Sacs (sacsin molecular chaperone) - Rat Genome Database

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Gene: Sacs (sacsin molecular chaperone) Rattus norvegicus
Analyze
Symbol: Sacs
Name: sacsin molecular chaperone
RGD ID: 1307281
Description: Predicted to enable Hsp70 protein binding activity; identical protein binding activity; and proteasome binding activity. Predicted to be involved in negative regulation of inclusion body assembly. Predicted to be located in mitochondrion and nucleus. Human ortholog(s) of this gene implicated in Charlevoix-Saguenay spastic ataxia. Orthologous to human SACS (sacsin molecular chaperone); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 4-amino-2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC290301; LOC305940; RGD1305416; sacsin; similar to RIKEN cDNA E130115J16; spastic ataxia of Charlevoix-Saguenay (sacsin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,461,853 - 39,546,419 (+)NCBIGRCr8
mRatBN7.21535,285,783 - 35,370,335 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,285,782 - 35,370,335 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01541,448,078 - 41,530,412 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,448,064 - 41,530,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01545,255,280 - 45,338,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41540,297,202 - 40,344,605 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11540,315,190 - 40,359,066 (+)NCBI
Celera1534,984,356 - 35,069,050 (+)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
1-nitropyrene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
7,12-dimethyltetraphene  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amphetamine  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
cantharidin  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
DDT  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dimethylarsinic acid  (ISO)
elemental selenium  (ISO)
folic acid  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
maneb  (ISO)
methylarsonic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-nitrosodiethylamine  (EXP)
nickel sulfate  (ISO)
nilotinib  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
pirinixic acid  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamibarotene  (ISO)
thioacetamide  (EXP)
valproic acid  (EXP,ISO)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (ISO)
mitochondrion  (ISO)
nucleus  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090   PMID:19208651   PMID:19666135   PMID:21700703   PMID:23250129   PMID:31505169   PMID:35053415  


Genomics

Comparative Map Data
Sacs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81539,461,853 - 39,546,419 (+)NCBIGRCr8
mRatBN7.21535,285,783 - 35,370,335 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1535,285,782 - 35,370,335 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01541,448,078 - 41,530,412 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1541,448,064 - 41,530,398 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01545,255,280 - 45,338,141 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41540,297,202 - 40,344,605 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11540,315,190 - 40,359,066 (+)NCBI
Celera1534,984,356 - 35,069,050 (+)NCBICelera
Cytogenetic Map15p12NCBI
SACS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381323,328,830 - 23,433,702 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1323,288,689 - 23,433,763 (-)EnsemblGRCh38hg38GRCh38
GRCh371323,902,969 - 24,007,841 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361322,800,966 - 22,840,626 (-)NCBINCBI36Build 36hg18NCBI36
Build 341322,800,966 - 22,840,626NCBI
Celera134,965,968 - 5,070,846 (-)NCBICelera
Cytogenetic Map13q12.12NCBI
HuRef134,715,591 - 4,820,305 (-)NCBIHuRef
CHM1_11323,871,558 - 23,976,445 (-)NCBICHM1_1
T2T-CHM13v2.01322,535,642 - 22,640,549 (-)NCBIT2T-CHM13v2.0
Sacs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391461,375,870 - 61,478,142 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1461,375,906 - 61,478,144 (+)EnsemblGRCm39 Ensembl
GRCm381461,138,421 - 61,240,693 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1461,138,457 - 61,240,695 (+)EnsemblGRCm38mm10GRCm38
MGSCv371461,757,294 - 61,859,530 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361460,092,567 - 60,194,803 (+)NCBIMGSCv36mm8
Celera1458,906,142 - 59,008,250 (+)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1432.13NCBI
Sacs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554973,706,882 - 3,754,663 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554973,701,515 - 3,752,627 (-)NCBIChiLan1.0ChiLan1.0
SACS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21422,945,914 - 23,049,302 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11314,052,946 - 14,156,634 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0134,642,078 - 4,745,453 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11322,936,013 - 22,978,366 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1322,937,320 - 22,982,553 (-)Ensemblpanpan1.1panPan2
SACS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12515,207,959 - 15,297,483 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2515,207,839 - 15,296,078 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2515,291,066 - 15,380,653 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02515,344,721 - 15,434,496 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2515,344,724 - 15,433,719 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12515,219,819 - 15,309,238 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02515,221,010 - 15,310,645 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02515,277,258 - 15,366,849 (+)NCBIUU_Cfam_GSD_1.0
Sacs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945117,374,760 - 117,516,578 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366881,987,054 - 2,079,173 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366881,987,075 - 2,079,148 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SACS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl112,382,906 - 2,442,316 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1112,382,406 - 2,455,756 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2111,722,558 - 1,743,861 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SACS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.133,217,640 - 3,323,801 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl33,216,397 - 3,323,754 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605741,209,226 - 41,315,831 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sacs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477614,290,198 - 14,460,046 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477614,290,186 - 14,395,303 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sacs
757 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:46
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000019551, ENSRNOT00000038665, ENSRNOT00000075479
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat

Markers in Region
D15Hmgc1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,337,101 - 35,337,216 (+)MAPPERmRatBN7.2
Rnor_6.01541,497,179 - 41,497,293NCBIRnor6.0
Rnor_5.01545,304,908 - 45,305,022UniSTSRnor5.0
RGSC_v3.41540,311,375 - 40,311,490RGDRGSC3.4
RGSC_v3.41540,311,376 - 40,311,490UniSTSRGSC3.4
Celera1535,035,815 - 35,035,929UniSTS
RH 3.4 Map15227.8UniSTS
RH 3.4 Map15227.8RGD
Cytogenetic Map15p12UniSTS
RH142830  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,354,510 - 35,354,680 (+)MAPPERmRatBN7.2
Rnor_6.01541,514,588 - 41,514,757NCBIRnor6.0
Rnor_5.01545,322,317 - 45,322,486UniSTSRnor5.0
RGSC_v3.41540,328,785 - 40,328,954UniSTSRGSC3.4
Celera1535,053,226 - 35,053,395UniSTS
RH 3.4 Map15230.3UniSTS
Cytogenetic Map15p12UniSTS
AW524447  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21535,369,907 - 35,370,003 (+)MAPPERmRatBN7.2
Rnor_6.01541,529,985 - 41,530,080NCBIRnor6.0
Rnor_5.01545,337,714 - 45,337,809UniSTSRnor5.0
RGSC_v3.41540,344,181 - 40,344,276UniSTSRGSC3.4
Celera1535,068,623 - 35,068,718UniSTS
RH 3.4 Map15231.3UniSTS
Cytogenetic Map15p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 38 20 4 16 4 8 8 74 4 22 8 8
Low 3 5 34 34 3 34 3 30 16 3
Below cutoff 3 3 3 1 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001427721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006221975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006252169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017599898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017604921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274273 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274274 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274275 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274276 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274278 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000019551   ⟹   ENSRNOP00000019551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1535,285,782 - 35,370,335 (+)Ensembl
Rnor_6.0 Ensembl1541,448,064 - 41,530,398 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000098951   ⟹   ENSRNOP00000095452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1535,285,782 - 35,370,335 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000113056   ⟹   ENSRNOP00000095721
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1535,325,872 - 35,370,335 (+)Ensembl
RefSeq Acc Id: NM_001427721   ⟹   NP_001414650
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,501,902 - 39,546,419 (+)NCBI
RefSeq Acc Id: XM_006252167   ⟹   XP_006252229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,461,853 - 39,546,416 (+)NCBI
mRatBN7.21535,285,783 - 35,370,335 (+)NCBI
Rnor_6.01541,448,078 - 41,530,412 (+)NCBI
Rnor_5.01545,255,280 - 45,338,141 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039093905   ⟹   XP_038949833
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,523,577 - 39,546,416 (+)NCBI
mRatBN7.21535,347,480 - 35,370,335 (+)NCBI
RefSeq Acc Id: XM_063274272   ⟹   XP_063130342
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,461,860 - 39,546,416 (+)NCBI
RefSeq Acc Id: XM_063274273   ⟹   XP_063130343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,499,629 - 39,546,416 (+)NCBI
RefSeq Acc Id: XM_063274274   ⟹   XP_063130344
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,511,146 - 39,546,416 (+)NCBI
RefSeq Acc Id: XM_063274275   ⟹   XP_063130345
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,461,859 - 39,533,208 (+)NCBI
RefSeq Acc Id: XM_063274276   ⟹   XP_063130346
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,461,859 - 39,533,824 (+)NCBI
RefSeq Acc Id: XM_063274277   ⟹   XP_063130347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,461,859 - 39,533,208 (+)NCBI
RefSeq Acc Id: XM_063274278   ⟹   XP_063130348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81539,461,859 - 39,528,602 (+)NCBI
RefSeq Acc Id: XP_006252229   ⟸   XM_006252167
- Peptide Label: isoform X1
- UniProtKB: D4A1D3 (UniProtKB/TrEMBL),   A0A8I6ATI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019551   ⟸   ENSRNOT00000019551
RefSeq Acc Id: XP_038949833   ⟸   XM_039093905
- Peptide Label: isoform X5
- UniProtKB: A6K6B1 (UniProtKB/TrEMBL),   A0A8I6B374 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000095452   ⟸   ENSRNOT00000098951
RefSeq Acc Id: ENSRNOP00000095721   ⟸   ENSRNOT00000113056
RefSeq Acc Id: XP_063130346   ⟸   XM_063274276
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063130345   ⟸   XM_063274275
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063130347   ⟸   XM_063274277
- Peptide Label: isoform X8
RefSeq Acc Id: XP_063130348   ⟸   XM_063274278
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063130342   ⟸   XM_063274272
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063130343   ⟸   XM_063274273
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001414650   ⟸   NM_001427721
RefSeq Acc Id: XP_063130344   ⟸   XM_063274274
- Peptide Label: isoform X4
Protein Domains
HEPN   J

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699739
Promoter ID:EPDNEW_R10262
Type:multiple initiation site
Name:Sacs_1
Description:sacsin molecular chaperone
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01541,448,084 - 41,448,144EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307281 AgrOrtholog
BioCyc Gene G2FUF-13513 BioCyc
Ensembl Genes ENSRNOG00000014509 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019551.7 UniProtKB/TrEMBL
  ENSRNOT00000098951.1 UniProtKB/TrEMBL
  ENSRNOT00000113056.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.110 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
InterPro DnaJ_dom_sf UniProtKB/TrEMBL
  DnaJ_domain UniProtKB/TrEMBL
  HATPase_C_sf UniProtKB/TrEMBL
  HEPN UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:305940 UniProtKB/TrEMBL
NCBI Gene 305940 ENTREZGENE
PANTHER SACSIN UniProtKB/TrEMBL
  SACSIN UniProtKB/TrEMBL
Pfam HEPN UniProtKB/TrEMBL
PharmGKB SACS RGD
PhenoGen Sacs PhenoGen
PROSITE DNAJ_2 UniProtKB/TrEMBL
  HEPN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014509 RatGTEx
SMART HEPN UniProtKB/TrEMBL
Superfamily-SCOP ATP_bd_ATPase UniProtKB/TrEMBL
  DnaJ_N UniProtKB/TrEMBL
  Nucleotidyltransferase substrate binding subunit/domain UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6ATI0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6B374 ENTREZGENE, UniProtKB/TrEMBL
  A6K6B1 ENTREZGENE, UniProtKB/TrEMBL
  D4A1D3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-02-06 Sacs  sacsin molecular chaperone  Sacs  spastic ataxia of Charlevoix-Saguenay (sacsin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-06-15 Sacs  spastic ataxia of Charlevoix-Saguenay (sacsin)  RGD1305416  similar to RIKEN cDNA E130115J16   Data merged from RGD:1305416 1643240 APPROVED
2008-11-20 Sacs  spastic ataxia of Charlevoix-Saguenay (sacsin)  Sacs  sacsin   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sacs  sacsin   Sacs_predicted  sacsin (predicted)  'predicted' is removed 2292626 APPROVED
2008-04-30 RGD1305416  similar to RIKEN cDNA E130115J16   RGD1305416_predicted  similar to RIKEN cDNA E130115J16 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1305416_predicted  similar to RIKEN cDNA E130115J16 (predicted)  LOC290301_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 Sacs_predicted  sacsin (predicted)      Symbol and Name status set to approved 70820 APPROVED
2005-01-12 LOC290301_predicted  similar to RIKEN cDNA E130115J16 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL