Brox (BRO1 domain and CAAX motif containing) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Brox (BRO1 domain and CAAX motif containing) Rattus norvegicus
Analyze
Symbol: Brox
Name: BRO1 domain and CAAX motif containing
RGD ID: 1307161
Description: Predicted to be involved in mitotic nuclear membrane reassembly. Predicted to be located in nuclear envelope. Orthologous to human BROX (BRO1 domain and CAAX motif containing); INTERACTS WITH aconitine; bis(2-ethylhexyl) phthalate; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: BRO1 domain- and CAAX motif-containing protein; BRO1 domain-containing protein BROX; LOC305031; MGC114362; RGD1307161; similar to 0610010K06Rik protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,451,736 - 97,471,598 (-)NCBIGRCr8
mRatBN7.21394,920,107 - 94,940,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,920,112 - 94,940,227 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,425,477 - 97,445,264 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,825,287 - 98,845,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,007,437 - 96,027,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,677,896 - 101,697,743 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,677,902 - 101,697,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,886,368 - 100,906,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,319,507 - 99,339,291 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,508,442 - 99,528,227 (-)NCBI
Celera1394,447,203 - 94,466,862 (-)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:19056867   PMID:19199708   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Brox
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,451,736 - 97,471,598 (-)NCBIGRCr8
mRatBN7.21394,920,107 - 94,940,189 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,920,112 - 94,940,227 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,425,477 - 97,445,264 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,825,287 - 98,845,074 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01396,007,437 - 96,027,220 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,677,896 - 101,697,743 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,677,902 - 101,697,684 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013100,886,368 - 100,906,452 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,319,507 - 99,339,291 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,508,442 - 99,528,227 (-)NCBI
Celera1394,447,203 - 94,466,862 (-)NCBICelera
Cytogenetic Map13q26NCBI
BROX
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381222,712,564 - 222,735,187 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1222,712,553 - 222,735,196 (+)EnsemblGRCh38hg38GRCh38
GRCh371222,885,906 - 222,908,529 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361220,952,529 - 220,972,732 (+)NCBINCBI36Build 36hg18NCBI36
Celera1196,105,074 - 196,125,277 (+)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,560,289 - 193,580,492 (+)NCBIHuRef
CHM1_11224,158,972 - 224,179,175 (+)NCBICHM1_1
T2T-CHM13v2.01221,946,320 - 221,968,943 (+)NCBIT2T-CHM13v2.0
Brox
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391183,057,916 - 183,078,839 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1183,057,916 - 183,078,813 (-)EnsemblGRCm39 Ensembl
GRCm381183,276,352 - 183,297,298 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1183,276,352 - 183,297,269 (-)EnsemblGRCm38mm10GRCm38
Celera1190,277,448 - 190,298,022 (-)NCBICelera
Cytogenetic Map1H5NCBI
Brox
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,797,657 - 1,818,708 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,797,657 - 1,819,359 (-)NCBIChiLan1.0ChiLan1.0
BROX
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,586,043 - 26,608,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,539,467 - 26,561,876 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,385,748 - 198,408,408 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,399,224 - 203,421,920 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,399,224 - 203,421,920 (+)Ensemblpanpan1.1panPan2
BROX
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13816,971,449 - 16,990,673 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3816,971,504 - 16,990,372 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3817,027,790 - 17,047,007 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03817,017,951 - 17,039,102 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3817,017,765 - 17,040,508 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13817,023,182 - 17,044,114 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03817,372,045 - 17,391,207 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03817,667,450 - 17,688,535 (+)NCBIUU_Cfam_GSD_1.0
Brox
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,717,189 - 54,741,113 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365266,496 - 30,743 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365266,185 - 30,108 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BROX
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1011,466,004 - 11,486,974 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11011,466,173 - 11,486,983 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21013,621,400 - 13,636,473 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BROX
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,835,448 - 6,858,097 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,834,584 - 6,858,052 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660557,073,830 - 7,096,754 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Brox
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,240,333 - 5,261,416 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,240,643 - 5,261,299 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Brox
96 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:863
Count of miRNA genes:316
Interacting mature miRNAs:417
Transcripts:ENSRNOT00000004949
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1366451204106807694Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat

Markers in Region
RH102121  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,923,059 - 94,923,193 (+)MAPPERmRatBN7.2
Rnor_6.013101,680,849 - 101,680,982NCBIRnor6.0
Rnor_5.013100,889,321 - 100,889,454UniSTSRnor5.0
RGSC_v3.41399,322,455 - 99,322,588UniSTSRGSC3.4
Celera1394,450,151 - 94,450,284UniSTS
Cytogenetic Map13q26UniSTS
RH138423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,921,598 - 94,921,742 (+)MAPPERmRatBN7.2
Rnor_6.013101,679,388 - 101,679,531NCBIRnor6.0
Rnor_5.013100,887,860 - 100,888,003UniSTSRnor5.0
RGSC_v3.41399,320,994 - 99,321,137UniSTSRGSC3.4
Celera1394,448,690 - 94,448,833UniSTS
Cytogenetic Map13q26UniSTS
RH129815  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21394,920,173 - 94,920,392 (+)MAPPERmRatBN7.2
Rnor_6.013101,677,963 - 101,678,181NCBIRnor6.0
Rnor_5.013100,886,435 - 100,886,653UniSTSRnor5.0
RGSC_v3.41399,319,569 - 99,319,787UniSTSRGSC3.4
Celera1394,447,265 - 94,447,483UniSTS
RH 3.4 Map13653.6UniSTS
Cytogenetic Map13q26UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000078834   ⟹   ENSRNOP00000073617
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,920,112 - 94,939,942 (-)Ensembl
Rnor_6.0 Ensembl13101,677,902 - 101,697,684 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106784   ⟹   ENSRNOP00000089243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,920,112 - 94,940,227 (-)Ensembl
RefSeq Acc Id: NM_001025669   ⟹   NP_001020840
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,451,736 - 97,471,519 (-)NCBI
mRatBN7.21394,920,112 - 94,939,899 (-)NCBI
Rnor_6.013101,677,901 - 101,697,684 (-)NCBI
Rnor_5.013100,886,368 - 100,906,452 (-)NCBI
RGSC_v3.41399,319,507 - 99,339,291 (-)RGD
Celera1394,447,203 - 94,466,862 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250354   ⟹   XP_006250416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,451,736 - 97,471,598 (-)NCBI
mRatBN7.21394,920,107 - 94,940,189 (-)NCBI
Rnor_6.013101,677,896 - 101,697,743 (-)NCBI
Rnor_5.013100,886,368 - 100,906,452 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017598835   ⟹   XP_017454324
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,451,736 - 97,471,349 (-)NCBI
mRatBN7.21394,920,107 - 94,939,759 (-)NCBI
Rnor_6.013101,677,896 - 101,697,611 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272389   ⟹   XP_063128459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,451,736 - 97,471,504 (-)NCBI
RefSeq Acc Id: NP_001020840   ⟸   NM_001025669
- UniProtKB: Q4V8K5 (UniProtKB/Swiss-Prot),   A6JGN3 (UniProtKB/TrEMBL),   A0A8I6ACA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250416   ⟸   XM_006250354
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017454324   ⟸   XM_017598835
- Peptide Label: isoform X1
- UniProtKB: Q4V8K5 (UniProtKB/Swiss-Prot),   A6JGN3 (UniProtKB/TrEMBL),   A0A8I6ACA4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073617   ⟸   ENSRNOT00000078834
Ensembl Acc Id: ENSRNOP00000089243   ⟸   ENSRNOT00000106784
RefSeq Acc Id: XP_063128459   ⟸   XM_063272389
- Peptide Label: isoform X2
Protein Domains
BRO1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8K5-F1-model_v2 AlphaFold Q4V8K5 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699084
Promoter ID:EPDNEW_R9608
Type:initiation region
Name:Brox_1
Description:BRO1 domain and CAAX motif containing
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.013101,697,698 - 101,697,758EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307161 AgrOrtholog
BioCyc Gene G2FUF-17043 BioCyc
Ensembl Genes ENSRNOG00000052963 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055011968 UniProtKB/Swiss-Prot
  ENSRNOG00060007841 UniProtKB/Swiss-Prot
  ENSRNOG00065017859 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000078834.2 UniProtKB/Swiss-Prot
  ENSRNOT00000106784.1 UniProtKB/TrEMBL
  ENSRNOT00055020352 UniProtKB/Swiss-Prot
  ENSRNOT00060012938 UniProtKB/Swiss-Prot
  ENSRNOT00065029896 UniProtKB/Swiss-Prot
Gene3D-CATH 1.25.40.280 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7460070 IMAGE-MGC_LOAD
InterPro BRO1_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BRO1_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  BROX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:305031 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114362 IMAGE-MGC_LOAD
NCBI Gene 305031 ENTREZGENE
PANTHER BRO1 DOMAIN-CONTAINING PROTEIN BROX UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23032 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam BRO1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Brox PhenoGen
PROSITE BRO1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052963 RatGTEx
  ENSRNOG00055011968 RatGTEx
  ENSRNOG00060007841 RatGTEx
  ENSRNOG00065017859 RatGTEx
SMART BRO1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6ACA4 ENTREZGENE, UniProtKB/TrEMBL
  A6JGN3 ENTREZGENE, UniProtKB/TrEMBL
  BROX_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-25 Brox  BRO1 domain and CAAX motif containing   RGD1307161  similar to 0610010K06Rik protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1307161  similar to 0610010K06Rik protein  RGD1307161_predicted  similar to 0610010K06Rik protein (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1307161_predicted  similar to 0610010K06Rik protein (predicted)  LOC305031_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC305031_predicted  similar to 0610010K06Rik protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL