Gene: Nup37 (nucleoporin 37) Rattus norvegicus
Analyze
Symbol:
Nup37
Name:
nucleoporin 37
Description:
Predicted to have porin activity. Predicted to be involved in transmembrane transport. Predicted to colocalize with the kinetochore. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NUP37 (nucleoporin 37); PARTICIPATES IN mRNA nuclear export pathway; RNA transport pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,6-dinitrotoluene; acrylamide.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC299706; nucleoporin Nup37
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
NUP37 (nucleoporin 37) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Nup37 (nucleoporin 37) HGNC
Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Nup37 (nucleoporin 37) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
NUP37 (nucleoporin 37) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
NUP37 (nucleoporin 37) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Nup37 (nucleoporin 37) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
NUP37 (nucleoporin 37) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
NUP37 (nucleoporin 37)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Nup37 (nucleoporin 37)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
nup37 (nucleoporin 37)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Nup37
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 7 28,715,299 - 28,750,978 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 7 28,701,690 - 28,743,326 (+) Ensembl Rnor_5.0 7 28,825,280 - 28,860,960 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 7 24,847,159 - 24,875,363 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 7 24,869,532 - 24,895,483 (+) NCBI Celera 7 19,736,956 - 19,765,160 (+) NCBI Celera Cytogenetic Map 7 q13 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - OMIM
Primary Autosomal Recessive Microcephaly 24 ISO RGD:1317159 7240710 OMIM
Gene-Chemical Interaction Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:1317159 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUP37 mRNA CTD PMID:22079256 (-)-epigallocatechin 3-gallate decreases expression ISO RGD:1317159 6480464 epigallocatechin gallate results in decreased expression of NUP37 mRNA CTD PMID:22079256 17alpha-ethynylestradiol decreases expression EXP 6480464 Ethinyl Estradiol results in decreased expression of NUP37 mRNA CTD PMID:15953391 more ... 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:1317160 6480464 [2 more ... CTD PMID:25510870 2,2',5,5'-tetrachlorobiphenyl multiple interactions ISO RGD:1317160 6480464 [2 more ... CTD PMID:25510870 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1317160 6480464 Tetrachlorodibenzodioxin affects the expression of NUP37 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of NUP37 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1317159 6480464 Lactic Acid results in decreased expression of NUP37 mRNA CTD PMID:30851411 2-methylcholine affects expression ISO RGD:1317159 6480464 beta-methylcholine affects the expression of NUP37 mRNA CTD PMID:21179406 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1317159 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUP37 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NUP37 mRNA CTD PMID:28628672 4,4'-sulfonyldiphenol multiple interactions ISO RGD:1317159 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUP37 mRNA CTD PMID:28628672 acrylamide increases expression EXP 6480464 Acrylamide results in increased expression of NUP37 mRNA CTD PMID:28959563 arsenous acid decreases response to substance ISO RGD:1317159 6480464 NUP37 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 benzo[a]pyrene decreases expression ISO RGD:1317160 6480464 Benzo(a)pyrene results in decreased expression of NUP37 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1317159 6480464 7 more ... CTD PMID:19150397 , PMID:20382639 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NUP37 mRNA CTD PMID:25181051 bisphenol A decreases expression ISO RGD:1317159 6480464 bisphenol A results in decreased expression of NUP37 mRNA CTD PMID:29275510 bisphenol A multiple interactions ISO RGD:1317159 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NUP37 mRNA CTD PMID:28628672 calcitriol decreases expression ISO RGD:1317159 6480464 Calcitriol results in decreased expression of NUP37 mRNA CTD PMID:21592394 calcitriol multiple interactions ISO RGD:1317159 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of NUP37 mRNA CTD PMID:21592394 carbon nanotube increases expression ISO RGD:1317160 6480464 Nanotubes, Carbon analog results in increased expression of NUP37 mRNA, Nanotubes, Carbon results in increased expression of NUP37 mRNA CTD PMID:25554681 casticin decreases expression ISO RGD:1317160 6480464 casticin results in decreased expression of NUP37 mRNA CTD PMID:28444820 cobalt dichloride decreases expression ISO RGD:1317159 6480464 cobaltous chloride results in decreased expression of NUP37 mRNA CTD PMID:19320972 copper(II) sulfate decreases expression ISO RGD:1317159 6480464 Copper Sulfate results in decreased expression of NUP37 mRNA CTD PMID:19549813 coumestrol increases expression ISO RGD:1317159 6480464 Coumestrol results in increased expression of NUP37 mRNA CTD PMID:19167446 dexamethasone multiple interactions ISO RGD:1317159 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUP37 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NUP37 mRNA CTD PMID:28628672 diarsenic trioxide decreases response to substance ISO RGD:1317159 6480464 NUP37 protein results in decreased susceptibility to Arsenic Trioxide CTD PMID:20707922 dicrotophos decreases expression ISO RGD:1317159 6480464 dicrotophos results in decreased expression of NUP37 mRNA CTD PMID:28302478 finasteride increases expression EXP 6480464 Finasteride results in increased expression of NUP37 mRNA CTD PMID:24136188 flutamide increases expression EXP 6480464 Flutamide results in increased expression of NUP37 mRNA CTD PMID:24136188 indometacin multiple interactions ISO RGD:1317159 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of NUP37 mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of NUP37 mRNA CTD PMID:28628672 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of NUP37 mRNA CTD PMID:30467583 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of NUP37 mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:1317160 6480464 Acetaminophen affects the expression of NUP37 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1317159 6480464 Acetaminophen results in decreased expression of NUP37 mRNA CTD PMID:21420995 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of NUP37 mRNA CTD PMID:19162173 potassium chromate decreases expression ISO RGD:1317159 6480464 potassium chromate(VI) results in decreased expression of NUP37 mRNA CTD PMID:22079256 potassium chromate multiple interactions ISO RGD:1317159 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NUP37 mRNA CTD PMID:22079256 rac-lactic acid decreases expression ISO RGD:1317159 6480464 Lactic Acid results in decreased expression of NUP37 mRNA CTD PMID:30851411 rotenone decreases expression EXP 6480464 Rotenone results in decreased expression of NUP37 mRNA CTD PMID:19013527 Salinomycin decreases expression ISO RGD:1317159 6480464 salinomycin results in decreased expression of NUP37 mRNA CTD PMID:19682730 sodium fluoride decreases expression ISO RGD:1317160 6480464 Sodium Fluoride results in decreased expression of NUP37 mRNA CTD PMID:27862939 Soman decreases expression EXP 6480464 Soman results in decreased expression of NUP37 mRNA CTD PMID:19281266 sulindac increases expression EXP 6480464 Sulindac results in increased expression of NUP37 mRNA CTD PMID:24136188 tert-butyl hydroperoxide increases expression ISO RGD:1317159 6480464 tert-Butylhydroperoxide results in increased expression of NUP37 mRNA CTD PMID:15336504 testosterone multiple interactions ISO RGD:1317159 6480464 [Testosterone co-treated with Calcitriol] results in decreased expression of NUP37 mRNA CTD PMID:21592394 testosterone decreases expression ISO RGD:1317159 6480464 Testosterone results in decreased expression of NUP37 mRNA CTD PMID:21592394 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of NUP37 mRNA CTD PMID:25729387 trimellitic anhydride increases expression ISO RGD:1317160 6480464 trimellitic anhydride results in increased expression of NUP37 mRNA CTD PMID:19042947 tungsten increases expression ISO RGD:1317160 6480464 Tungsten results in increased expression of NUP37 mRNA CTD PMID:30912803 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of NUP37 mRNA CTD PMID:23034163
Gene Ontology Annotations
Biological Process biological_process ND 1598407 09/2015: no relevant rat data RGD transmembrane transport IEA GO:0015288 1600115 GO_REF:0000108 GOC GO_REF:0000108 Cellular Component cellular_component ND 1598407 09/2015: no relevant rat data RGD kinetochore colocalizes_with ISO RGD:1317159 1624291 (PMID:15146057) RGD PMID:15146057 kinetochore IEA UniProtKB:Q8NFH4 , ensembl:ENSP000004480541600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear pore outer ring ISO RGD:1317159 1624291 (PMID:15146057), (PMID:17360435) RGD PMID:15146057 , PMID:17360435 nuclear pore outer ring IBA PANTHER:PTN000515834 , UniProtKB:Q8NFH4 13792537 PMID:21873635 GO_Central nucleoplasm ISO RGD:1317159 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q8NFH4 , ensembl:ENSP000004480541600115 GO_REF:0000107 Ensembl GO_REF:0000107 pore complex IEA UniProtKB-KW:KW-0626 1600115 GO_REF:0000038 UniProt GO_REF:0000038 Molecular Function molecular_function ND 1598407 09/2015: no relevant rat data RGD porin activity IEA UniProtKB-KW:KW-0626 1600115 GO_REF:0000038 UniProt GO_REF:0000038 protein binding ISO RGD:1317159 1624291 UniProtKB:P55735 more ... RGD PMID:15146057
Molecular Pathway Annotations
RGD Manual Annotations
mRNA nuclear export pathway ISO RGD:1317159 9743947 RGD Imported Annotations - KEGG (archival)
RNA transport pathway IEA 6907045 KEGG rno:03013
2298550 Neuinf6 Neuroinflammation QTL 6 3.3 nervous system integrity trait (VT:0010566) spinal cord RT1-B protein level (CMO:0002132) 7 1 34147172 Rat 9590142 Scort5 Serum corticosterone level QTL 5 24.4 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 7 1 34828535 Rat 7411566 Bw136 Body weight QTL 136 10.4 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 7 1 34828535 Rat 724560 Plsm3 Polydactyly-luxate syndrome (PLS) morphotypes QTL 3 0.0003 tibia length (VT:0004357) tibia length (CMO:0000450) 7 1 37009673 Rat 2317047 Wbc4 White blood cell count QTL 4 0.01 leukocyte quantity (VT:0000217) white blood cell count (CMO:0000027) 7 1 38119654 Rat 1300176 Hrtrt10 Heart rate QTL 10 3.19 heart pumping trait (VT:2000009) heart rate (CMO:0000002) 7 2653138 32258115 Rat 634336 Anxrr17 Anxiety related response QTL 17 3.66 locomotor behavior trait (VT:0001392) number of entries into a discrete space in an experimental apparatus (CMO:0000960) 7 2920071 124838025 Rat 61410 Bw19 Body weight QTL 19 6.2 0.001 body mass (VT:0001259) body weight (CMO:0000012) 7 5911477 50911477 Rat 631503 Bp102 Blood pressure QTL 102 1.9 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 7 5951969 50951969 Rat 10755438 Coatc9 Coat color QTL 9 0 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 7 9758045 54758045 Rat 9590102 Sffal5 Serum free fatty acids level QTL 5 8.62 0.001 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) 7 11647102 56647102 Rat 2298547 Neuinf5 Neuroinflammation QTL 5 3.7 nervous system integrity trait (VT:0010566) spinal cord Cd74 protein level (CMO:0002131) 7 12328467 67193263 Rat 1643004 Pain2 Pain QTL 2 1 mechanical nociception trait (VT:0002734) self mutilation severity score (CMO:0002145) 7 12328467 106995532 Rat 1578652 Bmd15 Bone mineral density QTL 15 5.2 femur mineral mass (VT:0010011) trabecular volumetric bone mineral density (CMO:0001729) 7 12687850 67801690 Rat 10755440 Coatc10 Coat color QTL 10 0 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 7 13952179 58952179 Rat 10059592 Kidm45 Kidney mass QTL 45 3.95 0.025 kidney mass (VT:0002707) both kidneys wet weight as percentage of body weight (CMO:0000140) 7 14445685 59445685 Rat 1582260 Bw72 Body weight QTL 72 3.2 0.0043 body mass (VT:0001259) body weight (CMO:0000012) 7 20215583 44668493 Rat 1582261 Bw69 Body weight QTL 69 3.2 0.0048 body mass (VT:0001259) body weight (CMO:0000012) 7 20215583 44668493 Rat 1582262 Bw75 Body weight QTL 75 3 0.0038 body mass (VT:0001259) body weight (CMO:0000012) 7 20215583 44668493 Rat 738033 Anxrr6 Anxiety related response QTL 6 4.1 exploratory behavior trait (VT:0010471) percentage of entries into a discrete space in an experimental apparatus (CMO:0000961) 7 22168412 67168412 Rat 70207 Niddm31 Non-insulin dependent diabetes mellitus QTL 31 3.9 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 7 24175337 32258115 Rat 10755451 Coatc11 Coat color QTL 11 0 coat/hair pigmentation trait (VT:0010463) pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812) 7 24731465 69731465 Rat 61369 Mcs2 Mammary carcinoma susceptibility QTL 2 3.38 mammary gland integrity trait (VT:0010552) mammary tumor number (CMO:0000343) 7 24738680 40433335 Rat 1354644 Spl4 Serum phospholipid level QTL 4 4.9 blood phospholipid amount (VT:0006084) blood phospholipid level (CMO:0001169) 7 25365633 57064364 Rat 1354637 Scl30 Serum cholesterol level QTL 30 3.7 blood cholesterol amount (VT:0000180) blood total cholesterol level (CMO:0000051) 7 25365633 57064364 Rat 1354639 Spl5 Serum phospholipid level QTL 5 3.9 blood LDL phospholipid amount (VT:0010505) blood low density lipoprotein phospholipid level (CMO:0001568) 7 25365633 60317612 Rat 1300132 Bp182 Blood pressure QTL 182 3.49 arterial blood pressure trait (VT:2000000) blood pressure time series experimental set point of the baroreceptor response (CMO:0002593) 7 25365633 93155402 Rat 2290372 Gluco33 Glucose level QTL 33 2.71 blood glucose amount (VT:0000188) blood glucose level area under curve (AUC) (CMO:0000350) 7 26508887 36346595 Rat 7411569 Bw137 Body weight QTL 137 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 7 28204653 73204653 Rat
Predicted Target Of
Count of predictions: 121 Count of miRNA genes: 86 Interacting mature miRNAs: 93 Transcripts: ENSRNOT00000006760 Prediction methods: Microtar, Miranda, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
