Fbxo8 (F-box protein 8) - Rat Genome Database

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Gene: Fbxo8 (F-box protein 8) Rattus norvegicus
Analyze
Symbol: Fbxo8
Name: F-box protein 8
RGD ID: 1307596
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction and regulation of catalytic activity. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be part of ubiquitin ligase complex. Orthologous to human FBXO8 (F-box protein 8); INTERACTS WITH bisphenol A; gentamycin; ketamine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: F-box only protein 8; LOC306436
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21633,665,305 - 33,711,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1633,665,306 - 33,711,272 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1637,275,499 - 37,320,608 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01640,686,858 - 40,731,967 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01636,920,558 - 36,965,664 (-)NCBIRnor_WKY
Rnor_6.01637,131,566 - 37,177,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,131,345 - 37,177,033 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01636,936,317 - 36,981,614 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41637,093,835 - 37,139,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11637,093,909 - 37,139,178 (-)NCBI
Celera1633,598,519 - 33,643,754 (-)NCBICelera
Cytogenetic Map16p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:10531037   PMID:12477932  


Genomics

Comparative Map Data
Fbxo8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21633,665,305 - 33,711,215 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1633,665,306 - 33,711,272 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1637,275,499 - 37,320,608 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01640,686,858 - 40,731,967 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01636,920,558 - 36,965,664 (-)NCBIRnor_WKY
Rnor_6.01637,131,566 - 37,177,033 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1637,131,345 - 37,177,033 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01636,936,317 - 36,981,614 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41637,093,835 - 37,139,103 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11637,093,909 - 37,139,178 (-)NCBI
Celera1633,598,519 - 33,643,754 (-)NCBICelera
Cytogenetic Map16p11NCBI
FBXO8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384174,236,658 - 174,283,667 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4174,236,658 - 174,283,667 (-)EnsemblGRCh38hg38GRCh38
GRCh374175,157,809 - 175,204,818 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364175,394,384 - 175,441,977 (-)NCBINCBI36Build 36hg18NCBI36
Build 344175,532,538 - 175,580,132NCBI
Celera4172,483,541 - 172,531,150 (-)NCBICelera
Cytogenetic Map4q34.1NCBI
HuRef4170,904,173 - 170,951,800 (-)NCBIHuRef
CHM1_14175,134,262 - 175,181,857 (-)NCBICHM1_1
T2T-CHM13v2.04177,576,496 - 177,623,506 (-)NCBIT2T-CHM13v2.0
Fbxo8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39857,004,189 - 57,046,974 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl857,004,125 - 57,046,974 (+)EnsemblGRCm39 Ensembl
GRCm38856,551,154 - 56,593,939 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl856,551,090 - 56,593,939 (+)EnsemblGRCm38mm10GRCm38
MGSCv37859,029,931 - 59,072,736 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36859,443,276 - 59,486,081 (+)NCBIMGSCv36mm8
Celera859,207,876 - 59,250,604 (+)NCBICelera
Cytogenetic Map8B2NCBI
Fbxo8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540332,798,818 - 32,845,675 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540332,798,827 - 32,845,684 (+)NCBIChiLan1.0ChiLan1.0
FBXO8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14178,696,995 - 178,744,895 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4178,696,995 - 178,744,895 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04166,462,626 - 166,509,875 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
FBXO8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12524,750,752 - 24,796,895 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2524,751,080 - 24,778,228 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2525,398,329 - 25,449,900 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02524,909,084 - 24,960,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2524,914,272 - 24,960,572 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12524,862,707 - 24,889,876 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02524,748,288 - 24,799,842 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02524,897,888 - 24,949,692 (-)NCBIUU_Cfam_GSD_1.0
Fbxo8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494324,863,769 - 24,920,201 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365165,282,768 - 5,333,695 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365165,281,972 - 5,333,890 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXO8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1415,896,001 - 15,932,174 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11415,896,006 - 15,933,154 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21417,053,787 - 17,078,237 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXO8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17120,319,470 - 120,374,705 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7120,317,943 - 120,358,767 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037100,368,376 - 100,423,982 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxo8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247695,810,501 - 5,866,948 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247695,801,794 - 5,866,513 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fbxo8
129 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:67
Interacting mature miRNAs:69
Transcripts:ENSRNOT00000014015
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139533930Rat
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16143534949Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338015043025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760943025077Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16422760943025077Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat

Markers in Region
RH141026  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21633,665,734 - 33,665,949 (+)MAPPERmRatBN7.2
Rnor_6.01637,131,694 - 37,131,908NCBIRnor6.0
Rnor_5.01636,936,679 - 36,936,893UniSTSRnor5.0
RGSC_v3.41637,093,963 - 37,094,177UniSTSRGSC3.4
Celera1633,598,647 - 33,598,861UniSTS
Cytogenetic Map16p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 57 41 19 41 4 4 74 35 34 11 4
Low 1 4 7 7 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000014015   ⟹   ENSRNOP00000014015
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1633,666,201 - 33,711,272 (-)Ensembl
Rnor_6.0 Ensembl1637,131,568 - 37,177,033 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084469   ⟹   ENSRNOP00000071387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1633,665,306 - 33,711,251 (-)Ensembl
Rnor_6.0 Ensembl1637,131,345 - 37,159,745 (-)Ensembl
RefSeq Acc Id: NM_001012050   ⟹   NP_001012050
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21633,665,607 - 33,711,215 (-)NCBI
Rnor_6.01637,131,566 - 37,177,033 (-)NCBI
Rnor_5.01636,936,317 - 36,981,614 (-)NCBI
RGSC_v3.41637,093,835 - 37,139,103 (-)RGD
Celera1633,598,519 - 33,643,754 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094499   ⟹   XP_038950427
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21633,665,305 - 33,699,660 (-)NCBI
RefSeq Acc Id: XM_039094500   ⟹   XP_038950428
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21633,665,305 - 33,689,217 (-)NCBI
RefSeq Acc Id: XM_039094501   ⟹   XP_038950429
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21633,665,307 - 33,711,124 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001012050 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950427 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950428 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950429 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH88452 (Get FASTA)   NCBI Sequence Viewer  
  EDL87147 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001012050   ⟸   NM_001012050
- UniProtKB: Q5M7U1 (UniProtKB/TrEMBL),   F1M701 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071387   ⟸   ENSRNOT00000084469
RefSeq Acc Id: ENSRNOP00000014015   ⟸   ENSRNOT00000014015
RefSeq Acc Id: XP_038950427   ⟸   XM_039094499
- Peptide Label: isoform X1
- UniProtKB: F1M701 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950428   ⟸   XM_039094500
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038950429   ⟸   XM_039094501
- Peptide Label: isoform X2
Protein Domains
F-box   SEC7

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5M7U1-F1-model_v2 AlphaFold Q5M7U1 1-319 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700076
Promoter ID:EPDNEW_R10600
Type:initiation region
Name:Fbxo8_1
Description:F-box protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01637,177,036 - 37,177,096EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307596 AgrOrtholog
BioCyc Gene G2FUF-11519 BioCyc
Ensembl Genes ENSRNOG00000010502 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000014015.7 UniProtKB/TrEMBL
  ENSRNOP00000071387 ENTREZGENE
  ENSRNOP00000071387.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000014015.8 UniProtKB/TrEMBL
  ENSRNOT00000084469 ENTREZGENE
  ENSRNOT00000084469.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1000.11 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7126921 IMAGE-MGC_LOAD
InterPro F-box_dom_cyclin-like UniProtKB/TrEMBL
  F-box_dom_like UniProtKB/TrEMBL
  Sec7 UniProtKB/TrEMBL
  SEC7_alpha_orthog UniProtKB/TrEMBL
  Sec7_sf UniProtKB/TrEMBL
KEGG Report rno:306436 UniProtKB/TrEMBL
MGC_CLONE MGC:95100 IMAGE-MGC_LOAD
NCBI Gene 306436 ENTREZGENE
Pfam F-box-like UniProtKB/TrEMBL
  Sec7 UniProtKB/TrEMBL
PhenoGen Fbxo8 PhenoGen
PROSITE FBOX UniProtKB/TrEMBL
  SEC7 UniProtKB/TrEMBL
SMART Sec7 UniProtKB/TrEMBL
Superfamily-SCOP F-box_dom_Skp2-like UniProtKB/TrEMBL
  Sec7 UniProtKB/TrEMBL
UniProt A0A8J8Y1I3_RAT UniProtKB/TrEMBL
  F1M701 ENTREZGENE
  Q5M7U1 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1M701 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Fbxo8  F-box protein 8  Fbxo8  F-box only protein 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Fbxo8  F-box only protein 8  Fbxo8_predicted  F-box only protein 8 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Fbxo8_predicted  F-box only protein 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED