,308 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,069,061 - 174,082,432 (-)NCBI
Celera4158,264,513 - 158,277,960 (-)NCBICelera
Cytogenetic Map4q43NCBI
WBP11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381214,784,582 - 14,803,478 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1214,784,582 - 14,803,486 (-)EnsemblGRCh38hg38GRCh38
GRCh371214,937,516 - 14,956,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361214,830,679 - 14,847,668 (-)NCBINCBI36Build 36hg18NCBI36
Build 341214,830,680 - 14,847,668NCBI
Celera1220,084,400 - 20,101,388 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1214,708,868 - 14,725,858 (-)NCBIHuRef
CHM1_11214,905,505 - 14,922,494 (-)NCBICHM1_1
T2T-CHM13v2.01214,661,939 - 14,680,843 (-)NCBIT2T-CHM13v2.0
Wbp11
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396136,790,652 - 136,805,214 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6136,790,652 - 136,805,231 (-)EnsemblGRCm39 Ensembl
GRCm386136,813,654 - 136,828,216 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6136,813,654 - 136,828,233 (-)EnsemblGRCm38mm10GRCm38
MGSCv376136,762,175 - 136,776,737 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366136,777,852 - 136,792,324 (-)NCBIMGSCv36mm8
Celera6139,822,906 - 139,837,714 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.72NCBI
Wbp11
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495541311,533,303 - 11,549,067 (-)NCBIChiLan1.0ChiLan1.0
WBP11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11215,189,323 - 15,206,377 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1215,189,323 - 15,206,377 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01214,791,495 - 14,809,460 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
WBP11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12731,805,590 - 31,822,602 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2731,805,590 - 31,821,147 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2714,626,424 - 14,643,484 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02732,114,165 - 32,129,069 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.12732,001,615 - 32,018,608 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,960,078 - 31,977,326 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02714,358,481 - 14,375,518 (-)NCBIUU_Cfam_GSD_1.0
Wbp11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,945,542 - 92,959,156 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365872,673,206 - 2,687,298 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WBP11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1557,749,948 - 57,766,788 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2561,196,695 - 61,205,103 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WBP11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11114,686,047 - 14,704,172 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1114,686,636 - 14,704,127 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606920,606,064 - 20,624,173 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wbp11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475223,220,021 - 23,235,739 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wbp11
8 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:41
Count of miRNA genes:35
Interacting mature miRNAs:37
Transcripts:ENSRNOT00000007402
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
6478778Anxrr51Anxiety related response QTL 510.25384locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4124778595169778595Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
RH129142  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24169,681,031 - 169,681,220 (+)MAPPERmRatBN7.2
Rnor_6.04170,772,214 - 170,772,402NCBIRnor6.0
Rnor_6.04170,154,309 - 170,154,497NCBIRnor6.0
Rnor_5.04234,414,495 - 234,414,683UniSTSRnor5.0
Rnor_5.04235,030,486 - 235,030,674UniSTSRnor5.0
RGSC_v3.44173,823,984 - 173,824,172UniSTSRGSC3.4
Celera4158,264,561 - 158,264,749UniSTS
Cytogenetic Map4q43UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000007402   ⟹   ENSRNOP00000007402
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,680,984 - 169,694,443 (-)Ensembl
Rnor_6.0 Ensembl4170,154,263 - 170,167,633 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072528   ⟹   ENSRNOP00000065287
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,680,984 - 169,694,443 (-)Ensembl
Rnor_6.0 Ensembl4170,772,647 - 170,783,725 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082235   ⟹   ENSRNOP00000069027
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,680,984 - 169,692,255 (-)Ensembl
Rnor_6.0 Ensembl4170,154,227 - 170,186,942 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082312   ⟹   ENSRNOP00000070403
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4169,680,983 - 169,691,058 (-)Ensembl
Rnor_6.0 Ensembl4170,772,163 - 170,810,080 (-)Ensembl
RefSeq Acc Id: NM_001009661   ⟹   NP_001009661
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24169,680,984 - 169,694,431 (-)NCBI
Rnor_6.04170,772,166 - 170,785,613 (-)NCBI
Rnor_5.04234,414,445 - 234,427,903 (-)NCBI
RGSC_v3.44173,823,936 - 173,837,308 (-)RGD
Celera4158,264,513 - 158,277,960 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001303017   ⟹   NP_001289946
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.24169,680,984 - 169,694,431 (-)NCBI
Rnor_6.04170,772,166 - 170,785,613 (-)NCBI
Celera4158,264,513 - 158,277,960 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001009661 (Get FASTA)   NCBI Sequence Viewer  
  NP_001289946 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87082 (Get FASTA)   NCBI Sequence Viewer  
  EDM01604 (Get FASTA)   NCBI Sequence Viewer  
  Q5PQQ2 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001009661   ⟸   NM_001009661
- UniProtKB: Q5PQQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001289946   ⟸   NM_001303017
- UniProtKB: Q5PQQ2 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000065287   ⟸   ENSRNOT00000072528
RefSeq Acc Id: ENSRNOP00000069027   ⟸   ENSRNOT00000082235
RefSeq Acc Id: ENSRNOP00000070403   ⟸   ENSRNOT00000082312
RefSeq Acc Id: ENSRNOP00000007402   ⟸   ENSRNOT00000007402

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQQ2-F1-model_v2 AlphaFold Q5PQQ2 1-641 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693466
Promoter ID:EPDNEW_R3991
Type:single initiation site
Name:Wbp11_1
Description:WW domain binding protein 11
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04170,783,755 - 170,783,815EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307911 AgrOrtholog
BioCyc Gene G2FUF-42597 BioCyc
Ensembl Genes ENSRNOG00000005505 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00000049593 Ensembl
Ensembl Protein ENSRNOP00000007402 ENTREZGENE
  ENSRNOP00000007402.5 UniProtKB/Swiss-Prot
  ENSRNOP00000065287.2 UniProtKB/TrEMBL
  ENSRNOP00000069027.1 UniProtKB/TrEMBL
  ENSRNOP00000070403.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000007402 ENTREZGENE
  ENSRNOT00000007402.6 UniProtKB/Swiss-Prot
  ENSRNOT00000072528.2 UniProtKB/TrEMBL
  ENSRNOT00000082235.2 UniProtKB/TrEMBL
  ENSRNOT00000082312.2 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7189215 IMAGE-MGC_LOAD
InterPro WW_dom-bd_prot_11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:297695 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94547 IMAGE-MGC_LOAD
NCBI Gene 297695 ENTREZGENE
PANTHER PTHR13361 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WW DOMAIN-BINDING PROTEIN 11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Wbp11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wbp11 PhenoGen
UniProt A0A0G2JUA6_RAT UniProtKB/TrEMBL
  A0A0G2JXU2_RAT UniProtKB/TrEMBL
  A0A8L2QW34_RAT UniProtKB/TrEMBL
  Q5PQQ2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Wbp11  WW domain binding protein 11  Wbp11_predicted  WW domain binding protein 11 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Wbp11_predicted  WW domain binding protein 11 (predicted)      Symbol and Name status set to approved 70820 APPROVED