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Gene: Sacs (sacsin molecular chaperone) Rattus norvegicus
Symbol: Sacs
Name: sacsin molecular chaperone
RGD ID: 1307281
Description: Predicted to have Hsp70 protein binding activity; chaperone binding activity; and proteasome binding activity. Predicted to be involved in negative regulation of inclusion body assembly. Predicted to localize to mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Charlevoix-Saguenay spastic ataxia. Orthologous to human SACS (sacsin molecular chaperone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC290301; LOC305940; RGD1305416; sacsin; similar to RIKEN cDNA E130115J16; spastic ataxia of Charlevoix-Saguenay (sacsin)
Homo sapiens (human) : SACS (sacsin molecular chaperone)  HGNC  Alliance
Mus musculus (house mouse) : Sacs (sacsin)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sacs (sacsin molecular chaperone)
Pan paniscus (bonobo/pygmy chimpanzee) : SACS (sacsin molecular chaperone)
Canis lupus familiaris (dog) : SACS (sacsin molecular chaperone)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sacs (sacsin molecular chaperone)
Sus scrofa (pig) : SACS (sacsin molecular chaperone)
Chlorocebus sabaeus (African green monkey) : SACS (sacsin molecular chaperone)
Heterocephalus glaber (naked mole-rat) : Sacs (sacsin molecular chaperone)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01541,448,078 - 41,530,412 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,448,064 - 41,530,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01545,255,280 - 45,338,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41540,297,202 - 40,344,605 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11540,315,190 - 40,359,066 (+)NCBI
Celera1534,984,356 - 35,069,050 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Sacs
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1307281
Created: 2005-01-12
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.