Ing5 (inhibitor of growth family, member 5) - Rat Genome Database

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Gene: Ing5 (inhibitor of growth family, member 5) Rattus norvegicus
Analyze
Symbol: Ing5
Name: inhibitor of growth family, member 5
RGD ID: 1307908
Description: Predicted to enable chromatin binding activity and methylated histone binding activity. Predicted to be involved in several processes, including DNA replication-dependent chromatin disassembly; positive regulation of apoptotic signaling pathway; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within negative regulation of fibroblast proliferation and positive regulation of apoptotic process. Predicted to be located in nucleoplasm. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Predicted to be active in nucleus. Orthologous to human ING5 (inhibitor of growth family member 5); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; gentamycin; thioacetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: inhibitor of growth protein 5; LOC363292
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,772,845 - 101,793,734 (+)NCBIGRCr8
mRatBN7.2994,326,549 - 94,343,392 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,326,548 - 94,344,220 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,762,026 - 102,778,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,897,415 - 107,914,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,253,524 - 106,270,444 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,932,932 - 100,950,233 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,932,545 - 100,952,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,586,087 - 100,603,189 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,076,701 - 93,094,002 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,281,098 - 93,298,207 (+)NCBI
Celera991,861,169 - 91,878,610 (+)NCBICelera
Cytogenetic Map9q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:12750254   PMID:16387653   PMID:16728974   PMID:18794358   PMID:21750715   PMID:22921202   PMID:24065767   PMID:31844418  


Genomics

Comparative Map Data
Ing5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89101,772,845 - 101,793,734 (+)NCBIGRCr8
mRatBN7.2994,326,549 - 94,343,392 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl994,326,548 - 94,344,220 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9102,762,026 - 102,778,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09107,897,415 - 107,914,334 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09106,253,524 - 106,270,444 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09100,932,932 - 100,950,233 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9100,932,545 - 100,952,416 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09100,586,087 - 100,603,189 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4993,076,701 - 93,094,002 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1993,281,098 - 93,298,207 (+)NCBI
Celera991,861,169 - 91,878,610 (+)NCBICelera
Cytogenetic Map9q36NCBI
ING5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382241,687,020 - 241,729,478 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2241,687,085 - 241,729,478 (+)EnsemblGRCh38hg38GRCh38
GRCh372242,626,435 - 242,668,893 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362242,290,129 - 242,317,569 (+)NCBINCBI36Build 36hg18NCBI36
Build 342242,361,445 - 242,388,884NCBI
Celera2236,316,253 - 236,341,094 (+)NCBICelera
Cytogenetic Map2q37.3NCBI
HuRef2234,396,720 - 234,424,015 (+)NCBIHuRef
CHM1_12242,647,558 - 242,674,989 (+)NCBICHM1_1
T2T-CHM13v2.02242,190,352 - 242,233,501 (+)NCBIT2T-CHM13v2.0
Ing5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,731,648 - 93,749,823 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl193,731,687 - 93,749,823 (+)EnsemblGRCm39 Ensembl
GRCm38193,803,926 - 93,822,101 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,803,965 - 93,822,101 (+)EnsemblGRCm38mm10GRCm38
MGSCv37195,700,542 - 95,718,678 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36195,634,371 - 95,652,507 (+)NCBIMGSCv36mm8
Celera196,750,076 - 96,766,171 (+)NCBICelera
Cytogenetic Map1DNCBI
cM Map147.34NCBI
Ing5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955542132,560 - 148,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955542135,634 - 160,991 (-)NCBIChiLan1.0ChiLan1.0
ING5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213144,396,425 - 144,439,598 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B144,426,265 - 144,451,842 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B128,979,282 - 129,007,476 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B247,769,128 - 247,793,902 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B247,755,552 - 247,793,893 (+)Ensemblpanpan1.1panPan2
ING5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12551,535,521 - 51,556,264 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2551,534,753 - 51,554,644 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2551,754,641 - 51,775,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02551,734,300 - 51,754,948 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2551,734,356 - 51,756,582 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12551,584,130 - 51,604,831 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02551,323,352 - 51,344,051 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02551,600,060 - 51,621,179 (+)NCBIUU_Cfam_GSD_1.0
Ing5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303192,946,863 - 192,962,731 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936745261,450 - 271,943 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936745261,371 - 271,447 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ING5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15140,264,766 - 140,279,010 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115140,264,708 - 140,279,020 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ING5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110127,733,768 - 127,770,794 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10127,746,546 - 127,774,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604071,550,856 - 71,575,851 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ing5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248475,648,233 - 5,662,044 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248475,648,199 - 5,659,038 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ing5
153 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:433
Count of miRNA genes:166
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000025683, ENSRNOT00000065058
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
724515Uae16Urinary albumin excretion QTL 168urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)958163035100929646Rat
1300134Bp185Blood pressure QTL 1853.73arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)961381434104821652Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
1578757Pur6Proteinuria QTL 63.30.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)96207227596470995Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
731171Glom6Glomerulus QTL 62.80.0003kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)964573531109573531Rat
1354626Bvd1Brain ventricular dilatation QTL 13.730.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)975712843111552878Rat
4889852Pur26Proteinuria QTL 26150.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)977813894101597663Rat
7794784Mcs31Mammary carcinoma susceptibility QTL 312.98mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)977813894111552878Rat
724547Cm21Cardiac mass QTL 212.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)979271511102910209Rat
1582203Gluco19Glucose level QTL 193.30.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)992491589100929786Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 18 32 16 19 16 65 31 35 11
Low 25 25 25 25 8 11 9 4 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025683   ⟹   ENSRNOP00000025683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl9100,932,545 - 100,952,416 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065058   ⟹   ENSRNOP00000062509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,326,919 - 94,344,220 (+)Ensembl
Rnor_6.0 Ensembl9100,932,932 - 100,950,233 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098886   ⟹   ENSRNOP00000087374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,326,570 - 94,343,391 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104628   ⟹   ENSRNOP00000094027
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,326,548 - 94,344,034 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111711   ⟹   ENSRNOP00000087453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl994,327,933 - 94,341,367 (+)Ensembl
RefSeq Acc Id: NM_001394332   ⟹   NP_001381261
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,773,896 - 101,790,739 (+)NCBI
mRatBN7.2994,326,549 - 94,343,392 (+)NCBI
RefSeq Acc Id: XM_063267473   ⟹   XP_063123543
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,772,845 - 101,793,734 (+)NCBI
RefSeq Acc Id: XM_063267474   ⟹   XP_063123544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,774,406 - 101,793,734 (+)NCBI
RefSeq Acc Id: XM_063267475   ⟹   XP_063123545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr89101,774,097 - 101,793,734 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000062509   ⟸   ENSRNOT00000065058
RefSeq Acc Id: ENSRNOP00000025683   ⟸   ENSRNOT00000025683
RefSeq Acc Id: ENSRNOP00000087453   ⟸   ENSRNOT00000111711
RefSeq Acc Id: ENSRNOP00000087374   ⟸   ENSRNOT00000098886
RefSeq Acc Id: ENSRNOP00000094027   ⟸   ENSRNOT00000104628
RefSeq Acc Id: NP_001381261   ⟸   NM_001394332
- UniProtKB: F7F3G6 (UniProtKB/TrEMBL),   B2RZ71 (UniProtKB/TrEMBL),   A0A8I6A7T0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063123543   ⟸   XM_063267473
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063123545   ⟸   XM_063267475
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063123544   ⟸   XM_063267474
- Peptide Label: isoform X2
Protein Domains
Inhibitor of growth protein N-terminal histone-   PHD-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ71-F1-model_v2 AlphaFold B2RZ71 1-240 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696890
Promoter ID:EPDNEW_R7408
Type:multiple initiation site
Name:Ing5_1
Description:inhibitor of growth family, member 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.09100,932,561 - 100,932,621EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307908 AgrOrtholog
BioCyc Gene G2FUF-26629 BioCyc
Ensembl Genes ENSRNOG00000018988 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000065058.4 UniProtKB/TrEMBL
  ENSRNOT00000098886 ENTREZGENE
  ENSRNOT00000098886.1 UniProtKB/TrEMBL
  ENSRNOT00000104628.1 UniProtKB/TrEMBL
  ENSRNOT00000111711.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
  6.10.140.1740 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9100546 IMAGE-MGC_LOAD
InterPro ING_fam UniProtKB/TrEMBL
  ING_N UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report rno:363292 UniProtKB/TrEMBL
MGC_CLONE MGC:189335 IMAGE-MGC_LOAD
NCBI Gene 363292 ENTREZGENE
PANTHER PTHR10333 UniProtKB/TrEMBL
  PTHR10333:SF41 UniProtKB/TrEMBL
Pfam ING UniProtKB/TrEMBL
PhenoGen Ing5 PhenoGen
PROSITE ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018988 RatGTEx
SMART ING UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
Superfamily-SCOP FYVE_PHD_ZnF UniProtKB/TrEMBL
UniProt A0A8I6A7T0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GKJ6_RAT UniProtKB/TrEMBL
  B2RZ71 ENTREZGENE, UniProtKB/TrEMBL
  D3ZDZ0_RAT UniProtKB/TrEMBL
  F7F3G6 ENTREZGENE
UniProt Secondary F7F3G6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Ing5  inhibitor of growth family, member 5   Ing5_predicted  inhibitor of growth family, member 5 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Ing5_predicted  inhibitor of growth family, member 5 (predicted)      Symbol and Name status set to approved 70820 APPROVED