Epc2 (enhancer of polycomb homolog 2)

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Gene: Epc2 (enhancer of polycomb homolog 2) Rattus norvegicus

Analyze

Symbol:

Epc2

Name:

enhancer of polycomb homolog 2

RGD ID:

1307271

Description:

Predicted to contribute to histone acetyltransferase activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to localize to Piccolo NuA4 histone acetyltransferase complex. Orthologous to human EPC2 (enhancer of polycomb homolog 2); PARTICIPATES IN INO80 family mediated chromatin remodeling pathway; INTERACTS WITH atrazine; bisphenol A; oxaliplatin.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

enhancer of polycomb homolog 2 (Drosophila); LOC362132

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EPC2 (enhancer of polycomb homolog 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Epc2 (enhancer of polycomb homolog 2)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Epc2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	EPC2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EPC2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Epc2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EPC2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	EPC2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Epc2 (enhancer of polycomb homolog 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	EPC2 (enhancer of polycomb homolog 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Epc2 (enhancer of polycomb homolog 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	epc2 (enhancer of polycomb homolog 2 (Drosophila))	Alliance	DIOPT (PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	EPL1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	E(Pc)	Alliance	DIOPT (OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	epc-1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	33,641,616 - 33,741,219 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	33,641,616 - 33,740,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	38,799,078 - 38,898,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	30,420,605 - 30,536,656 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	30,316,765 - 30,433,028 (+)	NCBI
Celera	3	32,058,204 - 32,153,476 (+)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant non-syndromic intellectual disability 1 (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

amiodarone (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

butanal (ISO)

carbon nanotube (ISO)

choline (ISO)

cyclosporin A (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

fluoranthene (ISO)

folic acid (ISO)

formaldehyde (ISO)

L-methionine (ISO)

leflunomide (ISO)

methyl methanesulfonate (ISO)

N-methyl-4-phenylpyridinium (ISO)

oxaliplatin (EXP)

paracetamol (ISO)

pentachlorophenol (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

propanal (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tetrachloroethene (ISO)

titanium dioxide (ISO)

topotecan (EXP)

trichostatin A (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

histone acetylation (IEA)

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

cellular_component (ND)

Piccolo NuA4 histone acetyltransferase complex (IBA)

Molecular Function

histone acetyltransferase activity (IBA)

molecular_function (ND)

Molecular Pathway Annotations Click to see Annotation Detail View

INO80 family mediated chromatin remodeling pathway (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3.	RGD automated import pipeline for gene-chemical interactions
4.	RGD comprehensive gene curation
5.	Watanabe S and Peterson CL, Cold Spring Harb Symp Quant Biol. 2010;75:35-42. doi: 10.1101/sqb.2010.75.063. Epub 2011 Apr 18.

Genomics

Comparative Map Data

Epc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	3	33,641,616 - 33,741,219 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	33,641,616 - 33,740,461 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	38,799,078 - 38,898,681 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	30,420,605 - 30,536,656 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	3	30,316,765 - 30,433,028 (+)	NCBI
Celera	3	32,058,204 - 32,153,476 (+)	NCBI		Celera
Cytogenetic Map	3	q12	NCBI

EPC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	2	148,644,440 - 148,787,569 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	2	148,644,751 - 148,788,491 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	2	149,402,560 - 149,545,136 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	2	149,119,038 - 149,261,606 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	2	149,236,299 - 149,378,867	NCBI
Celera	2	143,116,707 - 143,259,286 (+)	NCBI
Cytogenetic Map	2	q23.1	NCBI
HuRef	2	141,400,948 - 141,543,639 (+)	NCBI		HuRef
CHM1_1	2	149,408,018 - 149,550,591 (+)	NCBI		CHM1_1

Epc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	49,341,498 - 49,441,954 (+)	NCBI	GRCm39		mm39
GRCm38	2	49,450,755 - 49,551,947 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	49,451,486 - 49,551,948 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	49,307,006 - 49,407,129 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	2	49,273,525 - 49,373,192 (+)	NCBI			mm8
Celera	2	51,125,040 - 51,224,667 (+)	NCBI		Celera
Cytogenetic Map	2	C1.1	NCBI
cM Map	2	28.62	NCBI

Epc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955440	14,573,960 - 14,646,431 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955440	14,573,960 - 14,645,171 (+)	NCBI	ChiLan1.0	ChiLan1.0

EPC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	2B	153,005,269 - 153,148,789 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	2B	153,005,176 - 153,148,644 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	2B	11,074,397 - 11,218,181 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

EPC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	19	50,416,340 - 50,482,878 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	19	50,356,490 - 50,484,405 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Epc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936469	28,489,620 - 28,625,975 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EPC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	15	3,417,063 - 3,526,171 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	15	3,417,446 - 3,526,223 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	15	2,980,941 - 3,121,134 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

EPC2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	10	34,046,966 - 34,190,829 (+)	NCBI
ChlSab1.1 Ensembl	10	34,047,028 - 34,191,956 (+)	Ensembl

Epc2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624866	1,301,922 - 1,451,847 (+)	NCBI

Position Markers

D2Ertd694e

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	3	33,740,148 - 33,740,349	NCBI	Rnor6.0
Rnor_5.0	3	38,897,610 - 38,897,811	UniSTS	Rnor5.0
RGSC_v3.4	3	30,536,343 - 30,536,544	UniSTS	RGSC3.4
Celera	3	32,153,163 - 32,153,364	UniSTS
Cytogenetic Map	3	q12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	37891710	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	39773425	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	95176874	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	2631421	48562146	Rat
1558654	Bw56	Body weight QTL 56	4.5	0.0000171	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
6893355	Bw101	Body weight QTL 101	0.4	0.38	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
6893363	Bw105	Body weight QTL 105	2.6	0.0036	body mass (VT:0001259)	body weight (CMO:0000012)	3	6000748	34394365	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in mean arterial blood pressure (CMO:0000533)	3	6000748	51687917	Rat
70191	BpQTLcluster4	Blood pressure QTL cluster 4	3		arterial blood pressure trait (VT:2000000)	absolute change in systolic blood pressure (CMO:0000607)	3	6000748	51687917	Rat
1558647	Cm46	Cardiac mass QTL 46	5.4	0.0000055	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	6000866	34394121	Rat
1558650	Cm48	Cardiac mass QTL 48	4	0.0001	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	3	6000866	34394121	Rat
1558657	Cm43	Cardiac mass QTL 43	6.6	0.0000000293	heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	6000866	34394121	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	10094081	93415837	Rat
2298542	Neuinf11	Neuroinflammation QTL 11	3.9		nervous system integrity trait (VT:0010566)	spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)	3	10119318	79772001	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	10639528	127023997	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	heart rate (CMO:0000002)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	13126914	36600143	Rat
634306	Bp140	Blood pressure QTL 140	3.3	0.0013	arterial blood pressure trait (VT:2000000)	body weight (CMO:0000012)	3	13126914	36600143	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	13126914	41510346	Rat
731172	Bp151	Blood pressure QTL 151		0.04	arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	14090411	48562146	Rat
12879849	Bw180	Body weight QTL 180		0.037	body mass (VT:0001259)	body weight (CMO:0000012)	3	14090411	48562146	Rat
12879850	Cm91	Cardiac mass QTL 91		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	14090411	48562146	Rat
12879851	Cm92	Cardiac mass QTL 92		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	14090411	48562146	Rat
12879852	Cm93	Cardiac mass QTL 93		0.001	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	14090411	48562146	Rat
12879853	Am5	Aortic mass QTL 5		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	14090411	48562146	Rat
12879854	Kidm63	Kidney mass QTL 63		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	14090411	48562146	Rat
631676	Cm8	Cardiac mass QTL 8	7.03	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	3	18023664	63023664	Rat
10450794	Scl69	Serum cholesterol level QTL 69	6.3	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	21223803	66223803	Rat
10450804	Scl70	Serum cholesterol level QTL 70	4.7	0.001	blood LDL cholesterol amount (VT:0000181)	blood low density lipoprotein cholesterol level (CMO:0000053)	3	21223803	66223803	Rat
631685	Bp118	Blood pressure QTL 118	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	24655225	69655225	Rat
1298073	Cm13	Cardiac mass QTL 13	2.5		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	25633366	39248391	Rat
631832	Sach1	Saccharin preference QTL 1	2.7	0.02	consumption behavior trait (VT:0002069)	calculated saccharin drink intake volume (CMO:0001600)	3	28136728	45772990	Rat
2313049	Bss72	Bone structure and strength QTL 72	2.6	0.0001	tibia area (VT:1000281)	tibia midshaft cross-sectional area (CMO:0001717)	3	28136728	51687917	Rat
2313076	Bss74	Bone structure and strength QTL 74	2	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	3	28136728	51687917	Rat
2313079	Bss73	Bone structure and strength QTL 73	1.5		tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	3	28136728	51687917	Rat
2313093	Bmd77	Bone mineral density QTL 77	2.2	0.0001	tibia mineral mass (VT:1000283)	cortical volumetric bone mineral density (CMO:0001730)	3	28136728	51687917	Rat
2313101	Bmd76	Bone mineral density QTL 76	3.6	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	3	28136728	51687917	Rat
2302055	Pia30	Pristane induced arthritis QTL 30	3.5	0.001	blood autoantibody amount (VT:0003725)	serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)	3	29321714	74321714	Rat
9590286	Uminl1	Urine mineral level QTL 1	3.5	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	3	29682732	74682732	Rat
9590136	Scort3	Serum corticosterone level QTL 3	23.37	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	29682732	74682732	Rat
8552950	Pigfal12	Plasma insulin-like growth factor 1 level QTL 12	7.3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	29682732	74682732	Rat
8694196	Abfw2	Abdominal fat weight QTL 2	16.58	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	3	29682732	74682732	Rat
8694386	Bw159	Body weight QTL 159	4.52	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	3	29682732	74682732	Rat
1354590	Despr11	Despair related QTL 11		0.000031	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	3	29908255	74908255	Rat
2303593	Gluco46	Glucose level QTL 46	3		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	29908255	74908255	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	30114912	123700444	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	30846101	172879276	Rat
2301400	Cm68	Cardiac mass QTL 68		0.001	heart mass (VT:0007028)	heart wet weight to body weight ratio (CMO:0002408)	3	31103589	72989078	Rat
11565451	Bw177	Body weight QTL 177		0.002	body mass (VT:0001259)	body weight (CMO:0000012)	3	31103589	72989078	Rat
11565452	Kidm57	Kidney mass QTL 57		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	31103589	72989078	Rat
12879866	Cm94	Cardiac mass QTL 94		0.001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	31103589	72989078	Rat
12879867	Cm95	Cardiac mass QTL 95		0.047	heart right ventricle mass (VT:0007033)	heart right ventricle weight to body weight ratio (CMO:0000914)	3	31103589	72989078	Rat
12879868	Am6	Aortic mass QTL 6		0.001	aorta mass (VT:0002845)	aorta weight to aorta length to body weight ratio (CMO:0002722)	3	31103589	72989078	Rat
61356	Bp37	Blood pressure QTL 37	3		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	32130997	77130997	Rat
631647	Bp122	Blood pressure QTL 122	6.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	32130997	77130997	Rat
1300169	Bp177	Blood pressure QTL 177	2.96		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	3	33477354	62922975	Rat
1354589	Bw31	Body weight QTL 31	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	3	33477354	81136227	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	33477354	108914061	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	789
Count of miRNA genes:	310
Interacting mature miRNAs:	413
Transcripts:	ENSRNOT00000051953
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	26	25	16	18	16			74	22	34	11
Low	1	17	32	25	1	25	8	11		13	7		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108581	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234155	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07052041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07052042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021687	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021688	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01021689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000051953 ⟹ ENSRNOP00000040649

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	3	33,641,616 - 33,740,461 (+)	Ensembl

RefSeq Acc Id:

NM_001108581 ⟹ NP_001102051

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	33,641,616 - 33,740,461 (+)	NCBI
Rnor_5.0	3	38,799,078 - 38,898,681 (+)	NCBI
RGSC_v3.4	3	30,420,605 - 30,536,656 (+)	RGD
Celera	3	32,058,204 - 32,153,476 (+)	RGD

Sequence:

show sequence

AGGCGGCGGGAGTGCTCCCCCCTCCCCGCCCGCCCCGCCGCCGCCGCCCGGGCTGTTCCTGTAA
GGCGGGGAGACAATGAGTAAACTCTCCTTCCGAGCGCGGGCGCTGGACGCCGCCAAACCGCTGC
CCATCTACCGCGGCAAGGACATGCCTGATCTCAACGACTGCGTCTCCATCAACCGGGCCGTGCC
CCAGATGCCCACCGGGATGGAGAAGGAGGAGGAATCGGAACATCACTTACAGCGAGCTATTTCA
GCACAGCAAGTATTTAGAGAAAAAAAAGAGAGCATGGTCATTCCAGTTCCTGAGGCGGAGAGCA
ACGTCAACTATTACAATCGCTTGTACAAAGGGGAGTTTAAACAGCCCAAACAGTTCATTCATAT
TCAGCCTTTTAACCTAGACAATGAGCAACCAGATTATGATATGGATTCTGAAGATGAGACATTA
TTAAATAGACTTAACAGAAAGATGGAAATTAAACCTTTGCAATTTGAAATTATGATTGACAGAC
TTGAAAAAGCCAGTTCTAACCAGCTTGTAACACTTCAAGAAGCAAAACTGCTGCTGAATGAAGA
CGACTACCTTATTAAAGCTGTATATGACTACTGGGTGAGGAAACGCAAGAACTGCAGGGGGCCG
TCCCTCATCCCCCAGATTAAGCAAGAGAAGAGAGATGGCTCTACCAACAATGATCCTTATGTTG
CCTTTCGGAGGAGAACAGAGAAGATGCAGACTCGGAAGAACCGTAAGAATGATGAGGCTTCTTA
TGAAAAGATGCTGAAGCTGAGGCGGGAGTTCAGCAGAGCCATAACAATTTTGGAAATGATTAAG
AGAAGAGAGAAAACCAAACGGGAATTATTGCACTTAACGCTGGAAGTTGTGGAAAAAAGATATC
ATTTGGGAGACTATGGGGGTGAAATCCTTAATGAAGTGAAAGTTAATAGATCAGAAAAAGAGTT
ATATGCCAGTCCAGCAACTCTTCATAATGGAAATCATCACAAAGTTCAAGAATGTAAAACTAAG
CACCCTCATCATTTGTCTTTGAAAGAAGAGGCTTCTGACGTGGTCCGTCAAAAGAAGAAGCACC
CCAAGAAGCCTAAGGCAGAGGCTGTGCTAGCCCCGCCGCAGCCCACTCCTGAGACAGTGCCTGT
GATCAATAAGAGTGACATTAAGCAATATGACTTTCAGAGCTCAGATGAAGATGAATTTCCACAG
GTACCATCTCCAGCATCAGAACCTGAAGAAGAAAATGATCCTGATGGTCCCTGTGCTTTCAGAA
GGCGGGCAGGATGCCAGTATTATGCTCCGCGTTTGGACCAAGCTAATAACCATCCGTGTGAAAG
TTCAGAGTTGGCAGACTTGGATAAGTTGAGGTATAAGCATTGTCTCACAACACTTACAGTTCCA
AGAAGATGTATAGGGTTTGCCAGGAGGCGAATTGGCAGGGGTGGAAGGGTCATAATGGACCGAA
TATCCACAGAACATGACCCCGTCCTAAAACAGATAGACCCTGAGATGCTGAATGGGCTTTCAAG
CTCTTCCCAAACTATAGACTTTTCTTCTAATTTCTCTCGGACCAATGCTTCCAGTAAACCTTGT
GAAAATAGACTGTCCCTTTCTGAAATATTAAGCAATATCAGATCATGTCGACTACAGTGTTTCC
AGCCAAGGCTACTAAATGTACAGGACATTGATAGTGAAGAATGTACCTCAAGAAAACCAGGGCA
GACTGTGAGCAGTAAAAGGGTTTCTGCAGCATCTGTAGCTTTATTGAACACCAGCAAGAACGGC
ATATCAGTCACAGGGGGCATCACAGAAGAGCAGTTTCAGACACATCAACAGCAGCTAGCTCAAA
TGCAAAGGCAGCAACTCGCGCAGCTTCAGCAGAAACAGCAATCCCAGCATTCCTCACAGCAGAC
ACATCCAAAAGCACAGGGCTCAAGCACCTCGGACTGTATGTCTAAAACACTTGACTCAGCCAGC
GCCCACTTTGCTGCATCTGCAGTGGTCAGTGCTCCTGTTCCAAGTCGCAGTGAGGGATCTAAGG
AACAGAACACTGGCCACAACAATATGAATGGTGTTGTCCAGCCTTCAGGACCCTCTAAAACATT
ATATTCCACCAATATGGCTTTATCATCCAGCCCAGGGATTTCAGCTGTACAGCTTGTAAGGACA
GTTGGCCACACTACTACAAACCACTTGATCCCAGCGTTGTGCACAAGCAGTCCTCAGACACTTC
CCATGAACAATTCCTGCCTGACCAATGCAGTGCACCTCAATAATGTCAGTGTTGTTTCTCCTGT
CAATGTGCATATCAATACACGGACTTCAGCACCATCGCCAACAGCCTTAAAACTTGCCACAGTT
GCTGCCAGTATGGACAGAGTGCCAAAGGTTACTCCCAGCAGTGCCATCAGCAGCATAGCCAGAG
AGAACCATGAACCAGAAAGACTGGGTTTAAATGGAATAGCAGAGACAACAGTAGCTATGGAAGT
GACATAACGTAAAGTGTGTGGCTTTGACCTGTGTGGACGGTTGCAGTCATTCATATTCCAGCGG
AATACAAAGGCGACACTCTGGATCACAGAGCAGAACAATGGACCCAAATGGAGTACAGTATACC
GGATGTTAAGTCGATGTATGATGTATATTTTGTAAAATTGGGAAAATCACTACCTTGTAAAATA
GTTTATTTGTATCATCAATATTATTTCTGTTACTTGAATAGTAGATATTCATCATCATGCTTTT
GCACTTGAATTTGCAACTGAATGGATTTTAAAAATAATTCTTTAATGGGATCATGAGCATGAAA
TGGGATCCTGCATCACTTGTTTTAACTATTTATTTTGCCATGTTTACATTTTGTATCTTGTAAA
AAAAAATAAATCCAACTTTGTGTCTAAAAAGTTAAAGATTCATAGCTAGGAAATGAAATTCTTG
TAATTTTTTTCTAAAGGAACTGTAAAGTTTTCACTTGGTTCATTTTGTTTCACAATTTGACTAG
ATGGACTTTTTGGTAAACACTTTAGTGGCATTTCACTGTCAAATACGACTTCAAGGCAAAATAG
TATTTTCTATTACTGTGCAGGGGAAAGGGATGGATCGATACATGCAAATTTAATGTAGTAACTC
ACTTTTCCATATATTTTGAATGTATATTTCTATTTATAATACCAGTTTATAAAAAATAATTACA
CAGAAAAAGTGGACTAGGAAATTATGCATCTAGCACATTTAAACTGTGCAGATATGAAAATTTT
TCATGGATTACATTTTATCTGAAGACTGCATATTTTAACTGGCTTTAAAACTGTAACACACCAC
ATAAAAGATATTTACCAGGTATGTATTGCATCATATCATTGCAATAATTATTGGAAGTCTATAT
ATCGAGCCATCCCAGGTTTTGGGAGGGGGGAGGGTTGTGGCAAGATTGTCTTTTCAATTTTGGA
GAGTTTTCCTGTGGCTACAAGGCAAGTAACGGGTTGGAAAACGTCTGACTGTAAGTGTTGGACA
CCTTCATAGTGTAGTGTTTTAGTGACTTTTTTATACGGTTCTTGTACATTAGATACGTGTAGTG
GTGTTTCAGAATGTTTGTTTATGCACTAGTTCAGACAACTTTCCCTGTTACTTGTTCTTGATAA
GTGAAACCTGCAGGGAAATAAAAAATACATATCAAAAC

hide sequence

RefSeq Acc Id:

XM_006234155 ⟹ XP_006234217

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	33,641,640 - 33,741,219 (+)	NCBI
Rnor_5.0	3	38,799,078 - 38,898,681 (+)	NCBI

Sequence:

show sequence

CCCGCCCGCCCCGCCGCCGCCGCCCGGGCTGTTCCTGTAAGGCGGGGAGACAATGAGTAAACTC
TCCTTCCGAGCGCGGGCGCTGGACGCCGCCAAACCGCTGCCCATCTACCGCGGCAAGGACATGC
CTGATCTCAACGACTGCGTCTCCATCAACCGGGCCGTGCCCCAGATGCCCACCGGGATGGAGAA
GGAGGAGGAATCGGAACATCACTTACAGCGAGCTATTTCAGCACAGCAAGTATTTAGAGAAAAA
AAAGAGAGCATGGTCATTCCAGTTCCTGAGGCGGAGAGCAACGTCAACTATTACAATCGCTTGT
ACAAAGGGGAGTTTAAACAGCCCAAACAGTTCATTCATATTCAGCCTTTTAACCTAGACAATGA
GCAACCAGATTATGATATGGATTCTGAAGATGAGACATTATTAAATAGACTTAACAGAAAGATG
GAAATTAAACCTTTGCAATTTGAAATTATGATTGACAGACTTGAAAAAGCCAGTTCTAACCAGC
TTGTAACACTTCAAGAAGCAAAACTGCTGCTGAATGAAGACGACTACCTTATTAAAGCTGTATA
TGACTACTGGGTGAGGAAACGCAAGAACTGCAGGGGGCCGTCCCTCATCCCCCAGATTAAGCAA
GAGAAGAGAGATGGCTCTACCAACAATGATCCTTATGTTGCCTTTCGGAGGAGAACAGAGAAGA
TGCAGACTCGGAAGAACCGTAAGAATGATGAGGCTTCTTATGAAAAGATGCTGAAGCTGAGGCG
GGAGTTCAGCAGAGCCATAACAATTTTGGAAATGATTAAGAGAAGAGAGAAAACCAAACGGGAA
TTATTGCACTTAACGCTGGAAGTTGTGGAAAAAAGATATCATTTGGGAGACTATGGGGGTGAAA
TCCTTAATGAAGTGAAAGTTAATAGATCAGAAAAAGAGTTATATGCCAGTCCAGCAACTCTTCA
TAATGGAAATCATCACAAAGTTCAAGAATGTAAAACTAAGGTACCATCTCCAGCATCAGAACCT
GAAGAAGAAAATGATCCTGATGGTCCCTGTGCTTTCAGAAGGCGGGCAGGATGCCAGTATTATG
CTCCGCGTTTGGACCAAGCTAATAACCATCCGTGTGAAAGTTCAGAGTTGGCAGACTTGGATAA
GTTGAGGTATAAGCATTGTCTCACAACACTTACAGTTCCAAGAAGATGTATAGGGTTTGCCAGG
AGGCGAATTGGCAGGGGTGGAAGGGTCATAATGGACCGAATATCCACAGAACATGACCCCGTCC
TAAAACAGATAGACCCTGAGATGCTGAATGGGCTTTCAAGCTCTTCCCAAACTATAGACTTTTC
TTCTAATTTCTCTCGGACCAATGCTTCCAGTAAACCTTGTGAAAATAGACTGTCCCTTTCTGAA
ATATTAAGCAATATCAGATCATGTCGACTACAGTGTTTCCAGCCAAGGCTACTAAATGTACAGG
ACATTGATAGTGAAGAATGTACCTCAAGAAAACCAGGGCAGACTGTGAGCAGTAAAAGGGTTTC
TGCAGCATCTGTAGCTTTATTGAACACCAGCAAGAACGGCATATCAGTCACAGGGGGCATCACA
GAAGAGCAGTTTCAGACACATCAACAGCAGCTAGCTCAAATGCAAAGGCAGCAACTCGCGCAGC
TTCAGCAGAAACAGCAATCCCAGCATTCCTCACAGCAGACACATCCAAAAGCACAGGGCTCAAG
CACCTCGGACTGTATGTCTAAAACACTTGACTCAGCCAGCGCCCACTTTGCTGCATCTGCAGTG
GTCAGTGCTCCTGTTCCAAGTCGCAGTGAGGGATCTAAGGAACAGAACACTGGCCACAACAATA
TGAATGGTGTTGTCCAGCCTTCAGGACCCTCTAAAACATTATATTCCACCAATATGGCTTTATC
ATCCAGCCCAGGGATTTCAGCTGTACAGCTTGTAAGGACAGTTGGCCACACTACTACAAACCAC
TTGATCCCAGCGTTGTGCACAAGCAGTCCTCAGACACTTCCCATGAACAATTCCTGCCTGACCA
ATGCAGTGCACCTCAATAATGTCAGTGTTGTTTCTCCTGTCAATGTGCATATCAATACACGGAC
TTCAGCACCATCGCCAACAGCCTTAAAACTTGCCACAGTTGCTGCCAGTATGGACAGAGTGCCA
AAGGTTACTCCCAGCAGTGCCATCAGCAGCATAGCCAGAGAGAACCATGAACCAGAAAGACTGG
GTTTAAATGGAATAGCAGAGACAACAGTAGCTATGGAAGTGACATAACGTAAAGTGTGTGGCTT
TGACCTGTGTGGACGGTTGCAGTCATTCATATTCCAGCGGAATACAAAGGCGACACTCTGGATC
ACAGAGCAGAACAATGGACCCAAATGGAGTACAGTATACCGGATGTTAAGTCGATGTATGATGT
ATATTTTGTAAAATTGGGAAAATCACTACCTTGTAAAATAGTTTATTTGTATCATCAATATTAT
TTCTGTTACTTGAATAGTAGATATTCATCATCATGCTTTTGCACTTGAATTTGCAACTGAATGG
ATTTTAAAAATAATTCTTTAATGGGATCATGAGCATGAAATGGGATCCTGCATCACTTGTTTTA
ACTATTTATTTTGCCATGTTTACATTTTGTATCTTGTAAAAAAAAATAAATCCAACTTTGTGTC
TAAAAAGTTAAAGATTCATAGCTAGGAAATGAAATTCTTGTAATTTTTTTCTAAAGGAACTGTA
AAGTTTTCACTTGGTTCATTTTGTTTCACAATTTGACTAGATGGACTTTTTGGTAAACACTTTA
GTGGCATTTCACTGTCAAATACGACTTCAAGGCAAAATAGTATTTTCTATTACTGTGCAGGGGA
AAGGGATGGATCGATACATGCAAATTTAATGTAGTAACTCACTTTTCCATATATTTTGAATGTA
TATTTCTATTTATAATACCAGTTTATAAAAAATAATTACACAGAAAAAGTGGACTAGGAAATTA
TGCATCTAGCACATTTAAACTGTGCAGATATGAAAATTTTTCATGGATTACATTTTATCTGAAG
ACTGCATATTTTAACTGGCTTTAAAACTGTAACACACCACATAAAAGATATTTACCAGGTATGT
ATTGCATCATATCATTGCAATAATTATTGGAAGTCTATATATCGAGCCATCCCAGGTTTTGGGA
GGGGGGAGGGTTGTGGCAAGATTGTCTTTTCAATTTTGGAGAGTTTTCCTGTGGCTACAAGGCA
AGTAACGGGTTGGAAAACGTCTGACTGTAAGTGTTGGACACCTTCATAGTGTAGTGTTTTAGTG
ACTTTTTTATACGGTTCTTGTACATTAGATACGTGTAGTGGTGTTTCAGAATGTTTGTTTATGC
ACTAGTTCAGACAACTTTCCCTGTTACTTGTTCTTGATAAGTGAAACCTGCAGGGAAATAAAAA
ATACATATCAAAACACGGCCATGCTGCATATGTGTTTATTTCACCATGTGCACACAGTGTGAGC
GAGGACAGGAGGGACAGGCCGGCACGTGCAGCACATGTCCCCCCAGGCTTTCCTGGCATTGAGG
AGAAGGTCTAAGGCTCATCCCTGGGCTCGATTGGGTTTCAGATAATCCAATATAAACTACCTTT
GCTATGAAAGTTCTTAAACTATTTTACAGAATGTAAGTAATTTGCAGTATAGCAGTCATTGAAA
TCTCATAAATGAGCCTCCTTTTATAAGTAAATAGAGTATAGTGTAGAATTATATTGCGAGGGGG
TTTTGGAAGTCCTGGGAAATGTAAATATTTTTAATGAATATGATTAAAACCATTTCAAACCAAA
CATAATTTTATACCGTTTTTATATCTGCAGTCCTGAAAGTTGTAAACTTATTGTCAGTTAAATT
AATGGGCCAGGATTTCTGCTGAGAGTGGTTTTTATTCAGATCCTAAATGTAAAGCAATTTATGG
TCAAAACCACAGGGGGAAAAATAAATTTAATGACTTTGTCGGTTGTGACCTGATAGGATCCATG
CTCGTTTTTGCCATACTACCTCTGGGGTTCACTGCTGATGATATAAAGGAAATAACTTGATTGA
TATGTATATGACTGTGTTCATTCTGCTTACAGTTGGATGTATCTTGCTATTAAGAATTTGAAAC
AACTCAGTGCTAATTTCAGAGAAAGCTTCTCCCCTCCCCCATTTCGCTGAAGTAAAGCATGAAG
TTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001102051	(Get FASTA)	NCBI Sequence Viewer
	XP_006234217	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDM00465	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102051 ⟸ NM_001108581

- UniProtKB:

D4ADG5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQV
FREKKESMVIPVPEAESNVNYYNRLYKGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRL
NRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIP
QIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREK
TKRELLHLTLEVVEKRYHLGDYGGEILNEVKVNRSEKELYASPATLHNGNHHKVQECKTKHPHH
LSLKEEASDVVRQKKKHPKKPKAEAVLAPPQPTPETVPVINKSDIKQYDFQSSDEDEFPQVPSP
ASEPEEENDPDGPCAFRRRAGCQYYAPRLDQANNHPCESSELADLDKLRYKHCLTTLTVPRRCI
GFARRRIGRGGRVIMDRISTEHDPVLKQIDPEMLNGLSSSSQTIDFSSNFSRTNASSKPCENRL
SLSEILSNIRSCRLQCFQPRLLNVQDIDSEECTSRKPGQTVSSKRVSAASVALLNTSKNGISVT
GGITEEQFQTHQQQLAQMQRQQLAQLQQKQQSQHSSQQTHPKAQGSSTSDCMSKTLDSASAHFA
ASAVVSAPVPSRSEGSKEQNTGHNNMNGVVQPSGPSKTLYSTNMALSSSPGISAVQLVRTVGHT
TTNHLIPALCTSSPQTLPMNNSCLTNAVHLNNVSVVSPVNVHINTRTSAPSPTALKLATVAASM
DRVPKVTPSSAISSIARENHEPERLGLNGIAETTVAMEVT

hide sequence

RefSeq Acc Id:

XP_006234217 ⟸ XM_006234155

- Peptide Label:

isoform X1

- Sequence:

show sequence

MSKLSFRARALDAAKPLPIYRGKDMPDLNDCVSINRAVPQMPTGMEKEEESEHHLQRAISAQQV
FREKKESMVIPVPEAESNVNYYNRLYKGEFKQPKQFIHIQPFNLDNEQPDYDMDSEDETLLNRL
NRKMEIKPLQFEIMIDRLEKASSNQLVTLQEAKLLLNEDDYLIKAVYDYWVRKRKNCRGPSLIP
QIKQEKRDGSTNNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRREFSRAITILEMIKRREK
TKRELLHLTLEVVEKRYHLGDYGGEILNEVKVNRSEKELYASPATLHNGNHHKVQECKTKVPSP
ASEPEEENDPDGPCAFRRRAGCQYYAPRLDQANNHPCESSELADLDKLRYKHCLTTLTVPRRCI
GFARRRIGRGGRVIMDRISTEHDPVLKQIDPEMLNGLSSSSQTIDFSSNFSRTNASSKPCENRL
SLSEILSNIRSCRLQCFQPRLLNVQDIDSEECTSRKPGQTVSSKRVSAASVALLNTSKNGISVT
GGITEEQFQTHQQQLAQMQRQQLAQLQQKQQSQHSSQQTHPKAQGSSTSDCMSKTLDSASAHFA
ASAVVSAPVPSRSEGSKEQNTGHNNMNGVVQPSGPSKTLYSTNMALSSSPGISAVQLVRTVGHT
TTNHLIPALCTSSPQTLPMNNSCLTNAVHLNNVSVVSPVNVHINTRTSAPSPTALKLATVAASM
DRVPKVTPSSAISSIARENHEPERLGLNGIAETTVAMEVT

hide sequence

RefSeq Acc Id:

ENSRNOP00000040649 ⟸ ENSRNOT00000051953

Protein Domains

E_Pc_C EPL1

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

Visual

CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

Visual

CSV

TAB

Printer

Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

Visual

CSV

TAB

Printer

Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_6.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	33713580	33713581	G	A	snv	WKY/N (MCW)

Assembly: RGSC_v3.4

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
3	30509775	30509776	G	A	snv	WKY/N (KNAW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1307271	AgrOrtholog
Ensembl Genes	ENSRNOG00000029447	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000040649	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000051953	ENTREZGENE, UniProtKB/TrEMBL
InterPro	E_Pc_C	UniProtKB/TrEMBL
	Enhancer_of_polycomb-like	UniProtKB/TrEMBL
	Enhancer_polycomb	UniProtKB/TrEMBL
KEGG Report	rno:362132	UniProtKB/TrEMBL
NCBI Gene	362132	ENTREZGENE
PANTHER	PTHR14898	UniProtKB/TrEMBL
Pfam	E_Pc_C	UniProtKB/TrEMBL
	EPL1	UniProtKB/TrEMBL
PhenoGen	Epc2	PhenoGen
UniProt	D4ADG5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Epc2	enhancer of polycomb homolog 2	Epc2	enhancer of polycomb homolog 2 (Drosophila)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-11	Epc2	enhancer of polycomb homolog 2	Epc2	enhancer of polycomb homolog 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Epc2	enhancer of polycomb homolog 2 (Drosophila)	Epc2_predicted	enhancer of polycomb homolog 2 (Drosophila) (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Epc2_predicted	enhancer of polycomb homolog 2 (Drosophila) (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations