Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Brox | Rat | (1->4)-beta-D-glucan | multiple interactions | ISO | Brox (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of BROX mRNA | CTD | PMID:36331819 | Brox | Rat | 1,2-dichloroethane | increases expression | ISO | Brox (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of BROX mRNA | CTD | PMID:28960355 | Brox | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Brox (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of BROX mRNA | CTD | PMID:22206623 | Brox | Rat | 2,2',4,4'-Tetrabromodiphenyl ether | decreases expression | ISO | BROX (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Brox | Rat | 3,3',5,5'-tetrabromobisphenol A | decreases expression | ISO | BROX (Homo sapiens) | 6480464 | tetrabromobisphenol A results in decreased expression of BROX protein | CTD | PMID:31675489 | Brox | Rat | 3-isobutyl-1-methyl-7H-xanthine | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BROX mRNA more ... | CTD | PMID:28628672 | Brox | Rat | 4,4'-sulfonyldiphenol | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of BROX mRNA | CTD | PMID:28628672 | Brox | Rat | aconitine | increases expression | EXP | | 6480464 | Aconitine results in increased expression of BROX protein | CTD | PMID:33236894 | Brox | Rat | acrolein | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of BROX mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of BROX mRNA | CTD | PMID:32699268 | Brox | Rat | acrylamide | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Acrylamide results in increased expression of BROX mRNA | CTD | PMID:32763439 | Brox | Rat | aflatoxin B1 | increases methylation | ISO | BROX (Homo sapiens) | 6480464 | Aflatoxin B1 results in increased methylation of BROX gene | CTD | PMID:27153756 | Brox | Rat | all-trans-retinoic acid | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Tretinoin results in increased expression of BROX mRNA | CTD | PMID:33167477 | Brox | Rat | alpha-pinene | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of BROX mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of BROX mRNA | CTD | PMID:32699268 | Brox | Rat | benzo[a]pyrene | increases expression | ISO | Brox (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of BROX mRNA | CTD | PMID:22228805 | Brox | Rat | benzo[a]pyrene | affects methylation | ISO | BROX (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of BROX 5' UTR | CTD | PMID:27901495 | Brox | Rat | bis(2-ethylhexyl) phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of BROX promoter | CTD | PMID:23359474 | Brox | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of BROX promoter | CTD | PMID:23359474 | Brox | Rat | bisphenol A | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BROX mRNA | CTD | PMID:28628672 | Brox | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of BROX mRNA | CTD | PMID:25181051 | Brox | Rat | bisphenol F | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of BROX mRNA | CTD | PMID:28628672 | Brox | Rat | crocidolite asbestos | decreases expression | ISO | Brox (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of BROX mRNA | CTD | PMID:29279043 | Brox | Rat | cyclosporin A | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of BROX mRNA | CTD | PMID:25562108 | Brox | Rat | dexamethasone | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BROX mRNA more ... | CTD | PMID:28628672 | Brox | Rat | dibutyl phthalate | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate] affects the methylation of BROX promoter | CTD | PMID:23359474 | Brox | Rat | dioxygen | multiple interactions | ISO | Brox (Mus musculus) | 6480464 | [sulforaphane affects the susceptibility to Oxygen] which affects the expression of BROX mRNA | CTD | PMID:30529165 | Brox | Rat | diquat | increases expression | ISO | Brox (Mus musculus) | 6480464 | Diquat results in increased expression of BROX protein | CTD | PMID:36851058 | Brox | Rat | doxorubicin | decreases expression | ISO | BROX (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of BROX mRNA | CTD | PMID:29803840 | Brox | Rat | ethanol | affects splicing | ISO | Brox (Mus musculus) | 6480464 | Ethanol affects the splicing of BROX mRNA | CTD | PMID:30319688 | Brox | Rat | ethyl methanesulfonate | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Ethyl Methanesulfonate results in increased expression of BROX mRNA | CTD | PMID:23649840 | Brox | Rat | fenthion | decreases expression | ISO | Brox (Mus musculus) | 6480464 | Fenthion results in decreased expression of BROX mRNA | CTD | PMID:34813904 | Brox | Rat | fipronil | decreases expression | EXP | | 6480464 | fipronil results in decreased expression of BROX mRNA | CTD | PMID:34044035 | Brox | Rat | formaldehyde | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Formaldehyde results in increased expression of BROX mRNA | CTD | PMID:23649840 | Brox | Rat | indometacin | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of BROX mRNA more ... | CTD | PMID:28628672 | Brox | Rat | inulin | multiple interactions | ISO | Brox (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of BROX mRNA | CTD | PMID:36331819 | Brox | Rat | ivermectin | decreases expression | ISO | BROX (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of BROX protein | CTD | PMID:32959892 | Brox | Rat | methidathion | decreases expression | ISO | Brox (Mus musculus) | 6480464 | methidathion results in decreased expression of BROX mRNA | CTD | PMID:34813904 | Brox | Rat | methyl methanesulfonate | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Methyl Methanesulfonate results in increased expression of BROX mRNA | CTD | PMID:23649840 | Brox | Rat | ozone | multiple interactions | ISO | BROX (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of BROX mRNA more ... | CTD | PMID:32699268 | Brox | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Brox (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of BROX mRNA and [perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of BROX mRNA | CTD | PMID:36331819 | Brox | Rat | poly(I:C) | multiple interactions | EXP | | 6480464 | [Poly I-C co-treated with HU 211] results in decreased expression of BROX mRNA | CTD | PMID:26923065 | Brox | Rat | resorcinol | decreases expression | ISO | BROX (Homo sapiens) | 6480464 | resorcinol results in decreased expression of BROX mRNA | CTD | PMID:22623647 | Brox | Rat | sodium arsenite | increases expression | ISO | BROX (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of BROX mRNA | CTD | PMID:38568856 | Brox | Rat | sodium arsenite | increases expression | ISO | Brox (Mus musculus) | 6480464 | sodium arsenite results in increased expression of BROX mRNA | CTD | PMID:37682722 | Brox | Rat | Soman | decreases expression | EXP | | 6480464 | Soman results in decreased expression of BROX mRNA | CTD | PMID:19281266 | Brox | Rat | sulforaphane | multiple interactions | ISO | Brox (Mus musculus) | 6480464 | [sulforaphane affects the susceptibility to Oxygen] which affects the expression of BROX mRNA | CTD | PMID:30529165 | Brox | Rat | triphenyl phosphate | affects expression | ISO | BROX (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of BROX mRNA | CTD | PMID:37042841 | Brox | Rat | triptonide | increases expression | ISO | Brox (Mus musculus) | 6480464 | triptonide results in increased expression of BROX mRNA | CTD | PMID:33045310 | Brox | Rat | urethane | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Urethane results in increased expression of BROX mRNA | CTD | PMID:28818685 | Brox | Rat | valproic acid | increases expression | ISO | BROX (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of BROX mRNA | CTD | PMID:28001369 | |